No definition available.
Disorders related to short gestation and low birth weight, not elsewhere classified
EFO MESH Endpoint Browser PheWeb
P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
846 |
4. Check minimum number of eventsNone |
846 |
5. Include endpointsNone |
846 |
6. Filter based on genotype QC (FinnGen only) |
846 |
Control definitions (FinnGen only)
- Control exclude
- P16_DISORD_RELATED_LENGTH_GESTATION_FETAL_GROWTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P0[5-8]
- Name in latin
- Perturbationes ad gestationem brevem et pondus partuale leve pertinentes non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders related to short gestation and low birth weight, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Disorders related to length of gestation and fetal growth
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 51969 | 23864 | 28104 |
| Only index persons | 27383 | 12581 | 14802 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.74 | 0.68 | 0.79 |
| Only index persons | 0.52 | 0.46 | 0.57 |
| Median age at first event (years) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 846 | 487 | 359 |
| Unadjusted period prevalence (%) | 0.16 | 0.17 | 0.16 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 729
- Matched controls
- 7068
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P07.3
ICD-10 Finland
Other preterm infants
+∞
323.0
587
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
38.7
238.9
312
134
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
+∞
140.9
132
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
159.1
139.3
145
11
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
583.9
106.4
104
*
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
+∞
88.4
84
*
P05.1
ICD-10 Finland
Small for gestational age
+∞
87.3
83
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
120.8
72.5
78
7
P07.1
ICD-10 Finland
Other low birth weight
+∞
69.1
66
*
P07.2
ICD-10 Finland
Extreme immaturity
+∞
64.9
62
*
602
Kela drug reimbursment
Children's severe malnutrition
10.3
60.4
126
141
P05.0
ICD-10 Finland
Light for gestational age
+∞
50.0
48
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
180.6
50.0
52
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
11.0
44.0
87
86
WX722
NOMESCO Finland
PEEP
11.0
40.7
80
78
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
+∞
40.5
39
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
6.6
40.3
111
188
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
32.5
40.1
53
17
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
32.2
31
*
Z38.3
ICD-10 Finland
Twin, born in hospital
86.4
30.6
34
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
52.3
30.2
36
7
R4110
NOMESCO Finland
Physiotherapy
2.7
25.9
226
1021
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
21.7
21
*
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
6.2
21.7
60
101
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
16.4
21.2
34
21
WX882
NOMESCO Finland
High dependency care
3.0
20.8
130
470
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
14.5
19.7
33
23
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
19.5
166
722
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
19.3
180
826
J45.1
ICD-10 Finland
Nonallergic asthma
2.9
19.2
131
498
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
5.7
18.9
55
99
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
17.6
17
*
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
36.6
17.4
22
6
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
17.1
123
482
WX730
NOMESCO Finland
Conventional respirator
10.4
17.0
33
32
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.3
16.9
65
159
P07.0
ICD-10 Finland
Extremely low birth weight
+∞
16.5
16
*
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
+∞
16.5
16
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
9.5
16.2
33
35
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
10.1
15.7
31
31
P08.1
ICD-10 Finland
Other heavy for gestational age infants
+∞
15.5
15
*
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
7.7
15.2
35
46
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
4.4
15.0
55
128
A11JC
ATC
Vitamins, other combinations
28.4
15.0
20
7
RK520
NOMESCO Finland
NA
28.4
15.0
20
7
RK312
NOMESCO Finland
NA
13.0
15.0
26
20
XG413
NOMESCO Finland
Spirometry with oscillometry
4.7
14.4
49
106
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
13.3
132
613
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
13.3
241
1444
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
12.7
88
335
P22.8
ICD-10 Finland
Other respiratory distress of newborn
10.4
12.6
24
23
R62.0
ICD-10 Finland
Delayed milestone
2.9
12.4
79
286
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
12.0
201
1162
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
11.7
166
899
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
16.2
11.5
18
11
6BB16
NOMESCO Finland
NA
29.6
11.5
15
5
WX732
NOMESCO Finland
High frequency respirator
118.2
11.3
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
10.5
197
1180
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.4
10.2
86
366
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
15.8
10.2
16
10
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
10.5
10.1
19
18
RS220
NOMESCO Finland
NA
4.4
9.9
35
80
R03BA02
ATC
budesonide; inhalant
2.0
9.6
127
663
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
54.1
9.5
11
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.7
9.4
270
1832
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
9.2
126
669
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.1
133
725
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
6.6
9.0
22
33
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
9.0
155
894
Z94.0
ICD-10 Finland
Kidney transplant status
5.3
8.9
26
49
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
8.7
181
1111
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.3
8.6
17
18
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
4.3
8.6
31
73
RK410
NOMESCO Finland
NA
49.1
8.6
10
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
49.1
8.6
10
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.7
8.5
28
60
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
2.7
8.5
55
204
XA800
NOMESCO Finland
Neuropsychological investigation
2.2
8.4
84
388
137
Kela drug reimbursment
Uraemia requiring dialysis
6.8
8.4
20
29
P28.4
ICD-10 Finland
Other apnoea of newborn
27.0
8.4
11
*
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
+∞
8.2
8
*
P61.2
ICD-10 Finland
Anaemia of prematurity
+∞
8.2
8
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.8
8.1
22
38
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
8.1
85
405
RT150
NOMESCO Finland
NA
4.0
8.1
31
78
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.9
8.0
25
51
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
11.5
7.9
14
12
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
8.8
7.9
16
18
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
7.9
60
243
H66.9
ICD-10 Finland
Otitis media, unspecified
1.7
7.8
211
1391
A03FA02
ATC
cisapride; oral, rectal
3.2
7.8
39
122
R03AC02
ATC
salbutamol; inhalant
1.6
7.7
374
2857
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.9
7.7
30
77
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
9.3
7.6
15
16
WX704
NOMESCO Finland
Intubation
2.8
7.6
46
164
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.1
7.5
89
443
TPH07
NOMESCO Finland
Cathetrisation of artery
2.2
7.5
78
366
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
18.0
7.5
11
6
RK310
NOMESCO Finland
NA
8.7
7.4
15
17
WW500
NOMESCO Finland
Blood transfusion
3.2
7.4
37
116
XKC03
NOMESCO Finland
Water cystometry
6.1
7.4
19
31
ZX114
NOMESCO Finland
Intramuscular
4.0
7.4
28
70
WX725
NOMESCO Finland
Noninvasive ventilation
4.2
7.3
26
61
P77
ICD-10 Finland
Necrotizing enterocolitis of fetus and newborn
78.4
7.3
8
*
ZXA10
NOMESCO Finland
Bilateral
1.8
7.3
127
732
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
7.3
143
858
UDC00
NOMESCO Finland
Ear microscopy
2.1
7.2
77
369
A11CC03
ATC
alfacalcidol; systemic
4.0
7.1
27
68
KAC00
NOMESCO Finland
Nephrectomy
6.1
7.1
18
29
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.2
7.1
75
356
TJF80
NOMESCO Finland
Ostomy education
5.4
7.1
20
37
H50.31
ICD-10 Finland
Intermittent exotropia
3.3
7.1
34
104
7AA02
NOMESCO Finland
NA
29.4
7.1
9
*
P00.8
ICD-10 Finland
Fetus and newborn affected by other maternal conditions
19.6
7.0
10
5
R50.9
ICD-10 Finland
Fever, unspecified
1.7
6.9
171
1097
C08CA01
ATC
amlodipine; oral
3.4
6.9
31
90
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.4
6.8
59
254
RL140
NOMESCO Finland
NA
3.7
6.7
27
72
JF2AB
NOMESCO Finland
Colongraphy with X-ray
16.4
6.6
10
6
P59.9
ICD-10 Finland
Neonatal jaundice, unspecified
2.8
6.6
40
144
Z99.2
ICD-10 Finland
Dependence on renal dialysis
7.0
6.6
15
21
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
7.0
6.6
15
21
EMB30
NOMESCO Finland
Adenotomy
1.7
6.5
157
996
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
6.5
109
622
B03XA02
ATC
darbepoetin alfa; parenteral
12.0
6.5
11
9
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.8
6.4
38
134
P29.31
ICD-10 Finland
Persistent fetal circulation
9.8
6.4
12
12
H01AC01
ATC
somatropin; parenteral
2.8
6.4
38
135
R03BA05
ATC
fluticasone; inhalant
1.6
6.4
181
1204
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.4
111
639
B03XA01
ATC
erythropoietin; parenteral
6.1
6.3
16
26
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
5.2
6.3
18
34
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
5.6
6.3
17
30
P01.11
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes more than 7 days before delivery
+∞
6.2
6
*
A12AA04
ATC
calcium carbonate; oral
5.1
6.2
18
35
TJD20
NOMESCO Finland
Change of gastrostomy tube
4.1
6.1
22
53
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
6.1
52
223
FM2CE
NOMESCO Finland
NA
2.0
6.1
75
382
H53.0
ICD-10 Finland
Amblyopia ex anopsia
2.7
6.1
39
144
127
Kela drug reimbursment
Transplant complication
3.3
6.1
28
84
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.1
6.0
70
346
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
6.2
6.0
15
24
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
3.9
6.0
23
59
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
52
5.17
12.92
8.3
8.0
—
—
—
0
0
28
61
4.57
11.64
7.5
6.7
—
—
—
0
0
28
61
4.57
11.64
7.1
6.5
—
—
—
0
0
27
69
3.89
9.18
11.9
9.3
—
—
—
0
0
125
737
1.76
7.17
5.1
3.3
21.7
21.8
%
0.04
119
700
199
1337
1.58
6.88
16.9
11.4
1.4
1.3
mmol/l
2.32
193
1279
186
1237
1.59
6.70
3.3
3.7
—
—
—
0
0
37
140
2.63
6.70
4.9
4.4
24.3
24.0
umol/l
0.05
37
140
129
791
1.69
6.41
4.9
3.1
2.6
2.6
g/l
0.34
124
755
207
1425
1.54
6.38
22.3
9.6
0.9
0.9
mmol/l
0.04
152
1022
207
1429
1.54
6.29
22.5
9.6
5.1
5.0
kpa
2.44
201
1380
51
234
2.18
6.08
13.5
10.8
806.9
350.0
iu/ml
—
8
35
189
1316
1.51
5.44
21.8
9.5
9.5
9.7
kpa
0.67
182
1271
43
196
2.19
5.24
2.0
2.0
—
—
—
0
0
45
209
2.15
5.24
15.9
12.3
81.2
296.2
u/ml
1.49
11
25
134
872
1.58
5.23
16.4
13.4
0.8
0.8
mmol/l
0.48
128
842
51
252
2.02
5.06
2.5
2.3
—
—
—
0
0
51
254
2.01
4.96
1.8
1.4
—
—
—
0
0
51
254
2.01
4.96
1.8
1.4
—
—
—
0
0
135
891
1.56
4.95
5.0
3.1
13.6
14.0
umol/l
0.16
128
859
29
115
2.50
4.84
3.4
3.4
17.8
17.8
%
0.03
21
71
42
197
2.12
4.79
1.9
2.1
—
—
—
0
0
8
7
11.17
4.70
8.6
1.3
—
—
—
0
0
88
534
1.67
4.55
13.3
8.3
51.2
51.4
ng/l
0.02
88
522
343
2735
1.36
4.52
23.9
13.0
1.2
1.2
mmol/l
0.33
328
2617
126
846
1.52
4.26
21.8
14.2
5.7
5.1
mmol/l
1.15
121
833
354
2859
1.35
4.21
23.3
12.0
1.2
1.2
mmol/l
0.05
326
2652
136
935
1.49
4.11
2.5
5.1
1.8
1.8
mg/l
0.04
88
633
48
251
1.91
4.10
2.4
2.2
—
—
—
0
0
121
813
1.52
4.08
1.6
1.5
167.5
359.4
u/ml
2.05
109
771
7
7
9.76
3.93
1.9
3.7
—
—
—
0
0
15
47
3.13
3.85
2.0
1.9
2.5
1.4
mg/l
0.26
15
40
15
47
3.13
3.85
2.0
1.9
2.1
6.5
mg/l
2.36
15
37
15
47
3.13
3.85
2.0
1.9
0.8
1.3
mg/l
1.09
15
42
15
47
3.13
3.85
2.0
1.9
2.9
3.8
mg/l
—
10
37
45
239
1.87
3.69
16.6
9.8
23.1
22.9
mmol/l
0.17
45
223
182
1354
1.39
3.57
4.0
2.8
2.4
2.4
mmol/l
0.12
173
1236
104
703
1.50
3.41
1.5
1.4
20.4
18.7
nmol/l
0.54
87
633
29
136
2.10
3.37
5.5
5.6
2.5
2.3
ug/l
0.18
29
136
22
92
2.35
3.35
4.2
5.3
—
—
—
0
0
252
1990
1.32
3.33
8.0
8.4
32.9
22.3
umol/l
2.17
231
1819
16
57
2.75
3.33
10.4
3.2
130.0
158.6
umol/l
0.59
11
27
7
10
6.83
3.29
1.4
3.2
—
—
—
0
0
33
165
1.98
3.25
1.9
1.7
—
—
—
0
0
134
965
1.41
3.16
3.6
7.3
31.4
31.4
s
0.05
134
955
114
801
1.44
3.08
2.6
2.1
—
—
—
0
0
98
670
1.47
3.05
23.4
19.9
1.1
1.0
mg/l
1.70
98
659
372
3132
1.27
2.94
10.7
7.4
5.9
5.9
mmol/l
0.00
350
2934
35
186
1.86
2.91
1.9
1.9
—
—
—
0
0
78
514
1.52
2.91
10.9
12.3
106.2
105.7
mmol/l
0.50
78
509
73
481
1.52
2.74
3.2
8.6
2.8
2.7
g/l
0.09
67
474
188
2233
0.76
2.72
2.4
2.6
—
—
—
0
0
88
606
1.46
2.66
2.6
2.0
—
—
—
0
0
384
3275
1.25
2.63
7.6
5.6
141.1
119.4
u/l
3.38
371
3078
88
612
1.44
2.54
2.8
2.1
—
—
—
0
0
170
1316
1.32
2.53
10.7
9.9
23.7
23.6
mmol/l
0.25
164
1285
72
484
1.48
2.47
2.9
1.9
—
—
—
0
0
71
478
1.48
2.42
2.9
1.9
206.8
163.1
u/ml
0.39
34
222
70
472
1.48
2.37
1.5
1.4
547.7
15952827.2
pmol/l
0.50
62
420
165
1291
1.30
2.27
6.1
3.6
6.6
6.8
e6/l
0.06
137
1138
34
195
1.72
2.26
1.2
2.8
—
—
—
0
0
44
271
1.61
2.24
2.8
2.2
—
—
—
0
0
10
35
2.79
2.18
1.9
4.1
—
—
—
0
0
178
1414
1.28
2.18
14.0
10.3
1.0
1.1
mmol/l
0.11
145
1116
248
2052
1.24
2.14
4.5
4.4
—
—
—
0
0
181
2104
0.79
2.14
2.3
2.5
—
—
—
0
0
25
134
1.83
2.09
6.7
6.6
69.4
17.7
u/ml
0.68
25
126
171
1365
1.27
2.01
13.0
10.2
5.2
5.1
kpa
0.11
165
1338
22
115
1.88
1.99
1.0
1.1
—
—
—
0
0
177
1421
1.26
1.98
14.1
10.3
5.7
5.8
kpa
1.28
172
1387
6
15
3.90
1.98
1.0
1.0
—
—
—
0
0
97
719
1.35
1.96
7.7
7.9
6.0
6.2
umol/l
0.10
83
598
8
26
3.00
1.94
1.6
6.4
—
—
—
0
0
119
1441
0.77
1.94
2.0
2.3
—
—
—
0
0
6
16
3.65
1.88
1.0
1.4
—
—
—
0
0
42
269
1.54
1.86
6.1
7.2
203.5
226.5
ng/l
0.10
35
246
51
342
1.47
1.83
3.8
2.2
72.5
82.0
u/ml
—
5
20
275
2337
1.21
1.80
5.6
3.4
69.8
67.1
nmol/l
0.90
261
2220
101
1236
0.76
1.78
1.8
2.1
—
—
—
0
0
109
834
1.31
1.78
3.5
2.7
320.4
349.5
nmol/l
0.78
104
800
6
17
3.44
1.78
1.0
1.4
—
—
—
0
0
14
65
2.11
1.75
1.5
1.8
—
—
—
0
0
83
614
1.34
1.72
12.3
14.7
1.2
1.4
mmol/l
0.95
78
551
28
166
1.66
1.70
2.8
1.9
—
—
—
0
0
6
18
3.25
1.69
2.2
1.6
236.8
149.9
nmol/l
—
6
18
12
53
2.21
1.69
1.4
1.4
—
—
—
0
0
38
245
1.53
1.65
8.2
5.8
1.2
1.2
mmol/l
0.13
33
216
76
561
1.34
1.61
2.4
2.2
5.9
6.0
u/l
0.04
57
361
29
178
1.60
1.56
1.7
1.4
5.3
5.0
umol/l
0.23
29
160
29
178
1.60
1.56
14.9
8.1
56.2
57.2
%
0.08
29
173
0
41
0.00
1.53
0.0
1.1
—
—
—
0
0
221
1871
1.20
1.48
6.6
4.3
0.5
0.2
e6/l
0.38
170
1372
66
484
1.35
1.47
2.5
2.2
8.7
6.9
iu/l
0.46
50
316
20
113
1.73
1.47
1.8
1.9
—
—
—
0
0
597
5491
1.19
1.45
20.2
12.2
4.0
3.9
mmol/l
3.12
581
5308
61
444
1.36
1.43
2.0
2.2
8.9
8.7
nmol/l
0.05
54
345
46
319
1.42
1.43
10.7
14.1
-0.5
-0.3
mmol/l
0.11
36
246
25
372
0.64
1.40
1.2
1.1
5.7
10.4
u/ml
0.77
14
223
24
145
1.62
1.40
1.8
1.3
342.9
384.3
ug/g
0.47
16
69
247
2123
1.18
1.38
7.7
4.5
—
—
—
0
0
39
264
1.45
1.38
1.4
1.5
—
—
—
0
0
45
594
0.72
1.35
1.2
1.2
5.2
4.0
u/ml
0.12
15
207
142
1162
1.22
1.35
1.8
1.5
103.6
98.1
pmol/l
0.54
64
626
0
36
0.00
1.35
0.0
1.1
—
—
—
0
0
9
41
2.14
1.32
1.4
1.9
—
—
—
0
0
9
41
2.14
1.32
1.4
1.9
—
—
—
0
0
9
41
2.14
1.32
1.4
1.9
—
—
—
0
0
596
5499
1.17
1.32
20.2
12.2
139.4
139.4
mmol/l
0.10
583
5340
0
40
0.00
1.31
0.0
1.1
—
—
—
0
0
46
597
0.73
1.26
1.2
1.3
—
—
—
0
0
8
35
2.23
1.24
1.3
1.2
—
—
—
0
0
52
658
0.75
1.21
1.2
1.2
3.0
3.0
u/ml
0.00
36
418
42
297
1.39
1.20
2.2
1.7
—
—
—
0
0
147
1222
1.20
1.20
5.3
3.8
2.9
3.3
e6/l
0.16
94
693
8
37
2.11
1.18
1.1
1.9
—
—
—
0
0
23
332
0.66
1.15
1.1
1.1
2.1
0.4
u/ml
0.37
12
145
449
4080
1.14
1.15
11.7
10.9
3.4
3.5
e9/l
0.07
382
3401
0
35
0.00
1.14
0.0
1.1
—
—
—
0
0
16
92
1.70
1.14
7.2
11.4
10.3
9.2
mg/l
0.30
16
86
143
1194
1.19
1.12
5.1
3.7
0.9
1.0
e6/l
0.14
89
664
8
39
2.00
1.11
20.1
11.7
668.8
699.5
nmol/l
—
8
39
5
20
2.43
1.11
2.4
2.0
—
—
—
0
0
67
518
1.28
1.08
6.2
7.6
1813.7
1152.0
ng/l
0.55
59
430
6
120
0.48
1.06
1.0
1.6
—
—
—
0
0
42
305
1.35
1.05
1.5
1.6
1433.0
1018.5
nmol/l
1.95
33
238
7
33
2.06
1.02
1.4
1.2
—
—
—
0
0
63
756
0.79
1.01
1.2
1.2
—
50.0
—
0
8
36
465
0.74
0.99
1.4
1.5
—
—
—
0
0
17
104
1.60
0.99
1.2
1.2
—
—
—
0
0
10
169
0.57
0.98
1.9
1.4
—
—
—
0
0
21
297
0.68
0.98
1.1
1.1
5.0
8.2
u/ml
—
5
35
23
152
1.48
0.97
5.8
4.5
432.8
436.6
umol/l
0.03
23
144
0
31
0.00
0.95
0.0
1.5
—
2.1
—
0
26
16
238
0.64
0.95
1.7
1.7
—
—
—
0
0
31
406
0.73
0.94
1.1
1.1
9.6
6.8
u/ml
0.18
15
227
23
311
0.71
0.86
1.2
1.4
—
—
—
0
0
351
3183
1.12
0.86
4.0
3.2
51.4
55.2
ug/l
0.18
335
3026
0
23
0.00
0.79
0.0
1.1
—
—
—
0
0
185
1626
1.13
0.76
3.7
3.2
2.9
2.7
mg/l
0.70
168
1460
16
224
0.69
0.74
1.9
1.8
—
—
—
0
0
9
54
1.62
0.73
12.9
10.5
1.3
1.2
mmol/l
—
9
47
14
89
1.53
0.73
1.4
1.3
—
—
—
0
0
48
379
1.24
0.70
1.0
1.0
9.5
8.7
mu/l
0.32
43
329
9
56
1.56
0.70
2.6
2.0
1.0
0.8
ug/l
—
9
47
21
147
1.39
0.70
2.4
1.9
—
—
—
0
0
18
123
1.43
0.68
1.7
1.8
2.7
4.9
iu/l
—
8
45
7
41
1.66
0.68
1.0
1.0
—
—
—
0
0
643
6067
1.12
0.67
19.8
14.9
13.3
13.1
%
1.94
627
5949
37
286
1.27
0.66
3.0
2.0
—
—
—
0
0
10
60
1.62
0.65
19.8
10.7
1.2
1.2
mmol/l
—
10
55
8
126
0.61
0.64
1.0
1.1
—
—
—
0
0
5
28
1.73
0.64
1.2
1.1
—
—
—
0
0
281
2556
1.10
0.62
7.3
4.9
0.0
0.0
estimate
0.00
52
464
282
2567
1.10
0.62
5.3
3.3
0.0
0.0
estimate
0.00
47
437
0
19
0.00
0.60
0.0
1.1
—
0.0
—
0
11
37
290
1.25
0.60
1.0
1.0
3.0
3.3
kpa
0.64
31
244
18
235
0.74
0.59
1.3
1.5
—
—
—
0
0
12
78
1.50
0.58
1.2
1.4
—
—
—
0
0
161
1429
1.11
0.58
5.9
4.7
8.2
8.7
mmol/l
0.42
152
1352
14
95
1.44
0.56
1.3
1.3
—
—
—
0
0
37
293
1.23
0.56
1.0
1.0
-1.2
-2.5
mmol/l
—
10
68
37
293
1.23
0.56
1.0
1.0
7.4
7.2
kpa
0.15
31
247
9
58
1.51
0.54
1.3
1.2
—
—
—
0
0
9
59
1.48
0.54
1.3
1.2
—
—
—
0
0
19
138
1.34
0.54
4.8
4.5
51.8
51.2
%
0.07
19
138
176
1577
1.10
0.53
3.8
5.2
34.3
34.1
u/l
0.02
170
1515
30
233
1.26
0.53
13.6
18.0
0.7
0.8
%
0.15
30
233
38
304
1.22
0.53
1.1
1.3
266.8
225.1
miu/ml
0.33
19
131
6
96
0.60
0.52
1.3
3.7
—
—
—
0
0
6
96
0.60
0.52
1.3
3.7
—
—
—
0
0
35
410
0.82
0.51
1.6
1.8
—
—
—
0
0
548
5167
1.08
0.48
4.2
3.7
2.1
2.0
mu/l
0.93
512
4875
52
583
0.86
0.48
1.2
1.2
2.5
8.1
u/ml
1.10
17
162
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
7
45
1.51
0.48
1.0
1.2
—
55.7
—
0
10
25
193
1.26
0.48
4.9
3.2
80.4
91.7
ml/min/173m2
—
9
56
143
1277
1.10
0.47
6.3
3.4
0.0
0.0
estimate
0.00
48
435
7
46
1.48
0.47
1.0
1.2
—
82.0
—
0
10
14
99
1.38
0.47
1.1
1.2
—
—
—
0
0
279
2569
1.08
0.46
5.4
3.4
0.0
0.0
estimate
0.00
53
455
5
81
0.60
0.46
1.0
1.0
—
—
—
0
0
43
356
1.18
0.44
2.2
2.0
—
—
—
0
0
20
152
1.28
0.44
1.8
1.7
—
—
—
0
0
18
135
1.30
0.43
4.7
4.0
3.5
3.4
e9/l
0.11
18
135
280
2844
0.93
0.43
1.7
1.8
4.0
3.4
u/ml
0.12
56
525
16
118
1.32
0.43
1.4
1.2
—
—
—
0
0
603
5720
1.08
0.42
10.1
8.7
27.0
25.1
u/l
0.72
584
5527
89
782
1.12
0.41
2.6
2.2
12.0
57.1
ng/l
2.15
45
241
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
16
119
1.31
0.41
1.4
1.2
61.8
78.1
%
1.15
16
119
130
1166
1.10
0.41
3.2
2.9
56.6
55.6
u/l
0.06
125
1084
14
102
1.34
0.40
1.1
1.3
10.2
3.0
u/ml
—
6
60
759
7274
1.12
0.40
20.8
15.6
134.3
133.1
g/l
1.48
746
7159
337
3394
0.94
0.40
2.0
2.0
—
—
—
0
0
17
209
0.78
0.40
1.1
1.3
8.3
4.2
mg/l
0.53
11
132
0
18
0.00
0.39
0.0
1.6
—
55.8
—
0
18
5
34
1.43
0.39
3.2
3.1
—
—
—
0
0
5
35
1.39
0.38
1.0
1.2
—
—
—
0
0
19
228
0.80
0.37
1.2
1.3
—
—
—
0
0
20
238
0.81
0.37
1.8
1.5
0.0
0.0
iu/ml
—
5
64
57
619
0.88
0.37
1.2
1.2
11.3
25.8
iu/ml
0.81
11
125
14
174
0.78
0.36
1.2
1.9
—
—
—
0
0
28
321
0.84
0.36
1.1
1.2
—
—
—
0
0
6
40
1.46
0.36
1.3
1.3
—
—
—
0
0
6
41
1.42
0.35
1.0
1.1
—
78.5
ng/l
—
0
8
46
505
0.88
0.35
1.2
1.2
—
—
—
0
0
6
43
1.35
0.34
3.0
1.7
—
—
—
0
0
21
167
1.22
0.34
2.5
2.0
—
—
—
0
0
193
1780
1.07
0.31
5.3
3.0
—
—
—
0
0
19
151
1.22
0.31
11.9
7.0
1.0
1.2
inr
—
5
30
11
81
1.32
0.31
3.1
1.7
—
—
—
0
0
358
3573
0.95
0.30
6.8
3.8
538.2
226.7
e6/l
0.25
12
47
321
3209
0.95
0.29
3.4
2.5
1.3
1.4
mmol/l
2.61
300
3024
12
91
1.28
0.28
1.0
1.0
—
—
—
0
0
357
3368
1.05
0.26
8.1
6.0
115.7
114.8
ml/min/173m2
0.30
226
2154
14
110
1.24
0.26
2.4
1.6
—
—
—
0
0
22
182
1.18
0.25
1.2
1.1
—
—
—
0
0
10
123
0.79
0.25
1.1
1.3
4.6
7.0
u/ml
—
10
107
99
901
1.07
0.25
1.7
1.8
1.3
1.2
mmol/l
0.54
92
833
332
3305
0.96
0.24
3.6
2.7
4.2
4.3
mmol/l
0.42
312
3135
17
138
1.20
0.24
1.4
1.2
—
44.8
—
0
5
11
85
1.26
0.23
1.4
1.3
—
—
—
0
0
325
3231
0.96
0.22
3.4
2.5
2.6
2.6
mmol/l
0.18
304
3024
27
231
1.14
0.22
1.3
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
2.3
—
0
11
703
6871
0.95
0.21
4.1
3.9
—
—
—
0
0
17
192
0.86
0.21
1.1
1.1
—
—
—
0
0
69
715
0.93
0.21
1.2
1.3
—
—
—
0
0
21
177
1.15
0.20
1.2
1.1
—
—
—
0
0
0
13
0.00
0.20
0.0
1.5
—
—
—
0
0
0
13
0.00
0.20
0.0
2.2
—
—
—
0
0
0
13
0.00
0.20
0.0
3.8
—
12.8
—
0
7
0
13
0.00
0.20
0.0
1.0
—
—
—
0
0
55
494
1.08
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
4.4
—
—
—
0
0
324
3069
1.04
0.19
3.4
2.5
1.2
1.1
mmol/l
1.23
311
2910
660
6337
1.04
0.18
15.1
10.6
20.8
23.1
mg/l
1.03
479
4270
14
115
1.18
0.18
2.3
2.4
—
—
—
0
0
27
235
1.12
0.18
5.8
5.4
18.1
12.1
umol/l
0.65
27
203
5
67
0.72
0.17
1.2
1.6
12.5
8.7
umol/l
—
5
67
13
107
1.18
0.16
1.2
1.3
10.0
3.9
u/ml
—
7
54
8
67
1.16
0.16
1.0
1.0
—
—
—
0
0
8
68
1.14
0.16
3.5
1.7
—
—
—
0
0
28
298
0.91
0.16
1.1
1.1
—
—
—
0
0
9
78
1.12
0.15
1.1
1.1
—
—
—
0
0
62
568
1.06
0.15
1.4
1.3
276.3
152.5
iu/ml
0.79
19
181
411
3924
1.03
0.14
5.4
4.2
6.9
7.2
mm/h
0.32
386
3636
7
86
0.79
0.14
1.1
1.2
—
—
—
0
0
684
6582
1.04
0.14
16.9
14.0
39.5
39.3
%
0.64
610
5849
19
205
0.90
0.13
1.5
1.5
—
—
—
0
0
23
204
1.10
0.11
3.1
3.4
—
—
—
0
0
24
252
0.92
0.11
1.7
4.2
3.1
3.3
mmol/l
0.38
24
242
52
480
1.05
0.10
1.3
1.3
—
—
—
0
0
80
748
1.04
0.10
3.1
2.3
11516.6
6286.3
u/l
0.49
21
202
5
43
1.13
0.10
1.6
1.3
—
—
—
0
0
5
43
1.13
0.10
1.6
1.3
—
—
—
0
0
5
43
1.13
0.10
1.6
1.3
—
—
—
0
0
5
43
1.13
0.10
1.6
1.3
—
—
—
0
0
5
44
1.10
0.09
1.6
1.3
—
—
—
0
0
5
45
1.08
0.09
1.6
1.3
—
—
—
0
0
5
46
1.05
0.09
3.2
2.7
21.5
18.8
umol/l
—
5
46
5
46
1.05
0.09
1.2
1.2
207.2
252.8
iu/ml
—
5
46
61
568
1.04
0.09
2.0
2.0
—
—
—
0
0
6
53
1.10
0.09
1.3
1.4
—
—
—
0
0
6
57
1.02
0.08
1.0
1.1
247.0
281.9
mg/l
—
6
57
288
2825
0.98
0.08
4.6
4.4
29.3
24.9
u/l
1.14
274
2719
70
657
1.04
0.07
3.3
3.9
1905.2
1346.6
ng/l
0.21
35
358
6
68
0.85
0.07
2.3
2.9
7.0
49.0
u/ml
—
6
59
8
74
1.05
0.07
1.0
1.2
—
—
—
0
0
8
74
1.05
0.07
1.0
1.2
—
—
—
0
0
8
75
1.03
0.07
1.0
1.2
—
—
—
0
0
8
75
1.03
0.07
1.0
1.2
—
—
—
0
0
8
75
1.03
0.07
1.0
1.2
—
—
—
0
0
298
2856
1.02
0.07
3.8
2.9
35.4
35.8
mmol/mol
0.22
277
2694
10
86
1.13
0.07
1.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
83
1.05
0.07
1.4
1.2
—
—
—
0
0
9
86
1.01
0.07
1.1
1.4
—
—
—
0
0
38
384
0.96
0.06
1.6
1.9
—
—
—
0
0
9
98
0.89
0.06
1.0
1.1
—
—
—
0
0
9
101
0.86
0.06
1.7
1.5
6.0
7.4
u/l
—
9
90
483
4654
1.01
0.05
3.7
3.3
14.5
14.4
pmol/l
0.55
436
4149
17
176
0.93
0.05
1.5
1.4
—
—
—
0
0
17
176
0.93
0.05
1.5
1.4
—
—
—
0
0
17
176
0.93
0.05
1.5
1.4
—
—
—
0
0
17
176
0.93
0.05
1.5
1.4
—
—
—
0
0
358
3494
0.99
0.05
2.6
2.1
5.4
5.3
mmol/l
0.63
318
3209
17
155
1.06
0.04
1.6
1.4
—
—
—
0
0
28
261
1.04
0.03
1.7
4.2
401.2
399.5
mg/l
0.01
28
256
86
844
0.99
0.02
1.8
1.5
1.4
1.3
%
0.39
81
772
133
1300
0.99
0.02
5.1
2.8
1.0
1.0
kg/l
0.94
26
239
13
119
1.06
0.02
1.1
1.2
—
—
—
0
0
22
206
1.04
0.01
3.0
3.2
751.5
532.2
e6/l
0.97
22
141
29
274
1.03
0.01
1.2
1.3
—
—
—
0
0
11
113
0.94
0.01
1.1
1.3
2.6
16.4
u/ml
2.25
11
101
22
208
1.03
0.00
3.0
3.2
0.2
0.2
e9/l
0.36
22
142
14
131
1.04
0.00
2.8
2.5
1.2
2.1
mmol/l
—
9
105
13
127
0.99
0.00
2.7
1.6
—
—
—
0
0
22
210
1.02
0.00
3.1
3.3
8.9
9.4
%
0.12
22
192
12
119
0.98
0.00
2.6
2.5
—
—
—
0
0
18
175
1.00
0.00
1.7
2.0
—
—
—
0
0
18
175
1.00
0.00
1.5
1.6
10.9
6.1
ug/l
0.41
18
160
26
250
1.01
0.00
1.8
4.4
47.6
10.8
e6/l
0.42
20
180
93
902
1.00
0.00
1.1
1.1
—
—
—
0
0
31
301
1.00
0.00
7.2
2.8
—
—
—
0
0
12
121
0.96
0.00
1.0
1.3
—
—
—
0
0
8
84
0.92
0.00
1.1
1.1
191.3
202.1
mg/l
—
8
78
0
5
0.00
0.00
0.0
2.6
—
24.2
—
0
5
0
8
0.00
0.00
0.0
2.5
—
51.8
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
67
1.01
0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
58
1.00
0.00
1.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
20.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
74
0.92
0.00
1.6
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
20.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
9
95
0.92
0.00
2.2
1.6
—
—
—
0
0
5
49
0.99
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED | 3.516 [2.95, 4.19] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 21756 females with P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED | 2.27 [1.96, 2.63] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 236 out of 25440 males with P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED died.
Mortality risk
Mortality risk for people of age
years, who have P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.389% | 0.476% |
| 5 | 2.249% | 2.702% |
| 10 | 5.077% | 6.732% |
| 15 | 10.073% | 12.848% |
| 20 | 16.689% | 20.649% |
Relationships between endpoints
↥Index endpoint: P16_DISORD_RELATED_GESTATION_LOW_BIRTHWGHTT_NECIFIED – Disorders related to short gestation and low birth weight, not elsewhere classified
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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