Cardiovascular disorders originating in the perinatal period

P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P29 Cause of death: ICD-10 — P29 2 out of 7 registries used, show all original rules.	134
4. Check minimum number of events None	134
5. Include endpoints None	134
6. Filter based on genotype QC (FinnGen only)	134

Control definitions (FinnGen only)

Control exclude: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P2
Name in latin: Morbositates cardiovasculares origine perinatales

NAME	P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_EXCLUDE	P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P29
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P29
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cardiovascular disorders originating in the perinatal period based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	7884	3729	4154
Only index persons	4035	1874	2161
Unadjusted period prevalence (%)
Whole population	0.11	0.11	0.12
Only index persons	0.08	0.07	0.08
Median age at first event (years)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.01	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	134	76	58
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
124: Matched controls
1234

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P29.30

ICD-10 Finland

Delayed closure of the ductus arteriosus

+∞

51.7

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

+∞

36.2

P29.31

ICD-10 Finland

Persistent fetal circulation

+∞

33.9

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

20.7

32.8

P29.9

ICD-10 Finland

Cardiovascular disorder originating in the perinatal period, unspecified

+∞

29.3

P07.3

ICD-10 Finland

Other preterm infants

14.4

22.2

P27.1

ICD-10 Finland

Bronchopulmonary dysplasia originating in the perinatal period

+∞

20.3

P07.2

ICD-10 Finland

Extreme immaturity

207.6

18.0

WX722

NOMESCO Finland

PEEP

18.2

15.6

J45.1

ICD-10 Finland

Nonallergic asthma

5.8

12.9

H35.1

ICD-10 Finland

Retinopathy of prematurity

+∞

12.7

WX730

NOMESCO Finland

Conventional respirator

20.7

12.4

P29.1

ICD-10 Finland

Neonatal cardiac dysrhythmia

+∞

11.6

FDE00

NOMESCO Finland

Closure of patent ductus arteriosus

+∞

10.5

P29.8

ICD-10 Finland

Other cardiovascular disorders originating in the perinatal period

+∞

10.5

Z2221

NOMESCO Finland

Medical doctor

3.8

10.5

218

AA5HE

NOMESCO Finland

Brain ultrasound examination in a child

5.9

9.7

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

4.4

9.6

112

Q25.0

ICD-10 Finland

Patent ductus arteriosus

9.8

9.1

P07.01

ICD-10 Finland

Extremely low birth weight 500-749 g

+∞

8.4

ZXE10

NOMESCO Finland

More than one and less than three hours

3.0

7.5

272

P07.02

ICD-10 Finland

Extremely low birth weight 750-999 g

+∞

7.3

602

Kela drug reimbursment

Children's severe malnutrition

5.1

7.3

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.4

7.3

146

RK312

NOMESCO Finland

21.5

7.2

R4110

NOMESCO Finland

Physiotherapy

3.0

7.1

241

Z3231

NOMESCO Finland

Registered nurse

2.7

6.8

388

WX732

NOMESCO Finland

High frequency respirator

42.2

6.8

P07.10

ICD-10 Finland

Other low birth weight 1000-1499 g

23.9

6.8

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.8

6.7

271

P22.1

ICD-10 Finland

Transient tachypnoea of newborn

73.1

6.5

R4160

NOMESCO Finland

Other therapy enhancing rehabilitation

5.3

6.4

ZX114

NOMESCO Finland

Intramuscular

7.7

6.4

WX882

NOMESCO Finland

High dependency care

3.3

6.3

133

RK320

NOMESCO Finland

28.1

6.3

J38.0

ICD-10 Finland

Paralysis of vocal cords and larynx

28.1

6.3

RK412

NOMESCO Finland

+∞

6.3

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.8

6.3

242

XG413

NOMESCO Finland

Spirometry with oscillometry

6.6

6.2

Q21.11

ICD-10 Finland

Paten or persistent foramen ovale

10.8

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD and mortality.

Females

Parameter	HR [95% CI]	p-value
P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD	8.691 [4.36, 17.33]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.094

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 3415 females with P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD.

N-year risk	Females	Males
1	0.626%	No data
5	4.213%	No data
10	11.306%	No data
15	21.689%	No data
20	35.607%	No data

Relationships between endpoints

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Index endpoint: P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD – Cardiovascular disorders originating in the perinatal period

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cardiovascular disorders originating in the perinatal period

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints