This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Fetus and newborn affected by maternal use of alcohol

Endpoint Browser

P16_FET_NEWB_MATERN_USE_ALCOHOL

No definition available.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P04.3 Hospital discharge: ICD-9 — 7607A Cause of death: ICD-10 — P04.3 Cause of death: ICD-9 — 7607A 2 out of 7 registries used, show all original rules.	12
4. Check minimum number of events None	12
5. Include endpoints None	12
6. Filter based on genotype QC (FinnGen only)	12

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 4
Special: FETUSALCO
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P04
Name in latin: Fetus et neonatus usu alcohol matris affectus

NAME	P16_FET_NEWB_MATERN_USE_ALCOHOL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P043
HD_ICD_9	7607A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P043
COD_ICD_9	7607A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Fetus and newborn affected by maternal use of alcohol based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	659	317	341
Only index persons	407	198	209
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	0.33	0.27	0.27
Only index persons	0.87	0.83	0.90

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	12	8	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	0.88	0.23	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(1761868) Lipid panel - Serum or Plasma

0.00

1.17

0.0

2.4

—

(40758558) Short blood count panel - Blood

2.88

0.96

38.7

6.2

—

(42870588) Differential panel, method unspecified - Blood

2.88

0.96

21.4

8.4

—

(3044889) 12 lead EKG panel

2.51

0.74

2.0

2.1

—

(3029937) Albumin [Presence] in Urine by Test strip

0.00

0.67

0.0

4.8

—

0.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.67

0.0

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

2.13

0.52

2.4

5.3

0.0

0.1

e6/l

—

(3002582) Erythrocytes [#/volume] in Urine

2.04

0.51

2.4

5.4

73.6

72.2

e6/l

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.44

0.0

1.6

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.44

0.0

1.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.44

0.0

1.6

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.44

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.44

0.0

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.00

0.43

0.0

9.8

—

(3018095) Leukocytes [#/volume] in Urine

1.66

0.29

3.0

5.7

506.4

31.0

e6/l

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.22

0.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.22

0.0

1.2

—

(3022145) Colonoscopy Study observation

0.00

0.22

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.22

0.0

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.22

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.22

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.22

0.0

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.22

0.0

3.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.32

0.12

3.2

4.3

—

(3031040) Bacteria [#/volume] in Urine by Automated count

1.44

0.12

3.6

5.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.22

0.11

3.7

5.4

—

(3013512) EKG study

0.00

0.0

2.8

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3022621) pH of Urine by Test strip

0.00

0.0

3.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.0

10.3

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

0.0

7.4

—

32.4

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.00

0.0

5.5

—

6.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.2

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

1.7

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.0

1.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.5

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

2.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

0.87

0.00

11.2

4.6

5.6

6.7

mmol/l

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_FET_NEWB_MATERN_USE_ALCOHOL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_MATERN_USE_ALCOHOL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_FET_NEWB_MATERN_USE_ALCOHOL – Fetus and newborn affected by maternal use of alcohol

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fetus and newborn affected by maternal use of alcohol

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints