Fetus and newborn affected by maternal conditions that may be unrelated to present pregnancy

P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P00
  • Cause of death: ICD-10 P00

2 out of 7 registries used, show all original rules.

145

4. Check minimum number of events

None

145

5. Include endpoints

None

145

6. Filter based on genotype QC (FinnGen only)

135

Control definitions (FinnGen only)

Control exclude
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P0[0-4]
Name in latin
Fetus et neonatus condicionibus matris (etiam ad graviditatem praesentem non pertinentibus) affectus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10861 5151 5709
Only index persons 4967 2381 2586
Unadjusted period prevalence (%)
Whole population 0.15 0.15 0.16
Only index persons 0.09 0.09 0.10
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 135 67 68
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
145
Matched controls
1444
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
+∞
124.4
101
*
P07.3
ICD-10 Finland
Other preterm infants
28.4
79.0
62
37
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
15.5
45.5
46
42
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
14.8
31.7
31
26
P00.8
ICD-10 Finland
Fetus and newborn affected by other maternal conditions
+∞
26.9
25
*
P05.0
ICD-10 Finland
Light for gestational age
41.3
12.4
15
*
P00.2
ICD-10 Finland
Fetus and newborn affected by maternal infectious and parasitic diseases
+∞
11.6
11
*
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
30.6
10.9
14
5
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
15.0
9.4
15
11
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
12.6
9.3
16
14
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
13.7
9.1
15
12
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
9.4
8.6
17
20
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
+∞
8.4
8
*
602
Kela drug reimbursment
Children's severe malnutrition
4.6
7.8
20
49
P05.1
ICD-10 Finland
Small for gestational age
12.8
7.7
13
11
P07.1
ICD-10 Finland
Other low birth weight
+∞
7.3
7
*
WX722
NOMESCO Finland
PEEP
8.4
6.8
14
18
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.2
6.4
18
47
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
7
15
4.82
2.62
1.4
2.9
3.26
2.45
nmol/l
—
7
15
5
8
6.40
2.38
1.0
1.0
168.00
154.25
g/l
—
5
8
7
19
3.80
2.17
1.0
1.1
—
—
—
0
0
6
17
3.62
1.85
1.0
1.0
—
—
—
0
0
8
32
2.57
1.61
5.8
6.1
1.94
2.32
ug/l
—
8
32
22
341
0.58
1.56
1.5
1.6
—
—
—
0
0
14
232
0.56
1.25
2.6
3.1
1.02
1.02
kg/l
—
6
45
9
156
0.55
1.06
1.2
2.0
—
—
—
0
0
18
266
0.63
1.04
1.8
3.4
49.85
78.07
ug/g
0.53
13
209
8
145
0.52
0.99
1.3
2.0
—
—
—
0
0
6
118
0.49
0.99
1.5
2.5
—
—
—
0
0
0
28
0.00
0.99
0.0
2.6
—
1.65
—
0
28
0
32
0.00
0.96
0.0
5.8
—
—
—
0
0
8
46
1.77
0.83
1.9
2.0
—
—
—
0
0
7
124
0.54
0.82
1.3
2.1
—
—
—
0
0
0
27
0.00
0.78
0.0
11.1
—
—
—
0
0
10
158
0.60
0.77
1.2
2.0
—
—
—
0
0
10
158
0.60
0.77
1.2
1.9
—
—
—
0
0
22
293
0.70
0.76
2.6
2.0
—
—
—
0
0
10
157
0.61
0.75
1.2
2.0
—
—
—
0
0
36
286
1.34
0.73
5.8
11.7
22.75
23.50
mmol/l
0.91
36
286
13
189
0.65
0.71
1.4
1.8
—
—
—
0
0
14
94
1.53
0.68
2.7
2.5
4.44
7.44
iu/l
—
7
62
10
153
0.63
0.68
2.4
1.5
161.30
414.59
u/ml
—
10
138
8
126
0.61
0.67
1.3
1.2
0.19
3.46
u/ml
—
8
100
8
128
0.60
0.67
5.5
15.8
108.50
105.58
mmol/l
—
8
128
7
43
1.65
0.67
1.0
1.0
173.57
161.40
g/l
—
7
43
52
599
0.79
0.66
5.5
4.1
—
35.88
—
0
8
12
173
0.66
0.63
1.8
1.7
—
—
—
0
0
91
827
1.26
0.63
3.5
3.3
14.16
14.47
pmol/l
0.62
86
758
66
737
0.80
0.62
6.7
11.1
2.61
2.41
e9/l
0.62
53
619
15
105
1.47
0.62
2.6
2.5
6.74
5.63
u/l
—
7
72
0
20
0.00
0.61
0.0
5.6
—
1.47
—
0
20
0
22
0.00
0.60
0.0
6.8
—
—
—
0
0
0
22
0.00
0.60
0.0
9.2
—
2.08
—
0
17
15
204
0.70
0.59
2.4
1.6
—
—
—
0
0
8
121
0.64
0.57
1.6
1.8
—
—
—
0
0
12
169
0.68
0.57
2.8
1.8
—
—
—
0
0
37
434
0.80
0.53
8.0
10.0
—
—
—
0
0
57
634
0.83
0.48
4.9
4.4
—
—
—
0
0
12
163
0.71
0.48
2.1
1.6
—
—
—
0
0
66
723
0.83
0.47
6.7
11.1
0.60
0.57
e9/l
0.40
51
585
5
84
0.58
0.47
2.0
1.8
—
—
—
0
0
7
49
1.44
0.46
1.1
1.2
—
—
—
0
0
47
409
1.21
0.46
2.0
2.3
—
—
—
0
0
66
721
0.84
0.45
6.7
11.1
0.04
0.04
e9/l
0.33
51
583
14
183
0.74
0.45
2.0
2.2
1.15
1.42
mmol/l
0.68
14
170
21
167
1.30
0.44
2.0
6.9
1.13
2.08
mg/l
0.75
13
123
11
149
0.71
0.43
1.8
4.5
9.75
8.52
g/l
0.86
11
143
8
56
1.45
0.43
1.7
1.5
—
—
—
0
0
47
527
0.83
0.42
1.5
1.7
1.56
1.53
g/l
0.04
16
255
5
33
1.53
0.41
6.4
3.8
23.00
27.61
umol/l
—
5
33
11
79
1.42
0.41
1.0
1.0
18.09
19.47
mmol/l
0.62
11
79
11
79
1.42
0.41
1.0
1.0
-4.42
-2.98
mmol/l
—
5
33
11
79
1.42
0.41
1.0
1.0
—
—
—
0
0
70
756
0.85
0.40
7.7
13.3
3.44
3.40
e9/l
0.06
53
621
63
686
0.85
0.40
7.0
11.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
32
272
1.22
0.39
8.0
14.7
—
—
—
0
0
14
179
0.76
0.39
1.1
1.4
—
47.50
—
0
6
50
554
0.85
0.39
1.5
1.9
2.00
3.18
u/ml
—
7
90
62
563
1.17
0.37
15.7
14.2
1.23
1.23
mmol/l
0.19
57
526
6
41
1.48
0.36
1.0
1.1
—
—
—
0
0
6
41
1.48
0.36
1.2
1.2
—
—
—
0
0
5
80
0.61
0.36
1.4
2.2
—
—
—
0
0
6
42
1.44
0.36
1.2
1.2
—
—
—
0
0
7
51
1.39
0.32
1.1
1.1
—
4.43
—
0
7
69
735
0.88
0.30
7.4
12.0
0.18
0.22
e9/l
1.17
56
612
109
1126
0.86
0.30
12.0
12.2
24.98
23.79
mg/l
0.11
76
738
9
116
0.76
0.28
2.1
7.1
287.22
273.91
umol/l
—
9
108
25
286
0.84
0.28
4.2
3.3
—
—
—
0
0
18
212
0.82
0.27
2.2
1.7
—
—
—
0
0
5
73
0.67
0.26
3.6
3.6
—
—
—
0
0
66
700
0.89
0.26
8.6
13.0
0.00
0.00
e9/l
0.50
45
512
36
395
0.88
0.24
3.7
3.3
6.00
6.36
ph
—
5
46
30
267
1.15
0.23
2.2
4.3
—
—
—
0
0
20
229
0.85
0.23
3.0
4.6
0.97
1.15
inr
—
7
62
16
187
0.83
0.22
2.2
3.4
—
—
—
0
0
5
40
1.25
0.22
1.2
1.4
—
—
—
0
0
10
123
0.80
0.22
1.9
2.2
0.97
0.93
g/l
—
10
116
8
100
0.78
0.22
2.1
2.8
—
—
—
0
0
68
715
0.90
0.22
6.6
11.3
8.31
8.49
%
0.20
63
690
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
4.0
—
3.84
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
4567.17
—
0
6
0
12
0.00
0.21
0.0
27.2
—
0.63
—
0
12
0
12
0.00
0.21
0.0
3.6
—
31.33
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
9.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
16.40
—
0
5
0
13
0.00
0.21
0.0
5.0
—
1.00
—
0
13
0
13
0.00
0.21
0.0
1.0
—
43.13
—
0
8
6
48
1.26
0.20
10.2
25.7
—
—
—
0
0
56
593
0.90
0.20
2.1
2.2
5.39
5.38
mmol/l
0.03
50
544
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
52
1.16
0.19
1.5
2.1
—
—
—
0
0
30
328
0.89
0.19
7.8
10.6
35.50
37.28
g/l
0.75
30
316
7
59
1.19
0.18
1.3
1.4
—
—
—
0
0
38
352
1.10
0.16
5.7
4.8
—
—
—
0
0
20
181
1.12
0.12
5.4
4.9
—
—
—
0
0
13
146
0.88
0.11
4.2
8.5
6.57
8.04
umol/l
—
7
125
30
279
1.09
0.11
20.0
10.2
—
—
—
0
0
14
124
1.14
0.11
3.1
2.7
8.29
18.55
ng/l
—
7
51
36
339
1.08
0.10
20.6
16.5
24.81
24.75
mmol/l
0.03
36
339
5
44
1.14
0.10
3.0
4.3
33.98
35.99
%
—
5
44
5
46
1.09
0.09
3.0
3.8
572.00
533.38
e6/l
—
5
29
5
46
1.09
0.09
3.0
3.8
0.58
0.20
e9/l
—
5
29
5
47
1.06
0.09
3.0
4.2
1.83
1.53
e9/l
—
5
31
18
195
0.91
0.09
1.4
3.2
71.00
64.60
u/l
0.14
18
179
6
54
1.11
0.09
12.0
25.9
22.83
24.46
mmol/l
—
6
54
6
55
1.09
0.09
1.2
1.1
—
—
—
0
0
37
351
1.07
0.08
5.9
4.8
0.02
0.18
e6/l
2.21
26
254
33
313
1.06
0.07
19.4
10.7
—
7.41
—
0
12
26
274
0.93
0.07
2.7
5.1
9.17
8.69
mmol/l
0.14
26
268
18
193
0.92
0.07
2.4
1.6
84.40
97.20
pmol/l
—
6
100
15
137
1.10
0.07
3.3
6.4
55.94
62.70
e9/l
—
9
89
18
192
0.92
0.06
9.4
14.3
4.93
4.90
mmol/l
0.02
18
187
16
171
0.92
0.06
1.9
2.0
—
—
—
0
0
39
375
1.05
0.05
5.7
5.0
17.30
29.73
e6/l
0.46
28
278
109
1098
0.95
0.05
8.5
7.8
—
—
—
0
0
110
1107
0.96
0.04
15.8
18.0
13.25
13.16
%
0.26
110
1090
10
92
1.09
0.02
3.8
4.0
8.49
10.37
mg/mmol
—
10
83
10
93
1.08
0.01
2.8
3.7
81.05
140.29
mg/l
—
10
83
18
186
0.96
0.01
3.6
9.1
1.69
1.34
%
0.55
18
179
130
1289
1.04
0.00
15.3
17.6
273.54
273.29
e9/l
0.01
120
1216
35
343
1.02
0.00
1.9
2.0
—
—
—
0
0
130
1291
1.03
0.00
15.3
17.5
7.22
6.90
e9/l
0.82
119
1210
130
1291
1.03
0.00
15.3
17.5
4.72
4.62
e12/l
1.67
120
1214
24
234
1.03
0.00
5.4
4.4
0.69
1.94
e6/l
1.41
13
130
44
433
1.02
0.00
6.9
5.9
53.04
34.22
e6/l
0.22
29
285
113
1128
0.99
0.00
15.1
16.9
336.73
335.50
g/l
0.78
113
1111
23
229
1.00
0.00
4.6
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
222.03
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
9.48
—
0
9
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
24
238
1.01
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
33.50
—
0
5
5
59
0.84
-0.00
1.6
23.0
0.68
0.57
%
—
5
59
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
9
98
0.91
-0.00
6.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
58
0.85
-0.00
14.2
24.5
0.78
1.06
%
—
5
58
0
7
0.00
-0.00
0.0
5.0
—
4.24
—
0
7
8
88
0.90
-0.00
2.0
1.6
—
—
—
0
0
6
69
0.86
-0.00
2.0
1.5
—
—
—
0
0
5
58
0.85
-0.00
14.2
24.5
0.74
0.72
%
—
5
58
6
62
0.96
-0.00
3.7
2.5
5.48
5.21
pmol/l
—
6
54
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
134.60
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
3.37
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
435.50
—
0
6
0
5
0.00
-0.00
0.0
15.6
—
97.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
68
0.87
-0.00
2.8
1.2
—
—
—
0
0
5
51
0.98
-0.00
3.0
3.7
714.00
404.06
e6/l
—
5
32
0
6
0.00
-0.00
0.0
3.0
—
4.59
—
0
6
5
55
0.90
-0.00
14.2
25.7
98.00
95.11
%
—
5
55
0
8
0.00
-0.00
0.0
1.8
—
1.36
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
40.29
—
0
7
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
0.79
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_FET_NEWB_MATERN_COND_UNREL_PRESENT_PREGNAC – Fetus and newborn affected by maternal conditions that may be unrelated to present pregnancy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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