Chronic respiratory disease originating in the perinatal period

P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P27
  • Cause of death: ICD-10 P27

2 out of 7 registries used, show all original rules.

84

4. Check minimum number of events

None

84

5. Include endpoints

None

84

6. Filter based on genotype QC (FinnGen only)

71

Control definitions (FinnGen only)

Control exclude
P16_RESPI_CARDIOV_DISORD_SPECIFIC_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P2
Name in latin
Morbus respiratorius chronicus origine perinatalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2666 1099 1567
Only index persons 1532 618 914
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population - 0.00 0.00
Only index persons 0.03 0.00 0.04

-FinnGen-

Key figures

All Female Male
Number of individuals 71 40 31
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 0.18 0.24 0.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
84
Matched controls
836
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
101.9
76
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
124.0
101.4
57
14
602
Kela drug reimbursment
Children's severe malnutrition
30.6
48.2
37
21
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
19.4
43.8
57
82
P07.2
ICD-10 Finland
Extreme immaturity
+∞
43.5
38
*
J45.1
ICD-10 Finland
Nonallergic asthma
17.2
39.5
46
55
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
34.8
31
*
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
25.2
23
*
P07.3
ICD-10 Finland
Other preterm infants
34.0
23.9
31
14
R03BA02
ATC
budesonide; inhalant
8.8
22.1
41
82
WX722
NOMESCO Finland
PEEP
97.2
20.8
22
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
9.9
19.4
27
38
R4110
NOMESCO Finland
Physiotherapy
7.1
18.4
49
138
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
+∞
18.4
17
*
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
17.2
16
*
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
209.0
17.1
17
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
19.1
15.7
24
17
WX730
NOMESCO Finland
Conventional respirator
179.2
14.9
15
*
J45.9
ICD-10 Finland
Asthma, unspecified
6.3
14.9
35
85
Z3229
NOMESCO Finland
Other healthcare associate professional
7.0
14.5
28
56
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.8
14.4
41
118
J18.9
ICD-10 Finland
Pneumonia, unspecified
6.2
14.3
34
83
Z2446
NOMESCO Finland
Social worker
6.0
14.3
36
93
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
7.4
14.3
25
45
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
6.3
13.9
31
71
WX408
NOMESCO Finland
General anesthesy, balanced
5.5
13.9
46
150
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
+∞
13.9
13
*
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
13.9
13
*
R03AK07
ATC
formoterol and budesonide; inhalant
6.7
12.8
25
50
6BB16, ,
NOMESCO Finland
151.0
12.8
13
*
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
22.3
12.7
18
10
Z3231
NOMESCO Finland
Registered nurse
5.0
12.1
52
205
Z2445
NOMESCO Finland
Psychologist
5.8
12.1
28
66
Z2221
NOMESCO Finland
Medical doctor
5.0
11.7
38
119
Z3226
NOMESCO Finland
Physiotherapist
4.8
11.4
40
133
XG413
NOMESCO Finland
Spirometry with oscillometry
15.9
11.3
18
14
WX882
NOMESCO Finland
High dependency care
6.2
11.2
23
48
R03AC02
ATC
salbutamol; inhalant
6.9
10.8
72
389
ZXD05
NOMESCO Finland
Urgent procedure
4.7
10.4
34
106
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.1
10.4
21
43
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.0
10.3
29
80
ZXD10
NOMESCO Finland
Scheduled procedure
4.3
10.2
47
189
ZX114
NOMESCO Finland
Intramuscular
17.8
9.9
15
10
ZX108
NOMESCO Finland
Inhalation
62.2
9.9
11
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
20.5
9.8
14
8
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
10.5
9.4
18
21
P05.1
ICD-10 Finland
Small for gestational age
27.5
9.2
12
5
ZY010
NOMESCO Finland
Hospital outpatient
5.4
8.9
21
49
RK320, ,
NOMESCO Finland
99.2
8.6
9
*
WX725
NOMESCO Finland
Noninvasive ventilation
16.7
8.5
13
9
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
7.6
8.5
20
33
RK312, ,
NOMESCO Finland
+∞
8.5
8
*
RK520, ,
NOMESCO Finland
+∞
8.5
8
*
XA800
NOMESCO Finland
Neuropsychological investigation
5.0
8.3
21
52
ZXE10
NOMESCO Finland
More than one and less than three hours
3.8
8.3
38
148
RK310, ,
NOMESCO Finland
37.2
8.3
10
*
ZXE00
NOMESCO Finland
One hour or less
3.8
8.3
48
219
R03BA05
ATC
fluticasone; inhalant
3.8
8.2
40
162
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
7.3
7.9
19
32
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.3
7.8
18
41
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.9
7.8
31
109
R03DC03
ATC
montelukast; oral
4.1
7.6
27
87
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
15.2
7.6
12
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
7.6
24
71
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
8.7
7.6
16
22
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
87.1
7.5
8
*
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.1
7.4
18
31
ZX106
NOMESCO Finland
Intranasal
+∞
7.4
7
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
+∞
7.4
7
*
WX732
NOMESCO Finland
High frequency respirator
+∞
7.4
7
*
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
22.3
7.3
10
5
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
9.6
7.1
14
17
IGP01
NOMESCO Finland
Psychiatric family contact
5.0
7.1
17
40
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
8.4
7.1
15
21
WW500
NOMESCO Finland
Blood transfusion
10.0
6.8
13
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
6.8
37
158
RT150, ,
NOMESCO Finland
13.8
6.8
11
9
ZXA10
NOMESCO Finland
Bilateral
3.8
6.7
26
89
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.6
6.6
18
47
WX892
NOMESCO Finland
Monitored bed care
4.7
6.5
17
43
R62.0
ICD-10 Finland
Delayed milestone
4.5
6.4
18
48
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.5
6.4
16
29
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.5
6.4
29
110
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.2
6.3
49
255
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
7.7
6.3
14
21
JFB00
NOMESCO Finland
Partial resection of small intestine
+∞
6.3
6
*
RK412, ,
NOMESCO Finland
+∞
6.3
6
*
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
6.3
6
*
7707A
ICD-9 Finland
Other respiratory conditions of foetus and newborn, Chronic respiratory disease arising in the perinatal period[DYSPLASIA BRONCHOPULMONALIS NEONATALIS]
+∞
6.3
6
*
P29.31
ICD-10 Finland
Persistent fetal circulation
+∞
6.3
6
*
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.5
6.1
17
45
UGC02
NOMESCO Finland
Rigid bronchoscopy
16.5
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
91
3.27
5.17
2.2
1.4
95.60
97.37
pmol/l
—
10
49
32
161
2.58
4.02
6.0
13.9
—
—
—
0
0
51
325
2.43
3.78
24.4
15.3
1.24
1.23
mmol/l
0.27
46
299
12
31
4.32
3.65
1.9
1.3
—
—
—
0
0
57
392
2.39
3.41
8.6
13.4
—
—
—
0
0
60
423
2.44
3.38
7.8
11.9
2.72
2.54
e9/l
0.33
54
345
59
413
2.42
3.38
7.9
11.9
0.04
0.04
e9/l
0.35
51
325
62
444
2.49
3.37
9.5
14.3
3.41
3.63
e9/l
0.31
53
355
60
424
2.43
3.35
8.8
13.1
0.20
0.22
e9/l
0.46
55
341
31
166
2.36
3.32
4.6
12.8
23.45
23.33
mmol/l
0.09
31
166
59
415
2.39
3.31
7.9
11.8
0.63
0.57
e9/l
0.83
51
327
12
35
3.81
3.25
1.7
1.5
—
—
—
0
0
40
246
2.18
3.03
6.5
10.1
—
—
—
0
0
57
406
2.24
2.95
9.6
14.6
0.00
0.00
e9/l
0.50
49
292
30
166
2.24
2.93
32.9
10.5
24.33
24.04
mmol/l
0.32
30
166
11
38
3.16
2.51
1.5
1.3
—
—
—
0
0
28
160
2.11
2.47
34.6
11.5
—
—
—
0
0
8
22
3.89
2.42
1.6
2.0
—
—
—
0
0
6
13
4.86
2.30
2.0
2.2
—
—
—
0
0
43
298
1.89
2.15
4.0
3.2
35.82
36.35
mmol/mol
0.16
38
280
35
228
1.90
2.10
3.7
2.3
—
—
—
0
0
5
11
4.73
1.96
1.0
1.0
—
—
—
0
0
66
539
2.02
1.88
5.1
3.5
2.02
1.97
mu/l
0.16
61
503
33
219
1.82
1.83
2.7
4.1
—
—
—
0
0
31
205
1.80
1.72
35.2
18.1
25.06
24.65
mmol/l
0.29
31
205
69
580
2.03
1.69
26.6
16.7
4.01
3.95
mmol/l
0.83
69
562
69
583
2.00
1.62
26.6
16.7
139.03
139.26
mmol/l
0.42
69
569
6
20
3.13
1.60
6.2
5.8
2.58
2.68
ug/l
—
6
20
32
218
1.74
1.59
2.8
4.0
0.14
0.37
e6/l
0.63
20
153
7
27
2.72
1.54
1.3
1.1
—
—
—
0
0
5
15
3.46
1.54
4.2
3.4
22.00
20.53
umol/l
—
5
15
5
15
3.46
1.54
2.4
4.2
349.40
414.00
umol/l
—
5
15
33
231
1.69
1.47
2.7
4.4
12.09
33.51
e6/l
1.01
19
166
5
16
3.24
1.45
1.0
1.0
1.39
1.28
g/l
—
5
16
23
147
1.77
1.40
2.0
3.5
2.76
1.76
e6/l
0.37
12
79
73
639
2.05
1.39
16.4
8.9
—
—
—
0
0
20
123
1.81
1.38
5.0
5.0
—
—
—
0
0
5
17
3.04
1.37
4.0
4.4
2.21
2.40
mmol/l
—
5
17
22
141
1.75
1.33
1.2
1.2
—
—
—
0
0
49
395
1.56
1.17
3.6
4.5
—
—
—
0
0
35
262
1.56
1.15
3.5
5.3
11.50
26.92
e6/l
1.01
20
166
74
662
1.95
1.15
20.0
13.3
18.90
22.80
mg/l
0.75
58
469
14
82
1.84
1.12
12.3
22.0
1.09
1.02
mg/l
0.38
14
82
47
378
1.54
1.11
3.5
4.1
—
12.83
—
0
6
25
175
1.60
1.08
4.0
4.4
—
—
—
0
0
7
33
2.21
1.08
1.4
2.1
—
—
—
0
0
18
116
1.69
1.06
2.9
7.1
2.12
2.02
mg/l
0.04
13
89
0
29
0.00
1.00
0.0
1.0
—
—
—
0
0
7
36
2.02
0.99
1.6
2.0
—
—
—
0
0
6
27
2.30
0.95
1.0
1.1
—
—
—
0
0
11
63
1.85
0.94
1.9
1.5
—
—
—
0
0
13
83
1.66
0.79
1.7
2.9
8.50
17.85
ng/l
—
6
39
12
77
1.64
0.72
2.2
2.0
—
—
—
0
0
12
78
1.62
0.69
3.5
18.6
105.08
105.50
mmol/l
0.09
12
78
39
324
1.37
0.68
4.2
2.8
1.20
1.18
mmol/l
0.07
39
307
48
414
1.36
0.65
3.8
4.4
7.23
8.04
mm/h
0.34
43
384
12
80
1.57
0.63
1.2
1.5
—
334.55
—
0
11
23
178
1.39
0.60
2.9
3.4
—
—
—
0
0
6
36
1.71
0.58
8.2
26.3
22.67
24.39
mmol/l
—
6
36
6
37
1.66
0.56
1.0
1.3
—
—
—
0
0
9
62
1.50
0.55
3.2
2.8
—
—
—
0
0
6
40
1.53
0.52
2.5
27.6
0.70
0.61
%
—
6
40
72
674
1.44
0.49
27.2
18.0
333.35
335.33
g/l
1.23
72
669
5
84
0.57
0.48
1.2
1.3
0.11
3.89
u/ml
—
5
69
33
279
1.29
0.48
3.2
3.9
0.00
0.00
estimate
—
5
50
18
139
1.37
0.47
3.2
4.2
0.00
0.02
estimate
—
5
50
16
203
0.73
0.46
2.8
2.0
—
—
—
0
0
19
150
1.34
0.44
2.6
2.4
—
—
—
0
0
8
58
1.41
0.43
1.3
1.7
—
—
—
0
0
36
312
1.26
0.42
1.4
1.8
1.48
5.55
u/ml
—
6
41
5
33
1.54
0.42
1.0
1.0
—
—
—
0
0
17
134
1.33
0.40
2.8
3.1
605.50
568.22
mosm/kgh2o
0.21
12
109
5
76
0.63
0.38
1.0
1.2
0.22
2.64
u/ml
—
5
63
5
79
0.61
0.37
1.2
1.2
9.08
5.92
u/ml
—
5
66
5
79
0.61
0.37
1.2
1.2
0.16
1.14
u/ml
—
5
63
6
41
1.49
0.37
2.5
27.0
1.12
1.21
%
—
6
41
32
278
1.24
0.36
4.3
5.7
0.00
0.00
estimate
—
5
51
10
131
0.73
0.35
3.1
3.6
—
—
—
0
0
17
137
1.29
0.34
2.6
3.7
8.76
8.64
e6/l
0.01
12
117
32
281
1.22
0.32
3.3
4.0
0.00
0.00
estimate
—
5
46
7
53
1.34
0.31
1.4
1.6
—
—
—
0
0
5
72
0.67
0.27
1.0
1.0
—
—
—
0
0
5
38
1.33
0.23
3.6
5.6
3.26
3.33
mmol/l
—
5
38
5
38
1.33
0.23
9.6
24.9
0.56
0.76
%
—
5
38
5
40
1.26
0.23
1.2
2.0
—
—
—
0
0
5
40
1.26
0.23
1.0
2.0
—
—
—
0
0
5
41
1.23
0.22
1.4
1.2
—
—
—
0
0
5
41
1.23
0.22
3.8
5.2
445.80
385.44
mg/l
—
5
41
12
98
1.26
0.22
1.3
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
139.60
—
0
10
0
11
0.00
0.21
0.0
2.9
—
—
—
0
0
0
11
0.00
0.21
0.0
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
—
—
0
0
14
117
1.23
0.21
1.3
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
47
1.29
0.21
4.2
4.1
—
—
—
0
0
16
137
1.20
0.20
2.1
1.6
—
—
—
0
0
7
62
1.13
0.17
1.4
1.7
—
—
—
0
0
28
303
0.88
0.17
1.6
1.8
1.25
1.43
g/l
—
9
149
12
102
1.20
0.15
2.7
2.3
—
—
—
0
0
22
237
0.90
0.11
1.8
1.7
—
—
—
0
0
12
135
0.87
0.11
2.4
1.8
—
—
—
0
0
11
124
0.87
0.10
4.1
3.5
56.64
61.56
u/l
0.16
11
115
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
5
47
1.06
0.09
1.6
2.4
—
—
—
0
0
5
48
1.04
0.09
1.2
1.5
—
—
—
0
0
6
53
1.14
0.09
1.3
2.0
—
—
—
0
0
7
66
1.06
0.08
1.4
1.6
—
—
—
0
0
7
66
1.06
0.08
1.4
1.7
—
—
—
0
0
7
67
1.04
0.08
1.4
1.6
—
—
—
0
0
15
162
0.90
0.07
1.6
1.9
—
—
—
0
0
19
200
0.93
0.05
2.8
2.1
—
—
—
0
0
11
103
1.07
0.01
2.3
1.9
—
—
—
0
0
15
145
1.04
0.00
7.7
5.5
1.13
1.17
inr
—
8
33
0
8
0.00
0.00
0.0
16.6
—
8.77
—
0
8
0
8
0.00
0.00
0.0
6.6
—
1.00
—
0
8
6
64
0.93
0.00
1.5
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
1.43
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
28.03
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
38.46
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.6
—
1.23
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
49.40
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
63.20
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
3.69
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
228.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
87
0.91
-0.00
1.0
1.0
7.29
7.35
mu/l
—
8
87

Mortality – FinRegistry

Association

Association between endpoint P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: P16_CHRONIC_RESPI_DISEA_ORIGINA_PERINA_PERIOD – Chronic respiratory disease originating in the perinatal period

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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