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This is a non-core endpoint: only basic statistics are computed.

Melanoma in situ of trunk

CD2_INSITU_MELANOMA_TRUNK_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D03.5&
  • Cause of death: ICD-10 D03.5&

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D03
Name in latin
Melanoma in situ trunci

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 433 161 272
Unadjusted period prevalence (%) 0.10 0.05 0.12
Median age at first event (years) 69.20 65.60 71.33

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
371
Matched controls
3710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D03.5
ICD-10 Finland
Melanoma in situ of trunk
+∞
323.0
371
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
181.6
293.7
290
71
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
35.6
108.9
143
64
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
+∞
82.4
76
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
15.2
78.1
140
142
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
856.2
73.8
70
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
296.5
73.2
72
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
23.3
73.2
108
64
L57.0
ICD-10 Finland
Actinic keratosis
12.1
64.9
129
156
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
19.4
64.2
101
70
PJA12
NOMESCO Finland
Sentinel node biopsy
653.8
58.3
56
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
51.2
48
*
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
20.9
50.3
76
45
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
196.3
50.2
51
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
49.0
46
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
45.8
43
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
6.5
41.8
125
269
130
Kela drug reimbursment
Malignant tumour
+∞
39.3
37
*
S18
ICPC
Laceration/cut
4.3
38.8
242
1120
TQW99
NOMESCO Finland
Other minor procedure on skin
15.2
37.3
63
49
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
+∞
37.1
35
*
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
+∞
37.1
35
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
22.7
36.5
53
27
8720/3-C44.9
ICD-O-3
Malignant melanoma, NOS, of skin, NOS
+∞
34.9
33
*
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
+∞
33.9
32
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
19.5
31.5
48
28
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
41.3
27.6
34
9
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
27.4
26
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
27.4
26
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
19.3
26.4
40
23
ZZR00
NOMESCO Finland
Flap of skin
38.7
25.6
32
9
115
Kela drug reimbursment
Breast cancer
+∞
25.3
24
*
C43
ICD-10 Finland
Malignant melanoma of skin
+∞
25.3
24
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
+∞
23.2
22
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
29.5
22.6
30
11
ZXC50
NOMESCO Finland
Cryotherapy
18.6
22.2
34
20
C43.51
ICD-10 Finland
Malignant melanoma of the trunk originating in lentigo maligna
+∞
22.1
21
*
116
Kela drug reimbursment
Prostate cancer
+∞
22.1
21
*
S77
ICPC
Malignant neoplasm of skin
+∞
22.1
21
*
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
85.4
21.9
24
*
L82
ICD-10 Finland
Seborrhoeic keratosis
3.9
21.9
104
337
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
21.0
20
*
XQ846
NOMESCO Finland
Digital dermatoscopy and registration of nevi
+∞
21.0
20
*
SPAT1153
SPAT
Removal of sutures
3.0
20.9
175
859
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
20.0
19
*
C43.5
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of trunk
+∞
20.0
19
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
24.1
19.3
27
12
8720/2-C44.5
ICD-O-3
Melanoma in situ of skin of trunk
+∞
18.9
18
*
S82
ICPC
Naevus/mole
4.1
18.7
81
239
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
21.4
18.0
26
13
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
+∞
17.8
17
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
17.8
17
*
JN4BD
NOMESCO Finland
Extensive body CT
5.8
17.5
51
99
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
16.8
16
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
16.8
16
*
C43.62
ICD-10 Finland
Malignant melanoma of upper extremity including shoulder: 'superficial spreading' type
+∞
16.8
16
*
WF002
NOMESCO Finland
Radical radiotherapy
94.3
16.7
18
*
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
+∞
15.7
15
*
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
23.3
15.7
22
10
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
19.4
14.9
22
12
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
83.4
14.7
16
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
14.7
14
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
14.7
14
*
C43.72
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip: 'superficial spreading' type
+∞
14.7
14
*
L02BG04
ATC
letrozole; oral
155.8
14.6
15
*
L02AE02
ATC
leuprorelin; implant, parenteral
31.4
14.0
18
6
ZQZ00
NOMESCO Finland
Treatment of several skin areas
55.5
13.9
16
*
H02AB02
ATC
dexamethasone; systemic
13.5
13.6
23
18
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.6
13.6
122
589
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
29.6
13.1
17
6
8743/3-C44.9
ICD-O-3
Low cumulative sun damage melanoma of skin, NOS
+∞
12.6
12
*
8743/3-C44.5
ICD-O-3
Low cumulative sun damage melanoma of skin of trunk
+∞
12.6
12
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
12.6
12
*
Z2221
NOMESCO Finland
Medical doctor
2.5
12.3
119
593
D06BB10
ATC
imiquimod; topical
6.1
12.3
33
58
ZXC20
NOMESCO Finland
Use of chemical agents
14.0
12.1
20
15
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
48.3
12.0
14
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.1
11.7
37
79
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
67.1
11.7
13
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
11.5
11
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
11.5
11
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
11.5
11
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
11.5
11
*
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
+∞
11.5
11
*
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
123.6
11.5
12
*
N02BE01
ATC
paracetamol; systemic, rectal
2.6
10.8
322
2646
D03.7
ICD-10 Finland
Melanoma in situ of lower limb, including hip
61.8
10.7
12
*
D22
ICD-10 Finland
Melanocytic naevi
6.1
10.5
28
49
L02BB03
ATC
bicalutamide; oral
113.0
10.5
11
*
L02BA01
ATC
tamoxifen; oral
113.0
10.5
11
*
180
Kela drug reimbursment
Interferon alfa
+∞
10.5
10
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
10.5
10
*
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
+∞
10.5
10
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
10.5
10
*
C44.91
ICD-10 Finland
Unspecified localization of basocellular carcinoma of the skin
+∞
10.5
10
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
10.5
10
*
XQ845
NOMESCO Finland
Dermatoscopy
12.5
10.5
18
15
D23.5
ICD-10 Finland
Benign neoplasm: Skin of trunk
11.1
10.4
19
18
S29
ICPC
Skin symptom/complaint other
2.5
9.9
83
378
HAB40
NOMESCO Finland
Wedge excision of mammary gland
56.5
9.7
11
*
XQ848
NOMESCO Finland
Dermatological photography
6.9
9.6
23
35
Y77
ICPC
Malignant neoplasm prostate
+∞
9.4
9
*
C43.53
ICD-10 Finland
Malignant melanoma of the torso nodular
+∞
9.4
9
*
C43.70
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip without histology
+∞
9.4
9
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
9.4
9
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
9.4
9
*
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
6.3
9.4
24
40
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
11.1
9.4
17
16
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
7.8
9.0
20
27
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
24.7
9.0
12
5
ZXC15
NOMESCO Finland
Use of photodynamic technique
24.7
9.0
12
5
S26
ICPC
Fear of cancer of skin
16.8
8.6
13
8
Z31.5
ICD-10 Finland
Genetic counselling
8.2
8.5
18
23
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
8.2
8.5
18
23
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.1
8.4
15
14
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
8.4
8
*
8097/3-C44.9
ICD-O-3
Basal cell carcinoma, nodular of skin, NOS
+∞
8.4
8
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
8.4
8
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
L01BC06
ATC
capecitabine; oral
+∞
8.4
8
*
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
+∞
8.4
8
*
D03.9
ICD-10 Finland
Melanoma in situ, unspecified
+∞
8.4
8
*
ZXE00
NOMESCO Finland
One hour or less
2.0
8.1
144
905
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
8.1
137
847
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
8.0
97
524
A03FA01
ATC
metoclopramide; systemic, rectal
2.8
8.0
53
209
S21
ICPC
Skin texture symptom/complaint
2.7
7.9
56
231
XKD00
NOMESCO Finland
Uroflowmetry
2.3
7.9
84
426
JN4AD
NOMESCO Finland
Body CT examination
4.8
7.8
25
55
HA1AA
NOMESCO Finland
X-ray mammography
6.4
7.6
19
31
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.1
7.6
94
510
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
25.6
7.6
10
*
WX110
NOMESCO Finland
Local anesthesy
1.9
7.5
240
1842
WZC30
NOMESCO Finland
Teaching
2.7
7.5
50
199
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
81.6
7.4
8
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
81.6
7.4
8
*
A98
ICPC
Health maint/preventive medicine
3.1
7.4
351
3155
Z51.5
ICD-10 Finland
Palliative care
5.6
7.3
20
37
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
7.3
7
*
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
7.3
7
*
C43.69
ICD-10 Finland
Malignant melanoma of the upper extremity including shoulder other or unspecified histology
+∞
7.3
7
*
8742/2-C44.5
ICD-O-3
Lentigo maligna of skin of trunk
+∞
7.3
7
*
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
+∞
7.3
7
*
8742/3-C44.9
ICD-O-3
Lentigo maligna melanoma of skin, NOS
+∞
7.3
7
*
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
+∞
7.3
7
*
8720/3-C44.6
ICD-O-3
Malignant melanoma, NOS, of skin of upper limb and shoulder
+∞
7.3
7
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
+∞
7.3
7
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.4
6.9
24
58
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
9.6
6.8
13
14
E0000UV
ATC
NA
1.9
6.8
137
889
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
17.1
6.8
10
6
J01DB01
ATC
cefalexin; oral
1.9
6.6
292
2438
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.2
6.6
68
339
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
6.5
69
348
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
71.0
6.4
7
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
71.0
6.4
7
*
QBE00
NOMESCO Finland
Excision of loose skin or fold of skin from trunk
14.6
6.4
10
7
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
167
Kela drug reimbursment
Dabrafenib, trametinib and vemurafenib
+∞
6.3
6
*
1509
Kela drug reimbursment
Dabrafenib (adjuvant treatment)
+∞
6.3
6
*
A79
ICPC
Malignancy NOS
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
L01XE23
ATC
[U] dabrafenib; oral
+∞
6.3
6
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
6.3
6
*
C44
ICD-10 Finland
Other malignant neoplasms of skin
+∞
6.3
6
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
6.3
6
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
6.3
6
*
C43.30
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face without histology
+∞
6.3
6
*
3024
Kela drug reimbursment
Dabrafenib and trametinib (adjuvant treatment)
+∞
6.3
6
*
C43.71
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip originating in lentigo maligna
+∞
6.3
6
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
27.2
6.2
8
*
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
27.2
6.2
8
*
R4110
NOMESCO Finland
Physiotherapy
1.9
6.2
93
543
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
12.8
6.1
10
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_MELANOMA_TRUNK_EXALLC – Melanoma in situ of trunk

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).