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Respiratory and cardiovascular disorders specific to the perinatal period

EFO MESH Endpoint Browser PheWeb

P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P20-P29
  • Cause of death: ICD-10 — P20-P29

2 out of 7 registries used, show all original rules.

939

4. Check minimum number of events

None

939

5. Include endpoints

939

6. Filter based on genotype QC (FinnGen only)

939

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Perturbationes respiratoriae et cardiovasculares temporis perinatalis specificae

Similar endpoints

↥

List of similar endpoints to Respiratory and cardiovascular disorders specific to the perinatal period based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 72975 31693 41278
Only index persons 31986 13548 18438
Unadjusted period prevalence (%)
Whole population 1.05 0.91 1.15
Only index persons 0.62 0.50 0.70
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 939 505 434
Unadjusted period prevalence (%) 0.18 0.17 0.19
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
757
Matched controls
6856
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
+∞
211.8
200
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
16.2
132.7
233
183
P07.3
ICD-10 Finland
Other preterm infants
16.0
121.0
212
162
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
113.5
110
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
103.9
101
*
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
98.7
96
*
WX722
NOMESCO Finland
PEEP
21.2
63.2
97
47
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
576.0
58.3
59
*
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
55.9
55
*
P07.2
ICD-10 Finland
Extreme immaturity
236.5
46.7
49
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
42.5
42
*
P22.8
ICD-10 Finland
Other respiratory distress of newborn
195.7
38.6
41
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
11.9
32.1
61
50
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
30.3
30
*
P29.9
ICD-10 Finland
Cardiovascular disorder originating in the perinatal period, unspecified
+∞
27.2
27
*
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
27.2
27
*
WX882
NOMESCO Finland
High dependency care
3.3
26.4
150
474
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
6.7
25.9
69
101
602
Kela drug reimbursment
Children's severe malnutrition
5.0
25.8
88
175
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.6
25.2
93
201
H35.1
ICD-10 Finland
Retinopathy of prematurity
243.6
24.8
26
*
P24.0
ICD-10 Finland
Neonatal aspiration of meconium
+∞
23.2
23
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.7
22.6
179
699
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
20.4
138
486
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
8.2
19.3
44
51
P28.4
ICD-10 Finland
Other apnoea of newborn
+∞
19.1
19
*
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
32.0
18.1
24
7
J45.1
ICD-10 Finland
Nonallergic asthma
2.8
17.9
128
465
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
10.7
17.9
35
31
R4110
NOMESCO Finland
Physiotherapy
2.2
16.8
222
1103
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.0
16.4
69
169
P21.9
ICD-10 Finland
Birth asphyxia, unspecified
+∞
16.1
16
*
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.9
16.1
37
44
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
15.9
143
588
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
157.1
15.9
17
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
11.9
15.2
28
22
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
15.1
15
*
WX730
NOMESCO Finland
Conventional respirator
8.8
14.9
32
34
P07.1
ICD-10 Finland
Other low birth weight
24.4
14.9
21
8
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
6.6
14.3
37
53
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
8.8
14.0
30
32
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
138.2
13.9
15
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
13.7
97
348
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
9.7
13.3
27
26
P20.1
ICD-10 Finland
Intrauterine hypoxia first noted during labour and delivery
+∞
13.1
13
*
P05.1
ICD-10 Finland
Small for gestational age
7.1
12.7
31
41
XG413
NOMESCO Finland
Spirometry with oscillometry
4.2
12.6
48
108
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
14.7
11.5
19
12
P25.2
ICD-10 Finland
Pneumomediastinum originating in the perinatal period
+∞
11.0
11
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
7.7
10.5
24
29
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
10.4
69
239
R03BA05
ATC
fluticasone; inhalant
1.8
10.4
207
1174
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
7.4
10.3
24
30
ZX114
NOMESCO Finland
Intramuscular
5.0
10.1
32
60
P23.9
ICD-10 Finland
Congenital pneumonia, unspecified
+∞
10.0
10
*
P29.1
ICD-10 Finland
Neonatal cardiac dysrhythmia
+∞
10.0
10
*
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
5.1
10.0
31
57
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
4.0
9.9
39
91
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.4
9.8
85
340
J21.90
ICD-10 Finland
Acute obstructive bronchitis in children
2.6
9.7
71
259
R03AC02
ATC
salbutamol; inhalant
1.6
9.7
406
2838
P05.0
ICD-10 Finland
Light for gestational age
8.1
9.6
21
24
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
9.5
169
915
R03BA02
ATC
budesonide; inhalant
2.0
9.4
137
693
XA800
NOMESCO Finland
Neuropsychological investigation
2.2
9.2
96
423
R62.0
ICD-10 Finland
Delayed milestone
2.4
9.0
78
311
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
8.8
134
684
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
8.7
166
918
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
8.7
167
929
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
33.6
8.6
11
*
P29.8
ICD-10 Finland
Other cardiovascular disorders originating in the perinatal period
+∞
8.0
8
*
F80.1
ICD-10 Finland
Expressive language disorder
2.9
8.0
47
152
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
7.9
127
660
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.1
7.8
93
431
RT150
NOMESCO Finland
NA
3.6
7.7
34
89
M03BX01
ATC
baclofen; systemic
10.7
7.6
14
12
UGC02
NOMESCO Finland
Rigid bronchoscopy
4.5
7.5
25
51
WX704
NOMESCO Finland
Intubation
2.7
7.4
48
165
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
7.3
239
1538
RK312
NOMESCO Finland
NA
6.0
7.3
19
29
H50.30
ICD-10 Finland
Intermittent esotropy
3.3
7.2
34
95
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.0
7.2
41
130
Q25.0
ICD-10 Finland
Patent ductus arteriosus
3.6
7.1
31
81
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
7.0
66
277
P07.0
ICD-10 Finland
Extremely low birth weight
+∞
7.0
7
*
P24.1
ICD-10 Finland
Neonatal aspiration of amniotic fluid and mucus
+∞
7.0
7
*
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
9.9
6.8
13
12
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
9.9
6.8
13
12
7AA02
NOMESCO Finland
NA
27.4
6.8
9
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
27.4
6.8
9
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
2.9
6.8
39
124
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
18.3
6.8
10
5
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.6
128
708
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
3.2
6.6
32
92
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.5
200
1258
6BB16
NOMESCO Finland
NA
12.6
6.5
11
8
RK520
NOMESCO Finland
NA
6.9
6.4
15
20
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.0
6.4
79
375
WX732
NOMESCO Finland
High frequency respirator
20.6
6.3
9
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.5
6.2
266
1806
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
2.3
6.2
55
224
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
1.7
6.2
151
892
ZX108
NOMESCO Finland
Inhalation
4.0
6.2
23
53
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
63.9
6.2
7
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.8
6.1
39
132
P08.1
ICD-10 Finland
Other heavy for gestational age infants
9.2
6.1
12
12
P24.3
ICD-10 Finland
Neonatal aspiration of milk and regurgitated food
+∞
6.0
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
223
1359
1.61
8.16
15.5
9.5
—
—
—
0
0
22
50
4.00
7.66
1.0
1.0
—
—
—
0
0
244
1553
1.55
7.31
17.0
9.5
7.4
7.4
ph
—
9
56
244
1553
1.55
7.31
17.0
9.5
5.1
5.0
kpa
2.04
234
1506
143
823
1.65
6.47
1.5
1.5
207.5
358.4
u/ml
1.36
136
778
224
1440
1.51
6.29
16.4
9.3
9.5
9.8
kpa
1.95
214
1396
221
1436
1.49
5.85
14.4
11.4
1.4
1.3
mmol/l
1.31
212
1376
216
1417
1.47
5.41
12.5
11.8
—
—
—
0
0
12
22
4.92
5.39
1.2
1.5
—
—
—
0
0
432
3216
1.38
5.24
10.7
7.9
5.8
6.0
mmol/l
0.69
413
3018
321
2283
1.39
5.11
8.5
9.2
—
—
—
0
0
219
1456
1.45
5.09
8.9
9.8
23.7
23.6
mmol/l
0.05
209
1427
393
2901
1.37
4.93
20.6
13.6
1.2
1.2
mmol/l
0.31
379
2785
197
1294
1.46
4.86
3.2
3.7
—
—
—
0
0
223
1509
1.42
4.67
3.3
3.8
—
—
—
0
0
229
1563
1.41
4.56
12.4
10.1
1.3
1.1
mmol/l
0.37
182
1243
401
3013
1.33
4.30
20.2
12.3
1.2
1.2
mmol/l
0.12
378
2802
68
360
1.74
4.21
1.0
1.0
11.8
8.2
mu/l
2.11
61
312
36
154
2.13
4.16
1.7
2.0
—
—
—
0
0
400
3022
1.32
4.06
9.2
10.2
—
—
—
0
0
188
1266
1.41
4.00
4.5
3.8
2.4
3.0
e6/l
0.47
112
715
218
1507
1.38
3.97
11.6
9.9
5.3
5.1
kpa
0.67
213
1476
504
3954
1.31
3.79
9.2
9.5
37.3
35.7
%
2.06
489
3785
495
3880
1.30
3.72
8.9
9.4
47.3
48.8
%
1.67
482
3725
285
2073
1.33
3.70
5.6
4.5
227.8
33.8
e6/l
0.50
219
1560
17
54
2.84
3.66
15.7
10.9
1.2
1.2
mmol/l
0.29
17
49
508
4004
1.30
3.62
9.4
9.4
2.6
2.4
e9/l
1.53
448
3442
22
81
2.46
3.60
3.0
2.4
—
—
—
0
0
271
1965
1.33
3.58
5.1
4.3
—
—
—
0
0
481
3770
1.29
3.55
9.3
9.7
3.1
3.3
%
0.92
467
3607
484
3801
1.29
3.50
9.6
9.8
8.4
8.3
%
0.75
467
3634
470
3678
1.29
3.49
9.2
9.8
0.6
0.6
%
0.51
456
3523
268
1947
1.32
3.48
5.3
4.4
0.2
0.2
e6/l
0.24
202
1439
83
489
1.57
3.44
4.5
7.9
23.2
23.3
s
0.03
75
478
197
1374
1.36
3.35
3.6
2.9
2.4
2.4
mmol/l
0.13
185
1256
153
1025
1.40
3.33
3.9
4.5
—
—
—
0
0
524
4172
1.28
3.33
11.0
11.2
3.4
3.4
e9/l
0.11
452
3479
505
4003
1.28
3.32
10.2
10.3
0.2
0.2
e9/l
0.60
446
3408
21
79
2.40
3.30
1.0
1.2
—
—
—
0
0
139
919
1.41
3.27
15.0
13.5
0.8
0.8
mmol/l
1.92
133
888
69
394
1.61
3.26
9.5
8.2
0.7
0.4
g/l
0.76
55
318
491
3894
1.27
3.14
9.6
9.5
0.0
0.0
e9/l
0.21
424
3245
464
3655
1.27
3.14
10.7
11.2
0.0
0.0
e9/l
0.80
373
2809
16
54
2.67
3.12
7.9
3.9
99.7
167.1
umol/l
—
9
29
490
3896
1.26
3.02
9.6
9.5
0.6
0.6
e9/l
2.53
423
3245
270
2010
1.28
2.84
7.6
8.9
34.2
22.3
umol/l
2.78
252
1827
16
57
2.53
2.83
1.4
1.6
—
—
—
0
0
9
20
4.04
2.79
1.0
1.0
—
—
—
0
0
125
836
1.39
2.76
2.1
1.8
—
—
—
0
0
136
929
1.36
2.64
6.0
7.4
1.5
1.4
%
1.04
130
881
8
17
4.22
2.63
13.0
16.5
—
—
—
0
0
32
157
1.85
2.62
3.5
4.6
25.9
23.8
umol/l
0.51
32
157
101
665
1.40
2.45
14.8
16.0
1.2
1.3
mmol/l
0.93
94
597
49
281
1.59
2.34
1.0
1.0
7.3
7.3
kpa
0.04
39
238
49
281
1.59
2.34
1.0
1.0
—
—
—
0
0
49
281
1.59
2.34
1.0
1.0
-3.3
-2.1
mmol/l
0.33
11
62
312
2410
1.23
2.32
6.9
5.4
53.7
54.9
e6/l
0.02
225
1622
53
314
1.54
2.22
1.8
1.8
—
—
—
0
0
48
278
1.57
2.21
1.0
1.0
3.6
3.3
kpa
0.33
38
236
58
351
1.51
2.20
6.5
5.1
0.4
0.3
%
0.15
18
81
664
5559
1.24
2.18
19.2
12.8
4.0
3.9
mmol/l
6.77
652
5371
63
390
1.47
2.15
1.7
1.3
—
—
—
0
0
91
605
1.38
2.11
2.0
2.0
—
—
—
0
0
38
211
1.63
2.09
2.8
2.2
—
—
—
0
0
38
211
1.63
2.09
2.8
2.2
—
—
—
0
0
31
163
1.72
2.08
7.2
7.4
—
—
—
0
0
61
379
1.47
2.06
7.1
5.9
0.6
0.5
%
0.24
25
118
38
212
1.62
2.05
2.8
2.2
—
—
—
0
0
38
212
1.62
2.05
2.8
2.2
—
—
—
0
0
57
350
1.48
2.04
7.2
6.0
0.0
0.0
%
0.00
20
94
81
532
1.39
2.03
2.3
1.7
—
—
—
0
0
193
1434
1.25
2.02
5.6
4.7
8.0
8.8
mmol/l
1.04
183
1365
662
5565
1.22
1.95
19.4
12.8
139.3
139.5
mmol/l
1.45
652
5405
19
87
1.97
1.95
2.6
5.0
0.5
1.0
%
0.86
14
69
106
733
1.33
1.93
4.8
8.8
4.9
6.6
umol/l
1.86
87
616
7
19
3.30
1.91
1.3
1.6
—
—
—
0
0
164
1203
1.26
1.91
5.5
4.5
1.1
1.1
inr
0.81
40
323
113
790
1.31
1.91
4.4
5.1
0.2
0.2
g/l
0.65
106
763
25
127
1.78
1.90
4.7
3.2
17.8
17.7
%
0.04
19
83
29
154
1.70
1.90
1.2
1.3
399.3
363.9
ug/g
0.41
16
77
21
102
1.86
1.84
1.1
1.5
4.6
4.3
u/ml
—
9
65
6
15
3.58
1.83
1.0
1.1
156.7
134.1
nmol/l
—
6
15
239
1838
1.22
1.80
12.0
8.8
36.7
38.1
g/l
2.93
233
1753
263
2047
1.20
1.75
4.4
4.4
—
—
—
0
0
736
6283
1.23
1.70
10.9
7.9
—
—
—
0
0
724
6175
1.22
1.66
19.1
15.2
13.3
13.1
%
2.33
714
6060
24
126
1.72
1.66
13.4
6.2
—
—
—
0
0
15
68
1.98
1.61
4.3
3.2
—
—
—
0
0
28
155
1.63
1.61
6.1
5.7
2.4
2.1
ug/l
0.19
28
155
28
155
1.63
1.61
1.6
1.6
0.2
0.2
nmol/l
1.09
21
128
7
141
0.44
1.57
1.4
1.1
—
—
—
0
0
76
519
1.33
1.54
2.3
2.3
10.6
7.6
iu/l
0.50
52
337
215
1662
1.20
1.53
3.3
3.4
2.7
2.7
mg/l
0.06
188
1509
15
70
1.93
1.50
1.3
1.1
—
—
—
0
0
17
83
1.84
1.49
16.8
8.5
—
—
—
0
0
60
398
1.37
1.47
1.3
1.5
—
—
—
0
0
36
217
1.50
1.46
3.4
5.4
—
—
—
0
0
7
135
0.46
1.45
1.4
1.5
—
—
—
0
0
27
153
1.59
1.43
10.1
5.5
—
—
—
0
0
55
363
1.37
1.40
2.6
2.3
—
—
—
0
0
126
934
1.24
1.37
3.7
5.2
1.5
1.9
mg/l
0.62
88
651
49
321
1.38
1.32
1.5
1.4
—
—
—
0
0
6
21
2.56
1.32
3.0
1.3
—
—
—
0
0
10
42
2.14
1.31
2.4
2.6
23.4
18.7
umol/l
—
10
42
54
360
1.36
1.31
7.7
5.9
0.0
0.1
%
0.09
24
108
5
16
2.80
1.27
1.2
1.4
—
—
—
0
0
126
942
1.22
1.27
1.7
1.9
1.4
1.2
mmol/l
1.24
115
875
428
3541
1.15
1.27
5.1
3.9
7.4
208.5
e6/l
—
5
44
174
1343
1.19
1.26
4.6
3.5
561.0
605.8
mosm/kgh2o
1.32
156
1165
351
2868
1.15
1.23
3.6
3.1
35.3
36.2
mmol/mol
0.95
328
2707
24
138
1.57
1.23
1.1
1.1
—
—
—
0
0
47
310
1.37
1.23
1.7
1.8
—
—
—
0
0
34
423
0.71
1.19
1.7
2.3
—
—
—
0
0
80
574
1.27
1.17
15.5
12.5
105.0
105.7
mmol/l
0.59
80
567
156
1202
1.19
1.16
5.3
4.1
7.4
7.4
ph
1.30
27
201
96
705
1.24
1.16
1.5
1.4
22.0
19.0
nmol/l
1.17
82
634
5
18
2.49
1.13
1.4
1.7
—
—
—
0
0
38
247
1.39
1.10
19.1
21.8
0.7
0.8
%
1.26
38
247
38
248
1.38
1.08
19.2
21.8
95.4
96.1
%
0.21
38
248
838
7326
1.25
1.04
19.7
15.7
7.1
6.9
e9/l
1.07
803
6931
16
87
1.65
1.04
1.1
1.1
—
—
—
0
0
174
1369
1.17
1.02
4.8
3.6
6.4
6.3
e6/l
0.05
157
1197
189
1497
1.16
1.01
4.7
3.2
—
—
—
0
0
162
1268
1.17
1.01
8.2
5.0
—
—
—
0
0
836
7310
1.24
1.01
19.6
15.6
85.5
85.8
fl
1.25
826
7188
151
1176
1.17
1.00
1.6
1.5
102.0
97.0
pmol/l
0.61
73
634
737
6379
1.16
0.98
13.4
10.9
21.6
23.4
mg/l
0.86
504
4255
836
7313
1.23
0.98
19.6
15.6
28.8
28.8
pg
0.59
826
7194
84
897
0.82
0.98
1.5
1.8
—
—
—
0
0
83
887
0.82
0.97
1.5
1.8
—
—
—
0
0
25
315
0.70
0.97
1.0
1.0
—
—
—
0
0
836
7314
1.23
0.97
19.7
15.6
4.6
4.6
e12/l
0.44
804
6904
17
96
1.59
0.97
7.2
3.4
—
—
—
0
0
65
711
0.80
0.95
1.4
1.9
—
—
—
0
0
84
894
0.82
0.95
1.5
1.8
—
—
—
0
0
49
341
1.30
0.94
16.8
16.8
-0.5
-0.1
mmol/l
0.37
44
265
124
956
1.18
0.94
1.9
1.7
—
—
—
0
0
78
834
0.82
0.92
1.4
1.9
—
—
—
0
0
836
7319
1.22
0.92
20.1
16.0
132.3
133.0
g/l
0.61
826
7206
44
303
1.31
0.92
1.4
1.6
1579.3
1056.9
nmol/l
2.36
31
239
19
112
1.52
0.91
1.5
1.4
—
—
—
0
0
55
609
0.79
0.90
1.5
2.4
—
—
—
0
0
83
878
0.83
0.89
1.5
1.8
—
—
—
0
0
834
7305
1.21
0.87
19.8
15.7
275.0
272.6
e9/l
0.45
801
6922
12
172
0.62
0.87
1.1
1.2
—
—
—
0
0
78
581
1.22
0.86
2.4
2.3
6.3
5.7
u/l
0.17
46
372
66
483
1.24
0.86
2.5
2.0
207.2
166.3
u/ml
0.34
28
222
11
57
1.73
0.85
1.6
1.3
—
—
—
0
0
11
57
1.73
0.85
1.2
1.3
—
—
—
0
0
8
40
1.79
0.84
1.3
1.4
—
—
—
0
0
738
6408
1.14
0.84
17.9
14.6
335.5
335.0
g/l
0.65
732
6333
395
3315
1.11
0.83
6.7
5.7
143.5
126.7
u/l
2.43
370
3126
36
245
1.32
0.83
8.8
5.9
1.2
1.2
mmol/l
0.71
30
222
98
750
1.19
0.82
2.4
2.3
91.1
46.8
ng/l
0.25
41
268
29
191
1.37
0.82
1.2
1.1
—
—
—
0
0
13
72
1.62
0.81
2.2
2.9
—
—
—
0
0
13
72
1.62
0.81
1.6
1.7
20.4
19.1
nmol/l
—
5
23
5
86
0.52
0.79
11.4
7.1
10.2
9.2
mg/l
—
5
75
109
1111
0.86
0.78
1.8
1.8
—
—
—
0
0
19
117
1.46
0.77
3.1
2.7
—
—
—
0
0
178
1434
1.13
0.77
3.5
2.5
—
—
—
0
0
67
499
1.21
0.76
3.6
4.0
1056.1
123.9
mg/l
0.52
56
413
30
202
1.34
0.75
1.4
1.9
—
—
—
0
0
5
22
2.03
0.73
1.6
2.2
—
—
—
0
0
5
22
2.03
0.73
1.4
1.0
—
—
—
0
0
153
1226
1.14
0.72
5.5
3.5
0.0
0.0
estimate
0.50
48
414
9
51
1.58
0.71
1.1
1.1
—
—
—
0
0
211
2043
0.90
0.69
2.0
1.8
—
—
—
0
0
7
37
1.69
0.69
1.0
1.1
—
—
—
0
0
7
37
1.69
0.69
1.0
1.1
—
—
—
0
0
5
24
1.86
0.68
3.8
4.0
4.8
4.5
mmol/l
—
5
24
13
76
1.53
0.67
2.0
1.9
166.9
191.8
mu/l
0.05
13
68
19
121
1.41
0.67
11.1
7.5
2.4
1.3
mmol/l
0.94
14
60
19
121
1.41
0.67
11.1
7.5
5.0
4.9
kpa
0.22
19
121
19
121
1.41
0.67
8.9
7.5
9.4
9.4
kpa
0.03
19
121
87
674
1.17
0.66
3.6
5.2
61.6
64.1
e9/l
0.22
60
421
342
2878
1.10
0.66
1.7
1.8
1.9
3.7
u/ml
1.78
60
519
5
25
1.79
0.66
1.0
1.4
—
—
—
0
0
41
296
1.25
0.64
1.4
1.6
—
—
—
0
0
88
686
1.16
0.62
3.0
3.9
1455.7
1427.4
ng/l
0.02
54
381
141
1137
1.13
0.62
3.8
2.9
50.6
57.2
u/l
1.14
128
1059
59
446
1.19
0.60
1.5
1.4
557.4
16625772.6
pmol/l
0.50
50
403
8
47
1.52
0.59
3.0
2.2
31.8
32.1
pg
—
8
47
322
2716
1.09
0.58
1.7
1.7
1.4
1.5
g/l
0.68
164
1400
21
246
0.76
0.58
1.1
1.1
—
—
—
0
0
15
95
1.42
0.56
1.4
2.3
—
—
—
0
0
34
245
1.25
0.56
1.1
1.2
—
—
—
0
0
48
360
1.20
0.55
1.8
1.7
4.2
4.2
e9/l
0.01
42
328
9
54
1.49
0.54
1.1
1.1
0.5
0.4
nmol/l
—
9
54
23
158
1.31
0.54
4.0
2.9
—
787.8
—
0
16
25
174
1.29
0.54
2.5
2.7
—
—
—
0
0
757
6631
1.11
0.53
17.5
14.7
39.1
39.2
%
0.31
686
5905
60
618
0.86
0.53
1.2
1.2
15.0
19.5
iu/ml
0.40
15
125
360
3065
1.08
0.51
3.2
2.7
1.1
1.1
mmol/l
0.32
342
2905
79
623
1.14
0.50
1.2
1.2
7.1
6.3
u/ml
0.17
61
464
13
160
0.72
0.50
1.8
2.3
—
64.8
—
0
21
24
168
1.28
0.50
1.6
1.4
—
—
—
0
0
189
1808
0.91
0.50
2.0
2.1
—
—
—
0
0
18
121
1.33
0.49
6.0
4.6
—
—
—
0
0
12
149
0.71
0.49
1.1
1.2
—
—
—
0
0
7
40
1.57
0.49
1.0
1.1
—
—
—
0
0
7
40
1.57
0.49
3.1
5.7
259.3
222.0
ug/l
—
7
40
10
60
1.49
0.48
1.3
1.2
—
—
—
0
0
77
611
1.14
0.46
1.2
1.2
0.9
1.0
u/ml
0.06
54
430
538
4662
1.07
0.46
3.5
3.3
14.5
14.4
pmol/l
0.79
491
4194
5
76
0.58
0.46
1.4
2.0
—
—
—
0
0
35
261
1.20
0.44
7.7
3.5
—
—
—
0
0
56
570
0.87
0.44
1.2
1.2
4.0
8.8
u/ml
0.70
15
147
37
389
0.84
0.43
1.2
1.4
—
—
—
0
0
34
254
1.20
0.43
1.4
1.5
9.4
10.5
u/ml
0.05
23
173
5
28
1.60
0.43
1.8
2.3
2.2
2.8
nmol/l
—
5
28
8
50
1.43
0.42
6.6
6.2
—
—
—
0
0
25
272
0.81
0.42
2.1
2.1
—
—
—
0
0
0
14
0.00
0.41
0.0
7.5
—
—
—
0
0
13
154
0.75
0.41
1.8
2.0
—
—
—
0
0
5
30
1.49
0.40
1.6
2.7
37.2
198.0
ug/min
—
5
21
230
1943
1.07
0.40
1.6
1.5
—
—
—
0
0
0
16
0.00
0.40
0.0
2.4
—
—
—
0
0
366
3143
1.06
0.40
3.9
3.3
52.5
56.6
ug/l
0.20
346
2992
0
17
0.00
0.39
0.0
4.2
—
0.4
—
0
17
426
3678
1.06
0.39
5.4
4.2
—
—
—
0
0
5
32
1.40
0.38
17.8
12.3
570.6
744.2
nmol/l
—
5
32
53
417
1.14
0.38
1.5
1.4
—
—
—
0
0
67
664
0.89
0.37
2.6
2.5
—
—
—
0
0
597
5212
1.06
0.37
4.1
3.7
2.2
2.0
mu/l
2.47
561
4919
6
37
1.45
0.36
1.0
1.1
—
—
nmol/l
—
0
0
6
38
1.41
0.35
1.0
1.2
—
—
—
0
0
82
668
1.10
0.34
1.2
1.3
3.0
3.0
u/ml
0.01
57
440
297
2547
1.06
0.34
5.1
3.4
0.0
0.0
estimate
0.00
50
412
6
41
1.31
0.33
1.0
1.2
—
—
—
0
0
52
414
1.13
0.32
4.8
3.8
—
—
—
0
0
39
305
1.15
0.31
1.0
1.1
—
—
—
0
0
149
1253
1.07
0.31
1.2
1.3
—
—
—
0
0
27
205
1.18
0.31
1.3
1.2
0.3
1.1
u/ml
—
8
61
27
206
1.17
0.29
15.9
19.5
—
—
—
0
0
20
213
0.83
0.29
1.1
1.5
—
12.0
—
0
7
8
99
0.72
0.29
1.0
1.1
—
—
—
0
0
28
215
1.17
0.29
4.7
3.9
—
—
—
0
0
33
257
1.15
0.29
1.2
1.3
238.9
206.5
miu/ml
0.23
21
110
61
495
1.11
0.29
4.2
4.4
240.7
7.8
mg/mmol
0.57
53
410
57
558
0.91
0.27
1.4
1.3
227.9
157.6
iu/ml
0.39
15
172
10
68
1.32
0.27
1.0
1.2
—
—
—
0
0
8
59
1.21
0.26
1.8
1.4
—
—
—
0
0
250
2311
0.95
0.26
2.5
2.1
—
—
—
0
0
35
277
1.13
0.25
1.2
1.5
3.6
3.6
u/ml
0.01
26
197
433
3949
0.96
0.25
4.8
4.5
8.0
7.1
mm/h
0.98
413
3661
27
210
1.15
0.25
1.4
1.3
1.6
20.8
u/ml
1.04
22
170
293
2534
1.05
0.24
7.0
5.0
0.0
0.0
estimate
0.00
52
441
6
76
0.70
0.24
1.2
1.2
—
—
—
0
0
5
33
1.35
0.23
1.0
1.4
—
—
—
0
0
147
1251
1.06
0.23
4.8
2.9
1.0
1.0
kg/l
1.12
27
235
73
606
1.08
0.23
1.2
1.2
5.1
4.2
u/ml
0.12
26
205
15
111
1.21
0.23
1.1
1.0
—
—
—
0
0
7
81
0.77
0.22
1.3
1.3
—
—
—
0
0
294
2548
1.04
0.22
5.1
3.4
0.0
0.0
estimate
0.00
54
432
22
170
1.16
0.22
1.5
1.7
2.3
9.7
u/ml
—
7
45
47
383
1.10
0.22
1.2
1.1
—
—
—
0
0
5
37
1.21
0.22
1.0
1.2
—
—
—
0
0
0
9
0.00
0.21
0.0
1.4
—
—
—
0
0
0
9
0.00
0.21
0.0
1.6
—
—
—
0
0
0
9
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
44.8
—
0
6
132
1233
0.95
0.21
4.3
3.0
—
—
—
0
0
239
2065
1.04
0.21
4.5
3.3
—
—
—
0
0
0
12
0.00
0.20
0.0
3.4
—
—
—
0
0
0
12
0.00
0.20
0.0
1.2
—
—
—
0
0
6
43
1.25
0.20
1.0
1.6
—
—
—
0
0
7
53
1.18
0.18
1.0
1.0
—
—
—
0
0
27
216
1.12
0.18
1.4
1.2
—
—
—
0
0
11
81
1.21
0.17
11.1
5.9
—
—
—
0
0
8
62
1.15
0.16
1.0
1.0
—
—
—
0
0
8
64
1.12
0.16
1.0
1.0
—
7.6
—
0
6
18
181
0.88
0.15
1.7
1.6
0.5
0.8
g/l
0.87
18
157
16
162
0.88
0.14
9.6
5.5
21.2
23.0
u/ml
0.04
16
154
31
300
0.92
0.14
1.1
1.2
—
—
—
0
0
32
309
0.92
0.14
1.1
1.1
—
—
—
0
0
18
143
1.13
0.13
5.3
4.2
50.8
50.1
%
0.08
18
143
32
264
1.08
0.13
5.2
3.9
708.1
394.9
mg/l
0.78
32
259
27
221
1.09
0.13
4.2
3.4
456.8
385.5
e6/l
0.32
22
141
47
395
1.06
0.12
1.1
1.1
13.2
6.6
u/ml
0.83
28
228
20
161
1.11
0.12
1.1
1.4
—
—
—
0
0
14
110
1.14
0.12
6.9
4.7
—
—
—
0
0
367
3231
1.02
0.10
3.4
2.7
2.6
2.6
mmol/l
0.46
345
3026
21
204
0.92
0.10
7.0
4.7
—
—
—
0
0
23
189
1.09
0.10
2.4
1.6
—
—
—
0
0
108
935
1.03
0.10
1.4
1.3
39.2
368.2
titre
—
6
35
135
1235
0.97
0.10
1.6
1.7
—
—
—
0
0
11
86
1.14
0.09
1.1
1.2
—
—
—
0
0
19
155
1.10
0.09
4.1
4.3
—
—
—
0
0
25
239
0.93
0.09
1.2
1.3
—
—
—
0
0
6
49
1.09
0.09
1.0
1.5
—
—
—
0
0
6
49
1.09
0.09
1.0
1.5
—
—
—
0
0
6
49
1.09
0.09
1.0
1.5
—
—
—
0
0
384
3461
0.98
0.08
2.6
2.2
5.4
5.3
mmol/l
0.62
347
3175
77
665
1.04
0.08
2.2
2.4
6036.5
6314.9
u/l
0.02
19
175
5
54
0.82
0.08
1.0
1.1
—
—
—
0
0
5
54
0.82
0.08
1.6
1.3
—
—
—
0
0
25
238
0.94
0.08
1.2
1.3
—
—
—
0
0
7
60
1.04
0.08
3.7
1.4
—
—
—
0
0
7
61
1.02
0.07
1.6
2.0
—
—
—
0
0
375
3312
1.02
0.07
3.4
2.8
4.2
4.3
mmol/l
0.40
350
3149
26
218
1.07
0.07
5.3
3.5
—
40.8
—
0
5
15
146
0.91
0.07
1.5
1.2
—
1.1
—
0
10
10
100
0.89
0.07
1.1
1.1
—
—
—
0
0
37
315
1.05
0.07
1.3
1.2
—
—
—
0
0
17
140
1.08
0.07
5.4
3.7
3.6
3.3
e9/l
0.37
17
140
108
942
1.03
0.07
2.1
1.7
—
—
—
0
0
12
118
0.91
0.07
1.9
1.5
—
—
—
0
0
12
118
0.91
0.07
1.9
1.4
—
—
—
0
0
8
81
0.88
0.07
1.0
1.1
462.9
215.1
mg/l
—
8
76
8
84
0.85
0.06
1.0
1.1
—
—
—
0
0
53
457
1.04
0.06
2.6
2.2
10.3
8.5
nmol/l
0.51
40
362
135
1185
1.02
0.05
1.8
1.6
—
—
—
0
0
51
441
1.03
0.05
1.9
1.9
2.4
2.4
mmol/l
0.15
40
369
104
911
1.02
0.05
1.4
1.6
—
—
—
0
0
17
142
1.07
0.05
1.7
1.3
—
—
—
0
0
157
1382
1.02
0.05
2.9
3.5
119.9
101.7
ug/g
0.14
131
1094
14
134
0.93
0.04
1.4
1.6
—
—
—
0
0
42
363
1.03
0.04
1.1
1.1
12.6
9.8
u/ml
0.26
27
225
17
143
1.06
0.04
1.2
1.4
—
—
—
0
0
10
97
0.92
0.03
1.2
1.7
—
—
—
0
0
26
224
1.04
0.02
24.1
21.0
—
—
—
0
0
16
150
0.95
0.02
20.2
24.2
11.6
11.4
%
0.09
16
150
18
167
0.96
0.01
1.4
1.8
—
—
—
0
0
28
243
1.03
0.01
5.6
4.2
—
—
—
0
0
90
809
0.99
0.01
1.5
1.6
872.7
506.1
titre
0.36
11
132
360
3205
1.00
0.00
3.4
2.6
1.4
1.4
mmol/l
1.22
336
3022
53
478
0.99
0.00
1.3
1.4
—
—
—
0
0
13
121
0.96
0.00
1.8
1.5
—
—
—
0
0
16
141
1.01
0.00
1.8
1.3
1.9
2.2
g/l
0.52
16
123
16
141
1.01
0.00
1.8
1.3
5.6
6.1
g/l
0.42
16
122
18
162
0.99
0.00
4.7
3.7
—
—
—
0
0
41
365
1.00
0.00
1.1
1.2
—
30.9
—
0
8
29
256
1.01
0.00
5.5
4.0
37.8
8.5
e6/l
0.37
23
183
36
326
0.98
0.00
1.1
1.1
1.9
0.3
u/ml
0.60
19
147
15
129
1.04
0.00
1.9
1.8
1.8
5.4
iu/l
—
6
42
20
178
1.00
0.00
2.5
2.0
—
—
—
0
0
29
257
1.01
0.00
5.5
4.0
156.7
226.1
e6/l
0.22
24
190
14
121
1.03
0.00
1.8
1.8
—
—
—
0
0
51
452
1.01
0.00
1.7
1.6
480.4
383.5
mu/l
0.43
46
417
17
149
1.02
0.00
1.5
1.7
—
—
—
0
0
11
103
0.95
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
6
59
0.91
0.00
1.8
3.0
22.4
31.6
ug/l
—
6
53
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
6
58
0.92
0.00
16.8
4.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
9
85
0.94
0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
9
82
0.98
0.00
1.1
1.0
—
—
—
0
0
9
83
0.97
0.00
1.7
1.8
—
—
—
0
0
8
72
0.99
0.00
1.5
2.6
—
273.8
—
0
19
5
48
0.93
0.00
3.4
2.3
—
—
—
0
0
8
73
0.98
0.00
1.1
1.3
9.4
9.1
umol/l
—
8
73
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
66.8
—
0
7
5
52
0.86
0.00
2.4
2.4
—
—
—
0
0
9
82
0.98
0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
1492.7
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD and mortality.

Females

Parameter HR [95% CI] p-value
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD 1.961 [1.64, 2.34] < 0.001
Birth year 0.997 [0.99, 1.01] 0.451

During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 29349 females with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.

Males

Parameter HR [95% CI] p-value
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD 2.368 [2.05, 2.74] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 38142 males with P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD died.

Mortality risk

Mortality risk for people of age

years, who have P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD.

N-year risk Females Males
1 0.176% 0.425%
5 1.096% 2.92%
10 2.92% 7.072%
15 5.676% 12.871%
20 10.052% 21.298%

Relationships between endpoints

↥

Index endpoint: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD – Respiratory and cardiovascular disorders specific to the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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