Respiratory distress of newborn

P16_RESPI_DISTR_NEWBO

newborn respiratory distress syndrome: Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P22 Cause of death: ICD-10 — P22 2 out of 7 registries used, show all original rules.	536
4. Check minimum number of events None	536
5. Include endpoints None	536
6. Filter based on genotype QC (FinnGen only)	536

Control definitions (FinnGen only)

Control exclude: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P2
Name in latin: Dyspnoea neonatalis

NAME	P16_RESPI_DISTR_NEWBO
CONTROL_EXCLUDE	P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P22
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P22
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Respiratory distress of newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	49038	21114	27923
Only index persons	18039	7483	10556
Unadjusted period prevalence (%)
Whole population	0.70	0.60	0.78
Only index persons	0.35	0.28	0.40
Median age at first event (years)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	536	278	258
Unadjusted period prevalence (%)	0.10	0.09	0.11
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
456: Matched controls
4260

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P22.1

ICD-10 Finland

Transient tachypnoea of newborn

4043.7

238.7

214

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

+∞

119.4

112

P22.9

ICD-10 Finland

Respiratory distress of newborn, unspecified

+∞

113.8

107

P07.3

ICD-10 Finland

Other preterm infants

21.7

106.8

167

110

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

14.8

78.5

142

126

WX722

NOMESCO Finland

PEEP

21.4

63.4

P22.8

ICD-10 Finland

Other respiratory distress of newborn

232.1

43.6

P07.2

ICD-10 Finland

Extreme immaturity

198.3

37.4

P29.30

ICD-10 Finland

Delayed closure of the ductus arteriosus

+∞

31.8

P27.1

ICD-10 Finland

Bronchopulmonary dysplasia originating in the perinatal period

311.9

30.4

P59.0

ICD-10 Finland

Neonatal jaundice associated with preterm delivery

13.8

30.0

WX882

NOMESCO Finland

High dependency care

3.8

25.8

131

412

P21.1

ICD-10 Finland

Mild and moderate birth asphyxia

+∞

20.4

AA5HE

NOMESCO Finland

Brain ultrasound examination in a child

4.2

19.7

212

602

Kela drug reimbursment

Children's severe malnutrition

5.0

18.6

132

H35.1

ICD-10 Finland

Retinopathy of prematurity

+∞

17.4

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.1

17.1

109

393

P07.11

ICD-10 Finland

Other low birth weight 1500-1999 g

13.7

16.8

P07.10

ICD-10 Finland

Other low birth weight 1000-1499 g

34.1

16.2

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.8

16.1

119

471

P07.02

ICD-10 Finland

Extremely low birth weight 750-999 g

154.3

15.1

P01.5

ICD-10 Finland

Fetus and newborn affected by multiple pregnancy

15.7

14.8

P29.31

ICD-10 Finland

Persistent fetal circulation

+∞

14.3

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

2.7

13.7

108

439

P07.1

ICD-10 Finland

Other low birth weight

48.1

12.5

R4110

NOMESCO Finland

Physiotherapy

2.2

12.4

152

775

Z3231

NOMESCO Finland

Registered nurse

2.1

12.4

224

1350

P36.90

ICD-10 Finland

Suspected bacterial sepsis of newborn

7.5

12.4

P07.01

ICD-10 Finland

Extremely low birth weight 500-749 g

+∞

12.2

P70.0

ICD-10 Finland

Syndrome of infant of mother with gestational diabetes

7.0

11.8

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.1

11.4

230

WX730

NOMESCO Finland

Conventional respirator

8.7

11.3

P70.4

ICD-10 Finland

Other neonatal hypoglycaemia

4.7

11.2

FDE00

NOMESCO Finland

Closure of patent ductus arteriosus

114.7

11.2

F82

ICD-10 Finland

Specific developmental disorder of motor function

3.6

10.5

139

WW804

NOMESCO Finland

Transfer from treating institution to higher-Level care, accompanied by doctor

6.8

10.1

P00.0

ICD-10 Finland

Fetus and newborn affected by maternal hypertensive disorders

9.7

10.1

J45.1

ICD-10 Finland

Nonallergic asthma

2.6

10.0

336

P39.9

ICD-10 Finland

Infection specific to the perinatal period, unspecified

7.2

9.8

P05.0

ICD-10 Finland

Light for gestational age

11.7

9.5

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.6

9.3

293

Z3226

NOMESCO Finland

Physiotherapist

2.0

9.2

154

875

P01.10

ICD-10 Finland

Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery

8.1

9.2

P05.1

ICD-10 Finland

Small for gestational age

6.3

8.5

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.0

8.5

122

648

P25.1

ICD-10 Finland

Pneumothorax originating in the perinatal period

+∞

8.1

Z2446

NOMESCO Finland

Social worker

2.0

7.9

124

680

G80.1

ICD-10 Finland

Spastic diplegic cerebral palsy

16.4

7.8

Z2221

NOMESCO Finland

Medical doctor

1.9

7.8

139

800

RK312

NOMESCO Finland

7.8

7.7

P70.1

ICD-10 Finland

Syndrome of infant of a diabetic mother

7.4

7.5

R03BA05

ATC

fluticasone; inhalant

1.8

7.2

142

841

P07.12

ICD-10 Finland

Other low birth weight 2000-2499 g

4.8

7.2

R03BA02

ATC

budesonide; inhalant

2.1

7.2

390

P21.0

ICD-10 Finland

Severe birth asphyxia

+∞

7.1

XG413

NOMESCO Finland

Spirometry with oscillometry

3.2

7.1

111

H50.30

ICD-10 Finland

Intermittent esotropy

3.8

6.6

F80.1

ICD-10 Finland

Expressive language disorder

3.0

6.6

120

Z01.0

ICD-10 Finland

Examination of eyes and vision

1.9

6.3

109

613

RK520

NOMESCO Finland

9.5

6.3

R62.0

ICD-10 Finland

Delayed milestone

2.3

6.2

260

WW805

NOMESCO Finland

Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse

7.8

6.1

TAW99

NOMESCO Finland

Other minor neurosurgical procedure

17.1

6.0

P52.0

ICD-10 Finland

Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn

17.1

6.0

Mortality – FinRegistry

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Association

Association between endpoint P16_RESPI_DISTR_NEWBO and mortality.

Females

Parameter	HR [95% CI]	p-value
P16_RESPI_DISTR_NEWBO	1.873 [1.51, 2.32]	< 0.001
Birth year	0.996 [0.99, 1.01]	0.39

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 19773 females with P16_RESPI_DISTR_NEWBO died.

Males

Parameter	HR [95% CI]	p-value
P16_RESPI_DISTR_NEWBO	1.898 [1.59, 2.26]	< 0.001
Birth year	0.985 [0.97, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 26033 males with P16_RESPI_DISTR_NEWBO died.

Mortality risk

Mortality risk for people of age

years, who have P16_RESPI_DISTR_NEWBO.

N-year risk	Females	Males
1	0.196%	0.286%
5	1.099%	1.786%
10	2.779%	4.573%
15	5.361%	8.709%
20	9.471%	14.853%

Relationships between endpoints

↥

Index endpoint: P16_RESPI_DISTR_NEWBO – Respiratory distress of newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Respiratory distress of newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints