No definition available.
Respiratory and cardiovascular disorders specific to the perinatal period
EFO MESH Endpoint Browser PheWeb
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
942 |
4. Check minimum number of eventsNone |
942 |
5. Include endpoints
|
942 |
6. Filter based on genotype QC (FinnGen only) |
874 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P
- Name in latin
- Perturbationes respiratoriae et cardiovasculares temporis perinatalis specificae
Respiratory and cardiovascular disorders specific to the perinatal period
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 72975 | 31693 | 41278 |
| Only index persons | 31986 | 13548 | 18438 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.05 | 0.91 | 1.15 |
| Only index persons | 0.62 | 0.50 | 0.70 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 874 | 472 | 402 |
| Unadjusted period prevalence (%) | 0.18 | 0.17 | 0.18 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 916
- Matched controls
- 8182
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
16.4
266.6
272
205
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
2852.6
260.6
249
*
P07.3
ICD-10 Finland
Other preterm infants
15.2
242.8
257
205
WX722
NOMESCO Finland
PEEP
22.2
156.8
129
60
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
131.3
128
*
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
118.6
116
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
117.6
115
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
706.1
72.1
73
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
12.2
72.1
79
63
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
71.9
71
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
5.3
53.7
123
234
P07.2
ICD-10 Finland
Extreme immaturity
90.4
50.0
57
6
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
48.3
48
*
P22.8
ICD-10 Finland
Other respiratory distress of newborn
235.9
47.3
50
*
WX882
NOMESCO Finland
High dependency care
3.4
41.8
177
532
602
Kela drug reimbursment
Children's severe malnutrition
4.8
41.0
103
211
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
40.2
40
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
8.6
37.8
52
57
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
9.2
35.2
46
47
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
5.4
34.9
74
130
WX730
NOMESCO Finland
Conventional respirator
10.6
34.1
40
35
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
10.7
33.3
39
34
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
31.1
31
*
P29.9
ICD-10 Finland
Cardiovascular disorder originating in the perinatal period, unspecified
+∞
31.1
31
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
30.8
222
888
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.1
29.3
47
62
P28.4
ICD-10 Finland
Other apnoea of newborn
+∞
29.1
29
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
28.0
177
660
P24.0
ICD-10 Finland
Neonatal aspiration of meconium
+∞
27.1
27
*
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
8.2
26.1
37
42
J45.1
ICD-10 Finland
Nonallergic asthma
2.7
26.0
161
592
H35.1
ICD-10 Finland
Retinopathy of prematurity
89.1
25.5
29
*
R4110
NOMESCO Finland
Physiotherapy
2.2
24.9
279
1344
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.9
24.7
79
194
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
6.0
24.4
46
72
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
23.0
23
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
8.0
23.0
33
38
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
8.4
21.6
30
33
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
7.2
21.2
33
42
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
25.1
21.1
30
11
Z3231
NOMESCO Finland
Registered nurse
1.9
19.5
378
2190
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
18.9
169
732
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
18.8
116
423
XG413
NOMESCO Finland
Spirometry with oscillometry
4.1
18.6
54
123
P21.9
ICD-10 Finland
Birth asphyxia, unspecified
+∞
18.0
18
*
P05.1
ICD-10 Finland
Small for gestational age
5.8
17.8
34
54
Z3226
NOMESCO Finland
Physiotherapist
2.0
17.2
249
1296
Z2446
NOMESCO Finland
Social worker
2.1
17.0
200
964
P05.0
ICD-10 Finland
Light for gestational age
7.6
16.8
25
30
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
163.8
16.8
18
*
Z2221
NOMESCO Finland
Medical doctor
1.9
15.8
252
1350
P07.1
ICD-10 Finland
Other low birth weight
25.1
15.6
22
8
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
15.6
213
1082
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
43.3
15.2
19
*
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
5.8
15.2
29
46
P25.2
ICD-10 Finland
Pneumomediastinum originating in the perinatal period
+∞
15.0
15
*
P20.1
ICD-10 Finland
Intrauterine hypoxia first noted during labour and delivery
+∞
15.0
15
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.7
15.0
85
296
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.7
14.2
47
118
J21.90
ICD-10 Finland
Acute obstructive bronchitis in children
2.5
14.2
94
354
R03BA02
ATC
budesonide; inhalant
2.0
13.8
180
895
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
136.1
13.8
15
*
R62.0
ICD-10 Finland
Delayed milestone
2.5
13.4
94
363
P23.9
ICD-10 Finland
Congenital pneumonia, unspecified
+∞
13.0
13
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
3.8
12.5
39
94
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
12.3
203
1089
R03BA05
ATC
fluticasone; inhalant
1.8
12.0
254
1467
P29.8
ICD-10 Finland
Other cardiovascular disorders originating in the perinatal period
+∞
12.0
12
*
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
3.4
12.0
44
119
F80.1
ICD-10 Finland
Expressive language disorder
3.0
11.8
55
172
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
22.1
11.8
17
7
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
11.7
167
854
ZX114
NOMESCO Finland
Intramuscular
3.9
11.7
35
82
RT150, ,
NOMESCO Finland
3.6
11.4
38
96
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
11.2
207
1147
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
11.1
318
1987
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
11.1
253
1488
P29.1
ICD-10 Finland
Neonatal cardiac dysrhythmia
+∞
11.0
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
10.9
276
1668
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
10.7
10.5
20
17
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
10.5
105
472
UGC02
NOMESCO Finland
Rigid bronchoscopy
4.3
10.3
27
57
R03AC02
ATC
salbutamol; inhalant
1.6
10.1
513
3653
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.8
10.0
51
168
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
9.8
147
761
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
9.7
76
309
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
2.3
9.7
76
309
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
9.6
99
450
H50.30
ICD-10 Finland
Intermittent esotropy
3.2
9.6
38
108
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.3
9.6
36
99
WX892
NOMESCO Finland
Monitored bed care
2.2
9.5
81
341
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
2.8
9.4
49
163
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
9.3
117
571
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.1
9.2
93
419
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
9.1
224
1337
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
9.1
38
112
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.6
8.8
341
2263
ZX108
NOMESCO Finland
Inhalation
3.9
8.5
25
58
RK312, ,
NOMESCO Finland
6.7
8.2
20
27
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.6
8.0
48
172
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
24.8
8.0
11
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
1.9
8.0
113
573
WX930
NOMESCO Finland
Thepapeutic hypothermia
+∞
8.0
8
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.1
7.9
77
342
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
7.9
176
1019
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.9
162
918
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.0
7.9
85
393
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.7
7.7
159
901
7AA02, ,
NOMESCO Finland
30.1
7.7
10
*
H01AC01
ATC
somatropin; parenteral
2.4
7.7
51
193
Z2445
NOMESCO Finland
Psychologist
1.8
7.6
135
734
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
19.9
7.6
11
5
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
1.6
7.6
181
1067
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.1
7.5
72
318
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
9.1
7.4
15
15
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.1
7.3
66
286
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.2
249
1597
P08.0
ICD-10 Finland
Exceptionally large baby
13.6
7.2
12
8
R56.8
ICD-10 Finland
Other and unspecified convulsions
1.9
7.2
94
464
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
3.5
7.1
25
66
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
72.1
7.1
8
*
6BB16, ,
NOMESCO Finland
10.7
7.1
13
11
P24.1
ICD-10 Finland
Neonatal aspiration of amniotic fluid and mucus
+∞
7.0
7
*
RK520, ,
NOMESCO Finland
8.0
7.0
15
17
A03FA02
ATC
cisapride; oral, rectal
2.6
6.9
40
142
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
1.9
6.8
83
400
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
6.8
160
936
J45.8
ICD-10 Finland
Mixed asthma
2.8
6.8
34
111
EMB30
NOMESCO Finland
Adenotomy
1.6
6.8
189
1153
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
6.8
45
170
H65.3
ICD-10 Finland
Chronic mucoid otitis media
1.7
6.7
134
751
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
8.4
6.7
14
15
E34.31
ICD-10 Finland
Short stature, prenatal disorder
3.7
6.7
21
51
ZXE00
NOMESCO Finland
One hour or less
1.5
6.6
328
2260
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.4
6.6
46
178
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
10.8
6.6
12
10
WX725
NOMESCO Finland
Noninvasive ventilation
2.8
6.5
32
104
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
6.5
73
343
FM2CE, ,
NOMESCO Finland
1.9
6.5
90
454
JDB10
NOMESCO Finland
Percutaneous gastrostomy
3.5
6.4
22
57
H66.9
ICD-10 Finland
Otitis media, unspecified
1.5
6.4
269
1792
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
6.4
94
483
M03BX01
ATC
baclofen; systemic
6.8
6.3
15
20
A28
ICPC
Limited function/disability NOS
2.0
6.3
69
321
WX732
NOMESCO Finland
High frequency respirator
20.3
6.3
9
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.7
6.3
123
686
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
7.5
6.3
14
17
UDQ02
NOMESCO Finland
Direct laryngoscopy
4.2
6.3
17
37
R03DC03
ATC
montelukast; oral
1.6
6.3
156
926
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.2
229
1484
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
3.0
6.2
27
82
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.8
6.2
100
529
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
63.1
6.1
7
*
P59.9
ICD-10 Finland
Neonatal jaundice, unspecified
2.3
6.1
45
179
ZXD05
NOMESCO Finland
Urgent procedure
1.6
6.1
176
1082
P08.1
ICD-10 Finland
Other heavy for gestational age infants
7.0
6.1
14
18
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
3.3
6.1
23
64
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
244
1551
1.55
7.41
16.9
9.4
1.06
0.78
mmol/l
0.76
180
1119
244
1555
1.55
7.31
17.0
9.5
5.11
4.99
kpa
2.01
234
1511
143
828
1.64
6.35
1.5
1.5
207.54
356.99
u/ml
1.35
136
783
224
1441
1.51
6.32
16.4
9.3
9.45
9.78
kpa
1.94
214
1400
222
1440
1.50
5.98
14.3
11.3
1.38
1.34
mmol/l
1.19
213
1381
24
74
2.95
5.38
8.5
10.4
—
—
—
0
0
21
60
3.18
5.33
9.7
7.8
—
—
—
0
0
434
3246
1.37
5.11
10.7
7.9
5.83
5.99
mmol/l
0.76
418
3046
219
1458
1.45
5.09
8.9
9.8
23.39
23.54
mmol/l
0.41
219
1458
199
1301
1.47
5.08
3.2
3.7
—
—
—
0
0
393
2918
1.36
4.73
20.6
13.5
1.23
1.23
mmol/l
0.35
380
2806
230
1567
1.42
4.67
12.4
10.0
1.27
1.09
mmol/l
0.50
184
1249
403
3029
1.34
4.37
20.1
12.3
1.23
1.23
mmol/l
0.11
380
2823
68
360
1.74
4.23
1.0
1.0
11.76
8.25
mu/l
2.11
61
312
219
1511
1.39
4.08
11.6
9.9
5.33
5.10
kpa
0.64
214
1480
189
1273
1.41
4.05
4.5
3.8
2.35
2.99
e6/l
0.50
113
718
21
71
2.68
4.04
7.0
6.8
—
—
—
0
0
21
71
2.68
4.04
6.4
6.7
—
—
—
0
0
506
3969
1.31
3.89
9.1
9.5
37.24
35.67
%
2.12
493
3811
497
3895
1.31
3.82
8.9
9.4
47.37
48.84
%
1.70
485
3743
43
205
1.92
3.75
2.0
2.0
—
—
—
0
0
27
108
2.27
3.70
1.0
1.1
—
—
—
0
0
184
1252
1.39
3.70
4.2
3.7
0.66
0.91
e6/l
0.85
108
695
286
2087
1.33
3.66
5.6
4.5
226.86
33.68
e6/l
0.50
220
1570
17
55
2.79
3.56
15.7
10.8
1.22
1.23
mmol/l
0.27
17
50
298
2196
1.31
3.54
6.2
4.6
—
—
—
0
0
269
1960
1.32
3.45
5.3
4.4
0.20
0.24
e6/l
0.23
203
1452
527
4195
1.29
3.43
10.9
11.2
3.42
3.45
e9/l
0.11
456
3500
198
1383
1.36
3.37
3.5
2.9
2.41
2.41
mmol/l
0.17
187
1272
160
1843
0.73
3.27
2.5
2.4
—
—
—
0
0
100
622
1.49
3.26
2.5
2.0
—
—
—
0
0
172
1952
0.74
3.18
2.6
2.5
—
—
—
0
0
139
925
1.40
3.17
15.0
13.4
0.79
0.81
mmol/l
1.23
134
898
16
54
2.68
3.12
7.9
3.9
99.67
167.07
umol/l
—
9
29
321
2431
1.28
3.01
4.7
3.5
69.68
67.87
nmol/l
0.59
305
2313
273
2032
1.28
2.92
7.5
8.9
34.12
22.21
umol/l
2.85
255
1849
48
258
1.70
2.90
2.6
2.3
—
—
—
0
0
51
279
1.67
2.89
1.8
1.3
—
—
—
0
0
51
279
1.67
2.89
1.8
1.3
—
—
—
0
0
123
815
1.40
2.88
2.5
2.1
—
—
—
0
0
48
261
1.68
2.79
2.8
2.5
—
—
—
0
0
98
631
1.43
2.70
2.8
2.1
—
—
—
0
0
32
157
1.85
2.64
3.5
4.6
25.94
23.77
umol/l
0.51
32
157
136
932
1.36
2.61
6.0
7.3
1.53
1.37
%
1.04
130
884
34
173
1.78
2.51
1.4
1.8
—
—
—
0
0
47
263
1.63
2.48
2.5
2.3
—
—
—
0
0
6
10
5.39
2.47
7.0
3.7
—
—
—
0
0
41
224
1.66
2.38
14.7
13.1
111.29
286.00
u/ml
—
7
30
49
281
1.59
2.35
1.0
1.0
7.29
7.25
kpa
0.04
39
238
49
281
1.59
2.35
1.0
1.0
-3.34
-2.07
mmol/l
0.33
11
62
7
15
4.19
2.35
7.1
7.9
—
—
—
0
0
197
1445
1.28
2.33
5.5
4.7
8.09
8.85
mmol/l
0.94
188
1383
6
11
4.90
2.32
2.3
3.4
—
—
—
0
0
11
35
2.83
2.30
1.1
1.4
—
—
—
0
0
181
1318
1.28
2.26
8.4
5.3
1.09
1.12
inr
0.35
46
354
48
278
1.57
2.23
1.0
1.0
3.56
3.27
kpa
0.33
38
236
668
5599
1.24
2.22
19.1
12.8
4.00
3.92
mmol/l
6.65
658
5412
51
300
1.55
2.22
2.0
1.7
—
—
—
0
0
735
6229
1.27
2.22
19.3
15.3
13.59
13.25
%
2.24
726
6116
44
253
1.58
2.11
15.1
10.6
647.67
431.09
iu/ml
—
9
35
38
211
1.64
2.10
2.8
2.2
—
—
—
0
0
108
740
1.34
2.10
4.8
8.8
4.89
6.56
umol/l
1.89
89
622
38
212
1.63
2.07
2.8
2.2
—
—
—
0
0
37
205
1.64
2.07
1.8
2.1
—
—
—
0
0
114
791
1.33
2.04
4.3
5.1
0.20
0.21
g/l
0.56
107
764
35
193
1.64
2.00
1.9
1.9
—
—
—
0
0
666
5605
1.22
1.99
19.4
12.8
139.27
139.46
mmol/l
1.43
658
5447
25
127
1.78
1.91
4.7
3.2
17.77
17.69
%
0.04
19
83
241
1851
1.22
1.87
11.9
8.8
36.67
38.15
g/l
2.96
235
1767
22
109
1.82
1.82
1.1
1.5
1.63
4.74
u/ml
—
8
57
29
157
1.67
1.79
1.2
1.3
399.31
363.90
ug/g
0.41
16
77
265
2063
1.21
1.79
3.5
3.6
—
—
—
0
0
39
230
1.54
1.72
2.8
2.3
—
—
—
0
0
39
231
1.53
1.70
2.8
2.3
—
—
—
0
0
217
1666
1.21
1.69
3.3
3.4
2.70
2.68
mg/l
0.03
189
1512
77
520
1.35
1.68
2.3
2.3
10.57
7.56
iu/l
0.50
53
338
21
106
1.79
1.66
1.1
1.5
4.56
4.22
u/ml
—
9
67
28
155
1.63
1.61
6.1
5.7
2.36
2.14
ug/l
0.19
28
155
19
94
1.82
1.60
1.2
1.2
—
—
—
0
0
28
156
1.62
1.58
1.6
1.6
0.16
0.24
nmol/l
1.13
21
129
16
75
1.92
1.58
3.2
1.7
—
—
—
0
0
6
18
2.99
1.55
2.2
1.7
—
—
—
0
0
5
113
0.39
1.52
1.0
1.6
—
—
—
0
0
20
103
1.75
1.50
4.9
5.3
—
—
—
0
0
42
262
1.45
1.46
2.0
1.5
—
—
—
0
0
127
941
1.24
1.40
3.7
5.2
1.47
1.92
mg/l
0.64
89
654
82
576
1.30
1.40
15.2
12.5
105.09
105.67
mmol/l
0.48
82
576
129
959
1.23
1.38
1.7
1.9
1.42
1.20
mmol/l
1.10
118
891
43
528
0.71
1.35
1.3
1.4
—
—
—
0
0
9
37
2.18
1.35
2.0
1.7
—
—
—
0
0
431
3566
1.15
1.31
5.0
3.8
7.40
204.07
e6/l
—
5
45
5
16
2.80
1.27
2.2
1.8
—
—
—
0
0
34
210
1.46
1.27
1.2
2.9
—
—
—
0
0
355
2903
1.15
1.27
3.7
3.1
35.33
36.25
mmol/mol
0.97
333
2740
39
248
1.42
1.26
18.7
21.7
0.68
0.77
%
1.37
39
248
10
43
2.09
1.25
2.4
2.7
23.44
18.64
umol/l
—
10
43
39
249
1.42
1.23
18.8
21.7
95.40
96.14
%
0.22
39
249
102
1096
0.81
1.21
1.9
2.0
—
—
—
0
0
60
414
1.32
1.19
1.7
1.8
—
—
—
0
0
80
574
1.27
1.18
7.7
7.3
1741.23
1084.44
ng/l
0.58
72
486
97
713
1.24
1.17
1.5
1.4
21.83
18.95
nmol/l
1.10
83
641
13
64
1.83
1.15
3.5
1.8
—
—
—
0
0
13
64
1.83
1.15
1.5
1.3
—
—
—
0
0
10
45
2.00
1.13
1.4
1.1
—
—
—
0
0
747
6865
0.85
1.12
4.1
3.8
—
—
—
0
0
742
6415
1.17
1.12
13.4
10.9
21.58
23.43
mg/l
0.84
508
4284
44
295
1.35
1.07
13.3
15.1
0.67
0.65
%
0.14
44
295
50
343
1.32
1.05
16.5
16.7
-0.61
-0.12
mmol/l
0.47
45
267
14
73
1.72
1.05
1.4
1.8
—
—
—
0
0
175
1377
1.17
1.04
4.7
3.6
6.35
6.28
e6/l
0.02
160
1222
153
1191
1.18
1.04
1.7
1.5
102.05
97.19
pmol/l
0.58
73
642
839
7345
1.24
1.03
20.5
16.8
39.38
39.54
%
0.46
810
7023
0
29
0.00
0.95
0.0
1.6
—
42.96
—
0
23
839
7354
1.23
0.95
19.7
15.7
4.61
4.63
e12/l
0.49
807
6944
839
7359
1.22
0.90
20.1
16.0
132.34
132.98
g/l
0.63
829
7247
123
1260
0.85
0.90
2.0
2.2
—
—
—
0
0
68
498
1.24
0.89
2.5
2.0
—
—
—
0
0
67
490
1.24
0.89
2.5
2.0
202.00
165.22
u/ml
0.29
28
226
156
1235
1.15
0.87
5.4
3.5
0.00
0.00
estimate
0.50
48
420
398
3341
1.11
0.87
6.7
5.7
142.88
126.14
u/l
2.43
373
3152
78
582
1.22
0.86
2.4
2.3
6.32
5.74
u/l
0.17
46
373
837
7345
1.21
0.85
19.8
15.8
274.93
272.57
e9/l
0.43
804
6961
8
40
1.79
0.84
1.3
1.4
—
—
—
0
0
41
284
1.30
0.84
5.9
3.2
—
—
—
0
0
6
101
0.53
0.84
1.2
1.5
5.45
9.98
u/l
—
6
91
44
309
1.29
0.82
1.3
1.6
1550.16
1057.61
nmol/l
2.22
32
244
13
72
1.62
0.81
1.6
1.7
20.40
19.13
nmol/l
—
5
23
5
86
0.52
0.79
11.4
7.1
10.22
9.22
mg/l
—
5
75
345
2888
1.11
0.78
1.7
1.8
1.85
3.64
u/ml
1.82
61
523
5
21
2.13
0.75
2.6
1.6
—
—
—
0
0
13
74
1.58
0.74
2.2
2.8
—
—
—
0
0
18
111
1.46
0.74
1.2
1.2
—
—
—
0
0
24
288
0.74
0.73
1.3
1.3
—
—
—
0
0
99
772
1.16
0.70
2.3
2.3
91.10
44.85
ng/l
0.27
41
282
7
37
1.70
0.69
1.0
1.1
—
—
—
0
0
20
128
1.40
0.69
2.8
1.6
—
—
—
0
0
14
83
1.51
0.69
1.3
1.2
—
—
—
0
0
5
24
1.87
0.68
3.8
4.0
4.76
4.47
mmol/l
—
5
24
665
5772
1.11
0.68
9.4
9.1
28.04
24.97
u/l
0.93
649
5580
28
191
1.32
0.67
1.1
1.1
—
—
—
0
0
89
692
1.16
0.66
3.0
3.9
1455.69
1412.99
ng/l
0.03
54
385
7
39
1.61
0.65
1.0
1.4
—
—
—
0
0
19
122
1.40
0.65
11.1
7.4
5.01
4.91
kpa
0.21
19
122
18
221
0.72
0.65
1.7
1.6
—
—
—
0
0
23
153
1.35
0.64
1.4
1.4
—
—
—
0
0
35
248
1.27
0.64
9.0
5.9
1.24
1.23
mmol/l
0.73
30
224
8
117
0.61
0.64
1.0
1.1
—
—
—
0
0
18
115
1.41
0.63
2.0
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
162
1.33
0.62
12.9
24.3
0.27
0.33
u/ml
0.81
15
105
27
186
1.31
0.61
1.1
1.1
—
—
—
0
0
62
647
0.85
0.61
1.3
1.3
—
—
—
0
0
323
2725
1.09
0.60
1.7
1.7
1.41
1.52
g/l
0.72
164
1410
365
3099
1.09
0.59
3.2
2.7
1.11
1.08
mmol/l
0.34
347
2935
543
4687
1.09
0.58
3.5
3.3
14.55
14.38
pmol/l
0.77
496
4219
10
57
1.57
0.58
1.1
1.2
—
—
—
0
0
6
31
1.73
0.58
2.0
2.2
2.08
2.61
nmol/l
—
6
31
72
737
0.86
0.56
1.4
1.4
1.33
1.33
%
0.00
67
676
141
1147
1.12
0.55
3.8
2.9
50.86
57.18
u/l
1.08
129
1069
20
134
1.34
0.55
1.2
1.2
—
44.82
—
0
5
38
411
0.82
0.55
1.5
1.4
—
—
—
0
0
9
55
1.47
0.53
1.1
1.1
0.51
0.44
nmol/l
—
9
55
79
622
1.15
0.52
1.2
1.2
7.11
6.29
u/ml
0.17
61
464
10
59
1.52
0.52
2.3
3.2
—
—
—
0
0
10
59
1.52
0.52
1.1
1.2
—
—
—
0
0
349
3264
0.93
0.51
7.5
6.4
112.27
112.62
ml/min/173m2
0.09
224
2040
65
507
1.16
0.49
4.0
4.3
231.94
7.72
mg/mmol
0.56
55
416
7
40
1.57
0.49
3.1
5.7
259.29
221.97
ug/l
—
7
40
7
98
0.64
0.49
1.3
1.1
—
—
—
0
0
18
209
0.76
0.48
1.1
1.1
—
—
—
0
0
10
128
0.69
0.48
2.3
2.3
—
—
—
0
0
77
610
1.14
0.48
1.2
1.2
0.93
1.01
u/ml
0.06
54
430
7
44
1.42
0.46
1.1
2.0
—
—
—
0
0
301
2566
1.07
0.43
5.0
3.4
0.00
0.00
estimate
-0.00
52
439
601
5242
1.07
0.43
4.1
3.7
2.15
1.99
mu/l
2.39
566
4947
5
28
1.60
0.43
1.2
1.1
—
—
—
0
0
58
455
1.15
0.42
1.5
1.4
557.40
16262599.41
pmol/l
0.50
50
412
6
85
0.63
0.42
1.3
1.1
—
—
—
0
0
34
255
1.20
0.42
1.4
1.5
9.42
10.45
u/ml
0.05
23
174
0
14
0.00
0.41
0.0
1.2
—
—
—
0
0
367
3155
1.07
0.40
3.9
3.3
52.88
56.62
ug/l
0.18
348
3003
0
16
0.00
0.40
0.0
2.1
—
—
—
0
0
0
16
0.00
0.40
0.0
1.9
—
—
—
0
0
5
32
1.40
0.38
1.6
2.5
37.20
192.45
ug/min
—
5
22
5
32
1.40
0.38
19.8
12.3
672.60
744.22
nmol/l
—
5
32
13
87
1.34
0.38
1.0
1.3
—
—
—
0
0
63
628
0.89
0.37
1.1
1.2
14.47
19.30
iu/ml
0.46
16
127
8
104
0.68
0.37
1.4
3.9
—
—
—
0
0
8
104
0.68
0.37
1.4
3.9
—
—
—
0
0
298
2773
0.94
0.37
3.9
4.9
25.77
26.93
u/l
0.19
289
2675
82
667
1.11
0.36
1.2
1.3
3.45
3.45
u/ml
0.00
60
473
26
194
1.20
0.35
7.1
3.4
73.45
92.93
ml/min/173m2
1.07
11
50
20
218
0.82
0.35
1.5
1.3
—
—
—
0
0
150
1258
1.08
0.34
4.7
2.9
1.02
1.02
kg/l
1.12
27
233
39
303
1.16
0.34
2.2
2.0
—
—
—
0
0
297
2552
1.06
0.33
7.0
5.0
0.00
0.00
estimate
-0.00
52
447
37
377
0.87
0.31
1.4
1.8
—
—
—
0
0
27
205
1.18
0.31
1.3
1.2
0.98
2.05
u/ml
0.40
21
141
298
2565
1.06
0.31
5.1
3.4
0.00
0.00
estimate
-0.00
54
437
13
147
0.79
0.31
1.8
1.3
—
—
—
0
0
7
89
0.70
0.31
1.1
1.1
—
—
—
0
0
7
49
1.28
0.30
1.3
1.1
—
81.91
—
0
11
59
580
0.90
0.29
1.2
1.2
3.87
8.60
u/ml
0.71
16
150
19
203
0.83
0.28
1.5
1.5
—
—
—
0
0
24
184
1.17
0.26
2.0
2.0
—
—
—
0
0
12
85
1.26
0.25
1.9
1.3
—
—
—
0
0
33
261
1.13
0.25
1.2
1.3
238.94
203.68
miu/ml
0.26
21
112
368
3370
0.96
0.24
2.1
2.0
—
—
—
0
0
436
3978
0.96
0.24
4.8
4.5
8.02
7.15
mm/h
0.92
416
3688
19
144
1.18
0.23
1.6
2.0
—
—
—
0
0
73
606
1.08
0.23
1.2
1.2
6.57
3.52
u/ml
0.60
58
449
28
220
1.14
0.23
5.1
3.5
—
—
—
0
0
5
34
1.32
0.23
1.2
1.2
—
—
—
0
0
5
35
1.28
0.23
1.0
1.7
—
—
—
0
0
27
212
1.14
0.23
1.4
1.3
1.64
20.55
u/ml
1.04
22
172
7
84
0.74
0.22
1.1
1.1
—
—
—
0
0
58
560
0.92
0.22
1.4
1.3
227.87
157.00
iu/ml
0.39
15
172
36
356
0.90
0.21
2.0
1.9
—
—
—
0
0
0
9
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.20
0.0
1.3
—
—
—
0
0
0
12
0.00
0.20
0.0
1.3
—
—
—
0
0
6
44
1.22
0.20
1.2
2.0
—
—
—
0
0
6
44
1.22
0.20
1.2
2.0
—
—
—
0
0
6
44
1.22
0.20
1.2
2.0
—
—
—
0
0
22
172
1.15
0.20
1.5
1.6
—
—
—
0
0
53
506
0.93
0.16
2.1
2.0
—
—
—
0
0
198
1719
1.04
0.15
4.8
3.1
—
—
—
0
0
12
91
1.18
0.15
1.2
1.3
—
—
—
0
0
9
74
1.09
0.14
1.0
1.0
—
—
—
0
0
7
78
0.80
0.14
1.0
1.1
—
—
—
0
0
372
3268
1.03
0.14
3.4
2.7
2.63
2.59
mmol/l
0.49
350
3076
9
98
0.82
0.13
1.1
1.1
—
—
—
0
0
47
395
1.07
0.13
1.1
1.1
13.30
6.16
u/ml
0.99
34
263
20
161
1.11
0.12
2.0
1.7
—
—
—
0
0
60
509
1.06
0.12
1.6
1.4
—
—
—
0
0
32
265
1.08
0.12
5.3
3.9
708.13
396.67
mg/l
0.77
32
260
17
169
0.90
0.12
1.6
1.4
—
—
—
0
0
17
169
0.90
0.12
1.6
1.4
—
—
—
0
0
17
169
0.90
0.12
1.6
1.4
—
—
—
0
0
17
169
0.90
0.12
1.6
1.4
—
—
—
0
0
54
508
0.95
0.12
1.3
1.3
—
—
—
0
0
20
162
1.11
0.11
1.5
2.1
—
—
—
0
0
380
3349
1.02
0.11
3.5
2.8
4.24
4.27
mmol/l
0.25
355
3197
103
951
0.96
0.11
1.1
1.1
—
—
—
0
0
28
269
0.93
0.11
1.2
1.4
—
—
—
0
0
12
94
1.14
0.10
1.2
1.5
—
—
—
0
0
19
186
0.91
0.10
1.9
1.7
—
—
—
0
0
33
313
0.94
0.09
1.1
1.1
—
—
—
0
0
5
43
1.04
0.09
1.0
1.3
—
—
—
0
0
55
471
1.05
0.09
1.9
2.6
24.47
28.69
u/l
1.06
49
384
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
6
49
1.09
0.09
1.3
1.2
—
61.64
—
0
11
77
666
1.04
0.08
2.2
2.4
5734.79
6313.32
u/l
0.04
20
175
388
3501
0.98
0.08
2.6
2.2
5.39
5.30
mmol/l
0.60
351
3214
11
87
1.13
0.08
1.1
1.2
—
—
—
0
0
11
87
1.13
0.08
1.1
1.2
—
—
—
0
0
5
58
0.77
0.08
1.0
1.3
—
—
—
0
0
11
88
1.12
0.07
1.1
1.2
—
—
—
0
0
11
88
1.12
0.07
1.1
1.2
—
—
—
0
0
11
88
1.12
0.07
1.1
1.2
—
—
—
0
0
8
82
0.87
0.07
1.0
1.1
462.88
217.73
mg/l
—
8
77
158
1388
1.02
0.06
2.9
3.4
119.17
102.58
ug/g
0.13
132
1100
58
534
0.97
0.06
1.2
1.2
—
—
—
0
0
18
172
0.93
0.06
1.6
1.9
—
—
—
0
0
10
99
0.90
0.06
3.0
1.5
—
—
—
0
0
20
190
0.94
0.05
1.5
1.5
—
—
—
0
0
42
362
1.04
0.05
1.1
1.1
12.59
9.83
u/ml
0.25
27
224
10
81
1.10
0.04
1.9
1.1
—
—
—
0
0
52
452
1.03
0.04
1.9
2.0
2.43
2.42
mmol/l
0.35
41
379
53
461
1.03
0.04
2.6
2.2
8.83
7.94
nmol/l
0.24
46
409
29
249
1.04
0.04
2.2
2.0
34.91
33.09
%
0.42
22
196
23
196
1.05
0.04
1.1
1.3
5.50
4.19
mg/l
0.22
18
123
35
323
0.97
0.04
1.2
1.2
—
—
—
0
0
365
3242
1.01
0.03
3.4
2.7
1.36
1.40
mmol/l
1.18
341
3069
12
115
0.93
0.03
1.5
1.2
—
—
—
0
0
17
144
1.06
0.03
4.9
4.2
50.35
50.19
%
0.02
17
144
50
455
0.98
0.02
1.7
1.6
386.29
383.19
mu/l
0.02
45
420
11
93
1.06
0.00
1.6
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
93
1.06
0.00
1.6
1.2
—
—
—
0
0
15
131
1.02
0.00
1.9
1.8
1.83
5.41
iu/l
—
6
43
11
102
0.96
0.00
1.2
1.3
—
—
—
0
0
29
257
1.01
0.00
5.5
4.0
37.78
8.55
e6/l
0.37
23
183
41
371
0.99
0.00
1.1
1.2
—
30.94
—
0
8
36
326
0.99
0.00
1.1
1.1
1.86
0.28
u/ml
0.59
19
152
16
141
1.01
0.00
4.9
3.7
3.60
3.26
e9/l
0.35
16
141
29
258
1.00
0.00
5.5
4.0
156.71
226.07
e6/l
0.22
24
190
13
119
0.98
0.00
2.8
1.6
—
—
—
0
0
28
249
1.00
0.00
1.5
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
44
1.02
0.00
1.4
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
0.91
-0.00
1.8
3.0
22.42
31.61
ug/l
—
6
53
0
5
0.00
-0.00
0.0
3.4
—
5.38
—
0
5
5
52
0.86
-0.00
2.4
2.4
35660.00
38894.23
ug/l
—
5
52
6
54
0.99
-0.00
2.3
1.5
—
—
—
0
0
7
66
0.95
-0.00
1.1
1.1
—
—
—
0
0
8
73
0.98
-0.00
1.1
1.3
9.44
9.12
umol/l
—
8
73
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
71
1.01
-0.00
1.5
2.6
—
273.83
—
0
19
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
58.80
—
0
5
0
6
0.00
-0.00
0.0
2.7
—
0.83
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
49
0.91
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD | 1.961 [1.64, 2.34] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.451 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 29349 females with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD | 2.368 [2.05, 2.74] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 38142 males with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.
Mortality risk
Mortality risk for people of age
years, who have P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.425% |
| 5 | 1.096% | 2.92% |
| 10 | 2.92% | 7.072% |
| 15 | 5.676% | 12.871% |
| 20 | 10.052% | 21.298% |
Relationships between endpoints
↥Index endpoint: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD – Respiratory and cardiovascular disorders specific to the perinatal period
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data