newborn respiratory distress syndrome: Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
536 |
4. Check minimum number of eventsNone |
536 |
5. Include endpointsNone |
536 |
6. Filter based on genotype QC (FinnGen only) |
536 |
Control definitions (FinnGen only)
- Control exclude
- P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P2
- Name in latin
- Dyspnoea neonatalis
Similar endpoints
↥List of similar endpoints to
Respiratory distress of newborn
based on the number of shared cases.
Similar with more cases:
- Respiratory and cardiovascular disorders specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 49038 | 21114 | 27923 |
| Only index persons | 18039 | 7483 | 10556 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.70 | 0.60 | 0.78 |
| Only index persons | 0.35 | 0.28 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 536 | 278 | 258 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 456
- Matched controls
- 4260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
4043.7
238.7
214
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
119.4
112
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
113.8
107
*
P07.3
ICD-10 Finland
Other preterm infants
21.7
106.8
167
110
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
14.8
78.5
142
126
WX722
NOMESCO Finland
PEEP
21.4
63.4
97
53
P22.8
ICD-10 Finland
Other respiratory distress of newborn
232.1
43.6
45
*
P07.2
ICD-10 Finland
Extreme immaturity
198.3
37.4
39
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
31.8
31
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
311.9
30.4
31
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
13.8
30.0
53
40
WX882
NOMESCO Finland
High dependency care
3.8
25.8
131
412
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
20.4
20
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.2
19.7
82
212
602
Kela drug reimbursment
Children's severe malnutrition
5.0
18.6
63
132
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
17.4
17
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
17.1
109
393
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
13.7
16.8
29
21
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
34.1
16.2
21
6
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
16.1
119
471
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
154.3
15.1
16
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
15.7
14.8
24
15
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
14.3
14
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.7
13.7
108
439
P07.1
ICD-10 Finland
Other low birth weight
48.1
12.5
15
*
R4110
NOMESCO Finland
Physiotherapy
2.2
12.4
152
775
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
7.5
12.4
29
38
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
12.2
12
*
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.0
11.8
29
41
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
11.4
68
230
WX730
NOMESCO Finland
Conventional respirator
8.7
11.3
24
27
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
4.7
11.2
38
80
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
114.7
11.2
12
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.6
10.5
49
139
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
6.8
10.1
25
36
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
9.7
10.1
20
20
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
10.0
82
336
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
7.2
9.8
23
31
P05.0
ICD-10 Finland
Light for gestational age
11.7
9.5
17
14
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.6
9.3
73
293
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
8.1
9.2
20
24
P05.1
ICD-10 Finland
Small for gestational age
6.3
8.5
22
34
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
8.5
122
648
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
8.1
8
*
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
16.4
7.8
12
7
RK312
NOMESCO Finland
NA
7.8
7.7
17
21
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
7.4
7.5
17
22
R03BA05
ATC
fluticasone; inhalant
1.8
7.2
142
841
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
4.8
7.2
23
47
R03BA02
ATC
budesonide; inhalant
2.1
7.2
81
390
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
7.1
7
*
XG413
NOMESCO Finland
Spirometry with oscillometry
3.2
7.1
36
111
H50.30
ICD-10 Finland
Intermittent esotropy
3.8
6.6
27
70
F80.1
ICD-10 Finland
Expressive language disorder
3.0
6.6
37
120
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.3
109
613
RK520
NOMESCO Finland
NA
9.5
6.3
12
12
R62.0
ICD-10 Finland
Delayed milestone
2.3
6.2
59
260
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
7.8
6.1
13
16
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
17.1
6.0
9
5
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
17.1
6.0
9
5
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
170
1238
1.40
3.15
13.5
10.2
1.0
0.7
mmol/l
0.68
117
889
170
1239
1.40
3.13
13.5
10.3
5.1
5.0
kpa
1.40
161
1203
88
574
1.51
2.90
1.6
1.5
257.4
358.5
u/ml
0.46
83
540
66
406
1.58
2.82
10.0
9.2
44.9
48.7
ng/l
0.64
66
401
161
1200
1.35
2.51
9.8
11.0
43.8
29.3
umol/l
1.99
150
1084
123
878
1.39
2.51
3.9
4.2
2.5
2.1
e6/l
0.21
77
519
34
181
1.79
2.50
15.7
11.5
22.6
22.8
mmol/l
0.12
34
171
56
347
1.55
2.34
1.0
1.0
9.9
8.3
mu/l
0.95
51
308
70
894
0.68
2.29
2.6
2.6
—
—
—
0
0
66
852
0.68
2.29
2.5
2.4
—
—
—
0
0
186
1433
1.31
2.28
5.6
5.1
—
—
—
0
0
157
1181
1.33
2.27
12.5
10.0
9.3
9.8
kpa
2.60
148
1145
0
55
0.00
2.27
0.0
1.1
—
—
—
0
0
119
859
1.37
2.25
3.7
4.2
0.6
0.9
e6/l
0.74
72
497
12
44
2.56
2.21
8.2
8.0
—
—
—
0
0
14
56
2.35
2.17
7.4
10.5
—
—
—
0
0
171
1317
1.30
2.07
4.7
4.9
0.2
0.2
e6/l
0.21
128
985
10
207
0.44
1.89
1.2
1.3
—
—
—
0
0
18
86
1.97
1.86
2.9
2.7
12.3
15.1
umol/l
1.23
18
86
148
1143
1.28
1.72
11.0
10.7
23.5
23.6
mmol/l
0.12
140
1117
74
519
1.37
1.68
2.4
2.2
—
—
—
0
0
43
273
1.50
1.66
1.0
1.0
-3.1
-2.1
mmol/l
0.27
12
61
43
273
1.50
1.66
1.0
1.0
7.4
7.3
kpa
0.15
37
234
34
205
1.57
1.65
1.5
1.4
—
—
—
0
0
34
205
1.57
1.65
1.5
1.4
—
—
—
0
0
390
3380
1.27
1.59
19.5
15.0
4.0
4.0
mmol/l
3.98
382
3261
138
1067
1.27
1.58
13.2
12.2
1.4
1.4
mmol/l
0.43
133
1015
14
65
2.02
1.58
1.0
1.1
—
—
—
0
0
42
270
1.48
1.54
1.0
1.0
3.5
3.3
kpa
0.19
36
232
251
2080
1.23
1.53
12.8
9.4
5.7
6.0
mmol/l
1.21
242
1967
12
54
2.08
1.47
5.7
7.0
—
—
—
0
0
12
54
2.08
1.47
5.4
6.9
—
—
—
0
0
27
159
1.61
1.46
1.3
3.2
—
—
—
0
0
248
2062
1.22
1.44
19.5
14.2
1.2
1.2
mmol/l
0.07
239
1937
13
61
2.00
1.44
1.4
2.0
—
—
—
0
0
53
362
1.40
1.43
1.4
1.4
22.1
20.1
nmol/l
0.42
47
317
61
427
1.37
1.42
2.4
2.1
—
—
—
0
0
39
252
1.47
1.41
2.4
2.6
—
72.8
—
0
11
389
3390
1.24
1.39
19.8
15.1
139.3
139.4
mmol/l
0.49
383
3292
7
27
2.42
1.38
1.1
1.3
—
—
—
0
0
181
1467
1.22
1.34
4.9
4.0
70.5
69.3
nmol/l
0.24
175
1395
109
836
1.26
1.33
3.9
3.0
2.4
2.4
mmol/l
0.39
104
761
21
120
1.65
1.29
3.6
4.9
27.7
23.9
umol/l
0.67
21
120
11
51
2.02
1.26
6.8
3.9
121.0
169.7
umol/l
—
5
27
48
332
1.37
1.22
2.6
2.4
6.8
6.4
iu/l
0.09
35
193
49
596
0.74
1.22
1.8
2.3
—
—
—
0
0
42
522
0.72
1.21
1.8
2.1
—
—
—
0
0
241
2023
1.19
1.20
20.5
15.8
1.2
1.2
mmol/l
0.17
234
1942
0
31
0.00
1.17
0.0
1.2
—
—
—
0
0
59
428
1.31
1.12
2.7
2.2
—
—
—
0
0
31
202
1.45
1.11
1.5
1.7
—
—
—
0
0
7
29
2.25
1.10
1.1
1.3
—
—
—
0
0
23
142
1.52
1.06
1.5
1.6
1877.4
1091.7
nmol/l
2.24
17
103
148
1203
1.20
1.04
14.6
11.1
0.9
1.0
mmol/l
0.16
115
934
84
647
1.24
1.01
14.5
15.8
0.8
0.8
mmol/l
1.24
79
622
310
2686
1.17
0.99
11.8
12.6
3.3
3.3
e9/l
0.02
259
2196
10
51
1.83
0.91
1.3
1.4
—
—
—
0
0
6
26
2.15
0.91
1.0
1.1
—
—
—
0
0
29
363
0.73
0.90
1.2
1.3
—
—
—
0
0
39
276
1.33
0.90
1.7
1.8
—
—
—
0
0
20
125
1.50
0.90
5.9
6.0
2.6
2.4
ug/l
0.15
20
125
6
28
2.00
0.86
1.3
1.5
—
—
—
0
0
80
626
1.22
0.84
1.6
1.5
107.1
99.0
pmol/l
0.47
36
315
29
358
0.74
0.84
1.6
1.4
1.4
1.4
%
0.08
29
325
10
53
1.76
0.82
1.2
1.2
—
—
—
0
0
64
491
1.24
0.82
18.1
17.5
1.3
1.4
mmol/l
0.49
58
440
24
160
1.41
0.80
15.4
14.9
121.5
253.4
u/ml
—
6
23
45
334
1.27
0.76
2.1
2.2
—
—
—
0
0
14
85
1.54
0.73
5.1
5.4
—
—
—
0
0
5
23
2.02
0.73
1.0
1.3
—
—
—
0
0
9
52
1.61
0.72
1.0
1.3
—
—
—
0
0
9
52
1.61
0.72
1.0
1.3
—
—
—
0
0
20
132
1.42
0.72
3.1
2.3
—
—
—
0
0
49
371
1.25
0.72
2.6
2.4
4.7
4.9
u/l
0.07
31
202
21
140
1.41
0.71
7.1
3.1
—
—
—
0
0
9
53
1.58
0.71
4.0
1.8
—
—
—
0
0
9
53
1.58
0.71
1.0
1.3
—
—
—
0
0
9
53
1.58
0.71
1.0
1.3
—
—
—
0
0
9
53
1.58
0.71
1.0
1.3
—
—
—
0
0
24
165
1.36
0.69
2.2
1.3
—
—
—
0
0
5
85
0.54
0.68
4.4
2.4
—
—
—
0
0
208
2071
0.89
0.67
2.2
2.1
—
—
—
0
0
44
332
1.25
0.67
2.2
2.2
161.1
153.3
u/ml
0.04
19
146
189
1617
1.13
0.66
3.1
2.9
1.1
1.1
mmol/l
0.07
178
1539
5
26
1.79
0.66
4.0
7.1
199.6
247.5
ug/l
—
5
26
12
73
1.54
0.63
1.3
1.9
—
—
—
0
0
23
160
1.35
0.63
2.1
2.0
—
—
—
0
0
8
46
1.62
0.62
1.1
1.3
—
—
—
0
0
103
850
1.15
0.61
3.9
4.0
—
—
—
0
0
5
28
1.66
0.61
2.0
2.9
24.5
16.7
umol/l
—
5
28
5
28
1.66
0.61
1.0
1.8
—
—
—
0
0
157
1579
0.89
0.59
6.6
6.0
114.7
114.6
ml/min/173m2
0.02
93
911
65
521
1.18
0.56
6.5
10.4
5.4
6.3
umol/l
0.58
51
434
30
344
0.80
0.55
1.2
1.3
—
—
—
0
0
12
76
1.47
0.54
1.3
1.2
—
—
—
0
0
429
3877
1.14
0.53
12.6
11.9
23.5
24.6
mg/l
0.27
281
2588
12
157
0.70
0.53
2.8
6.7
102.6
95.1
%
0.44
12
157
9
58
1.45
0.53
1.8
3.1
57.4
57.2
umol/l
—
9
58
10
62
1.50
0.50
1.0
1.3
—
—
—
0
0
7
43
1.52
0.48
4.6
2.0
—
—
—
0
0
207
1810
1.10
0.47
4.1
3.5
59.1
48.9
ug/l
0.52
199
1721
7
46
1.42
0.45
1.3
1.3
—
—
—
0
0
18
129
1.30
0.43
1.3
2.0
—
—
—
0
0
21
243
0.79
0.43
2.4
1.8
—
—
—
0
0
5
29
1.60
0.43
1.2
1.9
139.2
149.5
pmol/l
—
5
29
13
89
1.36
0.41
2.1
1.7
—
—
—
0
0
0
14
0.00
0.41
0.0
1.9
—
—
—
0
0
0
14
0.00
0.41
0.0
1.9
—
—
—
0
0
0
14
0.00
0.41
0.0
1.9
—
—
—
0
0
0
14
0.00
0.41
0.0
1.9
—
—
—
0
0
27
206
1.23
0.41
3.2
2.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
36
388
0.85
0.38
1.2
1.2
—
—
—
0
0
27
208
1.21
0.38
3.4
2.4
—
—
—
0
0
23
175
1.23
0.36
18.5
22.2
95.8
96.3
%
0.16
23
175
23
175
1.23
0.36
17.3
11.9
60.0
362.7
iu/ml
—
5
25
9
113
0.73
0.35
1.6
1.3
—
—
—
0
0
23
176
1.22
0.35
18.5
22.1
0.7
0.8
%
0.54
23
176
21
159
1.23
0.35
12.9
14.6
115.7
123.5
g/l
0.63
21
154
28
305
0.84
0.34
2.1
2.5
24.9
28.1
u/l
0.44
23
243
6
80
0.69
0.33
3.2
2.5
—
—
—
0
0
17
194
0.81
0.33
1.3
1.3
—
—
—
0
0
29
313
0.85
0.32
1.2
1.1
1.0
8.3
u/ml
—
6
78
43
447
0.88
0.30
3.1
4.4
1008.9
1319.9
ng/l
0.30
31
270
16
120
1.24
0.29
2.0
1.8
3.7
3.5
umol/l
0.09
16
105
33
267
1.16
0.29
3.1
2.2
9.6
9.1
nmol/l
0.08
26
189
120
1048
1.08
0.28
3.9
3.5
2.7
2.7
mg/l
0.02
107
955
32
336
0.88
0.26
1.2
1.2
13.3
15.5
iu/ml
—
6
71
42
350
1.12
0.25
6.1
7.4
298.4
1136.6
umol/l
0.47
42
338
13
97
1.25
0.25
1.2
1.4
—
—
—
0
0
9
71
1.18
0.24
1.0
1.3
—
—
—
0
0
371
3376
1.06
0.24
9.7
10.0
31.4
25.1
u/l
1.15
364
3254
216
1936
1.06
0.24
6.2
5.5
160.1
149.6
u/l
0.65
204
1817
81
702
1.08
0.24
6.0
3.7
0.0
0.0
estimate
0.00
23
234
64
640
0.92
0.24
1.1
1.1
—
—
—
0
0
65
558
1.09
0.24
4.3
7.0
1.6
2.4
mg/l
0.68
48
416
28
229
1.14
0.23
2.4
3.2
14.3
20.0
mu/l
0.70
28
217
424
3877
1.07
0.23
19.3
17.4
13.3
13.2
%
1.91
419
3813
7
86
0.75
0.22
2.4
1.5
—
—
—
0
0
7
88
0.73
0.22
2.0
1.6
—
—
—
0
0
21
168
1.17
0.22
1.7
2.1
—
—
—
0
0
15
165
0.84
0.22
1.1
1.1
—
—
—
0
0
303
2747
1.05
0.21
3.5
3.2
14.6
14.4
pmol/l
0.77
280
2493
443
4152
0.93
0.21
3.9
3.9
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
15
164
0.84
0.21
2.2
2.3
0.4
0.5
nmol/l
0.08
15
144
20
213
0.87
0.21
1.5
1.8
—
—
—
0
0
28
231
1.13
0.20
2.0
1.8
2.4
2.4
mmol/l
0.59
21
192
6
45
1.24
0.20
1.0
1.3
—
—
—
0
0
9
106
0.78
0.20
3.1
4.0
439.6
388.6
ug/l
—
9
96
192
1836
0.95
0.20
2.5
2.0
5.4
5.3
mmol/l
0.75
174
1665
24
197
1.14
0.19
3.2
2.8
5.7
5.2
pmol/l
1.15
24
179
23
240
0.88
0.19
1.1
1.1
2.6
0.2
u/ml
0.62
13
117
32
270
1.10
0.17
2.1
2.1
—
11.3
—
0
12
7
58
1.12
0.17
1.1
1.0
—
—
—
0
0
5
65
0.71
0.17
1.8
1.3
—
—
—
0
0
8
63
1.18
0.16
1.1
1.0
—
—
—
0
0
8
63
1.18
0.16
1.0
1.0
—
—
—
0
0
14
111
1.17
0.16
7.1
3.5
68.5
93.2
ml/min/173m2
—
6
21
208
1880
1.04
0.16
1.8
1.9
2.9
4.7
u/ml
0.87
35
306
6
74
0.75
0.15
2.7
1.4
—
—
—
0
0
175
1578
1.04
0.15
3.4
3.2
35.0
36.4
mmol/mol
0.93
162
1487
18
148
1.13
0.14
31.3
24.0
76.1
71.3
%
0.90
18
148
82
727
1.05
0.14
5.1
2.9
1.0
1.0
kg/l
0.44
18
161
12
96
1.16
0.13
3.4
1.6
—
—
—
0
0
27
230
1.09
0.12
18.7
17.9
14.9
16.0
kpa
0.33
27
223
43
375
1.07
0.12
2.1
2.3
15.6
49.5
ng/l
1.53
20
141
444
4085
1.05
0.12
18.6
17.2
38.9
38.7
%
0.59
411
3712
164
1557
0.97
0.12
5.3
3.6
0.0
0.0
estimate
0.00
25
243
21
177
1.10
0.12
5.8
4.7
2.9
3.2
mmol/l
1.09
21
171
27
231
1.09
0.12
18.7
17.8
5.3
5.5
kpa
0.41
27
224
133
1201
1.04
0.11
5.1
4.6
—
—
—
0
0
163
1544
0.97
0.10
7.5
5.4
0.0
0.0
estimate
0.00
24
247
254
2389
0.97
0.10
4.2
4.8
8.1
7.1
mm/h
0.71
244
2239
11
116
0.88
0.10
1.2
1.3
—
—
—
0
0
5
40
1.16
0.10
2.6
2.5
—
—
—
0
0
46
448
0.95
0.10
1.2
1.2
3.6
4.3
u/ml
0.09
18
157
21
179
1.09
0.10
5.9
4.9
53.4
7.0
e6/l
0.42
16
125
20
170
1.09
0.09
5.1
3.6
23.2
24.8
%
0.32
20
170
180
1698
0.97
0.09
3.2
2.8
1.3
1.4
mmol/l
0.77
167
1607
6
52
1.07
0.08
1.2
1.9
133.0
117.3
%
—
6
52
19
162
1.09
0.08
1.9
2.0
—
—
—
0
0
24
238
0.93
0.08
1.1
1.1
—
—
—
0
0
7
59
1.10
0.08
1.3
1.3
—
—
—
0
0
7
59
1.10
0.08
1.3
1.3
—
—
—
0
0
7
59
1.10
0.08
1.3
1.3
—
—
—
0
0
7
61
1.06
0.08
7.0
5.3
29.1
24.1
ug/l
—
7
61
21
209
0.93
0.08
1.4
1.5
12.8
10.3
u/ml
0.08
15
153
6
68
0.82
0.07
1.2
1.1
—
—
—
0
0
8
68
1.09
0.07
1.1
1.5
—
—
—
0
0
14
118
1.10
0.07
1.2
1.3
250.3
218.2
miu/ml
—
9
46
7
77
0.84
0.07
1.6
4.3
—
—
—
0
0
7
77
0.84
0.07
1.6
4.2
—
—
—
0
0
18
179
0.93
0.06
1.7
2.1
—
—
—
0
0
51
489
0.96
0.06
1.3
1.3
4.3
2.8
u/ml
0.25
37
335
11
92
1.11
0.06
1.9
1.7
9.5
6.7
ug/l
0.30
11
84
36
320
1.05
0.06
1.4
1.3
241.8
148.3
iu/ml
—
8
88
64
577
1.03
0.06
1.8
2.0
1.5
1.2
mmol/l
0.95
58
536
17
148
1.07
0.04
1.2
1.2
—
—
—
0
0
27
261
0.96
0.04
1.1
1.1
14.2
10.5
u/ml
0.25
18
162
14
121
1.07
0.04
1.0
1.2
—
—
—
0
0
37
332
1.04
0.04
1.5
1.4
—
—
—
0
0
188
1756
0.99
0.03
3.3
3.0
4.2
4.2
mmol/l
0.43
174
1675
14
123
1.06
0.02
2.1
1.6
—
—
—
0
0
29
276
0.97
0.01
1.1
1.1
13.2
7.3
u/ml
0.47
19
167
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
14
124
1.05
0.01
12.2
29.4
0.2
0.3
u/ml
—
7
83
329
3056
0.99
0.00
4.0
3.5
2.2
2.1
mu/l
1.51
311
2885
184
1711
1.00
0.00
3.2
2.8
2.6
2.6
mmol/l
0.14
171
1604
14
135
0.96
0.00
2.1
2.2
—
—
—
0
0
17
160
0.98
0.00
1.6
1.2
—
—
—
0
0
33
303
1.01
0.00
2.5
2.5
93.7
7922.6
u/l
—
5
77
67
620
1.00
0.00
4.8
3.3
46.9
57.1
u/l
2.14
62
574
13
119
1.01
0.00
2.3
1.9
33.1
31.7
%
—
8
87
10
94
0.99
0.00
1.5
1.2
—
—
—
0
0
10
94
0.99
0.00
1.5
1.2
76.7
72.8
%
—
10
94
19
180
0.98
0.00
5.3
3.7
—
—
—
0
0
19
177
0.99
0.00
1.7
1.9
—
—
—
0
0
11
106
0.96
0.00
1.2
1.3
—
—
—
0
0
17
161
0.98
0.00
1.4
1.4
—
—
—
0
0
20
182
1.02
0.00
5.2
3.6
10.7
9.1
%
0.35
20
171
167
1548
1.00
0.00
5.3
3.6
0.0
0.0
estimate
0.00
24
227
104
963
1.00
0.00
5.3
3.2
—
—
—
0
0
13
125
0.96
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
0.7
—
0
8
0
6
0.00
0.00
0.0
1.0
—
15.0
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
6
56
0.99
0.00
1.2
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
8
82
0.90
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
5
48
0.97
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
21.9
—
0
9
6
62
0.90
0.00
2.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
69
0.94
0.00
1.3
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
64.6
—
0
9
8
79
0.94
0.00
2.8
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
240.7
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
67
0.97
0.00
1.6
1.1
—
—
—
0
0
5
52
0.89
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
67
0.97
0.00
1.6
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint P16_RESPI_DISTR_NEWBO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_RESPI_DISTR_NEWBO | 1.873 [1.51, 2.32] | < 0.001 |
| Birth year | 0.996 [0.99, 1.01] | 0.39 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 19773 females with P16_RESPI_DISTR_NEWBO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_RESPI_DISTR_NEWBO | 1.898 [1.59, 2.26] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 26033 males with P16_RESPI_DISTR_NEWBO died.
Mortality risk
Mortality risk for people of age
years, who have P16_RESPI_DISTR_NEWBO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.286% |
| 5 | 1.099% | 1.786% |
| 10 | 2.779% | 4.573% |
| 15 | 5.361% | 8.709% |
| 20 | 9.471% | 14.853% |
Relationships between endpoints
↥Index endpoint: P16_RESPI_DISTR_NEWBO – Respiratory distress of newborn
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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