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Melanoma in situ, other sites/unspecified

CD2_INSITU_MELANOMA_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

102

4. Check minimum number of events

None

102

5. Include endpoints

None

102

6. Filter based on genotype QC (FinnGen only)

102

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 102 52 50
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 66.86 63.36 70.50

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
928
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D03.9
ICD-10 Finland
Melanoma in situ, unspecified
+∞
98.0
76
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
29.5
28.6
39
22
D03.8
ICD-10 Finland
Melanoma in situ of other sites
+∞
20.6
19
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
22.6
16.7
24
14
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
176.6
14.9
15
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.7
11.1
27
47
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
9.1
9.6
20
27
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
+∞
9.5
9
*
L57.0
ICD-10 Finland
Actinic keratosis
5.8
9.3
28
64
8720/3-C44.9
ICD-O-3
Malignant melanoma, NOS, of skin, NOS
41.1
9.2
11
*
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
11.8
8.9
16
16
D03.5
ICD-10 Finland
Melanoma in situ of trunk
55.4
8.9
10
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
14.7
8.7
14
11
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
98.6
8.6
9
*
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
9.2
8.3
17
22
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.5
8.2
25
58
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
14.9
8.2
13
10
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.1
7.1
30
97
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
43.3
6.9
8
*
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
43.3
6.9
8
*
C43.99
ICD-10 Finland
Unspecified localization of malignant melanoma of the skin other or unspecified histology
74.8
6.5
7
*
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
74.8
6.5
7
*
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
+∞
6.3
6
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
16.4
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
113
7.13
21.67
1.8
1.2
—
—
—
0
0
83
345
8.55
19.93
4.7
2.2
—
—
—
0
0
28
76
4.70
9.99
1.5
1.3
—
—
—
0
0
7
8
9.28
3.83
1.1
1.3
—
—
—
0
0
22
94
2.71
3.73
1.9
1.7
—
—
—
0
0
80
604
2.50
3.64
5.2
3.9
14.9
14.9
pmol/l
0.04
71
538
58
391
2.12
3.39
5.9
6.0
1.2
1.2
mmol/l
0.73
52
351
45
279
2.10
3.25
3.0
2.1
—
—
—
0
0
58
402
2.03
3.03
3.4
3.9
0.0
0.0
estimate
0.00
15
78
59
414
2.01
2.95
3.4
3.9
0.0
0.0
estimate
0.00
16
72
58
407
1.99
2.88
4.2
5.2
0.0
0.0
estimate
0.00
16
77
41
261
1.95
2.65
4.4
4.0
—
—
—
0
0
5
7
7.43
2.57
1.0
1.1
—
—
—
0
0
15
64
2.58
2.53
3.7
3.5
—
—
—
0
0
64
486
1.85
2.30
9.5
8.6
3.9
4.3
e9/l
0.78
55
426
31
188
1.93
2.26
5.1
4.6
—
—
—
0
0
52
374
1.80
2.20
3.8
3.8
32.6
45.9
ng/l
0.57
35
269
44
301
1.81
2.20
3.1
3.9
—
—
—
0
0
40
266
1.83
2.19
3.4
3.0
7.3
7.4
mmol/l
0.04
31
215
72
578
1.84
2.04
5.5
4.2
—
—
—
0
0
16
79
2.22
1.98
3.6
2.0
548.1
408.7
nmol/l
0.34
16
72
30
189
1.83
1.92
2.8
2.6
10.7
4.7
e6/l
0.62
25
164
14
67
2.26
1.86
1.1
1.6
—
—
—
0
0
89
776
2.15
1.83
4.9
4.3
1.3
1.3
mmol/l
0.36
82
693
38
261
1.73
1.81
3.5
3.0
43.4
291.4
mg/l
0.51
27
170
40
279
1.71
1.81
4.9
3.8
11.5
7.4
mg/mmol
0.21
26
176
34
228
1.74
1.76
4.1
4.2
0.0
0.0
estimate
0.00
15
74
13
62
2.26
1.74
5.7
2.4
5.1
5.0
kpa
0.32
13
55
33
221
1.73
1.71
3.8
3.7
—
—
—
0
0
38
265
1.69
1.70
3.4
2.9
—
—
—
0
0
32
214
1.72
1.66
2.8
2.1
3.4
2.9
mg/l
0.64
27
188
92
820
2.24
1.65
21.9
15.3
22.3
25.3
mg/l
0.47
82
664
86
749
1.94
1.65
6.3
4.7
2.1
1.9
mu/l
0.31
77
668
95
868
2.38
1.60
23.9
17.9
88.1
81.3
umol/l
0.45
95
868
55
427
1.63
1.60
7.0
5.5
0.2
0.2
e9/l
0.98
47
376
13
65
2.15
1.57
5.8
4.0
—
—
—
0
0
43
318
1.61
1.50
3.3
3.3
2.4
2.3
mmol/l
0.15
37
275
53
414
1.58
1.46
6.7
5.2
0.6
0.6
e9/l
0.09
45
355
53
414
1.58
1.46
6.7
5.3
0.0
0.0
e9/l
0.18
45
356
18
105
1.87
1.45
1.1
1.3
—
—
—
0
0
37
266
1.61
1.44
4.0
3.2
16.4
279.5
e6/l
0.56
31
204
9
41
2.31
1.41
6.8
2.5
—
—
—
0
0
33
232
1.62
1.40
3.9
2.6
347.1
3802.2
umol/l
0.76
27
186
9
42
2.25
1.38
1.7
1.3
—
—
—
0
0
9
43
2.20
1.34
2.3
1.7
—
—
—
0
0
9
43
2.20
1.34
2.2
1.9
1.4
1.8
g/l
—
9
36
90
811
1.93
1.32
5.5
4.8
4.5
4.5
mmol/l
0.04
83
742
15
85
1.90
1.31
6.4
3.8
—
—
—
0
0
53
423
1.53
1.28
6.7
5.4
1.8
1.8
e9/l
0.08
47
374
33
237
1.58
1.27
3.9
3.1
2.0
0.6
e6/l
0.34
27
174
40
302
1.53
1.24
4.4
3.7
84.4
71.9
e6/l
0.11
33
221
90
816
1.88
1.22
5.8
4.9
6.4
6.0
mmol/l
0.73
81
737
89
805
1.83
1.21
5.5
4.7
1.5
1.5
mmol/l
0.02
82
726
92
843
1.93
1.15
22.3
14.5
—
—
—
0
0
12
66
1.93
1.14
4.8
3.3
0.6
0.8
%
—
5
20
16
98
1.75
1.11
1.1
1.3
—
—
—
0
0
47
375
1.47
1.09
13.8
7.6
1.2
1.2
inr
0.05
16
107
26
183
1.56
1.08
2.4
3.8
—
—
—
0
0
81
722
1.59
1.07
19.1
16.2
37.8
39.8
%
0.83
48
489
43
339
1.46
1.05
4.0
2.6
200.6
125.4
ug/l
0.82
38
305
17
109
1.67
1.01
2.8
2.6
1.9
1.8
%
0.11
17
96
0
29
0.00
0.99
0.0
1.1
—
—
—
0
0
90
831
1.71
0.93
5.9
5.4
2.6
2.6
mmol/l
0.00
83
754
31
236
1.45
0.89
3.9
2.9
—
—
—
0
0
41
330
1.41
0.87
5.8
5.0
2.6
2.0
ug/l
0.43
35
288
0
24
0.00
0.80
0.0
1.3
—
—
—
0
0
5
24
2.14
0.75
1.6
2.2
—
—
—
0
0
46
385
1.35
0.75
8.3
5.4
9.0
8.6
%
0.21
40
359
46
385
1.35
0.75
7.7
5.1
2.5
2.7
%
0.30
40
356
7
42
1.71
0.70
1.4
1.4
—
—
—
0
0
5
29
1.76
0.64
4.6
3.9
—
—
—
0
0
26
203
1.38
0.64
1.6
1.8
393.3
465.1
pmol/l
0.86
20
174
26
203
1.38
0.64
1.7
1.3
—
—
—
0
0
33
268
1.34
0.64
5.7
3.8
7.4
7.4
ph
0.08
11
51
66
593
1.32
0.62
5.2
4.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
0.3
—
0
20
46
395
1.30
0.60
8.0
5.3
27.2
25.9
%
0.33
40
365
42
359
1.29
0.56
15.6
9.6
0.0
0.0
e9/l
0.47
33
283
6
38
1.61
0.55
1.5
4.8
—
—
—
0
0
83
777
1.37
0.54
7.4
6.3
42.5
40.9
mmol/mol
0.62
74
722
43
371
1.27
0.53
8.0
5.0
0.6
0.6
%
0.12
38
343
17
130
1.37
0.48
1.7
1.8
—
—
—
0
0
32
270
1.27
0.46
7.9
5.0
—
—
—
0
0
44
387
1.24
0.45
7.9
5.1
56.0
58.8
%
0.60
38
361
34
291
1.25
0.44
3.3
3.4
—
—
—
0
0
29
244
1.26
0.43
1.5
1.6
23.7
20.8
nmol/l
0.23
21
203
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
118.6
—
0
7
5
34
1.49
0.41
2.8
2.9
—
—
—
0
0
23
190
1.27
0.39
4.7
3.0
1.0
0.8
ug/l
0.41
14
118
0
19
0.00
0.39
0.0
2.4
—
204.7
—
0
19
9
71
1.29
0.37
1.8
1.6
—
—
—
0
0
16
127
1.31
0.36
1.4
1.3
—
—
—
0
0
6
46
1.32
0.33
1.2
1.4
0.8
1.1
g/l
—
6
38
16
129
1.29
0.33
1.1
1.3
1.5
19.5
u/ml
—
7
54
41
369
1.19
0.31
2.4
2.0
98.5
92.7
pmol/l
0.22
21
181
7
54
1.32
0.31
1.4
1.7
8.6
11.0
g/l
—
7
45
7
56
1.27
0.30
1.7
1.6
—
—
—
0
0
22
187
1.23
0.30
2.4
1.7
1191.2
1143.1
nmol/l
0.08
13
135
10
76
1.35
0.29
2.3
2.4
—
—
—
0
0
13
104
1.29
0.28
1.8
3.0
11.1
9.3
umol/l
0.11
13
88
9
73
1.26
0.26
2.7
3.4
142.4
223.3
ng/l
—
9
63
6
85
0.69
0.25
2.2
6.4
1.0
1.3
mmol/l
—
6
80
0
11
0.00
0.21
0.0
1.5
—
1.0
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
52.7
—
0
6
0
12
0.00
0.21
0.0
3.7
—
4.9
—
0
12
6
47
1.29
0.21
2.8
2.4
—
—
—
0
0
0
14
0.00
0.20
0.0
9.3
—
105.4
—
0
14
0
14
0.00
0.20
0.0
9.3
—
11.4
—
0
14
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
7
59
1.20
0.18
1.6
1.2
—
—
—
0
0
6
77
0.77
0.16
1.5
1.4
—
—
—
0
0
10
83
1.23
0.16
1.9
1.4
—
—
—
0
0
27
247
1.13
0.15
8.5
4.3
—
—
—
0
0
68
658
1.10
0.13
25.9
19.0
14.0
13.8
%
0.44
63
643
15
168
0.87
0.13
1.2
1.1
0.6
0.9
u/ml
—
5
56
11
95
1.18
0.12
1.5
1.7
—
—
—
0
0
26
241
1.11
0.12
1.6
1.6
1.2
1.4
mmol/l
0.44
17
208
5
47
1.07
0.09
2.0
2.4
0.9
1.2
%
—
5
47
6
53
1.14
0.09
3.3
3.7
—
—
—
0
0
21
218
0.95
0.02
6.1
6.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
5
53
0.94
0.00
2.6
8.7
24.6
25.0
mmol/l
—
5
47
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.3
4.6
—
—
—
0
0
5
50
1.00
0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.93
0.00
1.8
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
20.3
—
0
9
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
10.3
—
0
8
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
9
95
0.94
0.00
2.2
3.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
7
77
0.90
0.00
1.9
8.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
7.1
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_MELANOMA_NOS – Melanoma in situ, other sites/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).