Fetus and newborn affected by maternal conditions that may be unrelated to present pregnancy

P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P00 Cause of death: ICD-10 — P00 2 out of 7 registries used, show all original rules.	145
4. Check minimum number of events None	145
5. Include endpoints None	145
6. Filter based on genotype QC (FinnGen only)	145

Control definitions (FinnGen only)

Control exclude: P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P0[0-4]
Name in latin: Fetus et neonatus condicionibus matris (etiam ad graviditatem praesentem non pertinentibus) affectus

NAME	P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC
CONTROL_EXCLUDE	P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P00
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P00
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fetus and newborn affected by maternal conditions that may be unrelated to present pregnancy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	10861	5151	5709
Only index persons	4967	2381	2586
Unadjusted period prevalence (%)
Whole population	0.15	0.15	0.16
Only index persons	0.09	0.09	0.10
Median age at first event (years)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	145	71	74
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
130: Matched controls
1301

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P00.0

ICD-10 Finland

Fetus and newborn affected by maternal hypertensive disorders

+∞

110.8

P07.3

ICD-10 Finland

Other preterm infants

25.1

39.0

P00.8

ICD-10 Finland

Fetus and newborn affected by other maternal conditions

+∞

23.7

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

13.1

22.3

P70.4

ICD-10 Finland

Other neonatal hypoglycaemia

12.4

15.4

P00.2

ICD-10 Finland

Fetus and newborn affected by maternal infectious and parasitic diseases

+∞

12.7

P07.11

ICD-10 Finland

Other low birth weight 1500-1999 g

25.9

10.5

P05.0

ICD-10 Finland

Light for gestational age

22.2

10.0

P01.5

ICD-10 Finland

Fetus and newborn affected by multiple pregnancy

+∞

8.4

P05.1

ICD-10 Finland

Small for gestational age

11.9

7.5

P07.12

ICD-10 Finland

Other low birth weight 2000-2499 g

13.1

7.2

P70.0

ICD-10 Finland

Syndrome of infant of mother with gestational diabetes

10.9

6.7

P22.1

ICD-10 Finland

Transient tachypnoea of newborn

7.2

6.6

P01.10

ICD-10 Finland

Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3022411) Androstenedione [Moles/volume] in Serum or Plasma

4.82

2.62

1.4

2.9

3.3

2.4

nmol/l

—

(3026820) Hemoglobin [Mass/volume] in Venous cord blood

6.40

2.38

1.0

168.0

154.3

g/l

—

(40765089) Chromosome analysis panel - Blood by G-banded

3.80

2.17

1.0

1.1

—

(3022670) pH of Venous cord blood

3.62

1.85

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

1.97

1.67

1.4

1.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.64

1.62

1.0

1.6

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

2.57

1.61

5.8

6.1

1.9

2.3

ug/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

163

0.46

1.47

2.0

2.1

—

(3019150) Specific gravity of Urine by Refractometry

231

0.52

1.47

2.5

3.1

1.0

kg/l

—

(3003694) ABO and Rh group [Type] in Blood

337

0.62

1.29

1.6

—

(3016879) Cocaine [Presence] in Urine

146

0.52

1.11

1.3

2.0

—

(3027944) Amphetamines [Presence] in Urine

157

0.54

1.06

1.2

2.0

—

(3011288) Drugs identified in Urine by Screen method

118

0.49

0.99

1.5

2.6

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.99

0.0

2.6

—

1.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.96

0.0

5.8

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.72

0.94

2.2

2.4

6.1

10.9

nmol/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.95

0.90

1.9

2.0

—

(3048689) Calprotectin [Mass/mass] in Stool

267

0.66

0.87

2.3

3.4

73.9

78.2

ug/g

0.05

210

(40760892) CBC W Ordered Manual Differential panel - Blood

233

0.64

0.87

5.3

6.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

124

0.54

0.82

1.3

2.1

—

(3028300) Cannabinoids [Presence] in Urine

159

0.60

0.78

1.2

2.0

—

(3027008) Opiates [Presence] in Urine

159

0.60

0.78

1.2

1.9

—

(3020891) Body temperature

0.00

0.78

0.0

11.1

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.78

0.0

3.7

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.78

0.0

3.7

—

(3000764) Benzodiazepines [Presence] in Urine

158

0.60

0.77

1.2

2.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

169

0.62

0.76

1.6

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

292

0.71

0.75

2.3

2.1

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.55

0.71

2.7

2.5

4.4

7.5

iu/l

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

189

0.65

0.71

1.4

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

111

1174

0.75

0.69

16.2

17.1

39.8

38.9

1.44

104

1045

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

277

0.71

0.69

2.6

3.6

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

1.65

0.67

1.0

173.6

161.4

g/l

—

(3005322) IgE [Units/volume] in Serum or Plasma

152

0.63

0.66

2.4

1.5

161.3

414.6

u/ml

—

138

(3009214) Lutropin [Units/volume] in Serum or Plasma

104

1.49

0.64

2.6

2.5

6.7

5.7

u/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

262

0.72

0.63

2.1

2.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

597

0.79

0.63

5.5

4.1

—

35.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.61

0.0

1.7

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.61

0.0

5.6

—

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.60

0.0

7.0

—

(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection

0.00

0.60

0.0

5.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

356

0.76

0.60

3.1

4.9

—

(3027653) Mycophenolate [Mass/volume] in Serum or Plasma

0.00

0.60

0.0

9.2

—

2.1

—

(3042936) Bacteria identified in Isolate by Culture

121

0.64

0.57

1.6

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

169

0.68

0.57

2.8

1.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

823

1.23

0.56

3.4

3.3

14.2

14.5

pmol/l

0.53

755

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

278

0.75

0.56

2.2

2.6

—

(40758558) Short blood count panel - Blood

436

0.79

0.55

8.0

9.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

190

0.71

0.55

2.0

2.3

—

(40768804) Tissue Pathology biopsy report

200

0.72

0.53

2.4

1.6

—

(3019198) Lymphocytes [#/volume] in Blood

737

0.82

0.51

6.9

11.1

2.6

2.4

e9/l

0.57

618

(3044889) 12 lead EKG panel

406

1.23

0.50

2.0

2.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

553

0.82

0.48

1.5

1.9

2.0

3.2

u/ml

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.44

0.47

1.0

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.58

0.47

2.0

1.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

1.44

0.46

1.1

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

632

0.83

0.46

4.8

4.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

162

0.71

0.46

2.0

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

448

0.82

0.46

3.7

3.6

0.0

estimate

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

126

0.69

0.45

3.9

9.7

91.3

89.0

—

126

(3005719) IgG [Mass/volume] in Serum or Plasma

150

0.71

0.45

1.8

4.4

9.8

8.5

g/l

0.84

144

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

183

0.74

0.45

2.0

2.2

1.2

1.4

mmol/l

0.69

170

(4010399)

1.45

0.43

1.8

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

445

0.83

0.42

6.1

5.2

0.0

estimate

—

(3007164) IgA [Mass/volume] in Serum or Plasma

526

0.84

0.41

1.5

1.7

1.6

1.5

g/l

0.04

255

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

1.53

0.41

1.4

1.5

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

1.53

0.41

6.4

3.8

23.0

27.6

umol/l

—

(3032185) JC virus DNA [#/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.41

0.0

7.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.41

0.0

4.1

—

(3004959) Base excess in Arterial cord blood by calculation

1.42

0.41

1.0

-4.4

-3.0

mmol/l

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

1.42

0.41

1.0

18.1

19.5

mmol/l

0.62

(3006598) pH of Arterial cord blood

1.42

0.41

1.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

105

0.65

0.41

1.0

2.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

180

0.75

0.40

1.1

1.4

—

47.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

1.48

0.40

2.4

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.8

—

(3024932) HLA-DR beta [Type]

0.00

0.40

0.0

1.2

—

(3024471) HLA-A [Type]

0.00

0.40

0.0

1.0

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

0.00

0.39

0.0

6.6

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

0.00

0.39

0.0

6.6

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

1.40

0.38

1.0

1.1

—

4.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

1.40

0.38

2.6

1.9

—

(3000991) Gas panel - Venous blood

273

1.21

0.38

8.0

14.7

—

(3001604) Monocytes [#/volume] in Blood

723

0.86

0.37

6.9

11.1

0.6

e9/l

0.41

584

(3003740) Influenza virus B Ag [Presence] in Specimen

1.48

0.36

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

0.61

0.36

1.4

2.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.44

0.36

1.2

—

(3006315) Basophils [#/volume] in Blood

721

0.86

0.35

6.9

11.1

0.0

e9/l

0.32

583

(21494755) Public health laboratory ask at order entry panel

1.37

0.35

1.0

1.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.37

0.32

2.2

1.9

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

1.39

0.32

1.1

—

4.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

756

0.87

0.31

7.9

13.3

3.4

e9/l

0.06

621

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.33

0.31

2.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

109

1127

0.85

0.31

12.4

12.2

25.0

23.8

mg/l

0.11

742

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

105

0.74

0.30

3.4

8.4

121.3

173.7

—

105

(3026493) Urate [Moles/volume] in Serum or Plasma

117

0.75

0.28

2.1

7.0

287.2

274.2

umol/l

—

109

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

563

1.14

0.28

16.0

14.2

1.2

mmol/l

0.11

525

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

168

1.22

0.28

2.1

6.8

1.1

2.1

mg/l

0.75

123

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

1.26

0.28

1.0

1.1

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

127

0.77

0.27

1.4

1.3

1.4

—

114

(3011397) Hemoglobin [Presence] in Urine by Test strip

285

0.85

0.27

4.2

3.4

—

(3044640) Blood type and Crossmatch panel - Blood

264

1.17

0.26

2.2

4.3

—

(3032080) INR in Blood by Coagulation assay

211

0.83

0.26

3.2

4.5

1.1

1.2

inr

—

(3025941) Bacteria identified in Stool by Culture

1.36

0.24

1.2

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.32

0.23

1.4

1.2

—

(36304419) Bacteria [Presence] in Urine

354

1.13

0.23

5.6

4.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

125

1.22

0.22

3.1

2.7

8.1

18.3

ng/l

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.25

0.22

1.2

1.4

—

(3023368) Bacteria identified in Blood by Culture

182

1.17

0.22

5.6

4.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

585

0.90

0.22

2.4

2.0

—

(3028026) IgM [Mass/volume] in Serum or Plasma

123

0.80

0.22

1.9

2.2

1.0

0.9

g/l

—

116

(3013512) EKG study

101

0.78

0.22

2.1

2.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.19

0.21

1.4

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

207

0.85

0.21

2.1

1.7

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(3041082) Glomerular basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

2.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.21

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.1

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3041672) Baker's yeast Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.21

0.0

1.2

—

4567.2

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.6

—

31.3

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.3

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.21

0.0

9.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

27.2

—

0.6

—

(3013115) Eosinophils [#/volume] in Blood

734

0.90

0.21

7.6

12.0

0.2

e9/l

1.15

611

(3021589) Normoblasts [#/volume] in Blood

704

0.90

0.21

9.2

12.9

0.0

e9/l

0.50

517

(3015736) pH of Urine

361

0.88

0.21

3.5

3.4

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

3.3

—

(3008092) Baker's yeast IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.5

—

16.4

—

(3027300) Silver Birch IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.26

0.20

10.2

25.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

185

0.84

0.20

2.2

3.4

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.20

0.0

1.6

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.20

0.0

1.0

—

(4035726)

1.20

0.20

1.5

2.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.18

0.19

2.3

1.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

591

0.91

0.19

2.1

2.2

5.4

mmol/l

0.04

543

(3023511) Choriogonadotropin [Units/volume] in Urine

1.19

0.18

1.3

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.17

0.18

1.3

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.78

0.16

1.5

1.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

527

0.92

0.16

6.2

7.4

114.8

114.7

ml/min/173m2

0.02

310

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.75

0.16

1.5

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

130

1.17

0.15

2.5

2.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.78

0.15

2.0

1.6

—

(3019069) Monocytes/100 leukocytes in Blood

715

0.93

0.14

6.9

11.3

8.4

8.5

0.16

690

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.19

0.14

1.0

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

354

1.09

0.14

5.8

4.8

0.0

0.2

e6/l

2.18

256

(3024561) Albumin [Mass/volume] in Serum or Plasma

330

0.92

0.12

8.4

10.5

35.5

37.3

g/l

0.80

318

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

146

0.88

0.11

4.2

8.5

6.6

8.0

umol/l

—

125

(3022313) Gas panel - Capillary blood

279

1.09

0.11

20.0

10.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

339

1.08

0.10

20.6

16.5

24.8

mmol/l

0.03

339

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

196

0.90

0.10

1.4

3.2

69.3

64.5

u/l

0.10

180

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.16

0.10

3.4

1.3

—

(44790049)

1.16

0.10

1.2

2.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.16

0.10

3.4

1.3

—

(44806118)

1.16

0.10

1.2

2.0

—

(44790047)

1.16

0.10

1.2

2.0

—

(44790048)

1.16

0.10

1.2

2.0

—

(21494815) CD4 cells/100 lymphocytes in Specimen

1.14

0.10

3.0

4.3

—

(3002582) Erythrocytes [#/volume] in Urine

379

1.07

0.10

5.5

5.0

17.0

29.3

e6/l

0.47

283

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

1.09

0.09

3.0

3.8

572.0

533.4

e6/l

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

1.09

0.09

3.0

3.8

0.6

0.2

e9/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.06

0.09

2.0

2.3

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

1.06

0.09

3.0

4.2

—

(3011412) CD3 cells [#/volume] in Blood

1.06

0.09

3.0

4.2

1.8

1.6

e9/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

311

1.07

0.09

19.4

10.7

1.3

1.2

mmol/l

0.11

227

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.11

0.09

12.0

25.9

22.8

24.5

mmol/l

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

1.09

0.09

1.2

1.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.80

0.08

4.0

2.5

5.9

5.2

pmol/l

—

(3009508) Creatinine [Moles/volume] in Urine

275

0.93

0.08

2.7

5.1

9.2

8.7

mmol/l

0.15

265

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.09

0.08

2.3

1.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.09

0.08

1.1

—

(3000492) Spirometry study

0.83

0.08

2.0

1.5

—

(40761536) Microorganisms panel - Urine sediment

0.80

0.08

3.2

3.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

119

1200

0.93

0.07

3.9

3.7

—

(3009343) pH of Capillary blood

313

1.06

0.07

19.4

10.8

—

7.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

193

0.92

0.07

9.4

14.3

4.9

mmol/l

0.02

188

(3023520) Reticulocytes [#/volume] in Blood

137

1.10

0.07

3.3

6.4

55.9

62.7

e9/l

—

(3000494) Fungus identified in Specimen by Culture

0.90

0.06

6.0

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

191

0.93

0.05

2.4

1.6

84.4

97.4

pmol/l

—

100

(3003338) MCHC [Mass/volume]

112

1128

0.95

0.05

15.1

16.8

336.8

335.5

g/l

0.81

112

1111

(3018095) Leukocytes [#/volume] in Urine

436

1.04

0.04

6.8

5.9

51.7

33.8

e6/l

0.21

290

(1761868) Lipid panel - Serum or Plasma

169

0.94

0.04

1.8

2.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

169

0.94

0.04

1.1

—

(3026008) Bacteria identified in Urine by Culture

229

0.95

0.03

4.6

2.5

—

(40761511) CBC panel - Blood by Automated count

109

1096

0.96

0.03

8.7

7.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

131

1.07

0.03

2.6

2.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

230

1.05

0.03

5.4

4.4

0.7

0.6

e6/l

0.11

125

(3002385) Erythrocyte distribution width [Ratio]

110

1105

0.96

0.03

16.2

17.8

13.3

13.1

0.44

110

1088

(3020682) Albumin/Creatinine [Ratio] in Urine

1.08

0.01

3.8

4.1

8.5

10.3

mg/mmol

—

(42870588) Differential panel, method unspecified - Blood

584

0.98

0.01

6.9

11.5

—

(3027945) Reticulocytes/100 erythrocytes in Blood

185

0.96

0.00

3.6

9.2

1.7

1.3

0.55

179

(3007461) Platelets [#/volume] in Blood

130

1289

1.04

0.00

15.7

17.6

274.4

273.0

e9/l

0.08

120

1216

(3012516) Albumin [Mass/volume] in Urine

1.06

0.00

2.8

3.6

81.0

138.8

mg/l

—

(3010813) Leukocytes [#/volume] in Blood

130

1291

1.03

0.00

15.6

17.5

7.2

6.9

e9/l

0.92

119

1210

(36660697) Celiac disease serology panel - Serum

237

1.01

0.00

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

233

0.98

0.00

2.4

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

401

0.99

0.00

5.6

5.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

344

0.98

0.00

1.9

2.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

154

0.97

0.00

2.6

2.0

—

(3026361) Erythrocytes [#/volume] in Blood

130

1290

1.03

0.00

15.6

17.5

4.7

4.6

e12/l

1.49

120

1213

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

235

1.02

0.00

5.4

4.4

0.7

1.9

e6/l

1.38

132

(723473) SARS-CoV-2 (COVID-19) IgA Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(1001833) Epstein Barr virus DNA [Units/volume] (viral load) in Blood by NAA with probe detection

0.00

0.0

7.9

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.90

0.00

14.2

25.7

98.0

95.1

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

1.4

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

9.5

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3040893) Potassium [Moles/volume] in Capillary blood

0.00

0.0

5.0

—

4.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

9.5

—

(3027305) Fractional oxyhemoglobin in Arterial cord blood

0.00

0.0

1.0

—

33.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.87

0.00

2.8

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.90

0.00

1.7

1.5

—

(3032868) Hemoglobin electrophoresis panel in Blood

0.00

0.0

1.8

—

(21491979) Prolactin monomeric [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

435.5

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.6

—

(723474) SARS-CoV-2 (COVID-19) IgG Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.6

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.4

—

(3035401) Herpes virus 6 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

5.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.3

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.5

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

3.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.0

1.4

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40760512) CD34 cells/100 cells in Bone marrow

0.00

0.0

2.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.4

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3014038) Collagen crosslinked N-telopeptide [Moles/volume] in Urine

0.00

0.0

2.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.8

—

1.4

—

(3009410) PHENobarbital [Moles/volume] in Serum or Plasma

0.00

0.0

15.6

—

97.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.85

0.00

14.2

24.5

0.7

—

(3031309) Prolactin monomeric/Prolactin.total in Serum or Plasma

0.00

0.0

1.0

—

76.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

8.6

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.1

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

109.9

—

(3032641) Amino acids panel - Urine

0.00

0.0

1.4

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.85

0.00

14.2

24.5

0.8

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.91

0.00

2.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.5

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.3

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.8

—

134.6

—

(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen

0.00

0.0

2.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

0.0

1.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

1.5

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

0.0

1.9

—

(3008860) Bordetella pertussis IgM Ab [Presence] in Serum

0.00

0.0

1.4

—

(3000060) B lymphocytes [#/volume] in Blood

0.98

0.00

3.0

3.7

714.0

404.1

e6/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.95

0.00

1.2

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

3.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC – Fetus and newborn affected by maternal conditions that may be unrelated to present pregnancy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fetus and newborn affected by maternal conditions that may be unrelated to present pregnancy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints