Cardiovascular disorders originating in the perinatal period

P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P29 Cause of death: ICD-10 — P29 2 out of 7 registries used, show all original rules.	134
4. Check minimum number of events None	134
5. Include endpoints None	134
6. Filter based on genotype QC (FinnGen only)	134

Control definitions (FinnGen only)

Control exclude: P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P2
Name in latin: Morbositates cardiovasculares origine perinatales

NAME	P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_EXCLUDE	P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P29
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P29
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cardiovascular disorders originating in the perinatal period based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	7884	3729	4154
Only index persons	4035	1874	2161
Unadjusted period prevalence (%)
Whole population	0.11	0.11	0.12
Only index persons	0.08	0.07	0.08
Median age at first event (years)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.01	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	134	76	58
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
124: Matched controls
1234

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P29.30

ICD-10 Finland

Delayed closure of the ductus arteriosus

+∞

51.7

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

+∞

36.2

P29.31

ICD-10 Finland

Persistent fetal circulation

+∞

33.9

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

20.7

32.8

P29.9

ICD-10 Finland

Cardiovascular disorder originating in the perinatal period, unspecified

+∞

29.3

P07.3

ICD-10 Finland

Other preterm infants

14.4

22.2

P27.1

ICD-10 Finland

Bronchopulmonary dysplasia originating in the perinatal period

+∞

20.3

P07.2

ICD-10 Finland

Extreme immaturity

207.6

18.0

WX722

NOMESCO Finland

PEEP

18.2

15.6

J45.1

ICD-10 Finland

Nonallergic asthma

5.8

12.9

H35.1

ICD-10 Finland

Retinopathy of prematurity

+∞

12.7

WX730

NOMESCO Finland

Conventional respirator

20.7

12.4

P29.1

ICD-10 Finland

Neonatal cardiac dysrhythmia

+∞

11.6

FDE00

NOMESCO Finland

Closure of patent ductus arteriosus

+∞

10.5

P29.8

ICD-10 Finland

Other cardiovascular disorders originating in the perinatal period

+∞

10.5

AA5HE

NOMESCO Finland

Brain ultrasound examination in a child

5.9

9.7

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

4.4

9.6

112

Q25.0

ICD-10 Finland

Patent ductus arteriosus

9.8

9.1

P07.01

ICD-10 Finland

Extremely low birth weight 500-749 g

+∞

8.4

P07.02

ICD-10 Finland

Extremely low birth weight 750-999 g

+∞

7.3

602

Kela drug reimbursment

Children's severe malnutrition

5.1

7.3

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

3.4

7.3

146

RK312

NOMESCO Finland

21.5

7.2

R4110

NOMESCO Finland

Physiotherapy

3.0

7.1

241

WX732

NOMESCO Finland

High frequency respirator

42.2

6.8

P07.10

ICD-10 Finland

Other low birth weight 1000-1499 g

23.9

6.8

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.8

6.7

271

P22.1

ICD-10 Finland

Transient tachypnoea of newborn

73.1

6.5

R4160

NOMESCO Finland

Other therapy enhancing rehabilitation

5.3

6.4

ZX114

NOMESCO Finland

Intramuscular

7.7

6.4

WX882

NOMESCO Finland

High dependency care

3.3

6.3

133

RK320

NOMESCO Finland

28.1

6.3

J38.0

ICD-10 Finland

Paralysis of vocal cords and larynx

28.1

6.3

RK412

NOMESCO Finland

+∞

6.3

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.8

6.3

242

XG413

NOMESCO Finland

Spirometry with oscillometry

6.6

6.2

Q21.11

ICD-10 Finland

Paten or persistent foramen ovale

10.8

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044640) Blood type and Crossmatch panel - Blood

279

2.56

6.27

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

243

2.51

5.73

3.3

3.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

347

2.11

4.19

5.0

4.3

—

(3042936) Bacteria identified in Isolate by Culture

2.72

3.94

1.8

1.7

—

(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay

7.29

3.40

1.7

1.0

132.1

117.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.64

3.40

27.6

6.1

53.5

57.7

0.20

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.53

3.25

2.8

2.4

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.27

3.16

1.5

2.1

—

(4035726)

3.01

3.00

1.7

2.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.69

2.98

1.6

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.69

2.98

1.6

1.5

—

(3006109) Coagulation factor IX activity actual/normal in Platelet poor plasma by Coagulation assay

6.89

2.89

1.5

1.1

79.5

82.8

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

6.89

2.89

3.0

1.1

80.0

87.2

—

(3030467) Casts [#/volume] in Urine by Automated count

351

1.84

2.83

5.1

4.8

0.4

0.3

e6/l

0.08

258

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

250

1.92

2.83

4.5

4.1

2.4

2.3

e6/l

0.03

145

(3002582) Erythrocytes [#/volume] in Urine

371

1.81

2.76

5.8

5.0

1005.6

29.7

e6/l

0.48

281

(3000494) Fungus identified in Specimen by Culture

2.34

2.76

1.3

1.9

—

(3018095) Leukocytes [#/volume] in Urine

419

1.77

2.66

7.1

6.0

52.3

39.1

e6/l

0.16

288

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

130

2.13

2.65

5.6

3.7

19.1

20.5

0.24

124

(36304419) Bacteria [Presence] in Urine

351

1.78

2.57

4.7

4.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

387

1.76

2.55

6.3

5.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.97

2.53

1.6

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

155

2.01

2.53

4.3

6.8

1.3

2.6

mg/l

0.85

121

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

242

1.86

2.53

3.2

4.0

0.7

e6/l

0.04

137

(3008037) Lactate [Moles/volume] in Venous blood

6.42

2.38

15.2

2.8

1.2

1.1

mmol/l

—

(3000330) Specific gravity of Urine by Test strip

3.24

2.26

3.3

2.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.64

2.24

1.6

2.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

3.13

2.18

5.0

4.5

23.9

27.7

umol/l

—

(3023368) Bacteria identified in Blood by Culture

179

1.86

2.17

3.6

4.2

—

(3000504) BK virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

4.42

2.17

8.5

12.9

—

(40768446) Kidney Pathology biopsy report

3.62

2.08

2.3

2.7

—

(4306422)

4.12

2.05

1.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

364

0.52

2.05

1.9

2.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

2.06

2.01

2.2

2.6

24.0

9.1

iu/l

0.71

(4010399)

2.48

2.00

1.3

1.5

—

(3015736) pH of Urine

337

1.65

1.98

3.1

3.5

—

(3032185) JC virus DNA [#/volume] (viral load) in Serum or Plasma by NAA with probe detection

4.66

1.95

8.0

8.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

580

1.61

1.94

12.6

9.2

5.9

6.0

mmol/l

0.04

542

(3011397) Hemoglobin [Presence] in Urine by Test strip

271

1.67

1.87

3.2

3.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

415

1.59

1.83

7.1

5.6

0.0

estimate

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

2.67

1.83

3.4

4.9

93.9

90.8

—

(40758558) Short blood count panel - Blood

425

1.59

1.81

4.4

9.2

—

(3009261) Glucose [Presence] in Urine by Test strip

416

1.59

1.81

4.8

3.7

0.0

estimate

0.00

(3018418) pH of Serum or Plasma

206

1.72

1.80

8.8

4.2

7.4

—

(3035350) Ketones [Presence] in Urine by Test strip

417

1.58

1.79

4.8

3.7

0.0

estimate

—

(1616796) Gas panel - Central venous blood

2.76

1.75

11.9

6.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

582

1.55

1.71

26.1

13.8

1.2

mmol/l

0.05

546

(3009214) Lutropin [Units/volume] in Serum or Plasma

106

1.92

1.68

2.2

2.6

9.7

5.1

u/l

0.47

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

3.25

1.67

1.0

1.1

—

(3022229) Phosphate [Moles/volume] in Urine

2.89

1.67

2.6

3.9

15.6

17.3

mmol/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.25

1.65

1.5

1.9

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

3.65

1.62

1.0

1.3

80.4

91.4

—

(3003694) ABO and Rh group [Type] in Blood

334

1.57

1.61

2.0

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

578

1.52

1.59

4.8

4.0

—

25.1

—

(3022313) Gas panel - Capillary blood

317

1.57

1.59

18.1

10.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

156

1.73

1.56

6.0

3.4

12.6

13.3

umol/l

0.19

151

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.17

1.53

1.5

2.2

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

142

1.74

1.49

5.9

3.5

2.6

g/l

0.22

133

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.57

1.47

1.1

1.4

—

(3021901) Oxygen saturation in Capillary blood

2.57

1.47

7.9

11.9

—

(3003752) BK virus DNA [Units/volume] (viral load) in Urine by NAA with probe detection

3.19

1.44

5.8

5.7

—

(3032390) JC virus DNA [#/volume] (viral load) in Urine by NAA with probe detection

3.19

1.44

5.6

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.80

1.44

4.7

3.6

45.7

46.2

—

(3026008) Bacteria identified in Urine by Culture

228

1.59

1.41

4.1

2.3

—

(3000991) Gas panel - Venous blood

316

1.53

1.41

14.1

10.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.00

1.36

20.2

8.1

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.06

1.36

7.3

6.6

0.6

0.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

601

1.46

1.35

6.0

4.4

—

(3002032) Base excess in Venous blood by calculation

337

1.50

1.34

12.0

10.1

1.7

0.9

mmol/l

1.27

255

(3021447) Carbon dioxide [Partial pressure] in Venous blood

337

1.50

1.34

12.0

10.0

6.0

5.7

kpa

1.36

328

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.88

1.32

1.5

1.4

—

(3010421) pH of Blood

2.56

1.31

17.0

5.8

7.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.56

1.31

16.8

5.8

5.4

4.8

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

2.56

1.31

10.2

5.8

7.9

9.0

kpa

—

(3009542) Hematocrit [Volume Fraction] of Blood

121

1114

1.85

1.30

20.2

16.7

38.3

38.2

0.02

114

1016

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.11

1.29

1.6

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

117

1.72

1.25

2.6

2.1

—

(3020961) Endomysium IgA Ab [Titer] in Serum

195

0.52

1.24

1.4

—

110.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

142

1.65

1.23

2.4

2.1

—

(3014051) Protein [Presence] in Urine by Test strip

2.68

1.22

1.4

2.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

118

1.71

1.22

2.4

2.0

—

(3044889) 12 lead EKG panel

363

1.45

1.19

2.4

2.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

1.17

0.0

1.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

169

1.58

1.17

2.2

1.9

—

(40765089) Chromosome analysis panel - Blood by G-banded

2.55

1.15

1.2

1.1

—

(3020891) Body temperature

2.55

1.15

14.4

6.5

—

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

1.75

1.15

2.4

1.9

269.2

145.7

u/ml

—

(3035637) Corticotropin [Mass/volume] in Plasma

1.89

1.12

1.6

1.8

—

(3024354) Oxygen [Partial pressure] in Venous blood

330

1.44

1.11

12.2

10.0

5.3

5.2

kpa

0.01

322

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

330

1.44

1.11

18.8

10.0

24.6

24.1

mmol/l

0.86

330

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.73

1.11

2.4

1.9

—

(3022145) Colonoscopy Study observation

2.24

1.09

2.3

1.5

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

350

1.42

1.08

20.3

10.7

1.5

0.9

mmol/l

0.80

258

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.06

1.07

12.4

14.0

25.1

23.1

mmol/l

—

(44790047)

2.02

1.06

1.6

2.0

—

(44790048)

2.02

1.06

1.6

2.0

—

(44806118)

2.02

1.06

1.6

2.0

—

(44790049)

2.02

1.06

1.6

2.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

324

1.43

1.05

6.0

9.9

24.1

23.5

mmol/l

1.21

314

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.31

1.04

4.8

3.5

3.0

2.8

e9/l

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

2.31

1.04

2.8

2.3

11.6

12.2

umol/l

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.99

0.0

1.2

—

71.1

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

118

1.60

0.96

3.7

4.8

1273.8

1239.8

ng/l

0.01

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

538

0.73

0.95

1.9

2.0

1.4

4.0

u/ml

—

(3045414) Leukocytes [Presence] in Urine

2.27

0.94

1.7

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

106

1132

0.68

0.94

4.3

4.0

—

(42870588) Differential panel, method unspecified - Blood

578

1.35

0.94

7.9

10.4

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.96

0.90

1.4

4.2

65.9

63.2

g/l

—

(3019230) Fractional oxyhemoglobin in Venous blood

1.96

0.90

1.8

24.1

81.4

74.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

327

1.36

0.84

15.8

9.4

36.5

37.3

g/l

0.33

313

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

393

1.34

0.83

20.4

14.6

25.1

24.6

mmol/l

0.55

393

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

412

1.33

0.83

5.4

3.6

36.3

38.2

mmol/mol

0.48

387

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.80

0.0

1.4

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.78

0.0

2.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

406

1.32

0.77

11.2

5.8

117.2

111.8

ml/min/173m2

0.46

243

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

2.21

0.77

1.2

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

2.21

0.77

2.0

2.1

—

(3016038) Potassium [Moles/volume] in Urine

2.21

0.77

6.8

3.0

28.4

34.3

mmol/l

—

(3000492) Spirometry study

1.65

0.74

1.4

1.6

—

(3002256) Pathology report gross observation

1.72

0.73

1.2

—

(3022621) pH of Urine by Test strip

1.83

0.73

1.3

1.9

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.78

0.72

8.3

4.3

0.0

0.1

e6/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

520

0.77

0.70

1.6

1.8

1.5

1.4

g/l

0.15

244

(3024928) Oxygen saturation in Venous blood

1.66

0.67

2.0

23.8

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

101

934

1.32

0.65

25.1

14.6

4.0

mmol/l

0.24

101

904

(3019550) Sodium [Moles/volume] in Serum or Plasma

101

935

1.31

0.64

25.4

14.7

138.9

139.3

mmol/l

0.70

101

913

(40768797) Stomach Pathology biopsy report

1.63

0.63

2.1

1.5

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.69

0.62

1.0

1.2

—

(40768804) Tissue Pathology biopsy report

167

1.38

0.61

2.1

1.6

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.57

0.60

1.5

2.2

5.1

5.3

pmol/l

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.60

0.0

5.7

—

86.4

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.60

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.55

0.57

3.1

2.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.56

0.56

2.3

1.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.50

0.55

1.3

676.0

531.1

pmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

156

0.68

0.54

2.3

2.2

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

1.52

0.52

6.7

6.0

3.0

2.5

ug/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

219

0.74

0.49

1.9

2.4

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

102

1.41

0.49

5.5

4.2

31.7

21.8

nmol/l

1.16

102

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

165

1.32

0.48

2.4

1.4

123.4

98.8

pmol/l

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.63

0.43

1.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

1.41

0.43

1.1

2.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

567

0.83

0.43

1.8

2.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

137

0.71

0.42

1.7

1.8

—

(4027681)

0.00

0.41

0.0

1.1

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.41

0.0

1.6

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.41

0.0

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

102

0.67

0.41

1.1

1.2

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

39.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.41

0.0

1.1

—

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

0.00

0.40

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.44

0.39

1.4

1.3

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

1.44

0.39

2.6

5.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.39

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

1.34

0.38

8.6

3.7

—

(3007461) Platelets [#/volume] in Blood

124

1205

1.35

0.33

23.6

17.2

278.6

278.3

e9/l

0.01

118

1133

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.38

0.33

3.3

2.1

—

(3027945) Reticulocytes/100 erythrocytes in Blood

195

1.21

0.30

5.7

7.0

1.4

0.15

188

(40761511) CBC panel - Blood by Automated count

106

1017

1.19

0.30

15.5

8.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

300

1.17

0.29

6.3

3.3

2.5

2.7

mg/l

0.21

264

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

262

1.18

0.29

5.3

3.5

—

(3021589) Normoblasts [#/volume] in Blood

693

1.14

0.29

9.9

11.4

0.0

e9/l

0.00

491

(1761868) Lipid panel - Serum or Plasma

117

0.75

0.29

1.9

2.1

—

(3026361) Erythrocytes [#/volume] in Blood

124

1208

1.31

0.29

23.5

17.1

4.6

e12/l

0.15

118

1130

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.30

0.28

1.8

1.6

—

(3010813) Leukocytes [#/volume] in Blood

124

1209

1.30

0.27

23.4

17.1

7.0

7.2

e9/l

0.18

117

1132

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

487

1.14

0.27

1.9

2.2

5.4

5.3

mmol/l

0.18

436

(3016879) Cocaine [Presence] in Urine

105

1.26

0.25

1.0

2.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

168

0.81

0.25

1.1

—

(3020393) Adenovirus Ag [Presence] in Stool

1.36

0.24

1.4

2.7

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.29

0.23

2.6

2.2

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

1.26

0.22

9.6

24.2

0.3

u/ml

—

(3025941) Bacteria identified in Stool by Culture

1.26

0.22

1.0

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

751

1.12

0.22

9.7

11.7

3.1

3.3

e9/l

0.49

598

(3048929) Epstein Barr virus Ab [Presence] in Serum

173

1.18

0.22

2.2

1.7

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.19

0.21

1.4

1.2

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.21

0.0

2.6

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.21

0.0

1.3

—

(21494262) English walnut recombinant (rJug r) 3 IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

2.2

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

183

1.17

0.21

6.4

3.6

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.21

0.0

1.2

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

30.0

—

0.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

204.0

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.21

0.0

7.4

—

(3000722) Carnitine free (C0) [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

2.3

—

27.5

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

2.2

—

3.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

456

1.11

0.20

3.9

3.2

4.1

4.3

mmol/l

0.93

432

(3027944) Amphetamines [Presence] in Urine

109

1.21

0.19

1.2

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

128

1.19

0.18

1.7

1.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

1.24

0.18

1.0

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

131

0.82

0.18

2.0

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

1.19

0.18

1.0

1.1

—

4.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.76

0.17

1.2

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

1.23

0.17

5.6

4.5

1119.2

12.4

mg/mmol

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.76

0.16

1.0

1.1

—

(3000764) Benzodiazepines [Presence] in Urine

111

1.19

0.16

1.2

2.3

—

(3027008) Opiates [Presence] in Urine

111

1.19

0.16

1.2

2.2

—

(3028300) Cannabinoids [Presence] in Urine

112

1.17

0.14

1.2

2.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

109

1065

1.11

0.13

16.4

11.6

24.0

24.6

mg/l

0.08

713

(46235355) HIV 1 and 2 tests - Meaningful Use set

219

1.11

0.13

2.2

2.1

—

(3012516) Albumin [Mass/volume] in Urine

1.19

0.12

5.2

4.0

145.6

148.4

mg/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

436

1.08

0.12

3.8

3.0

2.5

2.6

mmol/l

0.04

408

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

1.17

0.10

1.2

1.5

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

1.14

0.10

2.4

1.7

—

(3023410) Appearance of Cerebral spinal fluid

1.11

0.10

2.2

6.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

439

1.07

0.09

3.8

2.9

1.4

mmol/l

0.02

412

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.06

0.09

1.4

2.5

—

(3044290) Cell count panel - Cerebral spinal fluid

1.06

0.09

2.0

6.2

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

1.04

0.09

1.8

5.7

2.4

3.4

mmol/l

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

1.04

0.09

2.0

6.1

171.0

3.3

e6/l

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

1.04

0.09

2.0

6.1

17597.8

924.9

e6/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

165

1.10

0.08

1.7

—

(3006315) Basophils [#/volume] in Blood

719

1.06

0.08

8.9

9.7

0.0

e9/l

0.30

562

(3014007) Fractional oxyhemoglobin in Arterial blood

0.82

0.08

47.4

16.4

86.5

95.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

204

0.92

0.08

11.7

5.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

760

1.06

0.08

3.2

3.1

14.4

14.3

pmol/l

0.04

702

(3003327) Ova and parasites identified in Stool by Light microscopy

1.07

0.07

1.5

1.7

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.06

0.07

2.0

2.7

23.8

31.4

u/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.88

0.07

1.1

1.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

374

1.06

0.06

6.9

5.3

24.7

26.9

u/l

0.17

363

(36660697) Celiac disease serology panel - Serum

241

0.94

0.05

1.1

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.10

0.04

1.0

2.2

—

(3029937) Albumin [Presence] in Urine by Test strip

200

1.06

0.03

6.1

3.5

0.0

estimate

—

(3019198) Lymphocytes [#/volume] in Blood

737

1.03

0.03

9.2

9.6

2.6

e9/l

0.19

609

(42870560) Thyrotropin [Units/volume] in Cord blood

128

0.93

0.03

1.0

14.0

7.4

mu/l

1.00

119

(3001604) Monocytes [#/volume] in Blood

721

1.02

0.01

9.0

9.6

0.6

e9/l

0.08

564

(3013512) EKG study

1.05

0.00

1.6

3.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

842

1.02

0.00

3.9

3.4

2.3

2.1

mu/l

0.43

788

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

224

0.98

0.00

1.9

2.6

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

174

0.97

0.00

4.2

2.7

282.2

348.7

nmol/l

0.76

166

(4146454)

0.00

0.0

3.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.1

—

188.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.0

—

0.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

1.0

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.3

—

97.1

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

0.3

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.1

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

0.0

2.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

6.6

—

570.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.8

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(723473) SARS-CoV-2 (COVID-19) IgA Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.89

0.00

1.0

1.2

—

(3014038) Collagen crosslinked N-telopeptide [Moles/volume] in Urine

0.00

0.0

2.6

—

(3001820) Epstein Barr virus nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3013180) HIV 1 RNA [Units/volume] (viral load) in Serum or Plasma by Probe with amplification

0.00

0.0

1.3

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.5

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

1.00

0.00

1.2

1.5

—

(723474) SARS-CoV-2 (COVID-19) IgG Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.02

0.00

1.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

1.00

0.00

2.0

5.8

1223.0

457.4

mg/l

—

(1001833) Epstein Barr virus DNA [Units/volume] (viral load) in Blood by NAA with probe detection

0.00

0.0

7.7

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.0

1.2

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

33.8

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD and mortality.

Females

Parameter	HR [95% CI]	p-value
P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD	8.691 [4.36, 17.33]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.094

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 3415 females with P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD.

N-year risk	Females	Males
1	0.626%	No data
5	4.213%	No data
10	11.306%	No data
15	21.689%	No data
20	35.607%	No data

Relationships between endpoints

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Index endpoint: P16_CARDIOV_DISORD_ORIGINA_PERINA_PERIOD – Cardiovascular disorders originating in the perinatal period

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cardiovascular disorders originating in the perinatal period

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints