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Fetus and newborn affected by noxious influences transmitted via placenta or breast milk

P16_FET_NEWB_NOXIO_INFLUENCES_TRANSMIT_PLACEN_BREAST_MILK

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P04
  • Cause of death: ICD-10 P04

2 out of 7 registries used, show all original rules.

34

4. Check minimum number of events

None

34

5. Include endpoints

None

34

6. Filter based on genotype QC (FinnGen only)

34

Control definitions (FinnGen only)

Control exclude
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P0[0-4]
Name in latin
Fetus et neonatus influentiis noxiis per placentam sive lac maternum translatis affectus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3798 1782 2014
Only index persons 1275 630 645
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.06
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 0.02 0.00 0.00
Only index persons 0.04 0.07 0.01

-FinnGen-

Key figures

All Female Male
Number of individuals 34 15 19
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 0.04 0.09 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
6
26
2.58
1.24
1.2
1.5
—
95.7
—
0
14
9
54
1.90
0.84
7.0
6.1
—
7.4
—
0
8
0
25
0.00
0.83
0.0
5.8
—
171.5
—
0
25
12
78
1.83
0.79
1.6
1.2
—
—
—
0
0
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
0
19
0.00
0.62
0.0
6.9
—
2.9
—
0
19
0
22
0.00
0.61
0.0
3.3
—
—
—
0
0
8
116
0.59
0.59
1.6
2.1
—
—
—
0
0
12
88
1.56
0.48
9.8
5.3
—
—
—
0
0
8
56
1.56
0.47
1.4
1.5
127.0
129.5
u/ml
—
8
49
8
60
1.43
0.44
3.3
3.0
—
—
—
0
0
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
0
16
0.00
0.42
0.0
1.7
—
320.7
—
0
16
0
17
0.00
0.42
0.0
1.6
—
1.6
—
0
7
5
76
0.60
0.41
4.4
10.3
32.0
31.6
s
—
5
76
29
266
1.61
0.41
9.7
11.8
—
—
—
0
0
21
180
1.44
0.38
18.0
21.4
1.2
1.2
mmol/l
0.01
21
173
21
180
1.44
0.38
14.9
20.2
1.2
1.2
mmol/l
0.08
21
170
7
53
1.40
0.33
7.9
5.5
—
1.0
—
0
18
15
123
1.39
0.33
4.0
4.8
39.1
52.3
ug/l
0.31
15
117
14
114
1.39
0.32
7.2
12.4
—
—
—
0
0
13
105
1.39
0.31
19.7
16.9
37.4
36.7
g/l
0.18
13
100
17
147
1.31
0.25
8.5
6.8
242.4
193.4
u/l
0.73
17
138
6
48
1.30
0.22
9.7
10.0
—
—
—
0
0
0
11
0.00
0.22
0.0
2.7
—
11.3
—
0
11
0
11
0.00
0.22
0.0
1.2
—
—
—
0
0
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
0
10
0.00
0.22
0.0
5.2
—
1.5
—
0
10
0
10
0.00
0.22
0.0
2.5
—
27.9
—
0
10
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
0
10
0.00
0.22
0.0
1.4
—
—
—
0
0
0
10
0.00
0.22
0.0
2.6
—
—
—
0
0
0
10
0.00
0.22
0.0
2.7
—
4.4
—
0
5
0
10
0.00
0.22
0.0
3.7
—
—
—
0
0
0
10
0.00
0.22
0.0
3.4
—
—
—
0
0
0
10
0.00
0.22
0.0
2.8
—
5.1
—
0
10
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
6
49
1.27
0.21
4.3
6.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
22.0
—
—
—
0
0
7
61
1.19
0.19
31.9
30.1
1.2
1.0
mg/l
—
7
61
5
64
0.74
0.19
2.2
1.4
—
—
—
0
0
10
83
1.29
0.18
2.1
5.4
—
—
—
0
0
7
86
0.77
0.17
2.1
2.2
—
—
—
0
0
10
115
0.82
0.13
3.5
4.8
4.1
4.2
mmol/l
—
10
110
10
115
0.82
0.13
3.5
4.2
1.2
1.4
mmol/l
—
10
106
22
205
1.21
0.12
8.5
14.0
—
—
—
0
0
15
165
0.84
0.12
2.1
2.1
0.9
1.1
g/l
—
6
70
16
175
0.84
0.12
9.0
6.3
—
—
—
0
0
10
114
0.83
0.11
3.5
4.4
2.6
2.6
mmol/l
—
10
108
13
144
0.84
0.11
13.5
16.1
24.6
24.9
mmol/l
0.24
13
144
13
117
1.18
0.10
7.8
13.3
10.6
10.0
kpa
0.44
13
112
13
117
1.18
0.10
7.4
6.7
—
—
—
0
0
7
64
1.12
0.09
1.3
2.0
—
—
—
0
0
10
91
1.14
0.05
11.1
4.4
—
—
—
0
0
13
126
1.05
0.00
18.1
14.7
1.5
1.4
mmol/l
0.19
13
120
12
124
0.95
0.00
13.9
14.0
—
—
—
0
0
17
168
1.02
0.00
13.8
13.5
—
—
—
0
0
0
5
0.00
0.00
0.0
17.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
9.3
—
4.9
—
0
7
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
428.4
—
0
5
0
7
0.00
0.00
0.0
3.1
—
214.6
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
28.7
—
0
5
0
5
0.00
0.00
0.0
1.2
—
3.7
—
0
5
0
7
0.00
0.00
0.0
9.3
—
10.0
—
0
7
0
7
0.00
0.00
0.0
4.4
—
4.4
—
0
7
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.0
—
166.1
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
7.3
—
0
8
8
81
0.98
0.00
1.1
1.5
—
—
—
0
0
28
282
0.96
0.00
14.9
16.6
15.4
23.9
mg/l
1.58
19
187
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
305.1
—
0
8
0
9
0.00
0.00
0.0
7.1
—
7.4
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
31.7
—
0.7
—
0
6
26
258
1.03
0.00
15.1
15.5
48.8
44.2
umol/l
0.45
26
258
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
1.1
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint P16_FET_NEWB_NOXIO_INFLUENCES_TRANSMIT_PLACEN_BREAST_MILK and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_NOXIO_INFLUENCES_TRANSMIT_PLACEN_BREAST_MILK.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_FET_NEWB_NOXIO_INFLUENCES_TRANSMIT_PLACEN_BREAST_MILK – Fetus and newborn affected by noxious influences transmitted via placenta or breast milk

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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