Melanoma in situ of scalp and neck

CD2_INSITU_MELANOMA_SCALPNECK

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D03.4& Cause of death: ICD-10 — D03.4& 2 out of 7 registries used, show all original rules.	76
4. Check minimum number of events None	76
5. Include endpoints None	76
6. Filter based on genotype QC (FinnGen only)	76

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D03
Name in latin: Melanoma in situ verticis cranii

NAME	CD2_INSITU_MELANOMA_SCALPNECK
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D034
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D034
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Melanoma in situ of scalp and neck based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Melanoma in situ of scalp and neck

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	76	25	51
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	70.48	71.86	69.80

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
70: Matched controls
700

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D03.4

ICD-10 Finland

Melanoma in situ of scalp and neck

+∞

100.6

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

55.1

42.4

L57.0

ICD-10 Finland

Actinic keratosis

9.1

12.9

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

8.8

12.3

8720/2-C44.9

ICD-O-3

Melanoma in situ of skin, NOS

142.5

11.8

D22.4

ICD-10 Finland

Melanocytic naevi of scalp and neck

52.4

11.4

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

9.9

10.2

R23.8

ICD-10 Finland

Other and unspecified skin changes

6.0

9.2

D22.9

ICD-10 Finland

Melanocytic naevi, unspecified

15.5

8.8

D48.5

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Skin

7.2

7.4

S18

ICPC

Laceration/cut

4.1

7.3

242

D04.3

ICD-10 Finland

Carcinoma in situ: Skin of other and unspecified parts of face

19.1

7.0

D03.31

ICD-10 Finland

Melanoma in situ in another or unspecified part of the face

25.4

6.9

8742/2-C44.9

ICD-O-3

Lentigo maligna of skin, NOS

76.5

6.5

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

29.6

6.4

QXA25

NOMESCO Finland

Destruction of lesion of skin, site unspecified

10.1

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

13.34

30.09

1.9

1.2

—

(40768804) Tissue Pathology biopsy report

240

8.13

15.20

4.3

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

313

2.75

4.21

6.2

5.0

35.2

34.6

g/l

0.36

295

(42870588) Differential panel, method unspecified - Blood

225

2.64

4.17

9.0

5.0

—

(3037522) Nuclear Ab [Titer] in Serum

3.04

3.82

1.6

1.4

573.3

429.5

titre

—

(4035726)

3.06

3.39

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

115

2.59

3.35

3.5

2.9

1.3

1.7

e6/l

0.14

(3013115) Eosinophils [#/volume] in Blood

329

2.38

3.20

9.3

5.6

0.2

e9/l

0.82

290

(3018095) Leukocytes [#/volume] in Urine

257

2.29

3.12

4.9

3.7

305.2

70.2

e6/l

0.71

192

(3002582) Erythrocytes [#/volume] in Urine

226

2.24

2.96

4.1

3.3

99.9

56.4

e6/l

0.37

178

(3001604) Monocytes [#/volume] in Blood

320

2.23

2.84

9.0

5.2

0.7

0.6

e9/l

0.39

267

(3006315) Basophils [#/volume] in Blood

321

2.22

2.80

9.0

5.3

0.0

e9/l

0.24

273

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

455

2.51

2.77

3.3

3.7

15.4

15.0

pmol/l

0.49

380

(36304419) Bacteria [Presence] in Urine

197

2.19

2.75

3.8

2.8

—

(40768443) Skin Pathology biopsy report

3.94

2.67

1.0

1.2

—

(3036489) Thrombin time

4.13

2.54

1.5

2.4

23.3

21.4

—

(3019198) Lymphocytes [#/volume] in Blood

329

2.12

2.54

9.2

5.2

1.8

1.7

e9/l

0.26

294

(3009542) Hematocrit [Volume Fraction] of Blood

533

2.81

2.50

22.2

18.7

41.1

39.2

1.41

319

(3005719) IgG [Mass/volume] in Serum or Plasma

2.91

2.50

2.8

2.7

10.7

10.1

g/l

0.15

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

123

2.25

2.46

3.2

2.5

0.4

1.0

e6/l

1.08

(3015377) Calcium [Moles/volume] in Serum or Plasma

231

2.06

2.42

4.9

3.8

2.4

2.3

mmol/l

0.65

194

(3021589) Normoblasts [#/volume] in Blood

276

2.05

2.42

12.8

11.2

0.0

e9/l

0.50

232

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

327

2.03

2.30

8.7

7.1

1.2

mmol/l

0.67

291

(3007164) IgA [Mass/volume] in Serum or Plasma

104

2.25

2.27

1.9

1.6

2.4

3.3

g/l

0.71

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

168

2.06

2.22

1.9

1.7

1.6

1.3

mmol/l

0.58

130

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

3.95

2.21

1.3

1.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.74

2.11

1.4

2.3

75.3

84.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

608

2.91

2.07

22.0

17.3

72.0

73.3

ml/min/173m2

0.19

497

(3013650) Neutrophils [#/volume] in Blood by Automated count

385

1.99

2.05

12.6

9.6

4.4

4.3

e9/l

0.04

334

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

528

2.34

1.98

9.5

8.1

77.0

82.2

u/l

0.60

488

(3034770) Mitochondria Ab [Titer] in Serum

3.98

1.97

1.5

1.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

613

2.80

1.91

5.8

5.1

4.4

mmol/l

0.19

550

(40760888) Immunoglobulin light chains.free panel - Serum

3.74

1.87

12.2

6.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

353

1.87

1.83

10.5

8.2

1.2

mmol/l

0.33

292

(3030467) Casts [#/volume] in Urine by Automated count

213

1.87

1.83

4.0

2.9

0.1

0.3

e6/l

1.34

167

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

1.78

0.0

2.0

—

7.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.04

1.74

1.0

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.04

1.74

1.0

1.6

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

2.46

1.73

1.1

2.0

1.4

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.46

1.73

1.1

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.76

1.71

1.0

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

208

1.83

1.71

4.3

3.2

0.7

0.8

ug/l

0.18

149

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.98

1.69

1.6

2.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.19

1.67

2.8

1.7

—

(3000492) Spirometry study

2.40

1.66

1.8

1.6

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.74

1.64

1.4

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

110

1.97

1.62

2.8

2.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

598

2.30

1.61

4.9

4.5

1.4

1.3

mmol/l

0.57

526

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

285

1.76

1.59

2.0

2.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.35

1.59

1.2

1.7

—

(3018418) pH of Serum or Plasma

213

1.77

1.56

5.2

4.5

7.4

—

(3052851) Hemolysis interference index of Serum or Plasma

3.49

1.55

3.0

4.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.49

1.55

1.0

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

610

2.42

1.53

6.0

5.1

1.4

mmol/l

0.05

539

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.55

1.52

2.8

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.55

1.52

3.3

2.7

—

(40768797) Stomach Pathology biopsy report

1.97

1.50

1.5

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

471

1.84

1.47

4.9

4.0

14.4

14.2

mm/h

0.03

422

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

271

1.71

1.47

4.6

3.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.27

1.46

1.4

1.6

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.55

1.43

1.0

1.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

574

2.14

1.42

5.1

4.5

2.2

2.1

mu/l

0.12

493

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.07

1.38

1.0

1.1

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.07

1.38

1.0

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

609

2.11

1.33

7.7

7.1

41.4

41.7

mmol/mol

0.07

560

(3004588) Protein electrophoresis panel - Serum or Plasma

2.07

1.31

4.6

2.7

—

(3009508) Creatinine [Moles/volume] in Urine

232

1.66

1.28

4.5

3.3

8.0

7.6

mmol/l

0.16

178

(3037467) Urinalysis macro (dipstick) panel - Urine

459

1.72

1.26

5.2

4.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.04

1.26

1.1

1.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.09

1.24

1.9

3.2

26.2

44.3

u/l

0.77

(3024928) Oxygen saturation in Venous blood

2.74

1.23

3.6

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.94

1.20

2.8

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.17

1.19

1.1

1.2

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.60

1.17

1.2

1.6

—

(3012544) pH of Venous blood

1.88

1.11

2.7

4.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

2.47

1.11

2.8

1.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.47

1.11

1.4

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

177

1.61

1.07

2.6

2.7

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

260

1.56

1.06

2.4

2.3

83.5

77.3

nmol/l

0.53

210

(3000494) Fungus identified in Specimen by Culture

101

1.74

1.04

1.4

1.3

—

(36660697) Celiac disease serology panel - Serum

2.10

1.03

1.0

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.32

0.96

1.3

2.7

—

(3012516) Albumin [Mass/volume] in Urine

230

1.50

0.89

5.1

3.4

49.4

64.8

mg/l

0.29

156

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.81

0.88

2.8

1.6

370.5

390.2

nmol/l

0.09

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.64

0.83

5.5

4.9

33.1

32.3

—

(3013512) EKG study

234

1.47

0.81

5.6

5.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.80

0.0

6.0

—

(3032080) INR in Blood by Coagulation assay

321

1.44

0.79

9.3

11.6

1.2

1.4

inr

—

(3021601) Nitrite [Presence] in Urine by Test strip

322

1.43

0.78

5.2

5.4

0.0

estimate

—

(3020682) Albumin/Creatinine [Ratio] in Urine

248

1.42

0.72

5.6

4.2

10.3

9.2

mg/mmol

0.10

161

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.78

0.72

3.0

4.3

0.0

0.1

e6/l

—

(3009261) Glucose [Presence] in Urine by Test strip

326

1.40

0.71

4.4

4.1

0.0

estimate

—

(3019225) pH of Specimen

1.59

0.60

9.4

5.2

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.72

0.58

2.7

2.2

—

(40758558) Short blood count panel - Blood

172

1.39

0.57

10.3

6.7

—

(40761536) Microorganisms panel - Urine sediment

1.59

0.56

3.7

3.9

—

(3000991) Gas panel - Venous blood

1.46

0.54

11.9

10.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

322

0.75

0.52

4.7

4.5

40.9

61.9

ng/l

0.58

251

(3035350) Ketones [Presence] in Urine by Test strip

320

1.30

0.49

4.5

4.1

0.0

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

233

1.32

0.48

2.7

—

(4010399)

1.44

0.46

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

141

1.36

0.46

4.6

4.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.45

0.45

5.3

5.2

4.5

60.2

ug/l

0.57

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(3049717) Cytology report of Urine Cyto stain

1.50

0.41

1.6

2.7

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.41

0.0

2.1

—

5.1

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.41

0.0

2.2

—

1.6

—

(3022145) Colonoscopy Study observation

1.34

0.39

1.8

1.4

—

(3042936) Bacteria identified in Isolate by Culture

117

1.35

0.39

1.2

1.8

—

(40761511) CBC panel - Blood by Automated count

636

1.45

0.39

18.6

18.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

298

1.26

0.38

5.6

4.7

19.7

21.4

0.34

165

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

378

1.25

0.37

6.9

5.4

2.4

3.1

ug/l

0.34

329

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

310

1.24

0.35

3.8

4.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.33

0.31

1.6

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

131

1.28

0.30

5.6

4.6

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

131

1.28

0.30

3.1

1.8

31.2

29.8

0.28

126

(3023368) Bacteria identified in Blood by Culture

236

1.22

0.30

5.2

4.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

316

1.20

0.28

2.6

2.1

83.8

92.8

pmol/l

0.47

155

(3026008) Bacteria identified in Urine by Culture

220

1.20

0.25

3.6

3.0

—

(1761868) Lipid panel - Serum or Plasma

183

1.20

0.23

4.1

3.6

—

(3029937) Albumin [Presence] in Urine by Test strip

193

1.20

0.23

5.0

4.4

0.0

estimate

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.27

0.23

5.8

9.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.7

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.3

—

(4094501)

0.00

0.21

0.0

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.3

—

90.7

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

4.4

—

105.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

4.4

—

4.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

4.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.20

0.0

4.3

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.5

—

90.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

188

1.16

0.17

3.8

3.7

—

(40761535) Cells panel - Urine sediment

1.16

0.17

3.1

3.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

0.77

0.15

1.6

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.04

0.09

15.8

7.1

25.6

24.9

mmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.04

0.09

20.2

9.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.14

0.09

2.0

1.5

—

(3019060) Gas panel - Arterial blood

1.10

0.08

2.4

4.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.03

0.07

2.0

2.4

0.3

0.2

g/l

—

(3022948) Iron [Moles/volume] in Serum or Plasma

139

1.10

0.06

2.0

2.3

16.2

12.8

umol/l

1.15

123

(3003694) ABO and Rh group [Type] in Blood

160

1.08

0.04

1.2

1.3

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

121

1.09

0.04

1.8

2.2

27.5

21.7

0.95

104

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

260

1.06

0.04

4.6

4.4

—

(3044889) 12 lead EKG panel

483

0.98

0.00

5.5

4.4

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

126

1.04

0.00

1.9

2.2

2.3

g/l

0.26

110

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

176

1.03

0.00

1.3

1.8

342.1

449.6

pmol/l

2.29

144

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.6

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.3

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(4306422)

0.00

0.0

1.3

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.7

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.6

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

2.4

—

0.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

15.7

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.6

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.1

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

26.8

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.4

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.4

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.4

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.1

—

101.8

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.4

—

2.6

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

2.8

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.4

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.6

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

0.84

0.00

2.8

2.3

116.4

220.3

ug/g

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.98

0.00

7.5

3.0

4.6

4.9

kpa

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.00

0.00

2.1

3.9

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(44806420)

0.00

0.0

2.8

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.6

—

7.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_MELANOMA_SCALPNECK – Melanoma in situ of scalp and neck

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Melanoma in situ of scalp and neck

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Melanoma in situ of scalp and neck (CD2_INSITU_MELANOMA_SCALPNECK)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints