Cardiovascular disorders originating in the perinatal period

P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P29 Cause of death: ICD-10 — P29 2 out of 7 registries used, show all original rules.	134
4. Check minimum number of events None	134
5. Include endpoints None	134
6. Filter based on genotype QC (FinnGen only)	120

Control definitions (FinnGen only)

Control exclude: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P2
Name in latin: Morbositates cardiovasculares origine perinatales

NAME	P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_EXCLUDE	P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P29
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P29
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cardiovascular disorders originating in the perinatal period based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	7884	3729	4154
Only index persons	4035	1874	2161
Unadjusted period prevalence (%)
Whole population	0.11	0.11	0.12
Only index persons	0.08	0.07	0.08
Median age at first event (years)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.01	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	120	71	49
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
134: Matched controls
1336

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

19.1

55.4

P29.30

ICD-10 Finland

Delayed closure of the ductus arteriosus

+∞

55.0

P07.3

ICD-10 Finland

Other preterm infants

17.0

44.0

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

+∞

38.3

P29.31

ICD-10 Finland

Persistent fetal circulation

+∞

34.9

P29.9

ICD-10 Finland

Cardiovascular disorder originating in the perinatal period, unspecified

+∞

33.7

P27.1

ICD-10 Finland

Bronchopulmonary dysplasia originating in the perinatal period

+∞

20.3

P07.2

ICD-10 Finland

Extreme immaturity

205.5

18.0

WX722

NOMESCO Finland

PEEP

22.1

16.7

J45.1

ICD-10 Finland

Nonallergic asthma

5.4

16.7

105

Z2221

NOMESCO Finland

Medical doctor

4.2

14.5

212

WX730

NOMESCO Finland

Conventional respirator

34.2

14.3

H35.1

ICD-10 Finland

Retinopathy of prematurity

+∞

12.7

P29.1

ICD-10 Finland

Neonatal cardiac dysrhythmia

+∞

12.7

P29.8

ICD-10 Finland

Other cardiovascular disorders originating in the perinatal period

+∞

12.7

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

4.0

11.7

136

AA5HE

NOMESCO Finland

Brain ultrasound examination in a child

4.8

10.8

FDE00

NOMESCO Finland

Closure of patent ductus arteriosus

+∞

10.5

ZXE10

NOMESCO Finland

More than one and less than three hours

3.3

10.4

255

Q25.0

ICD-10 Finland

Patent ductus arteriosus

11.4

10.4

602

Kela drug reimbursment

Children's severe malnutrition

5.1

10.2

R4160

NOMESCO Finland

Other therapy enhancing rehabilitation

5.8

9.6

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

4.6

9.6

WX404

NOMESCO Finland

Intravenous generell anesthesy

3.2

9.3

241

P07.01

ICD-10 Finland

Extremely low birth weight 500-749 g

+∞

8.4

R03AK06

ATC

salmeterol and fluticasone; inhalant

4.3

8.2

WX882

NOMESCO Finland

High dependency care

3.4

8.2

125

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.1

8.0

183

WX408

NOMESCO Finland

General anesthesy, balanced

2.8

7.7

300

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.3

7.5

125

R1100

NOMESCO Finland

General evaluation of the need for rehabilitation

4.4

7.4

XF400

NOMESCO Finland

ECG with 12 standard connections

2.9

7.4

190

Z3229

NOMESCO Finland

Other healthcare associate professional

3.5

7.4

103

P07.02

ICD-10 Finland

Extremely low birth weight 750-999 g

+∞

7.3

P22.1

ICD-10 Finland

Transient tachypnoea of newborn

+∞

7.3

R4110

NOMESCO Finland

Physiotherapy

2.8

7.3

254

P07.10

ICD-10 Finland

Other low birth weight 1000-1499 g

31.8

7.2

ZXD10

NOMESCO Finland

Scheduled procedure

2.7

7.2

332

FM2CE, ,

NOMESCO Finland

3.6

7.1

Z2446

NOMESCO Finland

Social worker

2.9

7.1

174

ZX114

NOMESCO Finland

Intramuscular

9.0

7.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.7

7.0

267

Z3226

NOMESCO Finland

Physiotherapist

2.7

6.9

246

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

4.0

6.9

RK312, ,

NOMESCO Finland

17.8

6.8

RK320, ,

NOMESCO Finland

42.1

6.8

WX732

NOMESCO Finland

High frequency respirator

42.1

6.8

ZXD20

NOMESCO Finland

Day surgery

4.1

6.7

Z3231

NOMESCO Finland

Registered nurse

2.6

6.7

399

ZXD05

NOMESCO Finland

Urgent procedure

2.9

6.7

159

P21.0

ICD-10 Finland

Severe birth asphyxia

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044640) Blood type and Crossmatch panel - Blood

278

2.57

6.32

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

243

2.51

5.73

3.3

3.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

347

2.11

4.19

4.1

3.6

—

(3042936) Bacteria identified in Isolate by Culture

2.72

3.94

1.8

1.7

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

7.29

3.40

1.7

1.0

132.14

117.00

—

(4035726) Immunohistochemistry procedure

3.01

3.00

1.7

2.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.69

2.98

1.6

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.69

2.98

1.6

1.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.64

2.97

27.6

6.1

53.55

57.66

0.20

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

6.89

2.89

3.0

1.1

80.00

87.22

—

(3006109) Coagulation factor IX activity actual/normal in Platelet poor plasma by Coagulation assay

6.89

2.89

1.5

1.1

79.50

82.78

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.53

2.88

2.8

2.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.27

2.85

1.5

2.1

—

(3030467) Casts [#/volume] in Urine by Automated count

351

1.84

2.83

5.1

4.8

0.40

0.33

e6/l

0.08

260

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

250

1.92

2.83

4.5

4.1

2.37

2.28

e6/l

0.03

145

(3002582) Erythrocytes [#/volume] in Urine

371

1.81

2.76

5.8

5.0

1005.63

29.70

e6/l

0.48

281

(3000494) Fungus identified in Specimen by Culture

2.32

2.69

1.3

1.9

—

(3018095) Leukocytes [#/volume] in Urine

419

1.77

2.66

7.1

6.0

52.32

39.12

e6/l

0.16

288

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

130

2.13

2.65

5.6

3.7

19.08

20.45

0.24

124

(36304419) Bacteria [Presence] in Urine

351

1.78

2.57

4.7

4.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

387

1.76

2.55

6.2

5.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

155

2.01

2.53

4.3

6.8

1.31

2.59

mg/l

0.85

121

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

242

1.86

2.53

3.2

4.0

0.71

0.74

e6/l

0.04

137

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.97

2.40

1.6

1.2

—

(3008037) Lactate [Moles/volume] in Venous blood

6.42

2.38

15.2

2.8

1.16

1.10

mmol/l

—

(3000330) Specific gravity of Urine by Test strip

3.24

2.26

3.3

2.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.64

2.24

1.6

2.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

3.13

2.18

5.0

4.5

23.89

27.67

umol/l

—

(3023368) Bacteria identified in Blood by Culture

179

1.86

2.17

3.6

4.2

—

(3000504) BK virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

4.42

2.17

8.5

12.9

—

(40768446) Kidney Pathology biopsy report

3.62

2.08

2.3

2.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

364

0.52

2.05

1.9

2.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.06

2.01

2.2

2.6

23.99

9.07

iu/l

0.71

(4200892) Spirometry reversibility

2.48

2.00

1.3

1.5

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

137

1.91

1.98

4.8

10.9

86.17

89.02

0.20

137

(3032185) JC virus DNA [#/volume] (viral load) in Serum or Plasma by NAA with probe detection

4.66

1.95

8.0

8.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

580

1.61

1.94

12.6

9.2

5.95

5.98

mmol/l

0.04

542

(3011397) Hemoglobin [Presence] in Urine by Test strip

271

1.67

1.87

3.2

3.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

414

1.60

1.86

7.1

5.6

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

415

1.59

1.83

4.8

3.7

0.00

estimate

-0.00

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

2.67

1.83

3.4

4.9

93.89

90.77

—

(3035350) Ketones [Presence] in Urine by Test strip

416

1.59

1.81

4.8

3.7

0.00

estimate

-0.00

(40758558) Short blood count panel - Blood

426

1.58

1.79

4.4

9.2

—

(3018418) pH of Serum or Plasma

207

1.71

1.77

8.8

4.2

7.37

7.40

—

(1616796) Gas panel - Central venous blood

2.76

1.75

11.9

6.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

583

1.55

1.69

26.1

13.8

1.24

1.23

mmol/l

0.05

548

(3009214) Lutropin [Units/volume] in Serum or Plasma

106

1.92

1.68

2.2

2.6

9.67

5.11

u/l

0.47

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

3.25

1.67

1.0

1.1

—

(3022229) Phosphate [Moles/volume] in Urine

2.89

1.67

2.6

3.9

15.56

17.26

mmol/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.25

1.65

1.5

1.9

—

(3003694) ABO and Rh group [Type] in Blood

333

1.57

1.63

2.0

1.5

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

3.65

1.62

1.0

1.3

80.40

91.36

—

(3031040) Bacteria [#/volume] in Urine by Automated count

577

1.53

1.61

4.6

4.0

—

25.14

—

(3022313) Gas panel - Capillary blood

317

1.57

1.59

18.1

10.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

156

1.73

1.56

6.0

3.4

12.64

13.31

umol/l

0.19

151

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.17

1.53

1.5

2.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

142

1.74

1.49

5.9

3.5

2.57

2.62

g/l

0.22

133

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.57

1.47

1.1

1.4

—

(3021901) Oxygen saturation in Capillary blood

2.57

1.47

7.9

11.9

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

3.19

1.44

5.8

5.7

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

3.19

1.44

5.6

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.80

1.44

4.7

3.6

45.67

46.18

—

(3000991) Gas panel - Venous blood

316

1.53

1.41

14.1

10.5

—

(3026008) Bacteria identified in Urine by Culture

229

1.58

1.38

3.9

2.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

600

1.47

1.37

6.0

4.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.00

1.36

20.2

8.1

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

337

1.50

1.34

12.0

10.0

5.98

5.75

kpa

1.36

328

(3002032) Base excess in Venous blood by calculation

337

1.50

1.34

12.0

10.1

1.67

0.85

mmol/l

1.42

256

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.88

1.32

1.5

1.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.56

1.31

16.8

5.8

5.45

4.76

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

2.56

1.31

10.2

5.8

7.93

9.03

kpa

—

(3010421) pH of Blood

2.56

1.31

17.0

5.8

7.40

7.38

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.11

1.29

1.6

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

117

1.72

1.25

2.6

2.1

—

(3020961) Endomysium IgA Ab [Titer] in Serum

195

0.52

1.24

1.4

—

110.63

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

142

1.65

1.23

2.4

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

118

1.71

1.22

2.4

2.0

—

(3045414) Leukocytes [Presence] in Urine

2.36

1.19

1.7

2.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

1.17

0.0

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

169

1.58

1.17

2.2

1.9

—

(3044889) 12 lead EKG panel

364

1.44

1.17

2.4

2.1

—

(3014051) Protein [Presence] in Urine by Test strip

2.55

1.15

1.4

2.2

—

(3020891) Body temperature

2.55

1.15

14.4

6.6

—

(40765089) Chromosome analysis panel - Blood by G-banded

2.55

1.15

1.2

1.1

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

1.75

1.15

2.4

1.9

269.20

144.43

u/ml

—

(3035637) Corticotropin [Mass/volume] in Plasma

1.89

1.12

1.6

1.8

—

(3024354) Oxygen [Partial pressure] in Venous blood

330

1.44

1.11

12.2

10.0

5.25

5.24

kpa

0.01

322

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

330

1.44

1.11

18.8

10.0

24.58

24.06

mmol/l

0.86

330

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.73

1.11

2.4

1.9

—

(3022145) Colonoscopy Study observation

2.24

1.09

2.3

1.5

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

350

1.42

1.08

20.3

10.7

1.51

0.92

mmol/l

0.80

258

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

2.02

1.06

1.6

2.0

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

2.02

1.06

1.6

2.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

324

1.43

1.05

6.0

9.9

24.10

23.31

mmol/l

1.75

324

(3020717) Zinc [Moles/volume] in Serum or Plasma

2.31

1.04

2.8

2.3

11.56

12.20

umol/l

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.31

1.04

4.8

3.5

3.02

2.83

e9/l

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

1.89

1.00

1.6

2.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

1.89

1.00

1.6

2.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.99

0.0

1.2

—

71.14

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

540

0.72

0.98

1.9

2.0

1.37

3.98

u/ml

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

118

1.60

0.96

3.7

4.8

1273.82

1239.80

ng/l

0.01

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

106

1132

0.68

0.94

4.3

4.0

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.96

0.90

1.4

4.2

65.89

63.20

g/l

—

(3019230) Fractional oxyhemoglobin in Venous blood

1.96

0.90

1.8

24.1

81.36

74.57

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

393

1.34

0.83

20.4

14.6

25.12

24.63

mmol/l

0.55

393

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

412

1.33

0.83

5.4

3.6

36.25

38.16

mmol/mol

0.48

387

(3024561) Albumin [Mass/volume] in Serum or Plasma

328

1.35

0.82

15.8

9.4

36.51

37.33

g/l

0.32

314

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.80

0.0

1.4

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.78

0.0

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.74

0.77

4.4

20.9

0.93

0.63

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

2.21

0.77

1.2

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

2.21

0.77

2.0

2.1

—

(3016038) Potassium [Moles/volume] in Urine

2.21

0.77

6.8

3.0

28.40

34.26

mmol/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

407

1.32

0.76

11.2

5.8

117.19

111.79

ml/min/173m2

0.46

243

(3014576) Chloride [Moles/volume] in Serum or Plasma

117

1.51

0.75

19.3

12.8

103.76

106.15

mmol/l

0.90

117

(3000492) Spirometry study

1.65

0.74

1.4

1.6

—

(3002256) Pathology report gross observation

1.72

0.73

1.2

—

(3022621) pH of Urine by Test strip

1.83

0.73

1.3

1.9

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.78

0.72

8.3

4.3

0.01

0.09

e6/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

521

0.76

0.72

1.6

1.8

1.51

1.43

g/l

0.15

244

(3024928) Oxygen saturation in Venous blood

1.66

0.67

2.0

23.8

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

101

934

1.32

0.65

25.1

14.6

4.01

3.99

mmol/l

0.24

101

904

(3019550) Sodium [Moles/volume] in Serum or Plasma

101

935

1.31

0.64

25.4

14.7

138.94

139.30

mmol/l

0.70

101

913

(40768797) Stomach Pathology biopsy report

1.63

0.63

2.1

1.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

131

1.43

0.62

22.9

17.3

1.37

1.38

mmol/l

0.03

125

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.69

0.62

1.0

1.2

—

(40768804) Tissue Pathology biopsy report

167

1.38

0.61

2.1

1.6

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.57

0.60

1.5

2.2

5.15

5.29

pmol/l

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.60

0.0

1.1

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.60

0.0

5.7

—

86.43

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.55

0.57

3.1

2.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.56

0.56

2.3

1.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

157

0.67

0.56

2.3

2.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.50

0.55

1.3

676.00

531.05

pmol/l

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

1.52

0.52

6.7

6.0

3.00

2.45

ug/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

219

0.74

0.49

1.9

2.4

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

102

1.41

0.49

5.5

4.2

31.66

21.77

nmol/l

1.16

102

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

166

1.31

0.46

2.4

1.4

123.44

98.34

pmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

568

0.83

0.44

1.8

2.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.63

0.43

1.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

137

0.71

0.42

1.7

1.8

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.41

0.0

2.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.41

0.0

1.6

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.41

0.0

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

102

0.67

0.41

1.1

1.2

—

(3011288) Drugs identified in Urine by Screen method

1.39

0.41

1.0

2.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.41

0.0

1.1

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

39.00

—

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

0.00

0.40

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.44

0.39

1.4

1.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

1.44

0.39

2.6

5.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.39

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.34

0.38

8.6

3.7

—

(3007461) Platelets [#/volume] in Blood

124

1205

1.35

0.33

23.6

17.2

278.64

278.44

e9/l

0.01

118

1133

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.38

0.33

3.3

2.1

—

(3027945) Reticulocytes/100 erythrocytes in Blood

195

1.21

0.30

5.7

7.0

1.40

1.35

0.15

188

(40761511) CBC panel - Blood by Automated count

106

1017

1.19

0.30

15.5

8.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

300

1.17

0.29

6.3

3.3

2.51

2.66

mg/l

0.21

264

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

262

1.18

0.29

5.3

3.5

—

(1761868) Lipid panel - Serum or Plasma

117

0.75

0.29

1.9

2.1

—

(3026361) Erythrocytes [#/volume] in Blood

124

1208

1.31

0.29

23.5

17.1

4.55

4.57

e12/l

0.15

118

1130

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.30

0.28

1.8

1.6

—

(3021589) Normoblasts [#/volume] in Blood

694

1.14

0.28

9.8

11.4

0.00

e9/l

-0.00

492

(3010813) Leukocytes [#/volume] in Blood

124

1209

1.30

0.27

23.4

17.1

7.05

7.16

e9/l

0.19

117

1132

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

487

1.14

0.27

1.9

2.2

5.41

5.30

mmol/l

0.18

436

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

169

0.81

0.26

1.1

—

(3016879) Cocaine [Presence] in Urine

105

1.26

0.25

1.0

2.3

—

(3020393) Adenovirus Ag [Presence] in Stool

1.36

0.24

1.4

2.7

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.29

0.23

2.6

2.2

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

1.26

0.22

9.6

24.2

0.28

0.33

u/ml

—

(3025941) Bacteria identified in Stool by Culture

1.26

0.22

1.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

173

1.18

0.22

2.3

1.7

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.19

0.21

1.4

1.2

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.21

0.0

2.6

—

(21494262) English walnut recombinant (rJug r) 3 IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

2.24

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.21

0.0

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

752

1.12

0.21

9.7

11.7

3.06

3.28

e9/l

0.48

599

(3041096) Erythrocytes [Presence] in Urine by Automated

183

1.17

0.21

6.4

3.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

203.96

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.21

0.0

7.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.21

0.0

1.2

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.4

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

30.0

—

0.64

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

455

1.12

0.20

3.9

3.2

4.06

4.26

mmol/l

0.94

431

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

2.2

—

2.96

—

(3000722) Carnitine free (C0) [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

2.3

—

27.49

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

132

0.82

0.19

2.0

—

(3027944) Amphetamines [Presence] in Urine

109

1.21

0.19

1.2

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

675

1.10

0.19

10.7

10.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

128

1.19

0.18

1.7

1.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

1.24

0.18

1.0

1.2

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

1.19

0.18

1.0

1.1

—

4.77

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.75

0.17

1.2

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

1.23

0.17

5.6

4.4

1119.18

12.39

mg/mmol

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.76

0.16

1.0

1.1

—

(3027008) Opiates [Presence] in Urine

111

1.19

0.16

1.2

2.2

—

(3000764) Benzodiazepines [Presence] in Urine

111

1.19

0.16

1.2

2.3

—

(3028300) Cannabinoids [Presence] in Urine

112

1.17

0.14

1.2

2.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

109

1065

1.11

0.13

16.4

11.6

23.98

24.68

mg/l

0.09

713

(3012516) Albumin [Mass/volume] in Urine

1.19

0.12

5.2

4.0

145.60

148.40

mg/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

220

1.11

0.12

2.2

2.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

436

1.08

0.12

3.8

3.0

2.54

2.55

mmol/l

0.04

407

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

438

1.07

0.10

3.8

2.9

1.42

mmol/l

0.02

411

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

1.17

0.10

1.2

1.5

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

1.14

0.10

2.4

1.7

—

(3023410) Appearance of Cerebral spinal fluid

1.11

0.10

2.2

6.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.06

0.09

1.4

2.5

—

(3044290) Cell count panel - Cerebral spinal fluid

1.06

0.09

2.0

6.2

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

1.04

0.09

2.0

6.1

171.00

3.25

e6/l

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

1.04

0.09

1.8

5.7

2.40

3.39

mmol/l

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

1.04

0.09

2.0

6.1

17597.80

924.94

e6/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

165

1.10

0.08

1.7

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.82

0.08

47.4

16.4

86.48

95.67

—

(3006315) Basophils [#/volume] in Blood

720

1.06

0.08

8.9

9.6

0.04

e9/l

0.29

563

(3003327) Ova and parasites identified in Stool by Light microscopy

1.05

0.07

1.5

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

761

1.05

0.07

3.2

3.1

14.36

14.33

pmol/l

0.04

703

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.06

0.07

2.0

2.7

23.78

31.42

u/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.88

0.07

1.1

1.2

—

(36660697) Celiac disease serology panel - Serum

242

0.94

0.06

1.1

1.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

375

1.05

0.06

6.9

5.3

24.69

26.85

u/l

0.17

364

(3029937) Albumin [Presence] in Urine by Test strip

199

1.06

0.04

6.1

3.5

0.00

estimate

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.10

0.04

1.0

2.2

—

(42870560) Thyrotropin [Units/volume] in Cord blood

128

0.93

0.03

1.0

14.01

7.38

mu/l

1.00

119

(3019198) Lymphocytes [#/volume] in Blood

739

1.03

0.02

9.2

9.6

2.56

2.64

e9/l

0.18

612

(3013512) EKG study

1.05

0.00

1.6

3.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

842

1.02

0.00

3.9

3.4

2.27

2.11

mu/l

0.43

788

(3001604) Monocytes [#/volume] in Blood

723

1.01

0.00

9.0

9.6

0.59

0.58

e9/l

0.09

566

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

224

0.98

0.00

1.9

2.6

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

174

0.97

0.00

4.2

2.7

282.18

348.68

nmol/l

0.76

166

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.9

—

6.60

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

6.6

—

570.40

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

0.53

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3004905) Lipase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

4.4

—

20.38

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

2.76

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.00

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

8.46

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.00

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

3.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

3.14

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.99

-0.00

1.2

1.5

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.02

-0.00

1.0

—

(723474) SARS-CoV-2 (COVID-19) IgG Ab [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

(3013180) HIV 1 RNA [Units/volume] (viral load) in Serum or Plasma by Probe with amplification

0.00

-0.00

0.0

1.3

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

1.00

-0.00

2.0

5.8

1223.00

457.42

mg/l

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

-0.00

0.0

1.0

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

-0.00

0.0

1.1

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

33.80

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

1.8

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

-0.00

0.0

1.1

—

188.00

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(723473) SARS-CoV-2 (COVID-19) IgA Ab [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

(1001833) Epstein Barr virus DNA [Units/volume] (viral load) in Blood by NAA with probe detection

0.00

-0.00

0.0

6.4

—

(3014038) Collagen crosslinked N-telopeptide [Moles/volume] in Urine

0.00

-0.00

0.0

2.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.0

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

-0.00

0.0

1.3

—

97.11

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

-0.00

0.0

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.89

-0.00

1.0

1.2

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.9

—

7.62

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

37477.78

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.93

-0.00

1.5

1.9

9.67

8.84

nmol/l

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

0.30

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

-0.00

0.0

1.2

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD and mortality.

Females

Parameter	HR [95% CI]	p-value
P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD	8.691 [4.36, 17.33]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.094

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 3415 females with P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD.

N-year risk	Females	Males
1	0.626%	No data
5	4.213%	No data
10	11.306%	No data
15	21.689%	No data
20	35.607%	No data

Relationships between endpoints

↥

Index endpoint: P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD – Cardiovascular disorders originating in the perinatal period

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cardiovascular disorders originating in the perinatal period

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints