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Chronic respiratory disease originating in the perinatal period

Endpoint Browser PheWeb

P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P27
  • Cause of death: ICD-10 — P27

2 out of 7 registries used, show all original rules.

81

4. Check minimum number of events

None

81

5. Include endpoints

None

81

6. Filter based on genotype QC (FinnGen only)

81

Control definitions (FinnGen only)

Control exclude
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P2
Name in latin
Morbus respiratorius chronicus origine perinatalis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2666 1099 1567
Only index persons 1532 618 914
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population - 0.00 0.00
Only index persons 0.03 0.00 0.04

-FinnGen-

Key figures

All Female Male
Number of individuals 81 42 39
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 0.04 0.04 0.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
67
Matched controls
671
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
7837.3
84.5
63
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
124.3
46.8
48
13
P07.2
ICD-10 Finland
Extreme immaturity
+∞
38.2
33
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
30.6
27
*
602
Kela drug reimbursment
Children's severe malnutrition
30.9
23.6
32
19
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
16.5
23.2
47
83
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
22.1
20
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
18.6
17
*
J45.1
ICD-10 Finland
Nonallergic asthma
12.7
18.0
37
59
WX722
NOMESCO Finland
PEEP
49.8
18.0
21
6
P07.3
ICD-10 Finland
Other preterm infants
22.6
16.5
24
16
R03BA02
ATC
budesonide; inhalant
10.1
15.4
36
69
F82
ICD-10 Finland
Specific developmental disorder of motor function
22.8
14.7
21
13
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
14.0
13
*
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
+∞
14.0
13
*
WX730
NOMESCO Finland
Conventional respirator
63.2
13.5
15
*
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
11.8
11
*
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
129.4
10.8
11
*
XG413
NOMESCO Finland
Spirometry with oscillometry
15.8
10.6
17
14
6BB16
NOMESCO Finland
NA
47.8
10.3
12
*
R4110
NOMESCO Finland
Physiotherapy
5.8
10.3
39
130
RK310
NOMESCO Finland
NA
+∞
9.6
9
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
10.1
9.5
19
25
J45.9
ICD-10 Finland
Asthma, unspecified
6.2
9.5
29
73
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
15.7
9.4
15
12
WX408
NOMESCO Finland
General anesthesy, balanced
5.2
9.3
42
163
P05.1
ICD-10 Finland
Small for gestational age
28.7
9.3
12
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.7
9.3
26
58
R03AC02
ATC
salbutamol; inhalant
6.0
9.1
55
289
WX704
NOMESCO Finland
Intubation
19.7
9.0
13
8
R03AK06
ATC
salmeterol and fluticasone; inhalant
7.6
8.6
21
38
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
6.0
8.3
25
60
WX725
NOMESCO Finland
Noninvasive ventilation
25.8
8.3
11
5
ZX114
NOMESCO Finland
Intramuscular
13.2
8.3
14
13
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
8.1
29
85
R03BA05
ATC
fluticasone; inhalant
4.5
7.7
36
136
RK320
NOMESCO Finland
NA
89.6
7.6
8
*
RK520
NOMESCO Finland
NA
89.6
7.6
8
*
XA800
NOMESCO Finland
Neuropsychological investigation
6.9
7.5
19
36
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
7.4
7
*
WX732
NOMESCO Finland
High frequency respirator
+∞
7.4
7
*
ZX108
NOMESCO Finland
Inhalation
16.1
7.2
11
8
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
19.2
7.0
10
6
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
19.2
7.0
10
6
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.5
6.6
17
33
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
76.9
6.5
7
*
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
9.2
6.5
13
17
WX882
NOMESCO Finland
High dependency care
5.0
6.4
22
60
RK312
NOMESCO Finland
NA
29.8
6.4
8
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.8
6.4
41
198
RK290
NOMESCO Finland
NA
+∞
6.3
6
*
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
6.3
6
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
11.7
6.3
11
11
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.9
6.2
21
57
UGC02
NOMESCO Finland
Rigid bronchoscopy
17.0
6.1
9
6

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
14
32
5.05
5.99
1.7
2.0
—
—
—
0
0
14
32
5.05
5.99
1.7
2.0
—
—
—
0
0
14
32
5.05
5.99
1.7
2.0
—
—
—
0
0
14
32
5.05
5.99
1.7
2.0
—
—
—
0
0
24
84
3.62
5.93
2.1
1.3
98.5
97.4
pmol/l
0.04
11
44
12
30
4.50
4.59
1.9
1.3
—
—
—
0
0
32
159
2.66
4.17
6.0
14.0
—
—
—
0
0
51
321
2.57
4.02
5.8
13.7
—
—
—
0
0
12
34
3.95
3.90
1.7
1.4
—
—
—
0
0
59
413
2.55
3.49
7.9
11.9
2.7
2.6
e9/l
0.29
53
338
58
403
2.52
3.49
8.0
12.0
0.0
0.0
e9/l
0.41
50
318
57
398
2.43
3.31
6.5
12.3
8.6
8.2
%
0.62
52
386
40
241
2.29
3.28
6.5
10.0
—
—
—
0
0
60
430
2.50
3.26
9.1
14.5
3.4
3.6
e9/l
0.18
51
346
57
405
2.35
3.08
8.1
11.9
0.6
0.6
e9/l
0.67
49
320
56
396
2.32
3.04
9.6
14.7
0.0
0.0
e9/l
0.50
48
286
30
165
2.29
3.00
32.9
10.6
24.3
24.0
mmol/l
0.32
30
165
11
37
3.27
2.79
1.5
1.3
—
—
—
0
0
28
158
2.17
2.58
34.6
11.6
—
—
—
0
0
8
22
3.90
2.42
1.6
2.0
—
—
—
0
0
6
13
4.86
2.30
2.0
2.2
—
—
—
0
0
33
208
1.98
2.22
2.7
4.1
—
—
—
0
0
5
11
4.74
1.96
1.0
1.0
—
—
—
0
0
32
208
1.88
1.92
2.8
4.1
0.1
0.4
e6/l
0.65
20
145
32
210
1.85
1.86
3.5
2.2
—
—
—
0
0
39
274
1.80
1.81
3.9
3.0
35.3
35.9
mmol/mol
0.19
34
256
31
203
1.84
1.80
35.2
18.2
25.1
24.7
mmol/l
0.32
31
203
33
222
1.81
1.75
2.7
4.3
12.1
34.2
e6/l
1.02
19
161
66
551
2.04
1.69
27.3
16.8
4.0
3.9
mmol/l
0.84
66
530
7
25
2.95
1.68
1.3
1.1
—
—
—
0
0
20
116
1.95
1.66
5.0
4.9
—
—
—
0
0
36
253
1.75
1.63
3.6
5.3
11.5
27.7
e6/l
1.04
20
161
66
554
2.00
1.62
27.3
16.9
139.0
139.2
mmol/l
0.41
66
537
63
521
1.91
1.62
5.1
3.5
2.0
2.0
mu/l
0.18
58
487
6
20
3.14
1.60
6.2
5.9
2.6
2.7
ug/l
—
6
20
5
15
3.46
1.54
2.4
4.2
349.4
414.0
umol/l
—
5
15
5
15
3.46
1.54
4.2
3.4
22.0
20.5
umol/l
—
5
15
22
137
1.82
1.47
1.2
1.2
—
—
—
0
0
5
16
3.24
1.45
1.0
1.0
1.4
1.3
g/l
—
5
16
5
17
3.05
1.37
4.0
4.4
2.2
2.4
mmol/l
—
5
17
70
611
2.03
1.36
16.4
8.9
—
—
—
0
0
18
110
1.81
1.27
2.9
7.4
2.1
2.1
mg/l
0.02
13
86
46
363
1.60
1.25
3.7
4.1
—
24.4
—
0
7
74
667
2.20
1.24
23.7
18.7
39.7
38.6
%
1.26
68
609
6
26
2.40
1.20
1.0
1.0
—
—
—
0
0
11
58
2.03
1.17
1.9
1.5
—
—
—
0
0
14
82
1.84
1.12
12.3
22.0
1.1
1.0
mg/l
0.38
14
82
25
174
1.62
1.11
4.0
4.4
—
—
—
0
0
71
635
1.91
1.09
20.6
13.4
18.7
22.8
mg/l
0.82
54
452
12
68
1.89
1.06
1.8
2.9
8.5
21.1
ng/l
—
6
29
7
35
2.08
1.02
1.6
2.0
—
—
—
0
0
7
35
2.08
1.02
1.4
2.0
—
—
—
0
0
0
29
0.00
1.00
0.0
1.0
—
—
—
0
0
46
378
1.49
0.94
3.7
4.5
—
—
—
0
0
6
31
2.00
0.86
1.0
1.5
—
—
—
0
0
12
75
1.70
0.79
1.2
1.6
—
392.7
—
0
11
9
56
1.67
0.75
3.2
2.8
—
—
—
0
0
27
213
1.39
0.64
2.9
3.8
—
—
—
0
0
11
72
1.60
0.62
2.3
2.1
—
—
—
0
0
46
398
1.35
0.61
3.8
4.4
7.1
7.7
mm/h
0.21
41
368
6
34
1.81
0.60
8.2
27.7
22.7
24.4
mmol/l
—
6
34
15
199
0.69
0.57
2.7
2.0
—
—
—
0
0
6
40
1.53
0.52
2.5
27.6
1.1
1.2
%
—
6
40
35
297
1.30
0.50
4.1
2.7
1.2
1.1
mmol/l
0.08
35
282
17
129
1.39
0.50
2.8
3.1
605.5
567.1
mosm/kgh2o
0.22
12
105
5
84
0.57
0.48
1.2
1.3
0.1
3.2
u/ml
—
5
61
5
32
1.59
0.43
1.0
1.0
—
—
—
0
0
17
133
1.34
0.42
2.6
3.7
8.8
8.6
e6/l
0.01
12
113
31
267
1.25
0.38
3.4
3.9
0.0
0.0
estimate
—
5
45
5
78
0.61
0.37
1.2
1.2
9.1
6.0
u/ml
—
5
65
5
78
0.61
0.37
1.2
1.2
0.2
1.1
u/ml
—
5
63
35
307
1.24
0.36
1.4
1.9
1.7
5.4
u/ml
—
5
42
6
46
1.32
0.33
4.2
4.2
—
—
—
0
0
14
111
1.31
0.31
1.1
1.6
—
—
—
0
0
7
54
1.32
0.31
1.1
1.6
—
—
—
0
0
7
55
1.29
0.31
1.4
1.6
—
—
—
0
0
18
149
1.26
0.30
2.7
2.4
—
—
—
0
0
10
126
0.76
0.27
3.1
3.7
—
—
—
0
0
5
72
0.67
0.27
1.0
1.0
—
—
—
0
0
20
170
1.23
0.27
3.1
3.4
—
—
—
0
0
12
96
1.29
0.25
1.2
1.7
—
—
—
0
0
5
37
1.37
0.24
9.6
25.5
0.6
0.8
%
—
5
37
5
37
1.37
0.24
3.6
5.7
3.3
3.3
mmol/l
—
5
37
5
40
1.26
0.23
3.8
5.4
445.8
374.0
mg/l
—
5
40
5
40
1.26
0.23
1.2
2.0
—
—
—
0
0
15
126
1.23
0.22
2.1
1.6
—
—
—
0
0
12
98
1.26
0.22
2.7
2.3
—
—
—
0
0
5
42
1.20
0.22
1.2
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
4.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
—
—
0
0
11
132
0.80
0.21
2.4
1.8
—
—
—
0
0
6
51
1.18
0.20
1.3
2.0
—
—
—
0
0
9
77
1.18
0.16
6.8
28.1
1.4
1.3
mmol/l
—
9
71
29
266
1.13
0.16
4.5
5.7
0.0
0.0
estimate
—
5
49
14
121
1.18
0.15
13.5
6.5
—
—
—
0
0
10
116
0.84
0.13
4.4
3.6
54.2
62.3
u/l
—
10
107
15
133
1.15
0.12
3.5
4.3
0.0
0.0
estimate
—
5
48
29
271
1.10
0.10
3.4
4.0
0.0
0.0
estimate
—
5
45
5
43
1.17
0.10
1.2
1.1
—
—
—
0
0
5
43
1.17
0.10
1.4
1.2
—
—
—
0
0
5
48
1.04
0.09
1.6
2.4
—
—
—
0
0
7
63
1.12
0.08
1.4
1.7
—
—
—
0
0
7
67
1.04
0.08
1.4
1.7
—
—
—
0
0
7
67
1.04
0.08
1.4
1.6
—
—
—
0
0
13
118
1.11
0.07
2.4
5.0
0.9
1.1
inr
—
6
28
10
90
1.12
0.05
2.3
1.7
—
—
—
0
0
22
230
0.93
0.05
1.8
1.6
—
—
—
0
0
29
300
0.94
0.05
1.6
1.8
1.2
1.4
g/l
—
10
147
15
157
0.94
0.02
1.5
1.8
—
—
—
0
0
19
194
0.97
0.00
2.8
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
16.6
—
8.8
—
0
8
0
8
0.00
0.00
0.0
1.4
—
33.8
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
1.4
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
228.1
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.91
0.00
1.5
1.7
—
—
—
0
0
7
68
1.03
0.00
1.4
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
7.3
—
1.2
—
0
6
8
87
0.91
0.00
1.0
1.0
7.3
7.4
mu/l
—
8
87
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
2.6
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
108.8
—
0
9

Mortality – FinRegistry

↥

Association

Association between endpoint P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD – Chronic respiratory disease originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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