Hydroxyapatite deposition disease

HYDROXY_DEPOT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M11.0 Cause of death: ICD-10 — M11.0 2 out of 7 registries used, show all original rules.	32
4. Check minimum number of events None	32
5. Include endpoints None	32
6. Filter based on genotype QC (FinnGen only)	32

Control definitions (FinnGen only)

Control exclude: RHEUMA_CHRYSTAL

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M11
Name in latin: Morbus hydroxyapatitum deponens

NAME	HYDROXY_DEPOT
CONTROL_EXCLUDE	RHEUMA_CHRYSTAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M110
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M110
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hydroxyapatite deposition disease based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	194	115	77
Only index persons	170	100	70
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	69.14	70.56	66.65
Only index persons	66.95	67.67	65.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	22	10
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	61.47	58.64	67.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

3.98

2.85

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

9.56

2.85

2.2

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.46

2.03

2.1

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

114

2.64

1.85

3.9

3.5

169.50

21.74

ng/l

0.46

(3013512) EKG study

2.60

1.80

3.4

3.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.74

1.58

1.4

2.5

—

(40761536) Microorganisms panel - Urine sediment

2.97

1.44

4.0

3.7

—

(3025941) Bacteria identified in Stool by Culture

2.83

1.37

1.3

1.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

119

2.17

1.26

2.8

2.1

76.13

80.59

nmol/l

0.37

104

(3013826) Glucose [Moles/volume] in Serum or Plasma

158

2.26

1.25

4.0

4.8

7.13

6.67

mmol/l

0.55

150

(3022145) Colonoscopy Study observation

2.70

1.21

1.4

1.1

—

(3042936) Bacteria identified in Isolate by Culture

2.60

1.19

1.4

2.6

—

(3018418) pH of Serum or Plasma

2.09

1.09

4.5

4.6

7.41

—

(3037467) Urinalysis macro (dipstick) panel - Urine

180

1.98

1.02

4.5

4.7

—

(3026008) Bacteria identified in Urine by Culture

1.96

0.96

1.9

3.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.22

0.92

4.2

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.07

0.87

1.3

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.89

0.86

2.7

3.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

132

1.83

0.83

16.9

13.7

1.13

1.18

inr

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.01

0.79

1.4

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

1.80

0.76

2.2

2.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.89

0.76

1.8

2.5

—

(36660697) Celiac disease serology panel - Serum

0.00

0.63

0.0

1.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

192

1.70

0.60

3.0

37.22

55.32

u/l

1.26

180

(3019069) Monocytes/100 leukocytes in Blood

122

1.62

0.58

8.7

6.3

9.24

8.60

0.45

115

(3006504) Eosinophils/100 leukocytes in Blood

122

1.62

0.58

8.3

5.9

2.51

2.68

0.15

115

(3018010) Neutrophils/100 leukocytes in Blood

124

1.58

0.53

7.8

6.0

58.36

57.34

0.13

116

(3002030) Lymphocytes/100 leukocytes in Blood

125

1.56

0.51

8.4

6.1

28.17

27.15

0.14

118

(3000494) Fungus identified in Specimen by Culture

1.66

0.44

1.0

1.2

—

(36304419) Bacteria [Presence] in Urine

1.48

0.43

2.8

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.42

0.0

1.3

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.42

0.0

9.1

—

0.86

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.42

0.0

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

129

1.48

0.42

4.8

8.2

1.22

mmol/l

0.03

114

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.41

0.0

7.6

—

(3022096) Basophils/100 leukocytes in Blood

120

1.47

0.40

8.5

5.7

0.57

0.63

0.21

113

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.49

0.39

2.3

3.5

22.50

35.01

u/l

1.17

(3009261) Glucose [Presence] in Urine by Test strip

132

1.42

0.35

4.1

4.3

0.00

estimate

—

(3023368) Bacteria identified in Blood by Culture

1.46

0.33

2.8

4.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

127

1.34

0.26

7.7

6.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.39

0.26

4.1

3.7

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.41

0.25

5.6

5.4

42.40

32.33

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

148

1.32

0.24

2.9

2.4

—

(40768797) Stomach Pathology biopsy report

1.34

0.22

1.2

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.0

—

0.73

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.22

0.0

5.2

—

0.00

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.22

0.0

2.1

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.22

0.0

5.4

—

0.00

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.22

0.0

6.7

—

1.06

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.22

0.0

5.4

—

0.00

—

(40768793) Breast Pathology biopsy report

0.00

0.22

0.0

1.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.6

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.22

0.0

6.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

3.0

—

0.82

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.21

0.0

3.6

—

23.32

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.21

0.0

3.2

—

121.54

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.21

0.0

4.0

—

42.79

—

(3021601) Nitrite [Presence] in Urine by Test strip

130

1.29

0.21

4.9

6.2

0.00

estimate

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.20

0.0

7.6

—

25.40

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.20

0.0

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.20

0.0

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

131

1.27

0.19

4.2

4.3

0.00

estimate

—

(3006315) Basophils [#/volume] in Blood

134

1.22

0.14

8.7

6.0

0.04

0.03

e9/l

0.04

122

(3001604) Monocytes [#/volume] in Blood

134

1.22

0.14

8.7

5.9

0.59

0.56

e9/l

0.34

124

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

105

1.23

0.13

2.3

2.0

112.82

105.52

pmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

107

1.19

0.10

4.1

4.5

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

1.20

0.09

2.7

2.0

126.80

154.48

u/l

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.76

0.09

5.4

5.8

0.83

2.23

ug/l

—

(3015736) pH of Urine

109

0.88

0.05

3.6

3.8

—

5.75

—

(3044889) 12 lead EKG panel

201

1.13

0.04

4.5

4.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

142

1.11

0.03

3.3

2.5

—

(40768804) Tissue Pathology biopsy report

124

0.95

0.00

2.0

1.9

—

(3003694) ABO and Rh group [Type] in Blood

0.88

0.00

1.6

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.85

-0.00

4.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

1.29

—

(1616796) Gas panel - Central venous blood

0.00

-0.00

0.0

1.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

64.22

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

4.5

—

234.67

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.7

—

1.37

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3021901) Oxygen saturation in Capillary blood

0.00

-0.00

0.0

1.6

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

-0.00

0.0

3.8

—

89.38

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

1.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

-0.00

0.0

1.5

—

25.57

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

4.6

—

20.56

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.4

—

3.83

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.0

—

(4034850) Laboratory test

0.00

-0.00

0.0

11.6

—

(1002224) Polysomnography panel

0.00

-0.00

0.0

1.0

—

(3003181) Sodium [Moles/volume] in Urine

0.00

-0.00

0.0

2.0

—

31.60

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

25.86

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3039000) Anion gap in Blood

0.00

-0.00

0.0

7.1

—

11.12

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.4

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.7

—

6.62

—

(1761868) Lipid panel - Serum or Plasma

0.90

-0.00

6.8

3.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

0.25

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

4.8

—

3.87

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

-0.00

0.0

1.5

—

8.45

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3018572) Chloride [Moles/volume] in Blood

0.00

-0.00

0.0

7.1

—

107.25

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.4

—

110.00

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

3.94

—

(3036489) Thrombin time

0.00

-0.00

0.0

3.9

—

22.25

—

Mortality – FinRegistry

↥

Association

Association between endpoint HYDROXY_DEPOT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have HYDROXY_DEPOT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: HYDROXY_DEPOT – Hydroxyapatite deposition disease

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hydroxyapatite deposition disease

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints