asphyxia neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
202 |
4. Check minimum number of eventsNone |
202 |
5. Include endpointsNone |
202 |
6. Filter based on genotype QC (FinnGen only) |
202 |
Control definitions (FinnGen only)
- Control exclude
- P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P2
- Name in latin
- Asphyxia intra partum
Similar endpoints
↥List of similar endpoints to
Birth asphyxia
based on the number of shared cases.
Similar with more cases:
- Respiratory and cardiovascular disorders specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13251 | 5713 | 7536 |
| Only index persons | 7432 | 3138 | 4294 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.16 | 0.21 |
| Only index persons | 0.14 | 0.12 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 202 | 116 | 86 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 168
- Matched controls
- 1678
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
119.5
100
*
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
64.9
58
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
20.2
39.1
61
46
P21.9
ICD-10 Finland
Birth asphyxia, unspecified
+∞
17.0
16
*
P24.0
ICD-10 Finland
Neonatal aspiration of meconium
+∞
11.6
11
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
10.5
10
*
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
105.7
9.5
10
*
P07.3
ICD-10 Finland
Other preterm infants
6.1
9.2
25
47
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
94.6
8.5
9
*
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
+∞
8.4
8
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
8.4
8
*
WX930
NOMESCO Finland
Thepapeutic hypothermia
83.6
7.5
8
*
WX730
NOMESCO Finland
Conventional respirator
14.6
7.0
11
8
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
5.8
6.4
17
32
G80.3
ICD-10 Finland
Dyskinetic cerebral palsy
+∞
6.3
6
*
G82.4
ICD-10 Finland
Spastic tetraplegia
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint P16_BIRTH_ASPHYXIA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_BIRTH_ASPHYXIA | 2.191 [1.71, 2.8] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 6809 males with P16_BIRTH_ASPHYXIA died.
Mortality risk
Mortality risk for people of age
years, who have P16_BIRTH_ASPHYXIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.517% |
| 5 | No data | 2.843% |
| 10 | No data | 7.153% |
| 15 | No data | 12.962% |
| 20 | No data | 22.039% |
Relationships between endpoints
↥Index endpoint: P16_BIRTH_ASPHYXIA – Birth asphyxia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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