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Melanoma in situ of scalp and neck

CD2_INSITU_MELANOMA_SCALPNECK

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D03.4&
  • Cause of death: ICD-10 D03.4&

2 out of 7 registries used, show all original rules.

76

4. Check minimum number of events

None

76

5. Include endpoints

None

76

6. Filter based on genotype QC (FinnGen only)

76

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D03
Name in latin
Melanoma in situ verticis cranii

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 76 25 51
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 70.48 71.86 69.80

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
70
Matched controls
700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D03.4
ICD-10 Finland
Melanoma in situ of scalp and neck
+∞
100.6
70
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
55.1
42.4
57
51
L57.0
ICD-10 Finland
Actinic keratosis
9.1
12.9
30
53
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.8
12.3
29
52
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
142.5
11.8
12
*
D22.4
ICD-10 Finland
Melanocytic naevi of scalp and neck
52.4
11.4
13
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
9.9
10.2
21
29
R23.8
ICD-10 Finland
Other and unspecified skin changes
6.0
9.2
29
74
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
15.5
8.8
14
11
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
7.2
7.4
18
32
S18
ICPC
Laceration/cut
4.1
7.3
48
242
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
19.1
7.0
10
6
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
25.4
6.9
9
*
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
76.5
6.5
7
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
29.6
6.4
8
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
10.1
6.4
12
14

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_MELANOMA_SCALPNECK – Melanoma in situ of scalp and neck

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).