Other conditions originating in the perinatal period

P16_OTH_COND_ORIGINA_PERINA_PERIOD

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P96 Cause of death: ICD-10 — P96 2 out of 7 registries used, show all original rules.	31
4. Check minimum number of events None	31
5. Include endpoints None	31
6. Filter based on genotype QC (FinnGen only)	31

Control definitions (FinnGen only)

Control exclude: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P9
Name in latin: Aliae condiciones origine perinatales

NAME	P16_OTH_COND_ORIGINA_PERINA_PERIOD
CONTROL_EXCLUDE	P16_OTH_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P96
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P96
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other conditions originating in the perinatal period based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2012	927	1083
Only index persons	815	376	439
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	0.08	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	16	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	13.45	23.97	2.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

5.50

4.82

9.7

6.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

4.76

4.39

5.5

6.1

1.4

0.4

e6/l

0.69

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

4.58

4.17

5.4

5.2

0.6

0.4

e6/l

0.30

(36304419) Bacteria [Presence] in Urine

4.12

3.59

9.6

5.7

—

(3022948) Iron [Moles/volume] in Serum or Plasma

4.39

3.54

8.8

4.5

10.2

15.2

umol/l

2.11

(3042936) Bacteria identified in Isolate by Culture

4.32

3.31

2.6

2.0

—

(3000991) Gas panel - Venous blood

3.68

3.05

16.3

17.6

—

(3012544) pH of Venous blood

3.59

2.98

16.1

15.1

—

(3026008) Bacteria identified in Urine by Culture

3.67

2.90

5.8

2.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

7.18

2.46

1.4

3.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.80

2.38

1.8

2.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.66

2.30

1.8

2.4

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

6.37

2.30

1.4

2.2

—

(3023368) Bacteria identified in Blood by Culture

3.21

2.29

5.2

5.0

—

(3015736) pH of Urine

2.95

2.19

12.0

4.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

5.72

2.15

1.4

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

4.68

2.15

1.3

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.21

2.08

1.8

2.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.38

2.04

1.3

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.84

2.04

2.9

4.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

4.11

1.94

1.2

2.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.11

1.94

2.8

2.6

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.11

1.94

2.8

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

178

3.08

1.91

9.8

4.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.74

1.90

3.4

2.7

—

(42870588) Differential panel, method unspecified - Blood

133

2.79

1.86

9.9

10.1

—

(3002256) Pathology report gross observation

3.46

1.85

1.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.36

1.79

1.4

1.8

—

(3021960) Folate [Moles/volume] in Serum or Plasma

3.04

1.63

1.6

1.2

20.1

17.5

nmol/l

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

2.67

1.53

36.8

25.8

2.2

1.2

mg/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.67

1.53

1.3

2.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

117

2.28

1.36

7.3

3.8

47.8

74.0

ug/l

0.58

112

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

3.10

1.34

2.0

1.2

2.1

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

109

2.24

1.31

10.0

11.4

20.4

27.2

umol/l

0.28

102

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.61

1.25

1.2

2.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.78

1.20

3.0

2.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.62

1.20

1.7

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.31

1.17

2.2

1.6

—

(40758558) Short blood count panel - Blood

113

2.12

1.16

6.9

9.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

2.28

1.08

8.3

3.8

15.8

508.4

mg/mmol

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.07

1.06

10.1

2.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.15

1.01

1.3

2.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.15

1.01

1.9

2.1

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.01

0.98

35.2

13.1

1.3

1.4

mmol/l

0.41

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

109

1.97

0.98

9.4

4.1

87.6

72.5

nmol/l

1.61

103

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

191

2.13

0.93

4.0

3.6

14.4

14.3

pmol/l

0.13

180

(3021589) Normoblasts [#/volume] in Blood

172

1.96

0.89

16.2

11.1

0.0

e9/l

0.48

129

(3044640) Blood type and Crossmatch panel - Blood

1.91

0.87

3.7

3.2

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.08

0.87

1.7

4.6

302.0

261.3

u/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.94

0.85

23.9

6.7

—

(3000494) Fungus identified in Specimen by Culture

2.01

0.84

1.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

155

1.82

0.75

11.7

4.3

39.3

37.3

mmol/mol

0.28

148

(3044889) 12 lead EKG panel

119

0.56

0.75

3.8

2.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.09

0.74

3.0

2.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.82

0.74

1.8

2.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.80

0.68

2.4

1.7

—

(40768804) Tissue Pathology biopsy report

1.79

0.65

1.9

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.74

0.63

2.4

2.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

160

1.70

0.63

5.2

4.1

2.4

2.6

mmol/l

0.48

153

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

160

1.70

0.63

5.0

3.8

1.5

mmol/l

0.22

153

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.62

0.0

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

112

1.66

0.60

5.2

4.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

162

1.66

0.58

5.1

4.1

4.4

4.5

mmol/l

0.07

155

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.64

0.52

9.5

3.7

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.64

0.52

16.5

14.0

2.0

1.6

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.63

0.49

3.3

3.1

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.54

0.47

5.4

6.7

29.5

30.6

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.61

0.44

2.2

9.2

89.0

89.7

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.56

0.42

1.4

1.3

—

19.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.42

0.0

1.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.53

0.41

10.0

6.3

36.5

34.5

u/l

0.10

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3022313) Gas panel - Capillary blood

1.52

0.38

15.5

12.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

161

1.47

0.38

18.9

7.1

160.4

135.0

u/l

0.56

154

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.43

0.32

24.5

17.7

23.7

24.8

mmol/l

0.70

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

220

1.40

0.27

4.8

4.2

1.9

2.1

mu/l

0.22

208

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.26

0.23

1.8

1.5

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.22

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.22

0.0

1.4

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.22

0.0

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.22

0.0

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.22

0.0

1.9

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.22

0.0

1.0

—

173.7

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.22

0.0

1.4

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.22

0.0

2.1

—

36.3

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.21

0.0

5.0

—

19.1

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.21

0.0

1.5

—

(1761868) Lipid panel - Serum or Plasma

1.29

0.20

2.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.32

0.20

13.5

2.8

2.4

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

244

1.41

0.19

4.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

114

0.82

0.12

1.2

2.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

250

1.25

0.09

41.4

13.5

91.8

58.7

umol/l

0.68

250

(3003694) ABO and Rh group [Type] in Blood

1.18

0.08

2.0

1.6

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(4062490)

0.00

0.0

1.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.3

—

(3011648) Oxygen content in Venous blood

0.00

0.0

30.7

—

11.7

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.0

5.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

4.0

—

20.6

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

0.0

1.0

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

3.6

—

1.8

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

44.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.7

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.8

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

2.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.4

—

258.8

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

5.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.00

0.0

4.6

—

(36660697) Celiac disease serology panel - Serum

0.95

0.00

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

9.0

—

(1175426) CD3 cells/100 lymphocytes in Blood

0.00

0.0

5.4

—

63.1

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

34.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.0

1.7

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.1

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

3.4

—

2.6

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

0.00

0.0

5.4

—

26.9

—

(3027831) CD3-CD16+CD56+ (Natural killer) cells/100 cells in Blood

0.00

0.0

5.3

—

11.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

40.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.6

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.0

5.7

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.8

—

46.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_OTH_COND_ORIGINA_PERINA_PERIOD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_OTH_COND_ORIGINA_PERINA_PERIOD.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_OTH_COND_ORIGINA_PERINA_PERIOD – Other conditions originating in the perinatal period

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other conditions originating in the perinatal period

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints