No definition available.
Disorders related to short gestation and low birth weight, not elsewhere classified
EFO MESH Endpoint Browser PheWeb
P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
846 |
4. Check minimum number of eventsNone |
846 |
5. Include endpointsNone |
846 |
6. Filter based on genotype QC (FinnGen only) |
846 |
Control definitions (FinnGen only)
- Control exclude
- P16_DISORD_RELATED_LENGTH_GESTATION_FETAL_GROWTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P0[5-8]
- Name in latin
- Perturbationes ad gestationem brevem et pondus partuale leve pertinentes non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders related to short gestation and low birth weight, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Disorders related to length of gestation and fetal growth
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 51969 | 23864 | 28104 |
| Only index persons | 27383 | 12581 | 14802 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.74 | 0.68 | 0.79 |
| Only index persons | 0.52 | 0.46 | 0.57 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 846 | 487 | 359 |
| Unadjusted period prevalence (%) | 0.16 | 0.17 | 0.16 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 729
- Matched controls
- 7068
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P07.3
ICD-10 Finland
Other preterm infants
+∞
323.0
587
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
38.7
238.9
312
134
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
+∞
140.9
132
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
159.1
139.3
145
11
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
583.9
106.4
104
*
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
+∞
88.4
84
*
P05.1
ICD-10 Finland
Small for gestational age
+∞
87.3
83
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
120.8
72.5
78
7
P07.1
ICD-10 Finland
Other low birth weight
+∞
69.1
66
*
P07.2
ICD-10 Finland
Extreme immaturity
+∞
64.9
62
*
602
Kela drug reimbursment
Children's severe malnutrition
10.3
60.4
126
141
P05.0
ICD-10 Finland
Light for gestational age
+∞
50.0
48
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
180.6
50.0
52
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
11.0
44.0
87
86
WX722
NOMESCO Finland
PEEP
11.0
40.7
80
78
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
+∞
40.5
39
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
6.6
40.3
111
188
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
32.5
40.1
53
17
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
32.2
31
*
Z38.3
ICD-10 Finland
Twin, born in hospital
86.4
30.6
34
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
52.3
30.2
36
7
R4110
NOMESCO Finland
Physiotherapy
2.7
25.9
226
1021
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
21.7
21
*
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
6.2
21.7
60
101
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
16.4
21.2
34
21
WX882
NOMESCO Finland
High dependency care
3.0
20.8
130
470
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
20.3
126
452
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
14.5
19.7
33
23
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
19.5
166
722
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
19.3
180
826
J45.1
ICD-10 Finland
Nonallergic asthma
2.9
19.2
131
498
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
5.7
18.9
55
99
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
17.6
17
*
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
36.6
17.4
22
6
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
17.1
123
482
WX730
NOMESCO Finland
Conventional respirator
10.4
17.0
33
32
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.3
16.9
65
159
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
16.6
281
1669
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
+∞
16.5
16
*
P07.0
ICD-10 Finland
Extremely low birth weight
+∞
16.5
16
*
Z3226
NOMESCO Finland
Physiotherapist
2.2
16.4
209
1102
E34.31
ICD-10 Finland
Short stature, prenatal disorder
9.5
16.2
33
35
Z2446
NOMESCO Finland
Social worker
2.3
16.1
175
856
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
10.1
15.7
31
31
P08.1
ICD-10 Finland
Other heavy for gestational age infants
+∞
15.5
15
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
7.7
15.2
35
46
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
4.4
15.0
55
128
RK520
NOMESCO Finland
NA
28.4
15.0
20
7
A11JC
ATC
Vitamins, other combinations
28.4
15.0
20
7
RK312
NOMESCO Finland
NA
13.0
15.0
26
20
XG413
NOMESCO Finland
Spirometry with oscillometry
4.7
14.4
49
106
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
14.1
223
1275
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
13.3
132
613
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
13.3
241
1444
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
12.7
88
335
P22.8
ICD-10 Finland
Other respiratory distress of newborn
10.4
12.6
24
23
R62.0
ICD-10 Finland
Delayed milestone
2.9
12.4
79
286
ZXE00
NOMESCO Finland
One hour or less
1.8
12.2
293
1921
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
12.0
201
1162
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
11.7
166
899
Z2221
NOMESCO Finland
Medical doctor
1.9
11.7
197
1138
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
16.2
11.5
18
11
6BB16
NOMESCO Finland
NA
29.6
11.5
15
5
WX732
NOMESCO Finland
High frequency respirator
118.2
11.3
12
*
Z3231
NOMESCO Finland
Registered nurse
1.7
10.9
283
1883
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
10.5
197
1180
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.4
10.2
86
366
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
15.8
10.2
16
10
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
10.5
10.1
19
18
RS220
NOMESCO Finland
NA
4.4
9.9
35
80
R03BA02
ATC
budesonide; inhalant
2.0
9.6
127
663
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
54.1
9.5
11
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.7
9.4
270
1832
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.9
9.3
139
763
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
9.2
126
669
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.1
133
725
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
6.6
9.0
22
33
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
9.0
155
894
Z94.0
ICD-10 Finland
Kidney transplant status
5.3
8.9
26
49
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
8.7
181
1111
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.3
8.6
17
18
ZXD05
NOMESCO Finland
Urgent procedure
1.8
8.6
157
921
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
4.3
8.6
31
73
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
49.1
8.6
10
*
RK410
NOMESCO Finland
NA
49.1
8.6
10
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.7
8.5
28
60
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
2.7
8.5
55
204
XA800
NOMESCO Finland
Neuropsychological investigation
2.2
8.4
84
388
137
Kela drug reimbursment
Uraemia requiring dialysis
6.8
8.4
20
29
P28.4
ICD-10 Finland
Other apnoea of newborn
27.0
8.4
11
*
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
8.2
8
*
P61.2
ICD-10 Finland
Anaemia of prematurity
+∞
8.2
8
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.8
8.1
22
38
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.3
8.1
75
336
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
8.1
85
405
RT150
NOMESCO Finland
NA
4.0
8.1
31
78
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.9
8.0
25
51
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
11.5
7.9
14
12
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
8.8
7.9
16
18
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
7.9
60
243
H66.9
ICD-10 Finland
Otitis media, unspecified
1.7
7.8
211
1391
A03FA02
ATC
cisapride; oral, rectal
3.2
7.8
39
122
R03AC02
ATC
salbutamol; inhalant
1.6
7.7
374
2857
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.9
7.7
30
77
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
9.3
7.6
15
16
WX704
NOMESCO Finland
Intubation
2.8
7.6
46
164
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.1
7.5
89
443
TPH07
NOMESCO Finland
Cathetrisation of artery
2.2
7.5
78
366
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
18.0
7.5
11
6
RK310
NOMESCO Finland
NA
8.7
7.4
15
17
WW500
NOMESCO Finland
Blood transfusion
3.2
7.4
37
116
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.2
7.4
78
372
XKC03
NOMESCO Finland
Water cystometry
6.1
7.4
19
31
ZX114
NOMESCO Finland
Intramuscular
4.0
7.4
28
70
WX725
NOMESCO Finland
Noninvasive ventilation
4.2
7.3
26
61
P77
ICD-10 Finland
Necrotizing enterocolitis of fetus and newborn
78.4
7.3
8
*
ZXA10
NOMESCO Finland
Bilateral
1.8
7.3
127
732
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.3
143
858
UDC00
NOMESCO Finland
Ear microscopy
2.1
7.2
77
369
A11CC03
ATC
alfacalcidol; systemic
4.0
7.1
27
68
KAC00
NOMESCO Finland
Nephrectomy
6.1
7.1
18
29
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.2
7.1
75
356
TJF80
NOMESCO Finland
Ostomy education
5.4
7.1
20
37
H50.31
ICD-10 Finland
Intermittent exotropia
3.3
7.1
34
104
7AA02
NOMESCO Finland
NA
29.4
7.1
9
*
P00.8
ICD-10 Finland
Fetus and newborn affected by other maternal conditions
19.6
7.0
10
5
R50.9
ICD-10 Finland
Fever, unspecified
1.7
6.9
171
1097
C08CA01
ATC
amlodipine; oral
3.4
6.9
31
90
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.4
6.8
59
254
RL140
NOMESCO Finland
NA
3.7
6.7
27
72
JF2AB
NOMESCO Finland
Colongraphy with X-ray
16.4
6.6
10
6
P59.9
ICD-10 Finland
Neonatal jaundice, unspecified
2.8
6.6
40
144
Z99.2
ICD-10 Finland
Dependence on renal dialysis
7.0
6.6
15
21
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
7.0
6.6
15
21
EMB30
NOMESCO Finland
Adenotomy
1.7
6.5
157
996
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
6.5
109
622
B03XA02
ATC
darbepoetin alfa; parenteral
12.0
6.5
11
9
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.8
6.4
38
134
P29.31
ICD-10 Finland
Persistent fetal circulation
9.8
6.4
12
12
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
6.4
92
494
H01AC01
ATC
somatropin; parenteral
2.8
6.4
38
135
R03BA05
ATC
fluticasone; inhalant
1.6
6.4
181
1204
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.4
111
639
B03XA01
ATC
erythropoietin; parenteral
6.1
6.3
16
26
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
5.2
6.3
18
34
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
5.6
6.3
17
30
P01.11
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes more than 7 days before delivery
+∞
6.2
6
*
A12AA04
ATC
calcium carbonate; oral
5.1
6.2
18
35
TJD20
NOMESCO Finland
Change of gastrostomy tube
4.1
6.1
22
53
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
6.1
52
223
FM2CE
NOMESCO Finland
NA
2.0
6.1
75
382
H53.0
ICD-10 Finland
Amblyopia ex anopsia
2.7
6.1
39
144
127
Kela drug reimbursment
Transplant complication
3.3
6.1
28
84
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
6.0
70
346
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
6.2
6.0
15
24
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
3.9
6.0
23
59
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
1.9
6.0
91
500
Mortality – FinRegistry
↥Association
Association between endpoint P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED | 3.516 [2.95, 4.19] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 21756 females with P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED | 2.27 [1.96, 2.63] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 236 out of 25440 males with P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED died.
Mortality risk
Mortality risk for people of age
years, who have P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.389% | 0.476% |
| 5 | 2.249% | 2.702% |
| 10 | 5.077% | 6.732% |
| 15 | 10.073% | 12.848% |
| 20 | 16.689% | 20.649% |
Relationships between endpoints
↥Index endpoint: P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED – Disorders related to short gestation and low birth weight, not elsewhere classified
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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