asphyxia neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
202 |
4. Check minimum number of eventsNone |
202 |
5. Include endpointsNone |
202 |
6. Filter based on genotype QC (FinnGen only) |
202 |
Control definitions (FinnGen only)
- Control exclude
- P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P2
- Name in latin
- Asphyxia intra partum
Similar endpoints
↥List of similar endpoints to
Birth asphyxia
based on the number of shared cases.
Similar with more cases:
- Respiratory and cardiovascular disorders specific to the perinatal period
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13251 | 5713 | 7536 |
| Only index persons | 7432 | 3138 | 4294 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.16 | 0.21 |
| Only index persons | 0.14 | 0.12 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 202 | 116 | 86 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 168
- Matched controls
- 1678
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
+∞
119.5
100
*
P21.0
ICD-10 Finland
Severe birth asphyxia
+∞
64.9
58
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
20.2
39.1
61
46
P21.9
ICD-10 Finland
Birth asphyxia, unspecified
+∞
17.0
16
*
P24.0
ICD-10 Finland
Neonatal aspiration of meconium
+∞
11.6
11
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
+∞
10.5
10
*
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
105.7
9.5
10
*
P07.3
ICD-10 Finland
Other preterm infants
6.1
9.2
25
47
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
94.6
8.5
9
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
8.4
8
*
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
+∞
8.4
8
*
WX930
NOMESCO Finland
Thepapeutic hypothermia
83.6
7.5
8
*
WX730
NOMESCO Finland
Conventional respirator
14.6
7.0
11
8
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
5.8
6.4
17
32
G82.4
ICD-10 Finland
Spastic tetraplegia
+∞
6.3
6
*
G80.3
ICD-10 Finland
Dyskinetic cerebral palsy
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
20
5.76
5.87
3.6
2.0
13.9
12.1
umol/l
0.64
11
20
53
338
1.77
2.99
3.5
2.6
2.4
2.4
mmol/l
0.01
46
306
9
22
4.23
2.92
1.1
1.0
—
—
—
0
0
6
9
6.83
2.88
3.5
2.2
21.9
24.9
umol/l
—
6
9
7
14
5.14
2.75
1.0
1.4
147.4
104.7
%
—
7
14
8
20
4.12
2.59
1.0
1.1
—
—
—
0
0
5
8
6.37
2.38
2.6
1.4
—
—
—
0
0
30
172
1.87
2.37
4.1
3.2
19.0
21.7
%
0.77
30
163
16
72
2.33
2.34
1.9
2.1
—
—
—
0
0
6
13
4.72
2.29
1.0
1.3
97.0
84.4
%
—
6
13
34
207
1.77
2.23
3.9
3.0
13.2
13.8
umol/l
0.23
34
198
11
44
2.59
2.05
1.9
1.8
—
—
—
0
0
46
318
1.58
1.87
2.7
3.2
—
—
—
0
0
48
342
1.53
1.71
25.4
8.7
0.6
1.1
mmol/l
0.39
39
239
5
14
3.63
1.62
2.6
1.5
—
—
—
0
0
5
14
3.63
1.62
1.0
1.7
—
—
—
0
0
30
194
1.64
1.60
2.5
2.2
17.5
15.6
ng/l
—
10
60
32
211
1.61
1.58
3.6
2.6
260.7
359.0
nmol/l
2.72
32
201
76
602
1.42
1.58
6.7
4.6
0.0
0.0
estimate
0.00
16
118
118
1009
1.41
1.58
10.1
10.9
3.2
3.5
e9/l
1.05
103
847
13
65
2.07
1.52
1.4
1.3
—
—
—
0
0
76
608
1.40
1.48
4.7
3.3
0.0
0.0
estimate
0.00
16
116
28
182
1.63
1.47
1.3
1.3
25.7
19.0
nmol/l
0.97
22
159
12
59
2.10
1.47
1.9
1.9
—
—
—
0
0
14
74
1.96
1.43
1.3
1.4
308.1
269.6
miu/ml
—
8
31
13
67
2.00
1.42
16.5
19.8
91.5
96.0
%
0.51
13
67
75
603
1.39
1.41
4.8
3.3
0.0
0.0
estimate
0.00
15
112
7
29
2.46
1.40
3.1
4.0
21.9
25.2
umol/l
—
7
29
27
177
1.61
1.38
2.3
2.6
2883.7
6972.8
u/l
—
8
50
6
23
2.66
1.37
2.2
1.4
—
—
—
0
0
9
43
2.14
1.32
2.1
1.9
—
—
—
0
0
45
336
1.44
1.27
8.8
11.4
1.1
1.1
mmol/l
0.05
35
264
100
855
1.34
1.23
5.4
5.2
125.3
115.9
u/l
0.55
93
802
11
57
1.98
1.19
3.1
1.3
—
—
—
0
0
11
57
1.98
1.19
3.1
1.3
—
—
—
0
0
8
41
1.99
1.10
1.5
1.5
—
—
—
0
0
7
131
0.52
1.03
3.4
1.8
—
—
—
0
0
94
812
1.29
1.02
3.6
2.5
2.7
2.6
mmol/l
0.19
94
767
64
525
1.32
1.02
3.9
4.3
—
—
—
0
0
11
61
1.85
1.00
2.0
2.0
—
—
—
0
0
9
49
1.88
1.00
2.1
1.9
—
—
—
0
0
12
69
1.79
0.99
17.3
19.3
0.7
0.7
%
0.05
12
69
12
69
1.79
0.99
17.3
19.3
0.9
1.1
%
0.59
12
69
7
36
1.98
0.98
2.4
1.4
—
—
—
0
0
81
691
1.29
0.96
23.0
11.7
1.2
1.2
mmol/l
0.41
74
639
54
436
1.33
0.95
10.7
8.8
36.3
38.2
g/l
1.22
54
412
51
409
1.33
0.94
2.5
3.4
2.8
2.7
mg/l
0.25
46
367
93
810
1.27
0.93
3.6
2.5
1.4
1.4
mmol/l
0.22
93
770
98
864
1.26
0.87
2.5
2.1
5.3
5.3
mmol/l
0.07
92
789
109
974
1.26
0.86
3.8
4.4
8.0
7.3
mm/h
0.26
104
902
155
1447
1.31
0.84
9.1
8.3
31.1
24.4
u/l
0.58
149
1389
46
372
1.31
0.80
26.8
13.8
24.1
24.7
mmol/l
0.75
46
372
9
56
1.64
0.73
3.0
5.4
1177.0
398.8
mg/l
—
9
56
35
276
1.32
0.73
5.8
3.9
1.6
2.4
e6/l
0.46
19
161
167
1586
1.31
0.71
14.6
10.4
17.9
23.2
mg/l
2.00
124
1052
11
69
1.63
0.70
19.5
19.4
22.7
23.9
mmol/l
0.81
11
69
162
1696
0.77
0.70
4.3
3.9
—
—
—
0
0
49
411
1.25
0.65
4.5
3.1
—
—
—
0
0
5
29
1.74
0.64
1.0
1.0
161.8
162.8
g/l
—
5
29
38
310
1.28
0.63
1.4
1.4
116.7
98.1
pmol/l
1.15
18
170
37
301
1.28
0.63
5.2
3.4
0.0
0.0
estimate
0.00
14
112
5
30
1.68
0.62
1.4
1.1
—
—
—
0
0
5
30
1.68
0.62
1.4
1.1
92.6
74.1
%
—
5
30
68
596
1.21
0.60
4.6
3.3
71.9
65.7
nmol/l
1.14
62
562
24
187
1.32
0.56
3.2
2.0
—
—
—
0
0
6
39
1.55
0.53
2.0
1.7
0.2
0.2
nmol/l
—
6
32
13
92
1.44
0.52
6.6
4.3
23.2
22.7
nmol/l
0.05
13
92
96
881
1.17
0.49
6.9
6.2
110.2
114.9
ml/min/173m2
1.01
68
558
7
49
1.44
0.46
1.9
3.6
24.9
27.3
%
—
7
49
33
276
1.23
0.46
6.1
3.8
0.8
0.9
e6/l
0.09
18
161
55
486
1.18
0.44
8.7
4.5
—
—
—
0
0
7
51
1.39
0.44
2.1
3.7
—
—
—
0
0
7
51
1.39
0.44
1.4
1.3
—
—
—
0
0
45
392
1.19
0.43
4.7
4.7
31.3
31.0
u/l
0.03
45
378
0
16
0.00
0.41
0.0
1.1
—
3.8
—
0
9
0
17
0.00
0.41
0.0
1.1
—
21.9
—
0
9
15
115
1.33
0.40
1.2
1.3
—
—
—
0
0
11
80
1.40
0.39
3.3
1.8
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
5
36
1.40
0.38
1.6
1.5
—
—
—
0
0
9
68
1.34
0.38
4.1
1.9
—
—
—
0
0
14
179
0.77
0.37
1.4
1.2
—
—
—
0
0
9
70
1.30
0.37
3.8
3.0
—
—
—
0
0
6
43
1.41
0.35
1.8
1.4
—
—
—
0
0
25
295
0.83
0.35
2.1
2.2
—
—
—
0
0
20
164
1.24
0.34
2.6
3.2
2952.6
1265.5
ng/l
—
8
88
6
45
1.34
0.34
2.2
1.2
—
—
—
0
0
6
45
1.34
0.34
2.2
1.2
—
—
—
0
0
6
45
1.34
0.34
2.2
1.2
—
—
—
0
0
135
1292
1.14
0.33
3.8
3.6
2.0
2.0
mu/l
0.01
129
1215
7
98
0.70
0.31
1.1
1.6
—
—
—
0
0
7
53
1.33
0.31
2.0
1.3
—
—
—
0
0
18
148
1.24
0.30
3.4
1.9
—
—
—
0
0
7
55
1.28
0.30
1.3
1.7
—
—
—
0
0
18
149
1.23
0.29
3.5
2.0
—
—
—
0
0
8
62
1.30
0.28
14.1
9.8
—
561.6
—
0
11
79
740
1.11
0.27
1.8
1.7
1.1
2.8
u/ml
0.95
14
138
16
132
1.23
0.26
1.2
1.3
—
—
—
0
0
48
438
1.13
0.26
8.2
4.2
0.1
0.2
e6/l
0.55
38
339
80
847
0.91
0.24
2.2
2.0
—
—
—
0
0
5
39
1.29
0.23
1.4
7.2
103.2
89.9
%
—
5
39
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
6.0
—
251.7
—
0
10
0
12
0.00
0.21
0.0
1.3
—
102.3
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
27.1
—
0
6
0
12
0.00
0.21
0.0
1.5
—
832.4
—
0
12
0
12
0.00
0.21
0.0
1.1
—
0.0
—
0
5
0
12
0.00
0.21
0.0
1.3
—
0.3
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
159
1625
0.90
0.21
18.5
13.8
39.7
39.4
%
0.30
141
1428
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
13
108
1.22
0.20
1.2
2.1
—
—
—
0
0
6
48
1.26
0.20
1.2
2.7
—
—
—
0
0
26
233
1.13
0.19
4.9
5.2
2.2
2.5
mg/l
0.06
19
159
13
110
1.19
0.17
8.4
8.2
173.8
162.2
%
0.21
13
110
12
140
0.85
0.15
1.8
1.9
—
—
—
0
0
13
149
0.86
0.14
1.2
1.2
186.0
174.7
iu/ml
—
5
50
5
62
0.80
0.08
2.0
1.6
—
—
—
0
0
5
65
0.76
0.08
1.2
1.2
—
—
—
0
0
49
506
0.96
0.06
2.6
2.5
—
—
—
0
0
14
129
1.09
0.06
1.2
1.2
—
—
—
0
0
116
1147
1.03
0.04
3.5
3.2
14.3
14.4
pmol/l
0.17
110
1024
11
119
0.92
0.04
1.9
1.4
—
—
—
0
0
23
239
0.96
0.03
1.0
1.1
—
—
—
0
0
26
252
1.04
0.02
1.8
1.9
1.6
1.2
mmol/l
1.17
26
233
16
153
1.05
0.01
1.2
1.3
0.2
2.9
u/ml
2.37
11
100
12
116
1.04
0.00
1.9
1.4
—
—
—
0
0
53
531
1.00
0.00
2.7
2.7
—
—
—
0
0
10
97
1.03
0.00
1.6
2.0
—
—
—
0
0
34
343
0.99
0.00
2.1
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
1.9
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
86
0.93
0.00
1.1
1.2
—
—
—
0
0
7
70
1.00
0.00
1.0
1.1
—
—
—
0
0
5
55
0.91
0.00
1.8
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
25.6
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
21.0
—
25.8
—
0
6
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
20.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
9.8
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
5
51
0.98
0.00
3.6
2.3
0.1
0.4
nmol/l
—
5
44
12
120
1.00
0.00
2.3
2.5
18.1
8.9
iu/l
—
7
78
Mortality – FinRegistry
↥Association
Association between endpoint P16_BIRTH_ASPHYXIA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_BIRTH_ASPHYXIA | 2.191 [1.71, 2.8] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 6809 males with P16_BIRTH_ASPHYXIA died.
Mortality risk
Mortality risk for people of age
years, who have P16_BIRTH_ASPHYXIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.517% |
| 5 | No data | 2.843% |
| 10 | No data | 7.153% |
| 15 | No data | 12.962% |
| 20 | No data | 22.039% |
Relationships between endpoints
↥Index endpoint: P16_BIRTH_ASPHYXIA – Birth asphyxia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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