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Respiratory distress of newborn

DOID EFO Endpoint Browser PheWeb

P16_RESPI_DISTR_NEWBO

newborn respiratory distress syndrome: Infant acute respiratory distress syndrome is a lung disorder that affects premature infants caused by developmental insufficiency of surfactant production and structural immaturity of the lungs. The symptoms usually appear shortly after birth and may include tachypnea, tachycardia, chest wall retractions (recession), expiratory grunting, nasal flaring and cyanosis during breathing efforts.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P22
  • Cause of death: ICD-10 — P22

2 out of 7 registries used, show all original rules.

533

4. Check minimum number of events

None

533

5. Include endpoints

None

533

6. Filter based on genotype QC (FinnGen only)

495

Control definitions (FinnGen only)

Control exclude
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P2
Name in latin
Dyspnoea neonatalis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 49038 21114 27923
Only index persons 18039 7483 10556
Unadjusted period prevalence (%)
Whole population 0.70 0.60 0.78
Only index persons 0.35 0.28 0.40
Median age at first event (years)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 495 254 241
Unadjusted period prevalence (%) 0.10 0.09 0.11
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
524
Matched controls
4855
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
4001.5
284.3
254
*
P07.3
ICD-10 Finland
Other preterm infants
20.1
207.5
194
138
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
13.7
139.2
156
146
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
137.3
129
*
WX722
NOMESCO Finland
PEEP
23.0
137.0
111
56
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
122.8
116
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
14.6
64.4
63
45
P22.8
ICD-10 Finland
Other respiratory distress of newborn
266.8
50.5
52
*
P07.2
ICD-10 Finland
Extreme immaturity
205.6
39.2
41
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
35.9
35
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
33.8
33
*
WX882
NOMESCO Finland
High dependency care
3.5
30.9
137
450
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.3
30.3
90
223
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
11.7
28.4
31
26
602
Kela drug reimbursment
Children's severe malnutrition
4.5
26.0
70
160
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
10.5
24.8
29
27
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
10.1
24.2
29
28
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.0
21.8
35
49
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
21.4
21
*
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
7.5
21.1
32
42
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
36.1
20.2
26
7
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
19.5
129
520
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
19.3
19
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
19.2
124
494
WX730
NOMESCO Finland
Conventional respirator
8.4
19.0
26
30
H35.1
ICD-10 Finland
Retinopathy of prematurity
182.3
18.1
19
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.9
17.7
56
144
R4110
NOMESCO Finland
Physiotherapy
2.3
16.5
183
927
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
16.1
124
534
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
5.4
15.4
32
58
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
15.2
15
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.9
15.0
80
285
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
4.3
14.8
40
91
P07.1
ICD-10 Finland
Other low birth weight
76.4
14.2
16
*
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
6.0
13.7
25
40
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
6.5
13.6
23
34
J45.1
ICD-10 Finland
Nonallergic asthma
2.5
13.3
95
393
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
133.0
13.1
14
*
P05.1
ICD-10 Finland
Small for gestational age
5.8
12.6
24
40
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
113.6
11.1
12
*
Z3231
NOMESCO Finland
Registered nurse
1.9
10.8
235
1472
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
8.5
10.7
23
26
XG413
NOMESCO Finland
Spirometry with oscillometry
3.5
10.5
38
107
F80.1
ICD-10 Finland
Expressive language disorder
3.3
10.4
41
122
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
10.1
10
*
Z2221
NOMESCO Finland
Medical doctor
2.0
10.1
150
825
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.1
161
908
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
51.9
9.4
11
*
P05.0
ICD-10 Finland
Light for gestational age
9.1
9.3
19
20
H50.30
ICD-10 Finland
Intermittent esotropy
3.8
9.2
29
74
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.7
8.9
29
76
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
8.3
8.9
19
22
R03BA05
ATC
fluticasone; inhalant
1.8
8.8
164
965
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.6
8.6
53
203
R03BA02
ATC
budesonide; inhalant
2.0
8.4
100
506
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
8.4
133
743
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
18.9
8.2
12
6
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
8.1
8
*
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
13.7
7.9
13
9
Z2446
NOMESCO Finland
Social worker
1.9
7.8
126
705
EMB30
NOMESCO Finland
Adenotomy
1.9
7.8
120
661
R62.0
ICD-10 Finland
Delayed milestone
2.2
7.7
66
294
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
7.7
139
807
RT150, ,
NOMESCO Finland
3.5
7.5
26
71
RK312, ,
NOMESCO Finland
7.0
7.3
17
23
WX725
NOMESCO Finland
Noninvasive ventilation
3.9
7.2
21
51
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
8.9
6.9
14
15
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
6.9
131
768
A03FA02
ATC
cisapride; oral, rectal
3.5
6.8
23
62
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
3.1
6.8
28
86
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
6.8
94
500
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
6.6
74
366
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
21.2
6.4
9
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
6.1
63
301
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.3
6.1
48
206
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
6.1
6
*
P28.4
ICD-10 Finland
Other apnoea of newborn
+∞
6.1
6
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
1.8
6.1
114
665
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
25.0
6.0
8
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
47
3.64
5.58
1.0
1.0
—
—
—
0
0
8
12
6.25
3.47
1.0
1.0
—
—
—
0
0
156
1104
1.44
3.42
11.7
10.2
—
—
—
0
0
9
17
4.97
3.30
1.2
1.5
—
—
—
0
0
170
1240
1.40
3.11
13.5
10.3
5.06
4.96
kpa
1.40
161
1205
170
1241
1.40
3.09
13.6
10.3
7.40
7.41
ph
—
5
37
88
573
1.51
2.92
1.6
1.5
257.43
358.61
u/ml
0.46
83
539
161
1190
1.37
2.66
9.8
11.0
43.77
29.56
umol/l
1.94
150
1074
183
1380
1.35
2.66
5.0
5.1
45.11
23.60
e6/l
0.54
139
1052
65
405
1.56
2.64
10.1
9.2
44.14
48.68
ng/l
0.83
65
400
123
878
1.39
2.50
3.9
4.2
2.46
2.09
e6/l
0.18
77
519
34
182
1.78
2.45
15.7
11.5
22.65
22.82
mmol/l
0.15
34
176
13
47
2.60
2.45
1.5
1.5
—
—
—
0
0
203
1571
1.32
2.43
8.8
10.1
—
—
—
0
0
56
347
1.55
2.34
1.0
1.0
9.91
8.29
mu/l
0.95
51
308
157
1181
1.33
2.27
12.5
10.0
9.34
9.81
kpa
2.60
148
1146
171
1312
1.31
2.13
4.7
4.9
0.17
0.20
e6/l
0.22
128
985
171
1315
1.30
2.09
4.5
4.8
—
—
—
0
0
428
3719
1.36
2.00
10.2
8.3
—
—
—
0
0
18
86
1.97
1.86
2.9
2.7
12.33
15.07
umol/l
1.23
18
86
148
1143
1.28
1.72
11.0
10.7
23.20
23.41
mmol/l
0.53
148
1143
43
273
1.50
1.66
1.0
1.0
—
—
—
0
0
43
273
1.50
1.66
1.0
1.0
-3.12
-2.12
mmol/l
0.27
12
61
43
273
1.50
1.66
1.0
1.0
7.40
7.27
kpa
0.15
37
234
251
2074
1.23
1.59
12.8
9.5
5.71
5.98
mmol/l
1.24
242
1962
42
270
1.48
1.54
1.0
1.0
3.46
3.27
kpa
0.19
36
232
387
3358
1.26
1.52
19.6
15.1
4.04
3.96
mmol/l
3.84
380
3241
137
1064
1.26
1.50
13.3
12.3
1.41
1.38
mmol/l
0.49
132
1013
293
2472
1.22
1.48
9.6
11.0
3.23
3.41
%
0.52
286
2377
43
283
1.44
1.42
1.5
1.3
—
—
—
0
0
39
252
1.47
1.41
2.4
2.6
—
72.79
—
0
11
294
2491
1.21
1.39
10.0
11.0
8.30
8.32
%
0.02
287
2396
305
2596
1.21
1.36
10.6
11.8
0.22
0.23
e9/l
0.40
257
2158
39
254
1.46
1.36
2.5
2.5
—
—
—
0
0
23
133
1.63
1.34
1.5
2.1
—
—
—
0
0
14
227
0.56
1.34
2.0
2.0
—
—
—
0
0
140
1105
1.24
1.33
12.3
12.2
—
—
—
0
0
386
3368
1.23
1.32
19.9
15.2
139.25
139.36
mmol/l
0.46
381
3273
281
2378
1.20
1.32
11.0
11.6
—
—
—
0
0
297
2527
1.21
1.31
9.8
10.7
0.04
0.04
e9/l
0.64
247
2049
87
650
1.29
1.31
4.2
4.8
—
—
—
0
0
246
2057
1.20
1.31
19.6
14.3
1.23
1.23
mmol/l
0.11
238
1936
52
360
1.38
1.31
1.4
1.4
22.06
20.09
nmol/l
0.41
47
315
180
1461
1.22
1.30
4.9
4.0
70.42
69.27
nmol/l
0.23
174
1389
21
120
1.65
1.29
3.6
4.9
27.67
23.92
umol/l
0.67
21
120
11
51
2.02
1.26
6.8
3.9
121.00
169.74
umol/l
—
5
27
47
322
1.39
1.26
1.9
1.8
—
—
—
0
0
285
2425
1.19
1.23
9.5
11.1
0.61
0.62
%
0.08
280
2339
48
332
1.37
1.22
2.6
2.4
6.81
6.44
iu/l
0.09
35
193
303
2593
1.20
1.22
9.6
10.7
38.52
37.02
%
1.30
296
2504
285
2427
1.19
1.21
11.2
12.6
0.00
0.01
e9/l
0.55
222
1810
296
2533
1.19
1.18
9.8
10.7
0.62
0.57
e9/l
1.31
246
2057
105
816
1.24
1.15
3.2
2.4
—
—
—
0
0
8
37
2.02
1.12
4.6
3.1
1.64
1.62
mmol/l
—
8
37
192
1590
1.19
1.10
6.4
6.0
57.94
57.09
e6/l
0.01
143
1084
18
104
1.63
1.08
2.6
5.3
—
—
—
0
0
239
2020
1.18
1.07
20.7
15.9
1.24
1.23
mmol/l
0.14
233
1941
301
2593
1.18
1.06
9.8
10.7
2.80
2.49
e9/l
1.16
255
2186
9
42
2.00
1.05
1.2
1.1
—
—
—
0
0
295
2539
1.18
1.05
9.4
10.6
45.86
47.00
%
0.81
287
2451
148
1203
1.19
1.04
14.6
11.1
0.88
0.94
mmol/l
0.09
116
936
120
1280
0.83
1.02
2.4
2.0
—
—
—
0
0
119
950
1.21
1.01
3.9
4.2
—
—
—
0
0
73
556
1.25
0.97
2.0
1.9
—
—
—
0
0
22
140
1.48
0.91
1.5
1.6
1877.35
1087.11
nmol/l
2.26
17
102
20
125
1.50
0.90
5.9
6.0
2.59
2.38
ug/l
0.15
20
125
307
2671
1.16
0.89
11.7
12.7
3.30
3.32
e9/l
0.03
257
2182
39
278
1.32
0.86
9.5
8.9
0.87
0.27
g/l
0.95
33
243
6
28
2.00
0.86
1.3
1.5
—
—
—
0
0
11
60
1.71
0.83
2.9
2.5
—
—
—
0
0
14
82
1.60
0.82
1.7
2.4
—
—
—
0
0
15
90
1.56
0.81
1.1
1.1
—
—
—
0
0
132
1363
0.86
0.75
1.9
1.9
—
—
—
0
0
9
50
1.68
0.75
1.1
1.2
—
—
—
0
0
56
428
1.24
0.75
1.6
1.8
—
—
—
0
0
188
1596
1.14
0.74
3.1
2.9
1.08
1.07
mmol/l
0.06
177
1518
5
23
2.02
0.73
1.0
1.0
—
—
—
0
0
9
52
1.61
0.72
7.4
3.3
—
—
—
0
0
7
37
1.76
0.71
9.3
7.2
—
—
—
0
0
49
371
1.25
0.71
2.6
2.4
4.68
4.93
u/l
0.07
31
202
9
53
1.58
0.71
1.0
1.2
—
—
—
0
0
78
621
1.19
0.70
1.7
1.5
106.51
99.15
pmol/l
0.41
35
313
33
239
1.30
0.68
1.8
1.8
—
—
—
0
0
13
177
0.67
0.67
1.2
1.4
—
—
—
0
0
5
26
1.79
0.66
4.0
7.1
199.60
247.46
ug/l
—
5
26
39
444
0.80
0.65
1.5
1.7
—
—
—
0
0
44
334
1.24
0.64
2.2
2.2
153.47
152.96
u/ml
0.00
19
146
39
443
0.80
0.64
1.5
1.8
—
—
—
0
0
43
482
0.81
0.63
1.7
1.8
—
—
—
0
0
28
201
1.31
0.63
25.4
19.2
0.56
0.63
%
0.53
28
201
8
45
1.66
0.62
1.0
1.3
—
—
—
0
0
5
28
1.66
0.61
2.0
2.9
24.52
16.66
umol/l
—
5
28
0
19
0.00
0.60
0.0
1.1
—
—
—
0
0
25
297
0.77
0.59
1.7
2.2
—
—
—
0
0
37
418
0.81
0.59
1.5
1.8
—
—
—
0
0
33
245
1.26
0.58
1.5
1.6
—
—
—
0
0
40
447
0.81
0.58
1.5
1.8
—
—
—
0
0
427
3851
1.15
0.57
12.6
12.0
23.57
24.78
mg/l
0.29
280
2566
65
520
1.18
0.57
6.5
10.4
5.35
6.35
umol/l
0.58
51
434
40
446
0.82
0.56
1.5
1.7
—
—
—
0
0
9
58
1.45
0.53
1.8
3.1
57.44
57.24
umol/l
—
9
58
30
224
1.26
0.52
8.5
6.5
0.40
0.55
%
0.36
20
99
70
733
0.87
0.50
5.3
4.3
7.37
7.39
ph
—
9
118
17
118
1.35
0.49
8.9
8.8
—
—
—
0
0
12
78
1.44
0.49
1.3
1.4
—
—
—
0
0
32
357
0.82
0.47
1.5
1.8
—
—
—
0
0
92
769
1.13
0.47
8.5
5.5
1.10
1.15
inr
0.51
23
170
27
202
1.25
0.47
1.9
2.0
—
—
—
0
0
19
136
1.31
0.46
7.5
3.2
—
—
—
0
0
7
46
1.42
0.45
7.3
6.1
—
—
—
0
0
17
120
1.32
0.45
2.7
2.9
—
—
—
0
0
75
622
1.14
0.44
1.8
1.7
—
—
—
0
0
11
72
1.42
0.43
1.2
1.1
—
—
—
0
0
12
80
1.40
0.43
2.5
2.8
—
—
—
0
0
57
464
1.16
0.43
1.4
1.6
—
—
—
0
0
5
29
1.60
0.43
1.2
1.9
139.20
149.52
pmol/l
—
5
29
5
29
1.60
0.43
1.0
1.1
—
—
—
0
0
6
86
0.64
0.43
5.7
4.4
47.00
48.07
%
—
6
86
205
1800
1.09
0.42
4.1
3.5
59.36
48.90
ug/l
0.54
198
1711
8
54
1.38
0.41
2.6
3.0
—
—
—
0
0
0
14
0.00
0.41
0.0
3.9
—
0.48
—
0
14
0
15
0.00
0.41
0.0
2.0
—
3.61
—
0
15
107
913
1.11
0.40
4.5
3.9
6.42
5.94
e6/l
0.17
96
805
27
207
1.22
0.39
8.5
6.6
0.11
0.04
%
0.44
18
79
27
207
1.22
0.39
8.2
5.4
0.37
0.41
%
0.11
19
94
5
33
1.41
0.38
27.4
5.1
0.90
0.93
%
—
5
28
26
200
1.22
0.37
1.6
1.6
—
—
—
0
0
13
91
1.33
0.37
4.8
4.4
—
—
—
0
0
23
175
1.23
0.36
1.0
1.1
—
—
—
0
0
64
657
0.89
0.36
5.1
3.2
—
—
—
0
0
23
176
1.22
0.35
18.5
22.8
95.79
96.24
%
0.14
23
176
6
41
1.36
0.34
1.2
1.3
—
—
—
0
0
31
334
0.85
0.34
2.3
2.7
—
—
—
0
0
23
177
1.21
0.33
18.5
22.7
0.71
0.76
%
0.52
23
177
29
229
1.18
0.33
1.2
1.2
—
—
—
0
0
6
84
0.66
0.33
5.2
3.7
3.69
3.07
e9/l
—
6
84
28
303
0.85
0.32
2.1
2.5
24.91
28.15
u/l
0.44
23
241
16
183
0.80
0.32
1.3
1.3
—
—
—
0
0
29
312
0.85
0.32
1.2
1.1
1.02
8.30
u/ml
—
6
77
480
4397
1.14
0.31
21.4
19.0
39.24
38.99
%
0.62
468
4225
481
4407
1.14
0.31
19.8
17.5
7.32
7.10
e9/l
0.59
460
4135
7
91
0.71
0.31
2.3
2.7
—
57.86
—
0
14
7
49
1.33
0.31
1.3
1.1
0.96
2.22
u/ml
—
7
41
81
692
1.10
0.30
6.0
3.7
0.00
0.00
estimate
-0.00
23
230
15
111
1.26
0.30
2.9
1.7
—
—
—
0
0
43
447
0.88
0.30
3.1
4.4
1008.90
1324.84
ng/l
0.31
31
269
16
120
1.24
0.29
2.8
1.6
—
—
—
0
0
16
120
1.24
0.29
1.3
1.3
440.00
380.39
ug/g
—
8
62
114
992
1.08
0.29
4.6
3.3
—
—
—
0
0
114
1122
0.93
0.29
1.6
1.5
—
—
—
0
0
204
1816
1.07
0.28
1.8
1.8
1.27
1.39
g/l
0.65
105
897
20
155
1.20
0.28
1.4
1.5
—
—
—
0
0
97
840
1.09
0.28
1.2
1.3
—
—
—
0
0
9
110
0.75
0.27
1.2
1.1
—
—
—
0
0
42
348
1.13
0.27
6.1
7.4
298.36
1140.82
umol/l
0.47
42
336
369
3350
1.07
0.27
9.7
10.0
31.44
25.05
u/l
1.14
362
3230
65
554
1.10
0.26
4.3
7.0
1.63
2.38
mg/l
0.71
48
412
5
68
0.68
0.26
1.0
1.4
—
—
—
0
0
119
1044
1.07
0.25
3.9
3.5
2.66
2.66
mg/l
0.01
107
952
136
1322
0.94
0.25
4.8
3.3
6.45
6.37
ph
0.16
20
178
12
89
1.26
0.24
1.9
1.7
—
—
—
0
0
69
593
1.09
0.24
1.9
1.9
—
—
—
0
0
32
332
0.89
0.23
1.2
1.2
13.25
15.50
iu/ml
—
6
70
26
211
1.15
0.23
9.3
6.6
0.06
0.06
%
0.00
17
85
28
229
1.14
0.23
2.4
3.2
14.29
19.99
mu/l
0.70
28
217
7
87
0.74
0.22
2.3
2.2
—
—
—
0
0
5
37
1.25
0.22
32.2
5.2
1.46
1.34
%
—
5
32
11
82
1.25
0.21
14.7
7.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
21
223
0.87
0.21
1.1
1.1
—
—
—
0
0
214
1923
1.05
0.21
6.3
5.5
161.19
150.13
u/l
0.69
202
1806
104
915
1.07
0.21
4.2
3.7
580.07
601.89
mosm/kgh2o
0.32
91
789
15
164
0.84
0.21
2.2
2.3
0.43
0.47
nmol/l
0.08
15
144
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
118.82
—
0
12
24
196
1.14
0.20
3.2
2.8
5.71
5.24
pmol/l
1.12
24
178
9
105
0.79
0.20
3.1
4.0
439.56
376.75
ug/l
—
9
95
13
100
1.21
0.20
1.1
1.4
—
—
—
0
0
301
2731
1.05
0.20
3.5
3.2
14.61
14.42
pmol/l
0.65
278
2479
86
842
0.94
0.20
1.7
2.1
—
—
—
0
0
190
1816
0.95
0.19
2.4
2.0
5.44
5.27
mmol/l
0.75
172
1647
479
4403
1.09
0.19
19.9
17.5
4.62
4.61
e12/l
0.22
461
4117
23
240
0.88
0.19
1.1
1.1
2.58
0.18
u/ml
0.62
13
120
21
171
1.14
0.18
5.8
5.0
—
—
—
0
0
7
54
1.20
0.18
20.7
9.1
—
—
—
0
0
32
269
1.11
0.18
2.1
2.1
—
11.08
—
0
13
11
84
1.22
0.18
5.4
4.7
—
—
—
0
0
82
721
1.06
0.17
5.1
2.8
1.02
1.02
kg/l
0.43
18
158
5
64
0.72
0.17
1.2
1.1
—
—
—
0
0
44
378
1.09
0.17
2.2
2.0
—
—
—
0
0
8
66
1.12
0.16
1.1
1.2
—
0.22
—
0
5
251
2374
0.96
0.16
4.2
4.8
8.12
7.09
mm/h
0.72
241
2225
9
73
1.14
0.15
1.1
1.1
—
—
—
0
0
207
1873
1.04
0.15
1.8
1.9
2.90
4.76
u/ml
0.90
35
302
133
1192
1.05
0.15
4.2
4.0
—
—
—
0
0
61
597
0.94
0.15
1.6
1.6
—
—
—
0
0
478
4400
1.07
0.15
20.0
17.6
278.74
276.50
e9/l
0.26
460
4133
12
129
0.86
0.14
2.0
1.5
0.55
0.73
g/l
0.37
12
113
89
860
0.95
0.14
2.9
3.5
158.47
85.46
ug/g
0.38
73
701
18
148
1.13
0.14
31.3
24.0
76.07
71.32
%
0.90
18
148
173
1561
1.04
0.14
3.5
3.3
35.03
36.39
mmol/mol
0.94
161
1472
21
175
1.12
0.14
5.8
4.8
2.85
3.21
mmol/l
1.08
21
169
43
373
1.07
0.13
2.1
2.3
15.65
49.86
ng/l
1.54
20
140
27
230
1.09
0.12
2.0
1.8
2.44
2.43
mmol/l
0.47
20
191
27
230
1.09
0.12
18.7
18.4
14.92
16.01
kpa
0.32
27
223
10
79
1.18
0.12
1.2
1.5
—
—
—
0
0
21
177
1.10
0.12
5.9
4.9
53.38
7.05
e6/l
0.42
16
123
27
231
1.09
0.11
18.7
18.3
5.33
5.48
kpa
0.42
27
224
15
155
0.89
0.11
7.5
5.4
—
—
—
0
0
46
448
0.95
0.10
1.2
1.2
3.99
3.08
u/ml
0.15
38
339
5
40
1.16
0.10
1.0
1.4
—
—
—
0
0
5
40
1.16
0.10
1.0
1.4
—
—
—
0
0
5
40
1.16
0.10
1.0
1.4
—
—
—
0
0
14
116
1.12
0.10
1.2
1.3
250.30
207.59
miu/ml
—
9
45
18
152
1.10
0.09
36.3
23.3
—
—
—
0
0
20
170
1.09
0.09
5.1
3.6
23.20
24.84
%
0.32
20
170
22
220
0.92
0.09
5.5
4.3
—
—
—
0
0
6
50
1.11
0.09
1.0
1.0
—
—
—
0
0
6
54
1.03
0.08
1.8
2.2
—
—
—
0
0
5
59
0.78
0.08
1.0
1.9
—
—
—
0
0
7
61
1.06
0.08
7.0
5.3
29.10
24.08
ug/l
—
7
61
21
209
0.93
0.08
1.4
1.5
12.76
10.34
u/ml
0.08
15
153
13
133
0.90
0.08
1.0
1.1
—
—
—
0
0
16
136
1.09
0.07
1.6
1.2
—
—
—
0
0
11
91
1.12
0.07
1.9
1.7
9.50
6.65
ug/l
0.30
11
83
9
79
1.06
0.07
1.0
1.0
—
—
—
0
0
9
94
0.89
0.06
1.0
1.2
—
—
—
0
0
164
1542
0.98
0.06
5.3
3.6
0.00
0.00
estimate
-0.00
25
239
163
1531
0.98
0.06
7.5
5.4
0.00
0.00
estimate
-0.00
24
243
240
2202
1.02
0.05
5.3
4.5
—
—
—
0
0
20
174
1.07
0.05
1.2
1.3
—
—
—
0
0
51
487
0.97
0.05
1.3
1.3
4.87
3.13
u/ml
0.30
38
356
20
175
1.06
0.05
1.2
1.3
—
—
—
0
0
10
84
1.11
0.04
1.6
1.7
—
—
—
0
0
16
158
0.94
0.04
1.8
1.8
—
—
—
0
0
27
261
0.96
0.04
1.1
1.1
14.24
10.50
u/ml
0.25
18
162
18
176
0.95
0.04
1.0
1.1
—
—
—
0
0
179
1674
0.99
0.04
3.2
2.8
1.34
1.38
mmol/l
0.78
166
1587
326
3034
0.99
0.03
4.0
3.5
2.25
2.07
mu/l
1.53
309
2864
14
122
1.06
0.03
6.0
4.5
—
—
—
0
0
13
113
1.07
0.02
42.8
28.9
11.00
11.67
%
0.41
13
113
23
221
0.96
0.02
1.1
1.6
3.22
3.88
u/ml
0.08
18
164
14
137
0.95
0.02
1.1
1.6
—
13.04
—
0
5
26
233
1.04
0.02
1.2
1.5
—
—
—
0
0
35
316
1.03
0.02
1.4
1.3
269.09
151.50
iu/ml
—
7
86
21
202
0.96
0.02
1.2
1.2
—
—
—
0
0
63
575
1.02
0.02
1.8
2.0
1.54
1.18
mmol/l
0.96
57
535
14
123
1.06
0.02
4.4
4.4
—
—
—
0
0
29
276
0.97
0.01
1.1
1.1
11.51
6.95
u/ml
0.40
22
184
183
1687
1.01
0.01
3.2
2.8
2.55
2.58
mmol/l
0.15
170
1586
43
392
1.02
0.01
23.3
14.1
104.98
105.77
mmol/l
0.47
43
392
49
460
0.99
0.00
1.2
1.2
5.80
5.27
u/ml
0.11
38
356
10
98
0.94
0.00
13.7
6.1
—
—
—
0
0
16
143
1.04
0.00
1.1
1.3
—
—
—
0
0
15
139
1.00
0.00
1.5
1.4
—
—
—
0
0
17
160
0.98
0.00
22.9
22.0
—
—
—
0
0
26
245
0.98
0.00
1.2
1.4
—
—
—
0
0
14
126
1.03
0.00
1.1
1.2
—
—
—
0
0
166
1537
1.00
0.00
5.3
3.6
0.00
0.00
estimate
-0.00
24
235
53
492
1.00
0.00
4.1
5.5
60.66
62.94
e9/l
0.23
37
291
20
182
1.02
0.00
5.2
3.6
10.70
9.16
%
0.33
20
182
20
182
1.02
0.00
5.2
3.7
66.70
65.48
%
0.12
20
182
49
452
1.00
0.00
1.2
1.2
1.28
0.80
u/ml
0.36
36
337
20
186
1.00
0.00
5.0
3.6
557.33
408.75
e6/l
0.58
15
120
187
1732
1.00
0.00
3.3
3.0
4.16
4.22
mmol/l
0.43
173
1656
32
295
1.01
0.00
2.4
2.5
93.66
8235.81
u/l
—
5
74
12
108
1.03
0.00
2.0
1.3
1.75
2.03
g/l
0.52
12
97
12
108
1.03
0.00
2.0
1.3
—
—
—
0
0
12
108
1.03
0.00
2.0
1.3
5.24
5.93
g/l
0.63
12
96
17
154
1.02
0.00
4.1
3.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
23.06
—
0
9
0
7
0.00
0.00
0.0
8.9
—
—
—
0
0
5
51
0.91
-0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
1818.75
—
0
8
7
68
0.95
-0.00
1.1
1.0
—
—
—
0
0
7
71
0.91
-0.00
10.7
9.2
4.99
4.85
kpa
—
7
71
6
55
1.01
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
34.17
—
0
6
7
71
0.91
-0.00
10.7
9.2
10.06
9.30
kpa
—
7
71
0
5
0.00
-0.00
0.0
1.4
—
208.00
—
0
5
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.0
—
—
—
0
0
7
68
0.95
-0.00
1.3
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
39.90
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
76.12
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
81
0.91
-0.00
2.0
1.7
—
—
—
0
0
5
49
0.94
-0.00
1.8
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1492.67
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
102.00
—
0
8

Mortality – FinRegistry

↥

Association

Association between endpoint P16_RESPI_DISTR_NEWBO and mortality.

Females

Parameter HR [95% CI] p-value
P16_RESPI_DISTR_NEWBO 1.873 [1.51, 2.32] < 0.001
Birth year 0.996 [0.99, 1.01] 0.39

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 19773 females with P16_RESPI_DISTR_NEWBO died.

Males

Parameter HR [95% CI] p-value
P16_RESPI_DISTR_NEWBO 1.898 [1.59, 2.26] < 0.001
Birth year 0.985 [0.97, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 26033 males with P16_RESPI_DISTR_NEWBO died.

Mortality risk

Mortality risk for people of age

years, who have P16_RESPI_DISTR_NEWBO.

N-year risk Females Males
1 0.196% 0.286%
5 1.099% 1.786%
10 2.779% 4.573%
15 5.361% 8.709%
20 9.471% 14.853%

Relationships between endpoints

↥

Index endpoint: P16_RESPI_DISTR_NEWBO – Respiratory distress of newborn

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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