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Melanoma in situ of trunk

CD2_INSITU_MELANOMA_TRUNK

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D03.5&
  • Cause of death: ICD-10 D03.5&

2 out of 7 registries used, show all original rules.

433

4. Check minimum number of events

None

433

5. Include endpoints

None

433

6. Filter based on genotype QC (FinnGen only)

433

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D03
Name in latin
Melanoma in situ trunci

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 433 161 272
Unadjusted period prevalence (%) 0.10 0.05 0.12
Median age at first event (years) 69.20 65.60 71.33

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
371
Matched controls
3710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D03.5
ICD-10 Finland
Melanoma in situ of trunk
+∞
323.0
371
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
80.0
246.1
290
158
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
31.2
104.7
143
73
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
136.0
73.0
76
7
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
286.4
71.0
70
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.7
56.9
140
241
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
10.5
48.1
101
128
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
18.1
47.7
76
52
L57.0
ICD-10 Finland
Actinic keratosis
6.7
43.7
129
275
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
6.6
37.5
108
217
S18
ICPC
Laceration/cut
3.7
30.9
242
1251
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.5
29.7
125
376
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
11.7
28.1
53
52
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
32.0
26.8
35
12
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
29.5
26.3
35
13
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
12.4
26.2
48
44
8720/3-C44.9
ICD-O-3
Malignant melanoma, NOS, of skin, NOS
36.0
26.0
33
10
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
31.7
24.5
32
11
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
5.8
23.7
72
148
C43
ICD-10 Finland
Malignant melanoma of skin
127.9
22.9
24
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
8.4
22.6
51
69
TQW99
NOMESCO Finland
Other minor procedure on skin
5.5
20.2
63
133
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
13.7
19.8
34
27
S82
ICPC
Naevus/mole
4.2
19.5
81
231
8720/2-C44.5
ICD-O-3
Melanoma in situ of skin of trunk
+∞
18.9
18
*
XQ846
NOMESCO Finland
Digital dermatoscopy and registration of nevi
105.4
18.7
20
*
SPAT1153
SPAT
Removal of sutures
2.7
18.4
175
909
L82
ICD-10 Finland
Seborrhoeic keratosis
3.4
18.3
104
384
PJA12
NOMESCO Finland
Sentinel node biopsy
5.4
17.8
56
119
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
25.5
17.5
24
10
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
7.9
17.3
40
56
C43.51
ICD-10 Finland
Malignant melanoma of the trunk originating in lentigo maligna
37.0
16.8
21
6
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
29.1
16.7
22
8
C43.62
ICD-10 Finland
Malignant melanoma of upper extremity including shoulder: 'superficial spreading' type
166.7
15.6
16
*
C43.5
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of trunk
39.9
15.5
19
5
ZZR00
NOMESCO Finland
Flap of skin
7.7
13.9
32
45
S77
ICPC
Malignant neoplasm of skin
14.8
12.9
21
15
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
7.5
12.9
30
43
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
8.9
12.5
26
31
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
11.6
12.2
22
20
D22
ICD-10 Finland
Melanocytic naevi
6.6
11.2
28
45
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
7.3
11.1
26
38
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
16.1
10.9
17
11
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
3.9
10.9
46
131
8743/3-C44.5
ICD-O-3
Low cumulative sun damage melanoma of skin of trunk
61.8
10.7
12
*
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
61.8
10.7
12
*
ZXC50
NOMESCO Finland
Cryotherapy
5.0
10.6
34
74
ZQZ00
NOMESCO Finland
Treatment of several skin areas
15.1
10.1
16
11
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
26.8
9.9
13
5
C43.72
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip: 'superficial spreading' type
20.7
9.9
14
7
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
18.1
9.5
14
8
8743/3-C44.9
ICD-O-3
Low cumulative sun damage melanoma of skin, NOS
30.9
9.5
12
*
D03.7
ICD-10 Finland
Melanoma in situ of lower limb, including hip
30.9
9.5
12
*
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
12.8
9.4
16
13
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
7.0
9.3
22
33
XQ845
NOMESCO Finland
Dermatoscopy
9.4
9.1
18
20
D06BB10
ATC
imiquimod; topical
4.3
9.1
33
82
D23.5
ICD-10 Finland
Benign neoplasm: Skin of trunk
7.6
8.6
19
26
C43.70
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip without histology
45.9
7.7
9
*
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
18.8
7.6
11
6
ZXC20
NOMESCO Finland
Use of chemical agents
6.0
7.6
20
35
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
9.1
7.6
15
17
C44.91
ICD-10 Finland
Unspecified localization of basocellular carcinoma of the skin
25.6
7.6
10
*
D03.9
ICD-10 Finland
Melanoma in situ, unspecified
81.6
7.4
8
*
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
13.7
7.4
12
9
S29
ICPC
Skin symptom/complaint other
2.2
7.4
83
432
XQ848
NOMESCO Finland
Dermatological photography
4.8
7.3
23
50
8742/2-C44.5
ICD-O-3
Lentigo maligna of skin of trunk
+∞
7.3
7
*
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
6.8
7.2
17
26
Z2221
NOMESCO Finland
Medical doctor
1.9
7.1
119
728
A98
ICPC
Health maint/preventive medicine
3.0
6.9
351
3174
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
6.6
6.7
16
25
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
3.8
6.5
26
72
8742/3-C44.9
ICD-O-3
Lentigo maligna melanoma of skin, NOS
71.0
6.4
7
*
180
Kela drug reimbursment
Interferon alfa
14.6
6.4
10
7
L01XE23
ATC
[U] dabrafenib; oral
+∞
6.3
6
*
D06BX02
ATC
ingenol mebutate; topical
7.9
6.2
13
17

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_MELANOMA_TRUNK – Melanoma in situ of trunk

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).