asphyxia neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
188 |
Control definitions (FinnGen only)
- Control exclude
- P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P2
- Name in latin
- Asphyxia intra partum
Similar endpoints
↥List of similar endpoints to
Birth asphyxia
based on the number of shared cases.
Similar with more cases:
- Respiratory and cardiovascular disorders specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13251 | 5713 | 7536 |
| Only index persons | 7432 | 3138 | 4294 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.16 | 0.21 |
| Only index persons | 0.14 | 0.12 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 188 | 108 | 80 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 200
- Matched controls
- 2000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
138.0
116
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
21.1
83.8
73
53
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
80.8
72
*
P21.9
ICD-10 Finland
Birth asphyxia, unspecified
+∞
19.1
18
*
P24.0
ICD-10 Finland
Neonatal aspiration of meconium
+∞
14.8
14
*
P07.3
ICD-10 Finland
Other preterm infants
5.8
13.9
27
52
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
63.5
10.7
12
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
10.5
10
*
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
104.8
9.5
10
*
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
+∞
9.4
9
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
7.3
8.6
20
30
WX930
NOMESCO Finland
Thepapeutic hypothermia
+∞
8.4
8
*
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
+∞
8.4
8
*
WX730
NOMESCO Finland
Conventional respirator
18.1
8.2
12
7
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.1
8.1
23
61
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.8
7.5
24
69
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
83.0
7.5
8
*
WX722
NOMESCO Finland
PEEP
11.5
7.4
13
12
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
7.3
7
*
P25.1
ICD-10 Finland
Pneumothorax originating in the perinatal period
+∞
7.3
7
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.2
6.6
18
46
M03BX01
ATC
baclofen; systemic
72.1
6.5
7
*
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
11.6
6.4
11
10
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
6.3
6
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
6.3
6
*
G82.4
ICD-10 Finland
Spastic tetraplegia
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
20
5.75
4.35
3.6
2.0
13.95
12.06
umol/l
0.64
11
20
53
338
1.77
3.00
3.5
2.6
2.40
2.41
mmol/l
0.03
47
308
9
22
4.23
2.92
1.1
1.0
—
—
—
0
0
6
9
6.83
2.89
3.5
2.2
21.87
24.88
umol/l
—
6
9
7
14
5.14
2.75
1.0
1.4
147.43
104.71
%
—
7
14
8
20
4.12
2.59
1.0
1.1
—
—
—
0
0
16
71
2.36
2.41
1.9
2.1
—
—
—
0
0
5
8
6.37
2.38
2.6
1.4
—
—
—
0
0
6
13
4.72
2.29
1.0
1.3
97.00
84.38
%
—
6
13
29
170
1.83
2.15
4.2
3.2
18.71
21.66
%
0.85
29
161
11
44
2.59
2.05
1.9
1.8
—
—
—
0
0
33
205
1.73
2.02
4.0
3.0
13.03
13.81
umol/l
0.26
33
197
46
317
1.59
1.90
2.7
3.2
—
—
—
0
0
30
190
1.68
1.72
2.5
2.2
17.50
15.77
ng/l
—
10
59
48
342
1.53
1.71
25.4
8.7
0.62
1.11
mmol/l
0.39
39
239
76
598
1.44
1.66
6.7
4.7
0.00
0.00
estimate
-0.00
16
118
5
14
3.63
1.62
2.4
2.1
—
—
—
0
0
5
14
3.63
1.62
2.6
1.5
—
—
—
0
0
5
14
3.63
1.62
1.0
1.7
—
—
—
0
0
32
210
1.62
1.61
3.6
2.6
260.69
359.70
nmol/l
2.74
32
200
13
64
2.10
1.58
1.4
1.3
—
—
—
0
0
76
603
1.42
1.57
4.7
3.3
0.00
0.00
estimate
-0.00
16
116
117
1005
1.40
1.50
10.2
10.9
3.19
3.47
e9/l
1.00
103
843
13
66
2.04
1.47
16.5
19.9
91.53
95.95
%
0.51
13
66
12
59
2.10
1.47
1.9
1.9
—
—
—
0
0
75
601
1.40
1.44
4.8
3.3
0.00
0.00
estimate
-0.00
15
114
14
74
1.96
1.43
1.3
1.4
308.13
269.64
miu/ml
—
8
31
7
29
2.46
1.40
3.1
4.0
21.86
25.24
umol/l
—
7
29
100
845
1.37
1.38
5.4
5.2
125.27
115.53
u/l
0.58
93
794
27
177
1.61
1.38
2.3
2.6
2883.70
6972.81
u/l
—
8
50
6
23
2.66
1.38
2.2
1.4
—
—
—
0
0
45
333
1.45
1.33
8.8
11.5
1.12
1.01
mmol/l
0.09
35
261
9
43
2.14
1.32
2.1
1.9
—
—
—
0
0
27
182
1.56
1.24
1.3
1.3
25.65
19.01
nmol/l
0.97
22
159
94
801
1.33
1.17
3.6
2.5
2.67
2.63
mmol/l
0.20
94
758
11
58
1.95
1.14
3.1
1.3
—
—
—
0
0
11
58
1.95
1.14
3.1
1.3
—
—
—
0
0
8
41
1.99
1.10
1.5
1.5
—
—
—
0
0
93
799
1.31
1.07
3.6
2.5
1.37
1.39
mmol/l
0.24
93
761
64
522
1.33
1.06
3.1
3.4
—
—
—
0
0
81
686
1.30
1.03
23.0
11.7
1.22
1.23
mmol/l
0.47
74
636
7
133
0.51
1.03
3.7
1.8
—
—
—
0
0
12
68
1.81
1.03
17.3
19.4
0.89
1.12
%
0.61
12
68
12
68
1.81
1.03
17.3
19.4
0.69
0.70
%
0.06
12
68
54
432
1.34
1.02
10.7
8.8
36.28
38.17
g/l
1.22
54
408
11
61
1.85
1.00
2.0
2.0
—
—
—
0
0
9
49
1.88
1.00
2.1
1.9
—
—
—
0
0
7
36
1.98
0.98
2.4
1.4
—
—
—
0
0
51
408
1.34
0.96
2.5
3.4
2.85
2.70
mg/l
0.24
46
366
98
858
1.28
0.95
2.5
2.1
5.30
5.31
mmol/l
0.09
92
782
21
143
1.52
0.94
9.7
13.3
103.33
105.23
mmol/l
0.52
21
143
167
1570
1.39
0.93
14.6
10.4
17.94
23.21
mg/l
2.01
124
1040
154
1434
1.32
0.88
9.1
8.3
31.04
24.30
u/l
0.58
148
1376
40
313
1.35
0.87
9.2
10.8
22.18
23.50
mmol/l
1.79
40
313
46
369
1.32
0.85
26.8
13.9
24.13
24.69
mmol/l
0.74
46
369
35
273
1.34
0.78
5.8
3.9
1.63
2.43
e6/l
0.47
19
159
108
972
1.24
0.78
3.8
4.4
8.07
7.29
mm/h
0.28
103
900
9
53
1.73
0.76
3.0
5.7
1177.00
367.87
mg/l
—
9
53
11
68
1.65
0.73
19.5
19.4
22.75
23.93
mmol/l
0.80
11
68
7
42
1.69
0.69
3.0
2.5
131.57
134.26
g/l
—
7
35
49
410
1.26
0.66
4.4
3.1
—
—
—
0
0
37
300
1.29
0.64
5.2
3.4
0.00
0.00
estimate
-0.00
14
112
5
29
1.74
0.64
1.0
1.0
161.80
162.79
g/l
—
5
29
68
593
1.22
0.64
4.6
3.3
71.91
65.59
nmol/l
1.16
62
559
5
30
1.68
0.62
1.4
1.1
92.60
74.07
%
—
5
30
96
871
1.20
0.59
6.9
6.2
109.92
114.96
ml/min/173m2
1.14
68
554
24
186
1.33
0.58
3.2
2.0
—
—
—
0
0
39
324
1.25
0.57
4.6
4.2
1.02
1.12
inr
1.78
14
94
13
91
1.46
0.54
6.6
4.2
23.23
22.26
nmol/l
0.09
13
91
6
39
1.55
0.53
2.0
1.7
0.17
0.22
nmol/l
—
6
32
45
383
1.23
0.53
4.7
4.8
31.29
31.05
u/l
0.02
45
369
6
40
1.52
0.52
5.0
3.8
47.00
49.97
%
—
6
40
37
309
1.24
0.52
1.4
1.4
116.72
98.06
pmol/l
1.15
18
170
55
480
1.20
0.51
8.7
4.5
—
—
—
0
0
33
273
1.25
0.50
6.1
3.8
0.78
0.92
e6/l
0.10
18
159
162
1680
0.81
0.50
4.3
3.9
—
—
—
0
0
7
49
1.44
0.46
1.9
3.6
24.86
27.27
%
—
7
49
10
69
1.47
0.45
1.7
18.8
0.64
0.61
%
—
10
69
7
51
1.39
0.44
1.4
2.0
—
—
—
0
0
7
51
1.39
0.44
1.4
1.3
—
—
—
0
0
7
51
1.39
0.44
1.4
2.0
—
—
—
0
0
7
51
1.39
0.44
2.1
3.7
—
—
—
0
0
7
51
1.39
0.44
2.0
3.7
8.29
8.02
%
—
7
51
183
1784
1.30
0.43
21.2
15.1
270.24
270.38
e9/l
0.01
174
1697
0
16
0.00
0.41
0.0
1.6
—
6.53
—
0
16
0
16
0.00
0.41
0.0
1.1
—
3.78
—
0
9
0
17
0.00
0.41
0.0
1.1
—
21.93
—
0
9
183
1786
1.29
0.40
21.1
15.0
4.62
4.63
e12/l
0.09
175
1696
15
115
1.33
0.40
1.2
1.3
—
—
—
0
0
11
80
1.40
0.39
3.3
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
20
161
1.27
0.39
2.5
3.2
2952.63
1294.85
ng/l
—
8
86
5
36
1.40
0.38
1.6
1.5
—
—
—
0
0
9
68
1.34
0.38
4.1
1.9
—
—
—
0
0
9
70
1.30
0.37
3.8
3.0
—
—
—
0
0
6
42
1.44
0.36
1.7
1.4
—
—
—
0
0
25
295
0.83
0.35
2.1
2.2
—
—
—
0
0
6
45
1.34
0.34
2.2
1.2
—
—
—
0
0
6
45
1.34
0.34
2.2
1.2
—
—
—
0
0
6
45
1.34
0.34
2.2
1.2
—
—
—
0
0
14
175
0.78
0.32
1.4
1.2
—
—
—
0
0
134
1285
1.13
0.31
3.8
3.6
2.00
2.00
mu/l
0.01
129
1208
7
97
0.71
0.31
1.1
1.6
—
—
—
0
0
7
53
1.33
0.31
2.0
1.3
—
—
—
0
0
48
433
1.14
0.30
8.2
4.2
0.12
0.19
e6/l
0.58
38
336
18
148
1.24
0.30
3.4
1.9
—
—
—
0
0
182
1784
1.22
0.30
22.2
16.1
39.84
39.70
%
0.18
175
1697
7
56
1.26
0.29
1.3
1.7
—
—
—
0
0
79
737
1.12
0.29
1.8
1.7
1.11
2.85
u/ml
0.95
14
138
18
149
1.23
0.29
3.5
2.0
—
—
—
0
0
8
62
1.30
0.28
14.1
9.8
—
561.64
—
0
11
16
132
1.23
0.26
1.2
1.3
—
—
—
0
0
5
38
1.32
0.23
1.4
7.2
103.20
89.76
%
—
5
38
80
843
0.91
0.22
2.2
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
173.91
—
0
11
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
6.0
—
251.70
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
102.25
—
0
12
0
12
0.00
0.21
0.0
1.3
—
0.30
—
0
12
0
12
0.00
0.21
0.0
1.5
—
832.42
—
0
12
0
12
0.00
0.21
0.0
1.0
—
27.06
—
0
6
0
12
0.00
0.21
0.0
1.1
—
0.01
—
0
5
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
13
108
1.22
0.20
1.2
2.1
—
—
—
0
0
6
48
1.26
0.20
1.5
2.0
—
—
—
0
0
6
48
1.26
0.20
1.5
2.0
—
—
—
0
0
6
48
1.26
0.20
1.2
2.7
—
—
—
0
0
26
232
1.14
0.20
4.9
5.2
2.24
2.45
mg/l
0.06
19
159
13
109
1.21
0.19
8.4
8.3
173.77
162.50
%
0.20
13
109
16
138
1.17
0.18
7.1
8.2
89.19
91.20
%
0.09
16
138
12
140
0.85
0.15
1.8
1.9
—
—
—
0
0
13
149
0.86
0.14
1.2
1.2
186.00
174.65
iu/ml
—
5
50
5
62
0.80
0.08
2.0
1.6
—
—
—
0
0
5
64
0.78
0.08
1.2
1.2
—
—
—
0
0
14
129
1.09
0.06
1.2
1.2
—
—
—
0
0
116
1144
1.03
0.05
3.5
3.2
14.28
14.38
pmol/l
0.17
110
1019
49
503
0.97
0.04
2.6
2.5
—
—
—
0
0
11
119
0.92
0.04
1.9
1.4
—
—
—
0
0
26
251
1.04
0.03
1.8
1.9
1.62
1.23
mmol/l
1.18
26
232
16
152
1.06
0.02
1.2
1.3
0.20
3.94
u/ml
3.26
11
110
12
116
1.04
0.00
1.9
1.4
—
—
—
0
0
12
119
1.01
0.00
2.3
2.4
18.09
8.37
iu/l
—
7
77
23
234
0.98
0.00
1.0
1.1
—
—
—
0
0
53
528
1.01
0.00
2.7
2.7
—
—
—
0
0
10
97
1.03
0.00
1.6
2.0
—
—
—
0
0
34
343
0.99
0.00
2.1
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
7
70
1.00
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
9.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1.85
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
21.0
—
25.83
—
0
6
5
56
0.89
-0.00
1.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
20.8
—
—
—
0
0
5
51
0.98
-0.00
3.6
2.3
0.11
0.41
nmol/l
—
5
44
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
25.60
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint P16_BIRTH_ASPHYXIA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_BIRTH_ASPHYXIA | 2.191 [1.71, 2.8] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 6809 males with P16_BIRTH_ASPHYXIA died.
Mortality risk
Mortality risk for people of age
years, who have P16_BIRTH_ASPHYXIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.517% |
| 5 | No data | 2.843% |
| 10 | No data | 7.153% |
| 15 | No data | 12.962% |
| 20 | No data | 22.039% |
Relationships between endpoints
↥Index endpoint: P16_BIRTH_ASPHYXIA – Birth asphyxia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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