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Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery

EFO Endpoint Browser PheWeb

P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P00-P04
  • Cause of death: ICD-10 — P00-P04

2 out of 7 registries used, show all original rules.

512

4. Check minimum number of events

None

512

5. Include endpoints

512

6. Filter based on genotype QC (FinnGen only)

465

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Fetus et neonatus factoribus maternis atque complicationibus graviditatis, laborum et partus affectus

Similar endpoints

↥

List of similar endpoints to Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 43198 19780 23410
Only index persons 16855 7854 9001
Unadjusted period prevalence (%)
Whole population 0.61 0.57 0.65
Only index persons 0.32 0.29 0.34
Median age at first event (years)
Whole population 0.01 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 465 255 210
Unadjusted period prevalence (%) 0.09 0.09 0.10
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
511
Matched controls
5049
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P07.3
ICD-10 Finland
Other preterm infants
24.6
250.1
208
137
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
13.8
146.3
160
162
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
+∞
112.3
104
*
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
+∞
107.8
100
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
+∞
100.0
93
*
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
14.2
62.5
60
47
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
11.6
51.6
56
53
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
18.8
51.4
42
24
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
+∞
45.3
43
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
7.8
42.7
63
89
WX722
NOMESCO Finland
PEEP
7.6
41.0
62
90
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
14.4
40.7
38
28
P05.1
ICD-10 Finland
Small for gestational age
10.9
32.3
36
35
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
6.4
30.4
53
89
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
11.6
30.1
32
29
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
+∞
27.2
26
*
P00.8
ICD-10 Finland
Fetus and newborn affected by other maternal conditions
+∞
26.2
25
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.2
25.7
77
207
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.8
24.5
35
47
P07.1
ICD-10 Finland
Other low birth weight
113.4
20.6
22
*
P07.2
ICD-10 Finland
Extreme immaturity
19.9
16.9
25
13
P05.0
ICD-10 Finland
Light for gestational age
14.8
16.4
27
19
602
Kela drug reimbursment
Children's severe malnutrition
3.6
16.1
56
166
P03.3
ICD-10 Finland
Fetus and newborn affected by delivery by vacuum extractor [ventouse]
+∞
14.6
14
*
P02.7
ICD-10 Finland
Fetus and newborn affected by chorioamnionitis
+∞
14.6
14
*
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
27.8
14.3
19
7
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
5.9
13.6
25
44
P03.0
ICD-10 Finland
Fetus and newborn affected by breech delivery and extraction
+∞
12.5
12
*
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
20.4
12.5
18
9
H35.1
ICD-10 Finland
Retinopathy of prematurity
27.1
12.0
16
6
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
5.4
11.9
24
46
P00.2
ICD-10 Finland
Fetus and newborn affected by maternal infectious and parasitic diseases
+∞
11.4
11
*
P04.1
ICD-10 Finland
Fetus and newborn affected by other maternal medication
+∞
11.4
11
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
10.8
10.8
20
19
A11JC
ATC
Vitamins, other combinations
10.8
10.8
20
19
P01.11
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes more than 7 days before delivery
+∞
10.4
10
*
P03.1
ICD-10 Finland
Fetus and newborn affected by other malpresentation, malposition and disproportion during labour and delivery
+∞
10.4
10
*
P21.0
ICD-10 Finland
Severe birth asphyxia
12.2
10.3
18
15
WX882
NOMESCO Finland
High dependency care
2.2
9.8
87
422
P04.2
ICD-10 Finland
Fetus and newborn affected by maternal use of tobacco
+∞
9.4
9
*
P04.4
ICD-10 Finland
Fetus and newborn affected by maternal use of drugs of addiction
+∞
9.4
9
*
Z76.2
ICD-10 Finland
Health supervision and care of other healthy infant and child
5.0
9.2
20
41
R4110
NOMESCO Finland
Physiotherapy
1.9
9.2
152
925
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
7.5
8.4
19
26
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
8.2
100
546
Z2446
NOMESCO Finland
Social worker
1.9
7.9
112
643
WX730
NOMESCO Finland
Conventional respirator
4.7
7.8
18
39
RK312, ,
NOMESCO Finland
9.5
7.8
15
16
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.4
7.6
27
81
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
3.1
7.6
31
102
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
7.2
99
563
P22.8
ICD-10 Finland
Other respiratory distress of newborn
7.4
7.2
16
22
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
7.0
74
383
J45.8
ICD-10 Finland
Mixed asthma
3.7
6.4
20
55
P29.31
ICD-10 Finland
Persistent fetal circulation
14.4
6.4
10
7
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
9.3
6.3
12
13
P02.6
ICD-10 Finland
Fetus and newborn affected by other and unspecified conditions of umbilical cord
+∞
6.2
6
*
P01.8
ICD-10 Finland
Fetus and newborn affected by other maternal complications of pregnancy
+∞
6.2
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
55
3.32
4.97
1.0
1.0
—
—
—
0
0
13
26
5.04
4.61
1.0
1.0
162.77
163.19
g/l
0.01
13
26
12
40
3.01
2.67
1.1
1.1
—
—
—
0
0
79
574
1.43
2.11
1.5
1.5
244.36
326.42
u/ml
0.38
74
539
16
74
2.17
2.11
1.0
1.0
—
—
—
0
0
238
2058
1.27
1.90
4.9
5.6
153.03
134.30
u/l
1.93
232
1927
9
196
0.44
1.88
1.0
1.0
—
—
—
0
0
113
894
1.32
1.79
3.1
2.6
—
—
—
0
0
107
840
1.33
1.79
4.2
4.3
2.11
2.41
e6/l
0.19
67
485
163
1358
1.27
1.74
5.3
5.2
14.85
23.30
e6/l
1.02
121
1017
155
1285
1.28
1.72
5.0
4.9
0.21
0.18
e6/l
0.10
113
954
124
1006
1.29
1.63
16.2
11.9
—
—
—
0
0
28
175
1.61
1.54
1.8
1.9
—
—
—
0
0
0
43
0.00
1.52
0.0
1.2
—
18.73
—
0
11
0
43
0.00
1.52
0.0
1.2
—
30.59
—
0
8
69
876
0.74
1.50
2.0
3.1
56.07
88.45
ug/g
1.26
55
708
25
383
0.63
1.49
1.2
1.2
1.09
6.71
u/ml
—
7
111
239
2110
1.22
1.47
7.8
9.2
5.94
5.91
mmol/l
0.07
227
1972
14
72
1.95
1.45
1.1
1.4
1.67
4.59
u/ml
—
6
46
19
109
1.75
1.43
1.2
1.3
446.00
391.44
ug/g
—
8
60
153
1295
1.24
1.40
5.0
4.8
—
—
—
0
0
120
988
1.26
1.40
11.3
13.4
1.47
1.37
mmol/l
2.23
114
947
39
270
1.46
1.39
1.7
1.3
—
—
—
0
0
8
163
0.48
1.37
2.5
3.9
35.15
36.95
%
—
8
163
225
1986
1.21
1.36
15.7
15.5
1.23
1.23
mmol/l
0.10
211
1863
10
193
0.50
1.36
1.7
1.5
—
—
—
0
0
0
38
0.00
1.34
0.0
1.2
—
—
—
0
0
7
145
0.47
1.34
2.0
5.8
—
—
—
0
0
183
1586
1.22
1.33
6.6
6.0
53.39
56.40
e6/l
0.04
126
1056
16
264
0.59
1.30
1.3
1.2
—
—
—
0
0
126
1053
1.24
1.29
16.4
11.9
9.41
9.73
kpa
1.08
120
1020
123
1033
1.23
1.20
2.6
4.1
—
—
—
0
0
18
108
1.67
1.19
1.6
1.5
—
—
—
0
0
0
36
0.00
1.14
0.0
1.0
—
—
—
0
0
39
516
0.73
1.13
2.3
4.6
8.67
8.46
g/l
0.16
39
499
106
884
1.23
1.11
4.2
4.2
6.44
6.83
e6/l
0.13
86
789
39
514
0.73
1.10
1.6
1.6
293.33
529.62
titre
—
6
79
5
21
2.37
1.07
1.2
8.4
45.10
38.02
%
—
5
21
85
695
1.25
1.06
3.7
4.5
—
—
—
0
0
29
398
0.70
1.05
1.2
1.2
13.17
18.08
iu/ml
—
8
89
17
105
1.62
1.03
1.5
1.4
—
—
—
0
0
17
105
1.62
1.03
1.5
1.4
—
—
—
0
0
71
851
0.80
1.01
3.0
6.1
1.04
1.14
inr
1.71
24
212
10
172
0.57
0.98
1.5
5.0
3.60
3.23
mmol/l
—
10
165
215
1937
1.17
0.95
16.5
16.7
1.24
1.23
mmol/l
0.34
208
1860
6
115
0.51
0.95
1.8
1.4
—
—
—
0
0
103
875
1.20
0.91
3.7
3.9
579.25
594.35
mosm/kgh2o
0.21
79
762
18
117
1.54
0.90
5.9
5.9
2.18
2.48
ug/l
0.27
18
117
199
1797
1.15
0.84
3.7
3.2
35.60
36.12
mmol/mol
0.27
185
1688
6
114
0.51
0.83
1.7
4.7
—
—
—
0
0
27
195
1.39
0.83
1.4
1.5
—
—
—
0
0
35
264
1.33
0.83
1.0
1.0
—
—
—
0
0
35
264
1.33
0.83
1.0
1.0
7.58
7.25
kpa
0.41
26
221
35
264
1.33
0.83
1.0
1.0
-3.59
-2.31
mmol/l
—
9
68
14
88
1.59
0.81
1.4
1.9
—
—
—
0
0
19
130
1.46
0.78
1.6
1.8
—
—
—
0
0
32
408
0.76
0.76
1.5
1.7
—
—
—
0
0
145
1289
1.16
0.75
6.0
10.0
40.72
28.74
umol/l
1.40
131
1178
18
123
1.46
0.74
8.7
5.9
—
—
—
0
0
7
38
1.83
0.73
1.9
1.8
—
—
—
0
0
7
38
1.83
0.73
1.6
1.8
—
—
—
0
0
6
108
0.54
0.73
8.5
27.5
10.80
11.40
%
—
6
108
34
262
1.30
0.71
1.0
1.0
2.65
3.38
kpa
2.44
25
219
156
1399
1.15
0.71
4.0
3.5
6.19
6.29
ph
0.29
24
173
17
117
1.45
0.69
2.1
2.0
—
—
—
0
0
7
42
1.66
0.68
5.1
8.6
1.37
1.41
%
—
7
37
178
1619
1.13
0.66
4.2
3.8
0.00
0.00
estimate
-0.00
22
281
178
1619
1.13
0.66
4.2
3.8
0.00
0.00
estimate
-0.00
20
280
28
213
1.32
0.65
3.7
3.0
5.25
5.16
pmol/l
0.14
28
194
73
622
1.19
0.65
10.8
16.1
0.80
0.81
mmol/l
0.18
67
604
19
254
0.73
0.64
4.2
2.4
—
—
—
0
0
103
905
1.16
0.63
3.2
3.1
2.42
2.41
mmol/l
0.35
96
831
5
29
1.71
0.63
1.6
1.2
—
—
—
0
0
21
275
0.74
0.62
1.2
1.5
—
—
—
0
0
5
30
1.65
0.60
1.0
1.2
—
—
—
0
0
5
30
1.65
0.60
1.6
1.2
—
—
—
0
0
39
468
0.81
0.60
1.5
1.7
—
—
—
0
0
186
1973
0.89
0.59
2.9
2.8
1.41
1.41
mmol/l
0.01
174
1863
176
1610
1.12
0.59
6.3
5.6
0.00
0.00
estimate
-0.00
22
287
192
2031
0.89
0.58
3.0
3.0
4.28
4.27
mmol/l
0.04
182
1932
13
88
1.47
0.58
6.8
7.6
—
—
—
0
0
42
497
0.82
0.57
1.5
1.7
—
—
—
0
0
8
121
0.65
0.55
1.9
1.5
1.03
0.68
g/l
—
8
102
111
994
1.13
0.53
4.0
3.5
—
—
—
0
0
250
2344
1.11
0.52
5.7
4.6
—
—
—
0
0
42
348
1.21
0.52
1.0
1.0
9.15
8.62
mu/l
0.13
35
301
46
385
1.20
0.51
3.0
2.4
7354.45
6209.69
u/l
0.06
11
106
46
533
0.84
0.51
5.8
9.0
4.82
6.36
umol/l
0.96
34
437
9
64
1.40
0.51
1.1
1.1
—
—
—
0
0
10
143
0.68
0.51
6.4
22.9
68.80
72.16
%
—
10
143
12
165
0.71
0.50
1.8
5.4
—
—
—
0
0
11
153
0.70
0.49
1.1
1.2
—
—
—
0
0
88
781
1.14
0.48
4.4
4.2
7.38
7.38
ph
0.17
12
129
17
218
0.76
0.46
1.8
1.9
—
—
—
0
0
48
548
0.85
0.46
2.0
1.6
—
—
—
0
0
339
3239
1.10
0.46
4.1
3.7
2.12
2.03
mu/l
0.70
315
3043
166
1534
1.10
0.45
6.7
9.9
—
—
—
0
0
51
437
1.17
0.45
1.5
1.4
23.57
20.51
nmol/l
0.71
43
378
44
504
0.85
0.44
1.4
1.7
—
—
—
0
0
9
125
0.71
0.44
3.8
2.7
—
—
—
0
0
34
282
1.20
0.43
10.1
8.8
0.29
0.34
g/l
0.17
28
234
21
165
1.27
0.42
1.2
1.2
—
—
—
0
0
5
32
1.55
0.42
1.0
1.2
—
—
—
0
0
263
2491
1.09
0.42
7.5
10.7
8.30
8.33
%
0.07
253
2387
16
203
0.77
0.41
1.1
1.1
—
—
—
0
0
8
58
1.37
0.41
6.4
4.9
28.01
25.61
ug/l
—
8
58
304
2899
1.09
0.41
3.7
3.3
14.46
14.40
pmol/l
0.14
276
2626
44
499
0.86
0.40
1.4
1.7
—
—
—
0
0
15
191
0.77
0.40
1.0
1.3
—
—
—
0
0
48
540
0.87
0.39
1.1
1.2
—
72.82
—
0
5
17
131
1.29
0.39
1.7
2.1
—
—
—
0
0
18
223
0.79
0.39
1.0
1.1
0.01
0.53
u/ml
—
7
113
283
2694
1.09
0.39
8.4
12.4
3.34
3.46
e9/l
0.41
229
2213
28
329
0.83
0.38
2.7
2.2
227.94
166.92
u/ml
0.44
16
153
28
231
1.21
0.38
7.7
6.3
0.06
0.00
%
0.48
17
90
12
88
1.36
0.38
1.1
1.4
—
—
—
0
0
9
67
1.33
0.38
2.4
2.7
—
—
—
0
0
11
145
0.74
0.37
6.0
22.3
—
—
—
0
0
10
133
0.74
0.36
1.5
1.2
—
—
—
0
0
45
504
0.87
0.36
1.4
1.7
—
—
—
0
0
65
579
1.13
0.36
2.1
1.9
—
—
—
0
0
26
305
0.83
0.35
1.8
2.5
21.75
30.26
u/l
1.61
20
247
165
1721
0.92
0.35
3.5
5.2
25.00
26.74
u/l
0.32
157
1653
192
1990
0.93
0.35
3.0
2.8
2.64
2.58
mmol/l
0.44
181
1868
273
2603
1.08
0.35
7.9
11.4
0.19
0.23
e9/l
2.55
228
2187
6
43
1.38
0.35
1.0
1.3
—
—
—
0
0
73
790
0.90
0.34
2.1
1.7
—
—
—
0
0
399
4017
0.92
0.33
12.5
12.0
21.20
23.50
mg/l
0.71
288
2711
6
45
1.32
0.33
1.3
1.5
—
—
—
0
0
71
768
0.90
0.33
1.8
1.6
—
—
—
0
0
33
376
0.86
0.33
8.2
14.6
106.39
105.73
mmol/l
0.45
33
376
6
85
0.69
0.33
4.3
2.8
14.82
14.81
umol/l
—
6
85
111
1023
1.09
0.33
6.4
11.3
22.84
23.42
mmol/l
1.55
111
1023
41
459
0.87
0.33
2.6
4.1
2516.13
1214.06
ng/l
0.37
23
268
6
46
1.29
0.32
4.7
4.3
2.00
1.66
mmol/l
—
6
46
6
46
1.29
0.32
1.8
1.9
—
—
—
0
0
16
195
0.80
0.32
1.4
1.5
1.27
12.46
u/ml
1.48
11
140
27
227
1.19
0.32
7.4
5.4
1.13
0.42
%
0.55
15
96
20
237
0.83
0.31
1.1
1.2
18.60
11.06
u/ml
0.34
11
143
22
258
0.84
0.31
1.0
1.1
9.83
8.08
u/ml
0.12
13
171
13
101
1.28
0.29
4.9
4.7
478.00
436.83
umol/l
0.37
13
95
149
1400
1.07
0.28
2.1
2.1
—
—
—
0
0
30
258
1.16
0.28
1.6
1.4
—
—
—
0
0
8
61
1.30
0.28
3.4
4.3
—
—
—
0
0
9
117
0.76
0.27
1.6
4.9
—
—
—
0
0
178
1834
0.94
0.27
1.8
1.8
2.29
4.00
u/ml
0.99
30
308
46
410
1.12
0.26
11.6
9.7
59.30
50.11
ng/l
0.51
46
405
30
337
0.87
0.26
1.8
2.1
—
—
—
0
0
11
85
1.28
0.26
1.0
1.1
—
—
—
0
0
13
158
0.81
0.26
2.8
3.9
60.82
63.03
g/l
0.36
13
151
170
1750
0.94
0.25
1.7
1.7
1.52
1.43
g/l
0.39
73
873
11
136
0.79
0.25
2.1
1.8
3.40
4.98
u/ml
0.20
11
136
18
210
0.84
0.25
1.6
1.6
3.04
4.08
u/ml
0.14
12
156
258
2477
1.06
0.25
7.5
10.6
2.81
3.34
%
3.78
251
2375
10
77
1.29
0.24
2.1
1.5
—
—
—
0
0
28
243
1.15
0.24
7.7
6.2
0.88
0.40
%
0.59
17
102
6
83
0.71
0.24
1.5
2.3
—
—
—
0
0
253
2430
1.06
0.23
7.6
10.6
0.63
0.61
%
0.21
247
2335
22
188
1.16
0.23
9.2
11.8
22.31
23.03
mmol/l
0.83
22
179
12
96
1.24
0.22
1.8
4.1
212.42
324.41
ug/l
0.37
12
87
7
93
0.74
0.22
1.1
1.8
165.57
138.49
ng/l
—
7
88
139
1314
1.06
0.22
1.8
1.9
—
—
—
0
0
163
1549
1.06
0.22
4.1
4.0
71.90
68.33
nmol/l
0.92
157
1468
0
10
0.00
0.21
0.0
10.2
—
35.10
—
0
10
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
5
42
1.18
0.21
2.0
1.6
168.80
665.14
pmol/l
—
5
36
0
12
0.00
0.21
0.0
4.1
—
—
—
0
0
0
12
0.00
0.21
0.0
4.2
—
14.33
—
0
12
12
97
1.23
0.21
2.9
3.3
21.93
20.09
mmol/l
0.17
12
89
0
13
0.00
0.20
0.0
1.3
—
—
—
0
0
0
13
0.00
0.20
0.0
12.2
—
13.60
—
0
13
0
13
0.00
0.20
0.0
1.1
—
—
—
0
0
219
2102
1.05
0.20
2.3
2.2
5.23
5.31
mmol/l
0.70
197
1910
367
3569
1.06
0.20
7.5
9.6
25.45
24.83
u/l
0.11
353
3438
461
4593
0.92
0.20
17.1
17.6
7.19
7.12
e9/l
0.17
439
4330
17
195
0.86
0.20
1.7
1.4
0.20
0.20
g/l
0.07
17
188
0
14
0.00
0.20
0.0
1.6
—
1440.86
—
0
14
461
4592
0.92
0.19
17.3
18.1
132.89
131.65
g/l
1.12
454
4519
26
229
1.13
0.19
9.8
16.6
-1.40
-0.09
mmol/l
0.89
20
182
68
631
1.07
0.19
2.7
6.3
1.39
2.20
mg/l
0.98
45
454
65
684
0.93
0.19
1.7
3.2
57.97
55.47
u/l
0.17
60
637
25
220
1.13
0.18
1.1
1.1
—
33.83
—
0
7
13
108
1.19
0.18
1.2
1.6
10.29
4.94
ug/l
0.48
13
100
73
681
1.07
0.18
2.1
1.8
—
—
—
0
0
262
2533
1.05
0.18
7.5
10.4
0.60
0.58
e9/l
0.60
215
2073
249
2516
0.96
0.18
4.2
4.6
6.28
7.28
mm/h
1.69
234
2343
57
527
1.08
0.17
18.6
22.1
1.07
1.05
mg/l
0.16
57
521
7
61
1.14
0.17
1.3
1.1
—
—
—
0
0
185
1881
0.96
0.17
2.8
2.8
1.05
1.09
mmol/l
0.51
174
1778
354
3548
0.95
0.17
15.7
15.1
139.17
139.32
mmol/l
0.62
346
3441
262
2535
1.04
0.17
7.5
10.4
0.04
0.04
e9/l
0.25
214
2073
37
336
1.09
0.17
2.3
2.2
6.99
6.47
iu/l
0.09
25
217
461
4588
0.93
0.17
17.1
17.6
4.63
4.59
e12/l
1.04
440
4318
263
2546
1.04
0.16
7.3
10.2
46.56
47.97
%
0.96
256
2453
461
4587
0.93
0.16
17.0
17.6
28.81
28.75
pg
0.24
453
4512
9
77
1.16
0.15
2.1
1.1
—
—
—
0
0
461
4586
0.93
0.15
17.0
17.6
85.50
85.55
fl
0.07
453
4508
18
200
0.89
0.15
6.9
18.5
0.66
0.63
%
0.12
18
200
248
2402
1.04
0.15
8.2
11.1
—
—
—
0
0
9
82
1.09
0.14
1.1
1.2
—
—
—
0
0
7
88
0.78
0.14
2.4
2.3
—
—
—
0
0
13
148
0.86
0.14
12.2
4.0
—
—
—
0
0
11
92
1.19
0.14
1.3
1.3
16.86
15.10
u/ml
0.04
11
86
461
4584
0.94
0.14
17.1
17.7
278.23
275.08
e9/l
0.44
440
4331
8
95
0.83
0.14
1.4
1.3
—
—
—
0
0
8
96
0.82
0.14
1.4
1.3
2.25
2.00
g/l
—
8
82
8
96
0.82
0.14
1.4
1.3
0.25
0.37
g/l
—
8
80
8
96
0.82
0.14
1.4
1.3
6.41
5.89
g/l
—
8
81
39
360
1.08
0.13
1.4
1.3
197.33
136.20
iu/ml
0.40
12
114
11
126
0.86
0.13
1.1
1.4
—
—
—
0
0
49
457
1.07
0.13
3.1
5.8
57.79
62.23
e9/l
0.30
32
288
114
1090
1.04
0.13
2.5
3.4
2.48
2.68
mg/l
0.50
97
986
461
4582
0.94
0.12
17.3
18.9
39.53
39.17
%
1.11
446
4391
21
228
0.91
0.12
1.4
1.4
—
—
—
0
0
27
246
1.09
0.12
2.0
2.1
—
16.16
—
0
14
38
352
1.07
0.12
2.5
1.9
—
—
—
0
0
267
2598
1.03
0.12
7.4
10.3
37.92
36.49
%
1.08
260
2505
17
151
1.12
0.11
10.0
21.1
—
—
—
0
0
27
247
1.08
0.11
1.6
2.0
—
—
—
0
0
18
196
0.90
0.11
1.6
1.4
1.19
1.12
g/l
0.56
18
188
25
228
1.09
0.11
8.3
6.2
0.00
0.13
%
0.74
12
84
398
3964
0.96
0.10
16.9
17.4
13.48
13.31
%
0.76
391
3897
16
175
0.90
0.10
1.3
1.3
—
—
—
0
0
22
236
0.92
0.10
7.3
18.3
124.77
125.27
g/l
0.04
22
231
102
978
1.04
0.10
9.2
13.3
—
—
—
0
0
18
162
1.10
0.10
1.3
1.3
4.44
21.56
u/ml
0.61
13
133
355
3540
0.97
0.10
15.6
15.0
4.02
3.95
mmol/l
2.78
346
3411
16
174
0.91
0.09
1.3
1.3
—
—
—
0
0
109
1049
1.03
0.09
7.4
12.0
5.21
5.25
kpa
0.11
104
1026
127
1284
0.97
0.09
1.6
1.6
—
—
—
0
0
6
53
1.12
0.09
1.0
1.0
—
—
—
0
0
206
2004
1.03
0.09
3.7
3.6
43.24
48.56
ug/l
0.55
198
1904
30
279
1.07
0.08
2.0
1.4
—
—
—
0
0
41
425
0.95
0.08
2.1
1.9
—
—
—
0
0
6
57
1.04
0.08
2.8
1.5
0.38
12.16
u/ml
—
6
50
142
1375
1.03
0.08
3.0
3.8
—
—
—
0
0
22
202
1.08
0.08
1.2
1.1
—
—
—
0
0
20
183
1.08
0.08
1.1
1.1
—
—
—
0
0
6
71
0.83
0.07
1.3
1.6
—
—
—
0
0
8
77
1.03
0.07
7.3
9.7
7.41
7.39
ph
—
8
71
7
80
0.86
0.07
11.6
9.3
—
—
—
0
0
9
85
1.05
0.07
1.1
1.4
—
—
—
0
0
47
447
1.04
0.07
2.6
2.3
54.18
45.47
ng/l
0.07
24
163
15
136
1.09
0.07
1.4
1.3
—
—
—
0
0
9
87
1.02
0.07
2.3
2.8
—
—
—
0
0
8
90
0.88
0.07
1.8
1.7
—
—
—
0
0
402
3950
1.03
0.06
9.8
8.8
—
—
—
0
0
9
99
0.90
0.06
1.4
1.2
—
—
—
0
0
38
360
1.05
0.06
2.2
2.3
6.63
5.48
u/l
0.35
23
220
17
156
1.08
0.06
2.8
3.7
—
—
—
0
0
18
166
1.07
0.06
12.5
21.3
94.41
95.74
%
0.18
18
166
57
580
0.97
0.06
2.1
1.9
—
—
—
0
0
13
118
1.09
0.05
3.7
5.0
23.77
24.03
umol/l
0.04
13
118
44
449
0.97
0.05
1.2
1.3
1.80
3.76
u/ml
0.73
32
323
110
1105
0.98
0.05
6.5
10.4
83.90
84.34
%
0.06
110
1096
80
774
1.03
0.05
3.7
3.2
1.02
1.02
kg/l
0.02
23
148
30
284
1.05
0.05
1.2
1.4
534.56
25969456.29
pmol/l
0.50
25
258
18
167
1.07
0.05
2.2
2.0
—
—
—
0
0
248
2431
1.02
0.04
9.1
12.1
0.00
0.01
e9/l
0.56
182
1814
83
805
1.02
0.04
1.3
1.2
—
—
—
0
0
111
1081
1.02
0.04
7.6
12.3
0.49
0.93
mmol/l
0.72
93
839
18
168
1.06
0.04
12.3
21.1
0.70
0.76
%
0.40
18
168
74
745
0.98
0.04
1.9
1.6
102.83
97.69
pmol/l
0.37
34
390
111
1083
1.02
0.03
7.6
12.2
5.65
5.75
kpa
0.63
106
1059
80
778
1.02
0.03
4.5
3.9
0.00
0.00
estimate
-0.00
20
272
14
130
1.07
0.03
1.0
1.2
—
—
—
0
0
41
415
0.97
0.02
1.1
1.2
1.73
3.09
u/ml
0.78
32
315
263
2608
0.99
0.01
7.6
10.3
2.66
2.46
e9/l
1.30
221
2213
23
234
0.97
0.01
1.8
1.8
—
—
—
0
0
60
600
0.99
0.01
2.0
1.8
—
—
—
0
0
17
162
1.04
0.00
1.2
1.3
144.67
265.28
miu/ml
—
6
73
110
1081
1.01
0.00
2.6
2.1
—
—
—
0
0
12
113
1.05
0.00
7.8
9.4
—
—
—
0
0
76
749
1.00
0.00
3.7
3.4
—
—
—
0
0
27
267
1.00
0.00
4.0
4.1
—
—
—
0
0
40
397
1.00
0.00
2.6
2.6
—
—
—
0
0
42
418
0.99
0.00
1.1
1.2
0.73
0.89
u/ml
0.14
29
310
10
100
0.99
0.00
5.1
4.2
45.80
48.50
%
—
10
100
43
426
1.00
0.00
1.1
1.2
4.68
5.65
u/ml
0.14
32
329
9
97
0.92
0.00
5.3
3.7
3.33
3.14
e9/l
—
9
97
7
70
0.99
0.00
8.0
10.4
5.16
4.85
kpa
—
7
70
7
70
0.99
0.00
8.1
9.8
9.54
9.18
kpa
—
7
70
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
14.25
—
0
6
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.01
-0.00
10.6
9.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
25.57
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
0.99
-0.00
1.0
1.2
—
0.27
—
0
6
8
87
0.91
-0.00
3.8
4.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.90
-0.00
1.2
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
403.33
—
0
9
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
77
0.90
-0.00
4.0
5.1
—
—
—
0
0
5
53
0.93
-0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
75.10
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
17.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV and mortality.

Females

Parameter HR [95% CI] p-value
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV 1.511 [1.16, 1.97] 0.002
Birth year 0.998 [0.99, 1.01] 0.664

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 18172 females with P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV died.

Males

Parameter HR [95% CI] p-value
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV 1.458 [1.19, 1.79] < 0.001
Birth year 0.991 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 21554 males with P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV died.

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV.

N-year risk Females Males
1 0.105% 0.363%
5 0.922% 1.99%
10 2.39% 4.812%
15 4.726% 9.086%
20 8.271% 14.988%

Relationships between endpoints

↥

Index endpoint: P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV – Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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