Fetus and newborn affected by complications of placenta, cord and membranes

P16_FET_NEWB_COMPLICATIO_PLACEN_CORD_MEMBRANES

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P02
  • Cause of death: ICD-10 P02

2 out of 7 registries used, show all original rules.

70

4. Check minimum number of events

None

70

5. Include endpoints

None

70

6. Filter based on genotype QC (FinnGen only)

56

Control definitions (FinnGen only)

Control exclude
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P0[0-4]
Name in latin
Fetus et neonatus complicationibus placentae, funiculi umbilicalis et membranarum fetalium affectus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3567 1640 1924
Only index persons 1327 609 718
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population 0.03 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 56 30 26
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
70
Matched controls
700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
+∞
29.2
26
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
20.8
16.1
24
17
P02.7
ICD-10 Finland
Fetus and newborn affected by chorioamnionitis
+∞
15.1
14
*
P07.3
ICD-10 Finland
Other preterm infants
18.2
13.5
21
16
P21.0
ICD-10 Finland
Severe birth asphyxia
128.5
10.7
11
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
38.3
8.3
10
*
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
22.9
7.4
10
5
WX722
NOMESCO Finland
PEEP
10.9
6.6
12
13
Z3229
NOMESCO Finland
Other healthcare associate professional
5.0
6.5
16
39
P07.2
ICD-10 Finland
Extreme immaturity
+∞
6.3
6
*
P02.6
ICD-10 Finland
Fetus and newborn affected by other and unspecified conditions of umbilical cord
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
10
27
4.14
3.02
1.5
1.4
—
—
—
0
0
31
193
2.09
2.29
3.0
3.7
6.22
6.35
ph
—
9
20
13
57
2.57
2.13
1.4
1.4
25.20
21.09
nmol/l
—
8
49
22
130
2.01
1.81
2.5
2.6
—
—
—
0
0
8
31
2.78
1.72
1.4
1.5
—
—
—
0
0
23
141
1.94
1.70
3.1
3.4
—
—
—
0
0
34
239
1.82
1.64
17.7
16.1
1.22
1.23
mmol/l
0.45
34
224
20
118
1.97
1.64
2.1
3.1
1.01
1.02
kg/l
—
5
25
7
26
2.87
1.63
5.9
2.7
5.33
5.12
pmol/l
—
7
21
22
139
1.85
1.46
2.3
3.1
—
—
—
0
0
43
332
1.77
1.46
4.3
4.7
—
—
—
0
0
9
41
2.37
1.43
1.9
1.5
267.89
326.15
mu/l
—
9
41
9
43
2.25
1.36
1.9
1.5
—
—
—
0
0
18
111
1.84
1.28
23.5
14.3
—
—
—
0
0
30
217
1.67
1.23
5.8
7.4
—
—
—
0
0
29
208
1.67
1.23
4.7
6.2
6.07
46.04
e6/l
1.37
20
141
8
38
2.24
1.23
1.6
2.3
—
—
—
0
0
27
190
1.69
1.23
1.7
1.6
—
—
—
0
0
18
120
1.67
0.98
26.3
15.1
4.93
4.90
kpa
0.11
18
114
9
52
1.84
0.97
1.6
1.3
—
—
—
0
0
23
165
1.59
0.94
3.7
5.0
0.20
0.24
e6/l
0.06
18
121
6
30
2.09
0.89
1.5
1.6
—
—
—
0
0
23
168
1.55
0.87
3.6
5.0
—
—
—
0
0
43
362
1.49
0.81
6.3
9.7
3.00
3.48
e9/l
1.22
35
299
0
24
0.00
0.81
0.0
4.5
—
4.56
—
0
16
0
24
0.00
0.81
0.0
4.5
—
3.37
—
0
24
0
24
0.00
0.81
0.0
3.7
—
19.83
—
0
24
0
24
0.00
0.81
0.0
4.5
—
1121.31
—
0
16
0
25
0.00
0.81
0.0
4.3
—
330.60
—
0
25
0
26
0.00
0.80
0.0
1.7
—
—
—
0
0
5
23
2.26
0.78
2.0
1.6
—
—
—
0
0
5
25
2.07
0.74
1.2
1.2
—
—
—
0
0
7
41
1.78
0.72
2.1
2.1
—
—
—
0
0
5
27
1.92
0.70
1.6
1.5
—
—
—
0
0
5
27
1.92
0.70
1.6
1.5
—
—
—
0
0
52
462
1.49
0.69
4.3
3.6
1.91
2.09
mu/l
0.66
46
428
16
114
1.52
0.66
28.6
14.9
9.94
9.87
kpa
0.05
16
108
37
312
1.39
0.64
2.2
2.3
5.13
5.40
mmol/l
1.07
32
283
16
115
1.51
0.64
3.4
4.4
4.83
2.41
e6/l
0.45
11
69
24
188
1.42
0.63
2.0
2.0
—
—
—
0
0
23
179
1.42
0.62
3.7
5.3
8.74
28.90
e6/l
0.73
18
136
15
107
1.51
0.62
4.6
11.6
22.60
23.43
mmol/l
0.60
15
107
16
116
1.49
0.61
1.9
1.8
—
—
—
0
0
0
20
0.00
0.61
0.0
1.8
—
—
—
0
0
0
20
0.00
0.61
0.0
3.5
—
24.10
—
0
20
0
21
0.00
0.61
0.0
3.3
—
2.09
—
0
15
0
21
0.00
0.61
0.0
3.3
—
66.05
—
0
21
0
21
0.00
0.61
0.0
3.3
—
724.53
—
0
15
0
21
0.00
0.61
0.0
3.4
—
38.82
—
0
21
0
21
0.00
0.61
0.0
5.0
—
—
—
0
0
0
22
0.00
0.60
0.0
4.8
—
—
—
0
0
0
22
0.00
0.60
0.0
6.3
—
227.73
—
0
22
46
405
1.40
0.60
4.3
3.3
14.59
14.41
pmol/l
0.22
41
371
0
23
0.00
0.59
0.0
3.3
—
495.29
—
0
17
12
84
1.52
0.53
4.4
3.8
—
—
—
0
0
8
119
0.63
0.51
1.9
5.6
—
1.13
—
0
25
35
302
1.32
0.48
4.5
9.5
—
—
—
0
0
24
196
1.34
0.48
1.8
1.9
—
—
—
0
0
5
31
1.66
0.44
1.2
1.9
—
—
—
0
0
18
143
1.35
0.42
1.7
2.8
2.88
2.57
mg/l
0.23
13
124
5
33
1.55
0.42
1.8
2.1
—
—
—
0
0
8
60
1.38
0.42
3.1
4.8
21.97
21.34
%
—
8
60
0
15
0.00
0.42
0.0
3.0
—
1255.13
—
0
15
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
15
116
1.37
0.41
4.5
11.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
4.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
58
544
1.39
0.40
10.7
7.6
—
—
—
0
0
31
269
1.27
0.39
7.2
8.5
6.70
5.86
mmol/l
0.77
31
251
6
43
1.43
0.36
1.2
1.3
—
—
—
0
0
6
43
1.43
0.36
3.7
3.8
15.77
43.62
mg/mmol
—
6
32
6
44
1.40
0.35
3.8
3.4
157.83
309.94
mg/l
—
6
33
37
331
1.25
0.35
6.0
8.5
0.03
0.04
e9/l
0.15
31
270
37
331
1.25
0.35
6.0
8.6
0.55
0.58
e9/l
0.30
31
270
13
102
1.34
0.33
2.2
3.5
—
—
—
0
0
12
93
1.35
0.32
1.2
1.4
109.40
95.36
pmol/l
—
5
53
16
130
1.30
0.32
1.8
1.8
—
—
—
0
0
10
129
0.74
0.31
1.3
1.1
—
—
—
0
0
58
550
1.32
0.31
14.5
10.4
19.33
23.03
mg/l
0.62
43
375
35
315
1.22
0.30
6.3
8.8
0.57
0.61
%
0.20
35
300
36
326
1.21
0.29
6.6
9.3
0.00
0.00
e9/l
-0.00
26
244
16
133
1.26
0.27
29.1
16.0
24.00
24.26
mmol/l
0.25
16
133
37
338
1.20
0.26
6.4
9.3
0.20
0.23
e9/l
0.22
31
288
38
349
1.19
0.25
5.9
8.3
2.71
2.50
e9/l
0.30
32
301
14
116
1.26
0.24
5.9
14.7
—
—
—
0
0
10
79
1.31
0.24
1.8
1.8
—
—
—
0
0
5
40
1.27
0.23
1.0
1.0
12.14
7.22
mu/l
—
5
40
20
175
1.20
0.22
2.5
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
5.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
2.53
—
0
12
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
45.58
—
0
12
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
4.25
—
0
13
35
323
1.17
0.21
6.3
8.7
3.17
3.35
%
0.16
35
304
7
57
1.25
0.19
9.7
22.3
1.00
1.13
mg/l
—
7
57
35
325
1.15
0.18
6.3
8.8
8.26
8.28
%
0.02
35
309
36
335
1.15
0.18
6.1
8.3
44.92
47.97
%
0.72
36
320
7
61
1.16
0.18
1.3
2.1
—
—
—
0
0
7
88
0.77
0.15
5.1
6.1
36.09
31.37
s
—
7
88
24
261
0.88
0.15
1.3
1.6
1.43
1.42
g/l
—
10
115
6
55
1.10
0.09
1.3
2.1
—
—
—
0
0
7
67
1.05
0.08
1.3
2.0
—
—
—
0
0
7
67
1.05
0.08
1.3
2.0
—
—
—
0
0
7
67
1.05
0.08
1.3
2.0
—
—
—
0
0
7
67
1.05
0.08
1.3
2.0
—
—
—
0
0
36
346
1.08
0.07
6.2
8.4
38.97
37.08
%
0.46
36
333
12
117
1.03
0.00
1.3
1.7
—
—
—
0
0
8
83
0.96
0.00
1.4
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
87.52
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
185.20
—
0
5
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
104.88
—
0
8
0
6
0.00
-0.00
0.0
4.5
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.2
—
8.98
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
165.33
—
0
9
0
9
0.00
-0.00
0.0
8.8
—
1.85
—
0
9
0
9
0.00
-0.00
0.0
3.2
—
4.71
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
1.14
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
73.22
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
7.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
4.56
—
0
7
5
54
0.92
-0.00
6.0
9.6
107.60
105.17
mmol/l
—
5
54
0
7
0.00
-0.00
0.0
1.1
—
10.94
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
6
64
0.93
-0.00
1.0
1.5
—
400.00
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
4.44
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
50
1.00
-0.00
1.4
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
78
1.03
-0.00
1.0
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_FET_NEWB_COMPLICATIO_PLACEN_CORD_MEMBRANES and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_COMPLICATIO_PLACEN_CORD_MEMBRANES.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_FET_NEWB_COMPLICATIO_PLACEN_CORD_MEMBRANES – Fetus and newborn affected by complications of placenta, cord and membranes

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data