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Other disorders originating in the perinatal period

EFO Endpoint Browser PheWeb

P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P90-P96
  • Cause of death: ICD-10 — P90-P96

2 out of 7 registries used, show all original rules.

376

4. Check minimum number of events

None

376

5. Include endpoints

376

6. Filter based on genotype QC (FinnGen only)

353

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Aliae morbositates origine perinatales

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19070 9095 9959
Only index persons 8108 4005 4103
Unadjusted period prevalence (%)
Whole population 0.27 0.26 0.28
Only index persons 0.15 0.15 0.16
Median age at first event (years)
Whole population 0.08 0.03 0.03
Only index persons 0.04 0.06 0.03

-FinnGen-

Key figures

All Female Male
Number of individuals 353 228 125
Unadjusted period prevalence (%) 0.07 0.08 0.06
Median age at first event (years) 2.08 3.18 0.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
376
Matched controls
3760
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P95
ICD-10 Finland
Fetal death of unspecified cause
+∞
64.5
60
*
P92.5
ICD-10 Finland
Neonatal difficulty in feeding at breast
694.3
61.6
59
*
P94.2
ICD-10 Finland
Congenital hypotonia
124.2
32.2
34
*
P92.9
ICD-10 Finland
Feeding problem of newborn, unspecified
+∞
27.4
26
*
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
9.2
27.1
34
40
P92.3
ICD-10 Finland
Underfeeding of newborn
+∞
25.3
24
*
P90
ICD-10 Finland
Convulsions of newborn
+∞
24.2
23
*
P92.0
ICD-10 Finland
Vomiting in newborn
133.5
23.9
25
*
P92.1
ICD-10 Finland
Regurgitation and rumination in newborn
89.1
23.0
25
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
4.8
20.3
49
113
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
18.1
59
171
P85
ICPC
Mental retardation
8.0
18.0
25
33
P07.3
ICD-10 Finland
Other preterm infants
4.6
16.2
41
98
O36.4
ICD-10 Finland
Maternal care for intrauterine death
62.8
15.9
18
*
P92.2
ICD-10 Finland
Slow feeding of newborn
+∞
15.7
15
*
G02CB01
ATC
bromocriptine; systemic
14.8
15.2
25
18
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.6
14.9
53
163
P94.1
ICD-10 Finland
Congenital hypertonia
+∞
14.7
14
*
R62.0
ICD-10 Finland
Delayed milestone
3.4
14.1
55
179
R4110
NOMESCO Finland
Physiotherapy
2.4
13.2
133
709
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
67.1
11.7
13
*
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
+∞
11.5
11
*
A03FA02
ATC
cisapride; oral, rectal
4.5
11.2
28
66
P21.0
ICD-10 Finland
Severe birth asphyxia
29.0
10.8
14
5
H50.30
ICD-10 Finland
Intermittent esotropy
5.2
10.7
22
44
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.5
10.6
80
371
P96.0
ICD-10 Finland
Congenital renal failure
+∞
10.5
10
*
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
11.1
10.4
19
18
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
33.6
10.4
13
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
5.5
10.2
20
38
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
7.9
9.5
21
28
P96.8
ICD-10 Finland
Other specified conditions originating in the perinatal period
+∞
9.4
9
*
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
22.4
9.4
13
6
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.1
8.9
38
130
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.7
8.9
21
47
WX722
NOMESCO Finland
PEEP
3.5
8.7
30
90
Z3226
NOMESCO Finland
Physiotherapist
2.1
8.6
109
622
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
20.6
8.5
12
6
G80.8
ICD-10 Finland
Other cerebral palsy
92.0
8.4
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
8.4
93
503
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
8.4
96
526
P94.9
ICD-10 Finland
Disorder of muscle tone of newborn, unspecified
+∞
8.4
8
*
P91.8
ICD-10 Finland
Other specified disturbances of cerebral status of newborn
+∞
8.4
8
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.2
8.2
75
377
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
2.8
7.8
42
164
RT190, ,
NOMESCO Finland
15.4
7.8
12
8
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
12.2
7.6
13
11
N05BA09
ATC
clobazam; oral
4.6
7.5
18
41
ZXE00
NOMESCO Finland
One hour or less
1.8
7.4
164
1117
Z2446
NOMESCO Finland
Social worker
2.1
7.4
81
436
Z37.0
ICD-10 Finland
Single live birth
2.6
7.4
46
194
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.4
7.3
54
246
RT490, ,
NOMESCO Finland
9.6
7.3
14
15
WX930
NOMESCO Finland
Thepapeutic hypothermia
+∞
7.3
7
*
P91.08
ICD-10 Finland
Acute neonatal cerebral ischaemia
+∞
7.3
7
*
P91.9
ICD-10 Finland
Disturbance of cerebral status of newborn, unspecified
+∞
7.3
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.3
149
989
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
3.8
7.1
22
61
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
4.0
7.1
20
52
N18.8
ICD-10 Finland
Other chronic renal failure
8.5
6.9
14
17
N03AX14
ATC
levetiracetam; systemic
3.6
6.8
22
63
RS142, ,
NOMESCO Finland
17.1
6.8
10
6
RL140, ,
NOMESCO Finland
5.7
6.7
18
33
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.9
6.6
19
50
N03AG01
ATC
valproic acid; systemic, rectal
2.9
6.6
31
113
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
6.5
64
329
G80.3
ICD-10 Finland
Dyskinetic cerebral palsy
71.0
6.4
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.4
120
770
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
11.3
6.3
11
10
M03BX01
ATC
baclofen; systemic
9.5
6.3
12
13
P96.9
ICD-10 Finland
Condition originating in the perinatal period, unspecified
+∞
6.3
6
*
P91.1
ICD-10 Finland
Acquired periventricular cysts of newborn
+∞
6.3
6
*
P94.8
ICD-10 Finland
Other disorders of muscle tone of newborn
+∞
6.3
6
*
P94.0
ICD-10 Finland
Transient neonatal myasthenia gravis
+∞
6.3
6
*
Z32.1
ICD-10 Finland
Pregnancy confirmed
2.2
6.2
53
258
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.2
67
358
RT150, ,
NOMESCO Finland
4.0
6.1
17
44

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
124
3.49
11.03
1.5
1.4
—
—
—
0
0
40
124
3.49
11.03
1.5
1.4
—
—
—
0
0
40
130
3.32
10.24
1.6
1.5
—
—
—
0
0
102
595
1.98
7.45
3.9
4.1
1.58
2.04
e6/l
0.38
61
343
149
989
1.84
7.31
5.9
4.8
16.20
93.39
e6/l
0.62
110
760
140
934
1.79
6.62
5.6
4.5
0.14
0.27
e6/l
1.13
99
709
129
844
1.80
6.48
3.9
3.5
—
—
—
0
0
139
941
1.76
6.16
5.4
4.4
—
—
—
0
0
27
95
2.98
6.08
3.4
2.1
—
—
—
0
0
163
1172
1.69
5.71
7.2
5.6
65.42
51.61
e6/l
0.15
114
787
197
1501
1.66
5.44
16.0
13.3
1.23
1.23
mmol/l
0.36
187
1389
210
1640
1.64
5.16
7.6
8.4
6.04
6.05
mmol/l
0.02
197
1511
10
12
8.52
5.09
1.8
1.6
—
—
—
0
0
151
1090
1.64
5.06
8.9
8.7
24.63
25.70
umol/l
0.10
141
1010
15
41
3.77
4.97
12.3
7.3
—
—
—
0
0
154
1127
1.62
4.83
5.2
3.3
5.91
6.16
ph
0.97
22
146
32
140
2.41
4.76
2.7
1.9
—
—
—
0
0
130
915
1.64
4.76
9.4
9.3
37.23
37.12
g/l
0.07
124
882
94
610
1.72
4.66
7.9
4.0
7.39
7.40
ph
0.33
19
103
109
738
1.67
4.62
13.0
11.4
7.39
7.42
ph
—
6
18
20
70
2.96
4.57
3.0
1.8
—
—
—
0
0
110
751
1.66
4.50
4.1
3.4
—
—
—
0
0
84
534
1.74
4.47
5.7
4.3
—
—
—
0
0
173
1321
1.57
4.44
5.0
3.6
0.00
0.00
estimate
-0.00
22
240
174
1331
1.57
4.43
5.1
3.6
0.00
0.00
estimate
-0.00
23
234
107
732
1.65
4.32
7.9
11.1
1.21
0.92
mmol/l
0.56
87
563
107
735
1.64
4.24
8.0
11.1
5.69
5.70
kpa
0.02
102
719
14
35
4.11
4.14
1.0
1.0
—
—
—
0
0
94
634
1.64
3.98
5.2
3.6
533.70
590.70
mosm/kgh2o
1.53
82
552
170
1319
1.53
3.92
7.3
5.3
0.00
0.00
estimate
-0.00
23
239
183
1450
1.51
3.78
16.6
14.4
1.23
1.23
mmol/l
0.25
178
1386
102
712
1.59
3.74
7.9
11.0
5.20
5.30
kpa
0.21
97
697
96
661
1.61
3.72
5.2
3.7
5.10
7.70
e6/l
1.06
84
593
96
663
1.60
3.67
12.8
10.8
—
—
—
0
0
231
1930
1.51
3.64
5.6
4.4
—
—
—
0
0
151
1165
1.49
3.47
4.0
3.4
—
—
—
0
0
53
318
1.78
3.42
2.4
2.1
—
—
—
0
0
11
27
4.16
3.42
1.3
1.1
—
—
—
0
0
96
674
1.57
3.40
10.8
11.8
—
—
—
0
0
99
701
1.56
3.38
3.4
2.4
—
—
—
0
0
11
30
3.74
3.11
1.3
1.1
—
—
—
0
0
6
8
7.60
3.06
1.5
2.6
—
—
—
0
0
52
322
1.71
3.02
6.2
5.0
79.52
63.15
e9/l
0.78
36
197
76
519
1.58
3.01
3.0
2.4
270.14
416.61
u/l
0.43
76
502
39
222
1.84
2.99
2.4
1.9
—
—
—
0
0
306
2763
1.58
2.98
21.2
14.1
139.29
139.38
mmol/l
0.30
300
2697
205
1716
1.43
2.92
10.1
5.9
127.98
123.02
u/l
0.34
198
1617
55
350
1.67
2.89
3.4
5.0
0.21
0.20
g/l
0.30
55
337
305
2765
1.55
2.78
22.0
14.0
3.96
3.95
mmol/l
0.22
297
2683
60
396
1.61
2.74
3.1
7.7
5.26
6.45
umol/l
0.39
51
326
47
291
1.70
2.73
7.4
12.7
106.21
105.67
mmol/l
0.33
47
291
8
19
4.28
2.69
1.0
1.3
—
—
—
0
0
85
611
1.51
2.67
5.3
3.1
1.02
1.02
kg/l
0.46
23
115
139
1101
1.42
2.63
8.2
9.9
—
—
—
0
0
14
56
2.56
2.56
1.3
1.3
3.20
4.12
u/ml
—
5
26
47
297
1.67
2.54
1.7
2.1
16.89
14.63
iu/l
0.21
37
203
22
110
2.06
2.46
2.1
1.7
—
—
—
0
0
105
802
1.43
2.40
15.4
15.9
24.42
24.48
mmol/l
0.10
105
802
5
8
6.32
2.38
1.4
1.5
180.26
90.10
mu/l
—
5
8
10
33
3.08
2.37
2.5
2.1
—
—
—
0
0
9
30
3.05
2.16
4.0
2.4
0.94
1.06
umol/l
—
9
30
32
193
1.72
2.07
1.8
1.7
—
—
—
0
0
222
1948
1.34
2.06
9.2
9.5
2.64
2.36
e9/l
0.79
191
1689
16
77
2.13
1.99
8.2
9.2
—
—
—
0
0
215
1884
1.33
1.98
9.4
9.6
0.04
0.04
e9/l
0.28
178
1576
14
64
2.23
1.97
12.6
5.0
—
—
—
0
0
252
2262
1.35
1.96
4.0
3.7
14.01
14.36
pmol/l
1.56
239
2090
215
1888
1.32
1.93
9.4
9.6
0.57
0.57
e9/l
0.14
178
1580
323
3029
1.47
1.85
22.3
16.8
13.72
13.55
%
0.47
318
2992
6
17
3.57
1.84
7.2
5.8
245.67
214.82
ug/l
—
6
17
5
12
4.21
1.83
3.6
2.3
104.60
105.75
mmol/l
—
5
12
282
2588
1.36
1.81
4.4
4.1
1.93
2.39
mu/l
0.51
274
2445
8
29
2.80
1.80
1.0
1.2
—
—
—
0
0
204
1793
1.30
1.76
9.6
9.9
0.60
0.64
%
0.52
199
1737
17
89
1.95
1.73
4.6
3.7
2.59
6.51
ug/l
—
9
62
11
48
2.33
1.72
1.6
2.2
—
—
—
0
0
11
48
2.33
1.72
3.6
2.3
13.96
13.08
umol/l
0.21
11
48
5
13
3.88
1.72
3.6
2.2
4.36
3.96
mmol/l
—
5
13
218
1939
1.30
1.69
9.8
10.5
0.21
0.22
e9/l
0.39
185
1652
25
150
1.71
1.68
1.8
1.8
—
—
—
0
0
15
76
2.01
1.66
1.2
1.2
—
—
—
0
0
38
256
1.54
1.63
1.9
2.2
5.94
6.95
u/l
0.30
25
149
5
14
3.60
1.62
8.8
1.1
177.14
11.10
u/l
—
5
14
5
14
3.60
1.62
2.2
1.9
—
—
—
0
0
207
1836
1.28
1.61
9.6
9.8
3.09
3.25
%
0.41
202
1779
36
241
1.55
1.59
1.2
1.2
—
—
—
0
0
325
3073
1.42
1.56
12.7
9.1
—
—
—
0
0
147
1254
1.28
1.54
1.9
1.6
1.58
1.59
g/l
0.03
80
636
182
1597
1.27
1.51
4.1
3.3
57.18
52.44
ug/l
0.20
177
1517
327
3099
1.42
1.51
18.8
11.8
21.75
21.61
mg/l
0.03
246
2174
13
65
2.04
1.50
2.5
2.0
2.20
2.10
mmol/l
—
8
48
17
94
1.85
1.50
1.2
1.2
0.25
3.61
u/ml
—
10
64
207
1849
1.27
1.47
9.7
9.9
8.05
8.28
%
0.62
202
1795
18
103
1.79
1.43
2.2
3.2
—
—
—
0
0
30
199
1.55
1.40
10.6
13.5
-0.00
-0.04
mmol/l
0.01
22
162
60
458
1.37
1.37
18.7
15.2
6.51
5.17
mmol/l
1.20
60
448
82
657
1.32
1.36
5.0
3.0
—
—
—
0
0
13
68
1.94
1.35
2.8
2.5
—
—
—
0
0
42
302
1.44
1.35
5.6
3.3
70.58
404.31
mg/l
0.84
34
215
11
54
2.07
1.34
13.0
7.9
2.04
2.58
mmol/l
—
5
31
11
54
2.07
1.34
13.0
7.9
5.15
4.92
kpa
0.38
11
54
11
54
2.07
1.34
13.0
7.9
10.18
9.26
kpa
0.77
11
54
51
381
1.39
1.33
1.6
1.3
22.88
20.86
nmol/l
0.44
46
330
8
34
2.38
1.30
2.0
1.1
—
—
—
0
0
9
44
2.07
1.27
2.3
1.7
—
—
—
0
0
26
171
1.56
1.27
10.4
5.4
0.67
0.48
%
0.28
12
75
75
601
1.31
1.25
1.7
1.8
—
—
—
0
0
6
25
2.42
1.25
8.0
7.7
8.75
5.71
mmol/l
—
6
25
9
45
2.02
1.24
3.0
2.7
—
—
—
0
0
9
45
2.02
1.24
11.2
8.4
—
—
—
0
0
78
632
1.30
1.20
1.8
1.6
91.32
99.72
pmol/l
0.98
44
331
55
424
1.35
1.19
4.0
2.7
18.08
20.99
ng/l
0.23
30
166
12
64
1.90
1.19
1.4
1.3
—
—
—
0
0
107
903
1.26
1.19
1.8
1.9
—
—
—
0
0
26
174
1.53
1.19
11.2
6.3
0.00
0.01
%
0.49
14
70
14
79
1.80
1.18
1.1
1.9
—
52.86
—
0
7
35
250
1.44
1.18
1.5
1.4
—
—
—
0
0
223
2044
1.22
1.13
12.1
11.7
3.61
3.50
e9/l
0.26
187
1711
15
88
1.73
1.13
1.4
1.3
335.50
366.96
ug/g
—
8
51
68
546
1.30
1.12
2.6
5.1
4.17
1.47
mg/l
0.51
55
402
7
33
2.14
1.06
1.9
1.9
—
—
—
0
0
208
1901
1.21
1.06
3.0
2.6
5.56
5.42
mmol/l
0.61
196
1744
40
300
1.37
1.04
6.4
3.9
17.16
65.83
mg/mmol
0.43
32
207
5
22
2.29
1.03
1.0
1.2
—
—
—
0
0
197
1794
1.21
1.03
11.0
10.2
—
—
—
0
0
12
68
1.79
1.01
3.9
4.6
25.33
25.10
umol/l
0.02
12
68
181
1639
1.20
1.00
5.0
3.6
37.07
36.87
mmol/mol
0.09
176
1559
18
116
1.58
0.98
5.3
5.6
—
—
—
0
0
25
174
1.47
0.98
11.2
6.2
0.00
0.04
%
1.08
11
69
116
1008
1.22
0.98
1.9
1.7
—
—
—
0
0
33
244
1.39
0.95
3.5
2.4
25.22
31.53
u/l
0.81
27
202
7
37
1.91
0.94
2.6
2.5
71.14
57.11
umol/l
—
7
37
7
37
1.91
0.94
1.3
1.5
—
—
—
0
0
7
37
1.91
0.94
2.9
2.6
—
—
—
0
0
86
727
1.24
0.94
2.1
1.7
—
—
—
0
0
25
178
1.43
0.89
1.4
1.3
—
—
—
0
0
52
417
1.29
0.88
1.4
1.5
746.67
492.75
titre
0.53
12
69
26
187
1.42
0.88
11.2
6.1
0.79
0.50
%
0.70
14
83
55
445
1.28
0.87
1.9
1.8
—
—
—
0
0
38
292
1.34
0.87
2.6
2.4
10164.88
4117.58
u/l
0.40
11
108
76
640
1.24
0.86
5.8
3.7
0.00
0.00
estimate
-0.00
21
230
25
179
1.42
0.86
2.9
2.4
—
—
—
0
0
8
46
1.75
0.83
2.5
4.8
1.61
1.42
mmol/l
—
8
46
6
32
1.89
0.82
4.0
2.4
—
—
—
0
0
6
32
1.89
0.82
1.7
1.7
13.00
13.05
%
—
6
32
103
900
1.20
0.81
2.5
2.1
—
—
—
0
0
8
47
1.72
0.81
6.3
5.1
0.38
1.40
%
—
8
40
8
47
1.72
0.81
1.7
4.4
—
—
—
0
0
16
106
1.53
0.80
1.2
1.2
—
—
—
0
0
21
148
1.44
0.79
1.6
1.5
1.14
1.14
g/l
0.05
21
140
6
33
1.83
0.79
1.2
1.1
0.10
2.07
u/ml
—
6
27
20
140
1.45
0.78
13.6
17.6
95.81
95.53
%
0.13
20
140
357
3494
1.43
0.77
25.1
18.7
38.47
39.07
%
1.43
352
3383
6
34
1.78
0.76
1.2
1.0
—
—
—
0
0
6
34
1.78
0.76
3.8
1.9
—
—
—
0
0
26
193
1.37
0.75
5.6
4.5
25.59
22.02
nmol/l
0.55
26
188
9
55
1.65
0.74
1.9
4.0
—
—
—
0
0
45
364
1.27
0.73
2.5
4.2
386.35
988.74
ng/l
1.40
23
206
23
168
1.39
0.73
1.7
1.5
—
—
—
0
0
357
3497
1.41
0.73
24.9
17.7
4.50
4.54
e12/l
1.01
346
3328
9
56
1.62
0.73
1.9
1.3
—
—
—
0
0
357
3500
1.40
0.69
24.9
17.7
7.30
6.99
e9/l
1.31
348
3329
9
59
1.54
0.69
10.3
4.2
51.89
51.53
%
—
9
59
20
145
1.40
0.67
1.6
1.5
0.20
0.21
g/l
0.11
20
139
356
3492
1.37
0.64
25.0
17.8
272.51
273.15
e9/l
0.06
348
3329
5
29
1.73
0.64
1.8
2.2
—
—
—
0
0
87
766
1.18
0.64
1.9
1.8
—
—
—
0
0
23
173
1.35
0.63
1.0
1.1
13.25
7.26
u/ml
0.49
15
118
74
643
1.19
0.63
1.9
2.1
—
—
—
0
0
27
209
1.31
0.62
5.4
2.2
—
—
—
0
0
5
30
1.68
0.61
1.2
1.4
—
—
—
0
0
191
1787
1.14
0.61
12.0
11.6
0.07
0.00
e9/l
0.50
144
1368
12
80
1.52
0.60
1.2
1.8
—
—
—
0
0
31
247
1.28
0.59
4.0
1.8
—
—
—
0
0
21
158
1.35
0.58
1.3
1.3
185.70
275.39
miu/ml
—
10
79
70
611
1.18
0.57
2.9
3.4
144.67
74.98
ug/g
1.14
59
489
30
239
1.28
0.57
1.6
1.5
—
—
—
0
0
19
142
1.36
0.55
14.2
17.3
0.73
0.72
%
0.04
19
142
41
341
1.23
0.55
3.5
2.8
—
—
—
0
0
92
825
1.15
0.54
2.7
3.4
3.02
2.62
mg/l
1.03
86
749
9
62
1.46
0.53
1.0
1.1
—
—
—
0
0
21
162
1.31
0.51
1.0
1.1
27.16
8.73
u/ml
0.98
12
103
9
65
1.39
0.51
2.1
4.2
—
—
—
0
0
35
290
1.23
0.50
1.7
1.5
—
—
—
0
0
33
397
0.81
0.49
1.3
1.2
116.28
19.90
iu/ml
—
9
115
7
45
1.57
0.49
1.0
1.1
—
—
—
0
0
142
1319
1.12
0.49
1.9
1.7
4.36
3.91
u/ml
0.09
23
226
7
47
1.50
0.48
2.9
1.6
—
—
—
0
0
7
50
1.41
0.45
1.1
1.0
—
—
—
0
0
17
130
1.32
0.44
1.4
1.5
0.37
3.86
u/ml
—
9
95
8
57
1.41
0.42
7.5
2.6
23.29
35.83
mmol/l
—
8
57
8
57
1.41
0.42
7.0
3.9
3.22
3.48
e9/l
—
8
57
14
105
1.35
0.41
2.4
3.6
37.90
36.46
%
0.26
14
105
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
77
696
1.13
0.41
8.2
7.0
1.03
1.12
inr
1.91
22
190
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
2.75
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
18
141
1.29
0.41
1.7
1.7
—
—
—
0
0
18
141
1.29
0.41
4.1
16.7
0.77
0.62
%
0.74
18
141
18
141
1.29
0.41
14.3
17.4
1.14
1.05
%
0.30
18
141
8
61
1.32
0.39
1.4
1.1
—
—
—
0
0
8
61
1.32
0.39
6.4
9.0
—
—
—
0
0
5
35
1.43
0.39
4.0
3.1
—
148.15
—
0
8
0
19
0.00
0.39
0.0
1.1
—
7.62
—
0
14
9
67
1.35
0.38
1.0
1.1
—
—
—
0
0
20
161
1.26
0.38
5.3
1.9
—
—
—
0
0
11
81
1.37
0.36
3.0
4.1
—
—
—
0
0
19
153
1.25
0.36
1.1
1.1
2.54
0.32
u/ml
—
10
87
15
189
0.79
0.35
1.1
1.0
—
—
—
0
0
6
89
0.67
0.33
1.3
1.4
—
—
—
0
0
23
192
1.21
0.33
1.3
1.3
—
—
—
0
0
6
47
1.28
0.32
7.7
7.0
1.30
1.44
%
—
6
41
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
6
47
1.28
0.32
1.0
1.0
—
—
—
0
0
33
286
1.17
0.32
3.8
1.7
—
—
—
0
0
15
119
1.27
0.32
14.4
18.0
—
—
—
0
0
7
52
1.35
0.31
1.4
1.9
—
—
—
0
0
14
173
0.80
0.29
1.3
1.4
—
—
—
0
0
32
282
1.15
0.26
1.3
1.3
200.80
176.25
iu/ml
—
5
97
13
160
0.81
0.26
1.6
1.3
—
—
—
0
0
5
74
0.67
0.26
3.8
26.5
12.86
11.70
%
—
5
74
35
392
0.88
0.26
1.3
1.2
2.37
5.57
u/ml
0.76
11
142
9
73
1.24
0.25
1.4
2.9
1415.67
843.33
e6/l
—
9
73
10
78
1.29
0.24
1.7
1.7
—
—
—
0
0
22
190
1.17
0.23
1.0
1.0
—
—
—
0
0
22
190
1.17
0.23
1.0
1.0
-3.01
-2.14
mmol/l
—
8
47
13
106
1.23
0.23
2.5
3.6
11.31
9.05
%
0.41
13
106
13
106
1.23
0.23
2.5
3.6
68.46
64.91
%
0.34
13
106
12
97
1.24
0.23
1.2
1.2
—
—
—
0
0
5
39
1.29
0.23
1.4
1.1
—
—
—
0
0
5
40
1.25
0.22
1.2
1.0
—
—
—
0
0
10
79
1.27
0.22
4.8
6.1
1.64
2.07
ug/l
—
10
79
62
577
1.09
0.21
1.3
1.2
—
—
—
0
0
5
42
1.19
0.21
1.2
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
48
442
1.10
0.21
2.0
1.6
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
79.50
—
0
9
24
212
1.14
0.20
1.5
1.4
—
—
—
0
0
23
203
1.14
0.19
8.2
3.3
—
—
—
0
0
22
246
0.89
0.17
1.3
1.2
—
—
—
0
0
24
216
1.12
0.16
2.5
2.2
206.93
178.30
u/ml
0.23
15
99
15
131
1.15
0.14
3.3
4.5
319.87
341.30
mg/l
0.11
15
131
13
112
1.17
0.14
2.2
19.3
—
—
—
0
0
12
103
1.17
0.14
4.3
5.4
—
—
—
0
0
31
287
1.09
0.13
1.2
1.2
0.57
5.71
u/ml
7.29
19
226
33
307
1.08
0.12
3.8
1.7
—
—
—
0
0
33
308
1.08
0.11
3.9
1.7
—
—
—
0
0
33
308
1.08
0.11
3.9
1.7
—
—
—
0
0
205
2018
1.03
0.10
5.2
4.4
8.15
7.98
mm/h
0.10
198
1902
14
126
1.12
0.09
1.4
1.6
1.06
12.75
u/ml
—
8
91
30
284
1.06
0.07
1.2
1.3
1.19
0.87
u/ml
0.12
18
214
123
1253
0.97
0.07
3.0
2.3
—
—
—
0
0
13
118
1.11
0.07
4.1
4.8
—
—
—
0
0
12
109
1.10
0.06
2.9
2.8
—
—
—
0
0
13
141
0.92
0.05
1.3
1.1
—
—
—
0
0
32
307
1.05
0.05
4.1
1.7
—
—
—
0
0
12
111
1.08
0.04
2.3
4.0
16.25
17.91
%
0.21
12
111
13
121
1.08
0.04
7.2
3.8
—
—
—
0
0
14
132
1.06
0.02
1.0
1.2
—
—
—
0
0
27
279
0.97
0.02
1.1
1.2
1.63
2.35
u/ml
0.24
20
217
16
168
0.95
0.02
1.1
1.1
—
—
—
0
0
14
133
1.05
0.01
1.0
1.2
—
—
—
0
0
31
303
1.03
0.01
1.2
1.3
1.34
3.07
u/ml
0.75
21
235
13
124
1.05
0.00
1.4
1.2
—
—
—
0
0
10
98
1.02
0.00
1.7
3.6
21.50
24.66
%
—
10
98
10
98
1.02
0.00
2.6
22.0
72.33
72.28
%
—
10
98
16
159
1.01
0.00
1.6
1.5
—
—
—
0
0
37
375
0.99
0.00
2.1
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
167.75
—
0
8
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
139.11
—
0
9
0
8
0.00
0.00
0.0
5.0
—
0.49
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.3
—
—
—
0
0
8
80
1.00
-0.00
2.1
2.4
8.63
6.80
ug/l
—
8
70
0
5
0.00
-0.00
0.0
2.0
—
437.40
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1581.33
—
0
6
5
50
1.00
-0.00
1.4
2.0
0.21
16.90
u/ml
—
5
41
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.5
36.88
21.69
u/l
—
5
49
5
51
0.98
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
72.81
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
85
0.94
-0.00
1.8
2.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint P16_OTH_DISORD_ORIGINA_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_OTH_DISORD_ORIGINA_PERINA_PERIOD 3.808 [2.79, 5.19] < 0.001
Birth year 0.998 [0.99, 1.01] 0.641

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 8343 females with P16_OTH_DISORD_ORIGINA_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_OTH_DISORD_ORIGINA_PERINA_PERIOD 3.23 [2.24, 4.66] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 9291 males with P16_OTH_DISORD_ORIGINA_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_DISORD_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 0.346% 0.536%
5 2.175% 3.4%
10 5.482% 9.188%
15 10.433% 16.711%
20 18.473% 26.947%

Relationships between endpoints

↥

Index endpoint: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD – Other disorders originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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