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Other disorders originating in the perinatal period

EFO Endpoint Browser PheWeb

P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P90-P96
  • Cause of death: ICD-10 — P90-P96

2 out of 7 registries used, show all original rules.

366

4. Check minimum number of events

None

366

5. Include endpoints

366

6. Filter based on genotype QC (FinnGen only)

366

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Aliae morbositates origine perinatales

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19070 9095 9959
Only index persons 8108 4005 4103
Unadjusted period prevalence (%)
Whole population 0.27 0.26 0.28
Only index persons 0.15 0.15 0.16
Median age at first event (years)
Whole population 0.08 0.03 0.03
Only index persons 0.04 0.06 0.03

-FinnGen-

Key figures

All Female Male
Number of individuals 366 230 136
Unadjusted period prevalence (%) 0.07 0.08 0.06
Median age at first event (years) 0.60 0.92 0.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
338
Matched controls
3360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P95
ICD-10 Finland
Fetal death of unspecified cause
+∞
57.9
54
*
P92.5
ICD-10 Finland
Neonatal difficulty in feeding at breast
+∞
52.4
49
*
P94.2
ICD-10 Finland
Congenital hypotonia
341.2
31.3
31
*
P92.9
ICD-10 Finland
Feeding problem of newborn, unspecified
+∞
26.3
25
*
P92.3
ICD-10 Finland
Underfeeding of newborn
+∞
24.2
23
*
P90
ICD-10 Finland
Convulsions of newborn
+∞
22.1
21
*
P92.1
ICD-10 Finland
Regurgitation and rumination in newborn
58.3
19.1
22
*
P92.0
ICD-10 Finland
Vomiting in newborn
73.9
18.9
21
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
5.4
15.3
47
97
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
9.1
14.8
31
37
P92.2
ICD-10 Finland
Slow feeding of newborn
+∞
13.6
13
*
G02CB01
ATC
bromocriptine; systemic
13.5
13.6
23
18
R4110
NOMESCO Finland
Physiotherapy
2.6
12.8
119
586
O36.4
ICD-10 Finland
Maternal care for intrauterine death
33.3
12.6
16
5
P94.1
ICD-10 Finland
Congenital hypertonia
+∞
12.5
12
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
12.1
54
161
R62.0
ICD-10 Finland
Delayed milestone
3.8
11.7
51
149
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
+∞
11.5
11
*
P21.0
ICD-10 Finland
Severe birth asphyxia
36.2
11.3
14
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.7
10.8
49
148
P85
ICPC
Mental retardation
9.2
10.4
21
24
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
11.7
10.1
18
16
P96.8
ICD-10 Finland
Other specified conditions originating in the perinatal period
+∞
9.4
9
*
P96.0
ICD-10 Finland
Congenital renal failure
+∞
9.4
9
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.9
9.4
60
232
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
24.7
8.9
12
5
P07.3
ICD-10 Finland
Other preterm infants
3.8
8.7
36
101
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
28.2
8.5
11
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
20.5
8.5
12
6
P94.9
ICD-10 Finland
Disorder of muscle tone of newborn, unspecified
+∞
8.3
8
*
A03FA02
ATC
cisapride; oral, rectal
5.0
7.6
23
48
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
13.7
7.4
12
9
RT490
NOMESCO Finland
NA
9.6
7.3
14
15
P91.9
ICD-10 Finland
Disturbance of cerebral status of newborn, unspecified
+∞
7.3
7
*
P91.8
ICD-10 Finland
Other specified disturbances of cerebral status of newborn
+∞
7.3
7
*
WX930
NOMESCO Finland
Thepapeutic hypothermia
+∞
7.3
7
*
H50.30
ICD-10 Finland
Intermittent esotropy
5.2
6.9
20
40
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
6.9
83
447
N18.8
ICD-10 Finland
Other chronic renal failure
8.0
6.7
14
18
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
12.5
6.6
11
9
RT190
NOMESCO Finland
NA
10.3
6.6
12
12
RL140
NOMESCO Finland
NA
5.7
6.4
17
31
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
6.1
6.4
16
27
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
4.9
6.3
19
40
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
18.3
6.3
9
5
P91.08
ICD-10 Finland
Acute neonatal cerebral ischaemia
+∞
6.3
6
*
P94.8
ICD-10 Finland
Other disorders of muscle tone of newborn
+∞
6.3
6
*
P91.1
ICD-10 Finland
Acquired periventricular cysts of newborn
+∞
6.3
6
*
P96.9
ICD-10 Finland
Condition originating in the perinatal period, unspecified
+∞
6.3
6
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
2.9
6.2
37
138
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.5
6.1
49
217
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.6
6.1
45
190
RT150
NOMESCO Finland
NA
5.7
6.0
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
110
3.63
10.87
1.5
1.5
—
—
—
0
0
37
110
3.63
10.87
1.5
1.5
—
—
—
0
0
37
115
3.47
10.16
1.6
1.5
—
—
—
0
0
145
970
1.82
6.90
6.0
4.8
16.3
95.3
e6/l
0.62
108
743
125
817
1.80
6.32
3.9
3.6
—
—
—
0
0
135
916
1.75
5.94
5.7
4.5
0.1
0.3
e6/l
2.07
95
691
159
1142
1.69
5.62
7.2
5.6
66.4
50.9
e6/l
0.17
112
766
134
920
1.72
5.58
5.5
4.4
—
—
—
0
0
193
1472
1.66
5.33
16.2
13.5
1.2
1.2
mmol/l
0.45
181
1359
14
35
4.12
5.21
1.0
1.0
—
—
—
0
0
104
680
1.74
5.09
5.9
10.5
23.8
23.5
mmol/l
0.59
94
662
204
1594
1.63
5.00
7.7
8.5
6.1
6.1
mmol/l
0.01
191
1475
15
41
3.77
4.97
12.3
7.3
—
—
—
0
0
128
891
1.67
4.96
9.4
9.4
37.3
37.1
g/l
0.14
122
856
11
24
4.69
4.81
1.3
1.1
—
—
—
0
0
24
91
2.75
4.75
3.4
2.1
—
—
—
0
0
109
736
1.68
4.70
13.0
11.4
7.4
7.4
ph
—
6
18
109
736
1.68
4.70
13.0
11.4
5.0
5.0
kpa
0.76
104
712
92
594
1.73
4.67
7.9
4.0
7.4
7.4
ph
0.32
19
101
145
1061
1.61
4.52
9.2
8.9
25.3
26.1
umol/l
0.07
136
982
82
518
1.75
4.48
5.9
4.3
—
—
—
0
0
9
12
7.66
4.38
1.8
1.6
—
—
—
0
0
106
726
1.65
4.28
8.0
11.2
1.3
1.0
mmol/l
0.59
86
557
106
729
1.64
4.20
8.0
11.1
5.7
5.7
kpa
0.02
101
713
11
27
4.17
4.19
1.3
1.1
—
—
—
0
0
9
13
7.07
4.18
1.8
1.5
—
—
—
0
0
30
136
2.31
4.15
2.4
1.8
—
—
—
0
0
181
1421
1.54
4.03
16.6
14.6
1.2
1.2
mmol/l
0.42
176
1354
100
686
1.63
3.98
13.7
11.1
9.5
9.7
kpa
0.53
95
662
92
618
1.65
3.98
5.0
3.6
525.1
591.8
mosm/kgh2o
1.92
80
537
105
731
1.61
3.93
3.7
3.4
—
—
—
0
0
164
1272
1.52
3.79
4.8
3.6
0.0
0.0
estimate
0.00
19
211
53
309
1.84
3.76
2.4
2.1
—
—
—
0
0
96
661
1.61
3.74
12.8
10.8
—
—
—
0
0
165
1285
1.52
3.72
4.9
3.6
0.0
0.0
estimate
0.00
21
221
96
662
1.61
3.72
3.2
2.5
—
—
—
0
0
101
708
1.59
3.65
7.9
11.1
5.2
5.3
kpa
0.14
96
693
17
63
2.78
3.54
1.9
1.6
—
—
—
0
0
93
645
1.59
3.50
5.3
3.7
4.2
7.8
e6/l
1.85
80
568
95
667
1.57
3.38
10.9
11.9
—
—
—
0
0
145
1116
1.50
3.38
5.4
4.5
—
—
—
0
0
222
1861
1.49
3.37
5.7
4.4
—
—
—
0
0
133
1008
1.50
3.33
5.3
3.4
—
—
—
0
0
161
1273
1.47
3.25
7.2
5.3
0.0
0.0
estimate
0.00
21
226
74
503
1.59
3.00
3.0
2.4
275.7
426.9
u/l
0.43
74
486
55
349
1.68
2.93
3.4
5.0
0.2
0.2
g/l
0.37
55
336
14
52
2.76
2.92
1.3
1.4
3.2
4.2
u/ml
—
5
25
8
19
4.28
2.69
1.0
1.3
—
—
—
0
0
296
2692
1.52
2.56
21.5
14.2
139.3
139.4
mmol/l
0.29
290
2626
50
321
1.65
2.55
6.3
5.0
80.8
63.0
e9/l
0.84
35
196
35
204
1.79
2.52
2.5
1.9
—
—
—
0
0
136
1082
1.41
2.51
8.3
10.0
—
—
—
0
0
198
1679
1.39
2.50
10.3
5.9
129.8
124.3
u/l
0.38
192
1581
105
799
1.44
2.47
15.4
16.0
24.4
24.5
mmol/l
0.10
105
799
5
8
6.32
2.38
1.6
2.6
—
—
—
0
0
5
8
6.32
2.38
1.4
1.5
180.3
90.1
mu/l
—
5
8
295
2694
1.49
2.37
22.4
14.2
4.0
4.0
mmol/l
0.25
287
2612
55
372
1.56
2.28
3.2
3.8
8.8
8.6
g/l
0.22
55
359
32
188
1.77
2.26
1.8
1.7
—
—
—
0
0
20
100
2.06
2.25
5.5
2.1
0.6
0.5
nmol/l
0.57
20
85
57
391
1.54
2.22
3.2
7.8
5.3
6.5
umol/l
0.37
49
323
9
30
3.05
2.16
4.0
2.4
0.9
1.1
umol/l
—
9
30
80
593
1.45
2.15
5.0
3.1
1.0
1.0
kg/l
0.54
22
113
9
31
2.95
2.08
2.8
2.5
—
—
—
0
0
5
10
5.05
2.07
3.6
2.5
104.6
106.0
mmol/l
—
5
10
44
290
1.59
2.04
1.8
2.1
14.4
14.6
iu/l
0.02
35
197
8
26
3.12
2.02
1.0
1.2
—
—
—
0
0
16
77
2.13
1.99
8.2
9.3
—
—
—
0
0
17
84
2.07
1.99
4.6
3.6
2.6
6.8
ug/l
—
9
58
14
64
2.23
1.97
12.6
5.0
—
—
—
0
0
5
11
4.59
1.94
3.6
2.4
4.4
4.0
mmol/l
—
5
11
9
33
2.77
1.94
2.6
2.1
—
—
—
0
0
216
1906
1.33
1.88
9.4
9.7
2.6
2.4
e9/l
0.74
184
1642
210
1847
1.32
1.87
9.0
9.6
47.0
48.9
%
1.06
204
1795
167
1423
1.32
1.86
8.7
10.6
—
—
—
0
0
6
17
3.57
1.84
7.2
5.8
245.7
214.8
ug/l
—
6
17
244
2196
1.33
1.82
4.0
3.7
14.0
14.4
pmol/l
1.50
231
2030
209
1849
1.30
1.72
9.6
9.7
0.0
0.0
e9/l
0.24
172
1542
11
48
2.33
1.72
1.6
2.2
—
—
—
0
0
11
48
2.33
1.72
3.6
2.3
14.0
13.1
umol/l
0.21
11
48
209
1850
1.30
1.71
9.6
9.8
0.6
0.6
e9/l
0.24
172
1543
200
1761
1.30
1.70
9.8
10.0
0.6
0.6
%
0.55
195
1706
25
150
1.72
1.68
1.9
1.8
—
—
—
0
0
316
2979
1.44
1.63
12.6
9.1
—
—
—
0
0
37
248
1.55
1.63
1.9
2.2
5.9
6.9
u/l
0.28
25
142
203
1798
1.29
1.62
9.7
10.0
3.1
3.3
%
0.38
197
1738
5
14
3.61
1.62
8.8
1.1
177.1
11.1
u/l
—
5
14
35
232
1.56
1.62
1.2
1.2
—
—
—
0
0
13
63
2.10
1.61
2.8
2.5
—
—
—
0
0
272
2507
1.33
1.60
4.4
4.1
1.9
2.4
mu/l
0.50
264
2368
42
292
1.50
1.57
2.5
2.1
1.0
1.0
g/l
0.03
42
278
10
44
2.31
1.54
1.2
1.2
—
—
—
0
0
19
108
1.80
1.54
1.9
1.7
—
—
—
0
0
18
101
1.82
1.51
2.3
3.3
—
—
—
0
0
13
65
2.04
1.50
2.5
2.0
2.2
2.1
mmol/l
—
8
48
42
295
1.48
1.50
5.6
3.3
70.6
408.2
mg/l
0.83
34
211
144
1231
1.28
1.49
1.9
1.6
1.6
1.6
g/l
0.04
77
623
212
1901
1.27
1.48
10.1
10.7
0.2
0.2
e9/l
0.45
179
1618
203
1811
1.27
1.48
9.8
10.0
8.1
8.3
%
0.66
198
1758
310
2925
1.39
1.48
22.5
16.9
13.5
13.3
%
1.12
305
2888
35
238
1.52
1.46
1.5
1.4
—
—
—
0
0
14
73
1.95
1.46
1.2
1.2
—
—
—
0
0
12
59
2.07
1.45
1.4
1.3
—
—
—
0
0
79
627
1.33
1.41
5.1
3.1
—
—
—
0
0
9
40
2.28
1.41
2.3
1.7
—
—
—
0
0
11
53
2.11
1.40
13.0
8.0
10.2
9.3
kpa
0.73
11
53
11
53
2.11
1.40
13.0
8.0
2.0
2.6
mmol/l
—
5
30
11
53
2.11
1.40
13.0
8.0
5.1
4.9
kpa
0.38
11
53
317
3010
1.40
1.38
19.0
11.9
22.1
21.5
mg/l
0.15
236
2107
6
23
2.63
1.37
8.0
8.3
8.7
5.8
mmol/l
—
6
23
29
192
1.55
1.37
10.9
13.9
-0.0
-0.0
mmol/l
0.01
22
158
175
1547
1.25
1.33
4.0
3.3
51.1
52.6
ug/l
0.08
170
1469
6
24
2.52
1.31
1.0
1.1
—
—
—
0
0
67
525
1.34
1.30
2.7
5.2
4.2
1.5
mg/l
0.50
54
385
8
34
2.38
1.30
2.0
1.1
—
—
—
0
0
9
44
2.07
1.27
11.2
8.6
—
—
—
0
0
9
44
2.07
1.27
3.0
2.8
—
—
—
0
0
59
457
1.35
1.24
18.7
15.2
6.4
5.2
mmol/l
1.04
59
447
18
110
1.67
1.17
5.3
5.8
—
—
—
0
0
104
877
1.26
1.17
1.8
1.9
—
—
—
0
0
15
87
1.76
1.17
1.4
1.3
335.5
368.6
ug/g
—
8
50
25
168
1.52
1.13
10.8
5.5
0.7
0.4
%
—
9
44
48
366
1.36
1.12
1.6
1.3
23.5
20.6
nmol/l
0.67
43
315
7
32
2.21
1.08
1.0
1.1
—
—
—
0
0
68
549
1.29
1.08
1.7
1.8
—
—
—
0
0
51
398
1.33
1.04
4.2
2.7
18.0
21.7
ng/l
0.28
28
155
5
22
2.29
1.03
1.0
1.2
—
—
—
0
0
74
608
1.27
1.03
1.8
1.6
91.4
99.2
pmol/l
0.81
40
316
39
292
1.38
1.03
6.6
3.9
17.2
66.2
mg/mmol
0.43
32
204
25
172
1.49
1.03
11.6
6.3
0.0
0.0
%
0.49
14
57
12
68
1.79
1.01
3.9
4.6
25.3
25.1
umol/l
0.02
12
68
7
35
2.02
1.00
2.6
2.6
71.1
57.8
umol/l
—
7
35
217
2002
1.21
0.99
12.3
11.8
3.6
3.5
e9/l
0.35
181
1672
87
733
1.25
0.98
1.9
1.8
—
—
—
0
0
7
36
1.96
0.97
2.9
2.5
—
—
—
0
0
7
37
1.91
0.94
1.3
1.5
—
—
—
0
0
321
3092
1.31
0.93
19.4
16.3
38.1
38.8
%
1.23
294
2796
13
78
1.69
0.92
1.2
1.9
—
52.9
—
0
7
200
1839
1.19
0.92
3.0
2.6
5.6
5.4
mmol/l
0.65
188
1689
51
406
1.30
0.91
1.4
1.5
746.7
499.7
titre
0.51
12
67
45
353
1.31
0.90
2.5
4.2
386.3
1008.2
ng/l
1.46
23
202
174
1584
1.19
0.88
5.0
3.7
37.3
36.9
mmol/mol
0.15
169
1507
110
961
1.21
0.88
1.9
1.7
—
—
—
0
0
6
30
2.02
0.87
4.0
2.5
—
—
—
0
0
24
171
1.43
0.85
11.6
6.3
0.0
0.0
%
0.49
11
55
23
163
1.44
0.84
1.7
1.5
—
—
—
0
0
8
46
1.76
0.83
1.8
4.5
—
—
—
0
0
53
431
1.27
0.82
2.0
1.9
—
—
—
0
0
6
33
1.83
0.79
1.2
1.0
—
—
—
0
0
189
1747
1.17
0.77
12.1
11.8
0.1
0.0
e9/l
0.50
142
1329
24
175
1.40
0.77
2.9
2.4
—
—
—
0
0
6
34
1.78
0.76
3.8
1.9
—
—
—
0
0
79
678
1.21
0.76
2.2
1.7
—
—
—
0
0
26
193
1.37
0.75
5.6
4.5
25.6
22.0
nmol/l
0.55
26
188
9
54
1.68
0.75
2.0
4.2
—
—
—
0
0
16
108
1.50
0.75
1.7
2.3
—
—
—
0
0
16
108
1.50
0.75
1.7
2.3
—
—
—
0
0
16
108
1.50
0.75
1.7
2.3
—
—
—
0
0
16
108
1.50
0.75
1.7
2.3
—
—
—
0
0
96
841
1.19
0.74
2.6
2.1
—
—
—
0
0
25
185
1.38
0.74
11.6
6.1
0.8
0.5
%
0.77
14
63
9
56
1.62
0.73
1.9
1.3
—
—
—
0
0
347
3399
1.40
0.70
25.0
17.8
4.5
4.5
e12/l
1.04
336
3231
9
58
1.57
0.70
1.0
1.1
—
—
—
0
0
20
144
1.41
0.69
1.6
1.5
0.2
0.2
g/l
0.09
20
138
27
205
1.34
0.69
5.4
2.2
—
—
—
0
0
23
170
1.38
0.69
1.0
1.1
9.4
7.3
u/ml
0.19
12
106
23
170
1.38
0.69
1.5
1.3
—
—
—
0
0
9
59
1.54
0.69
10.3
4.2
51.9
51.5
%
—
9
59
19
136
1.42
0.68
14.3
18.0
95.9
95.9
%
0.02
19
136
347
3401
1.39
0.67
25.1
17.9
7.3
7.0
e9/l
1.45
338
3232
31
242
1.31
0.67
4.0
1.8
—
—
—
0
0
15
103
1.48
0.66
1.2
1.2
—
—
—
0
0
7
44
1.60
0.65
2.7
4.9
1.7
1.4
mmol/l
—
7
44
5
29
1.73
0.64
1.8
2.2
—
—
—
0
0
5
29
1.73
0.64
1.2
1.4
—
—
—
0
0
29
226
1.31
0.64
1.6
1.5
—
—
—
0
0
20
147
1.38
0.63
1.6
1.5
1.1
1.1
g/l
0.01
20
139
71
615
1.19
0.63
5.5
3.7
0.0
0.0
estimate
0.00
19
216
35
281
1.27
0.62
1.7
1.5
—
—
—
0
0
35
281
1.27
0.62
2.7
2.4
10164.9
4434.0
u/l
0.38
11
100
346
3394
1.36
0.62
25.2
17.9
272.5
273.2
e9/l
0.07
338
3232
21
159
1.34
0.56
1.0
1.2
27.2
8.5
u/ml
1.00
12
102
70
613
1.18
0.55
2.0
2.1
—
—
—
0
0
9
64
1.42
0.52
1.0
1.1
—
—
—
0
0
7
45
1.57
0.49
1.0
1.1
—
—
—
0
0
32
385
0.81
0.48
1.3
1.2
116.3
20.6
iu/ml
—
9
108
7
47
1.50
0.48
2.9
1.6
—
—
—
0
0
12
165
0.72
0.47
1.3
1.4
—
—
—
0
0
18
138
1.32
0.46
14.9
17.7
0.7
0.7
%
0.15
18
138
39
330
1.20
0.46
3.6
2.8
—
—
—
0
0
7
50
1.41
0.45
1.1
1.0
—
—
—
0
0
20
158
1.28
0.42
5.3
1.9
—
—
—
0
0
19
149
1.29
0.42
1.3
1.3
202.3
276.3
miu/ml
—
9
76
69
618
1.14
0.42
4.5
5.1
1.0
1.1
inr
1.24
18
162
8
57
1.41
0.42
7.5
2.6
23.3
35.8
mmol/l
—
8
57
8
57
1.41
0.42
7.0
3.9
3.2
3.5
e9/l
—
8
57
8
58
1.39
0.42
1.4
1.1
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
2.8
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
11
79
1.40
0.41
1.2
1.8
—
—
—
0
0
138
1292
1.11
0.41
1.9
1.8
4.5
4.0
u/ml
0.11
22
220
88
805
1.12
0.39
2.7
3.4
3.0
2.6
mg/l
1.09
83
731
5
35
1.43
0.39
4.0
3.1
—
148.2
—
0
8
19
151
1.27
0.39
1.1
1.1
2.5
0.3
u/ml
—
10
84
0
19
0.00
0.39
0.0
1.1
—
7.6
—
0
14
67
603
1.14
0.39
2.9
3.4
148.6
75.3
ug/g
1.15
56
482
11
80
1.39
0.39
3.0
4.1
—
—
—
0
0
33
281
1.19
0.38
3.8
1.7
—
—
—
0
0
15
116
1.31
0.37
14.4
18.4
—
—
—
0
0
17
134
1.28
0.37
1.8
1.7
—
—
—
0
0
23
189
1.23
0.37
1.3
1.3
—
—
—
0
0
6
87
0.68
0.33
1.3
1.4
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
6
46
1.31
0.33
1.0
1.0
—
—
—
0
0
17
137
1.25
0.32
15.1
17.8
1.1
1.0
%
0.12
17
137
6
47
1.28
0.32
1.0
1.0
—
—
—
0
0
6
47
1.28
0.32
7.7
7.0
1.3
1.4
%
—
6
41
7
52
1.35
0.31
1.4
1.9
—
—
—
0
0
16
129
1.25
0.31
1.4
1.5
0.4
4.0
u/ml
—
9
95
24
204
1.19
0.29
1.5
1.4
—
—
—
0
0
15
183
0.81
0.28
1.1
1.0
—
—
—
0
0
8
63
1.28
0.28
2.3
4.3
—
—
—
0
0
62
569
1.11
0.27
1.3
1.2
—
—
—
0
0
12
150
0.79
0.27
1.7
1.3
—
—
—
0
0
5
74
0.67
0.26
3.8
26.5
12.9
11.7
%
—
5
74
9
73
1.24
0.25
1.4
2.9
—
708.3
—
0
8
10
78
1.29
0.24
1.7
1.7
—
—
—
0
0
22
190
1.17
0.23
1.0
1.0
—
—
—
0
0
22
190
1.17
0.23
1.0
1.0
-3.0
-2.1
mmol/l
—
8
47
13
106
1.23
0.23
2.5
3.6
68.5
64.9
%
0.34
13
106
5
38
1.32
0.23
1.4
1.1
—
—
—
0
0
5
39
1.29
0.23
1.2
1.0
—
—
—
0
0
10
79
1.27
0.22
4.8
6.1
1.6
2.1
ug/l
—
10
79
5
40
1.25
0.22
1.2
1.1
—
—
—
0
0
34
377
0.89
0.22
1.3
1.2
2.5
5.8
u/ml
—
10
134
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
19.7
—
0
7
33
298
1.12
0.20
3.8
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
79.5
—
0
9
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
33
299
1.11
0.19
3.9
1.7
—
—
—
0
0
33
299
1.11
0.19
3.9
1.7
—
—
—
0
0
15
128
1.18
0.18
3.3
4.6
319.9
340.8
mg/l
0.11
15
128
7
59
1.19
0.18
6.9
9.2
—
—
—
0
0
12
101
1.19
0.17
4.3
5.5
—
—
—
0
0
12
141
0.85
0.16
1.3
1.1
—
—
—
0
0
31
285
1.10
0.14
1.2
1.2
0.6
5.7
u/ml
7.29
19
226
13
112
1.17
0.14
2.2
19.4
—
—
—
0
0
45
425
1.07
0.12
2.0
1.6
—
—
—
0
0
32
298
1.08
0.12
4.1
1.7
—
—
—
0
0
11
95
1.16
0.11
1.2
1.2
—
—
—
0
0
118
1211
0.96
0.10
3.0
2.3
—
—
—
0
0
13
115
1.14
0.10
4.1
4.9
—
—
—
0
0
23
212
1.09
0.10
2.5
2.2
216.2
177.5
u/ml
0.31
14
96
21
193
1.09
0.10
8.8
3.3
—
—
—
0
0
30
282
1.07
0.09
1.2
1.3
1.2
0.9
u/ml
0.12
18
214
35
368
0.95
0.08
2.1
1.9
—
—
—
0
0
64
620
1.04
0.07
11.0
5.0
—
—
—
0
0
22
232
0.94
0.05
1.3
1.2
—
—
—
0
0
12
111
1.08
0.04
2.3
4.0
16.3
17.9
%
0.21
12
111
15
158
0.95
0.02
1.7
1.5
—
—
—
0
0
197
1960
1.01
0.02
5.3
4.5
8.2
7.9
mm/h
0.19
190
1848
10
107
0.93
0.02
3.1
2.7
—
—
—
0
0
13
124
1.05
0.00
1.4
1.2
—
—
—
0
0
27
276
0.98
0.00
1.1
1.2
0.6
3.6
u/ml
2.47
11
100
10
98
1.02
0.00
2.6
22.0
72.3
72.3
%
—
10
98
10
98
1.02
0.00
1.7
3.6
21.5
24.7
%
—
10
98
12
119
1.01
0.00
4.7
3.9
—
—
—
0
0
13
131
0.99
0.00
1.0
1.2
—
—
—
0
0
16
163
0.98
0.00
1.1
1.1
—
—
—
0
0
13
125
1.04
0.00
1.4
1.6
1.1
12.8
u/ml
—
8
91
6
61
0.98
0.00
1.0
1.3
—
—
—
0
0
7
78
0.90
0.00
2.1
2.4
9.5
6.9
ug/l
—
7
69
0
6
0.00
0.00
0.0
1.2
—
1581.3
—
0
6
0
7
0.00
0.00
0.0
1.4
—
72.8
—
0
7
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
8
85
0.94
0.00
1.7
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
30
300
1.00
0.00
1.2
1.3
1.4
2.6
u/ml
0.44
20
211
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
147.6
—
0
7
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
5.0
—
0.5
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
13
130
1.00
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
139.1
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
0.00
1.4
2.0
0.2
16.9
u/ml
—
5
41
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint P16_OTH_DISORD_ORIGINA_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_OTH_DISORD_ORIGINA_PERINA_PERIOD 3.808 [2.79, 5.19] < 0.001
Birth year 0.998 [0.99, 1.01] 0.641

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 8343 females with P16_OTH_DISORD_ORIGINA_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_OTH_DISORD_ORIGINA_PERINA_PERIOD 3.23 [2.24, 4.66] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 9291 males with P16_OTH_DISORD_ORIGINA_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_DISORD_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 0.346% 0.536%
5 2.175% 3.4%
10 5.482% 9.188%
15 10.433% 16.711%
20 18.473% 26.947%

Relationships between endpoints

↥

Index endpoint: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD – Other disorders originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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