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Disorders related to length of gestation and fetal growth

P16_DISORD_RELATED_LENGTH_GESTATION_FETAL_GROWTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P05-P08
  • Cause of death: ICD-10 P05-P08

2 out of 7 registries used, show all original rules.

991

4. Check minimum number of events

None

991

5. Include endpoints

991

6. Filter based on genotype QC (FinnGen only)

991

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Perturbationes ad longitudinem gestationis et crescendum fetus pertinentes

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 991 578 413
Unadjusted period prevalence (%) 0.19 0.20 0.18
Median age at first event (years) 0.00 0.00 0.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
853
Matched controls
8108
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P07.3
ICD-10 Finland
Other preterm infants
+∞
323.0
587
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
34.1
251.5
341
155
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
+∞
139.0
132
*
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
140.2
138.3
147
12
P05.1
ICD-10 Finland
Small for gestational age
+∞
121.7
116
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
224.5
100.9
104
5
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
+∞
87.4
84
*
P05.0
ICD-10 Finland
Light for gestational age
+∞
79.0
76
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
137.5
73.7
79
6
P07.1
ICD-10 Finland
Other low birth weight
+∞
68.4
66
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
13.5
65.1
118
95
P07.2
ICD-10 Finland
Extreme immaturity
+∞
64.2
62
*
602
Kela drug reimbursment
Children's severe malnutrition
9.2
58.3
129
153
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
175.0
49.4
52
*
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
28.6
42.9
59
21
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
6.3
42.0
119
202
WX722
NOMESCO Finland
PEEP
10.1
41.1
85
88
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
+∞
40.2
39
*
P08.0
ICD-10 Finland
Exceptionally large baby
+∞
39.1
38
*
P08.1
ICD-10 Finland
Other heavy for gestational age infants
+∞
37.1
36
*
Z38.3
ICD-10 Finland
Twin, born in hospital
62.8
32.5
38
6
H35.1
ICD-10 Finland
Retinopathy of prematurity
307.8
30.4
31
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
39.6
28.5
36
9
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
19.5
28.1
43
22
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
6.8
27.3
71
106
R4110
NOMESCO Finland
Physiotherapy
2.5
25.6
251
1160
WX882
NOMESCO Finland
High dependency care
3.2
24.5
146
498
P07.02
ICD-10 Finland
Extremely low birth weight 750-999 g
+∞
21.5
21
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
11.7
21.4
40
34
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
20.3
138
509
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
19.4
202
946
J45.1
ICD-10 Finland
Nonallergic asthma
2.8
19.0
138
529
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
18.5
136
526
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
11.1
18.5
35
31
Z3226
NOMESCO Finland
Physiotherapist
2.2
18.1
235
1216
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
5.0
17.9
59
119
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
17.8
179
819
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
17.5
321
1904
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
17.4
17
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
4.1
17.4
70
173
Z2446
NOMESCO Finland
Social worker
2.3
17.3
193
929
RK312
NOMESCO Finland
NA
19.5
17.3
26
13
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
7.9
17.0
39
49
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
16.7
259
1432
XG413
NOMESCO Finland
Spirometry with oscillometry
5.0
16.7
55
111
R62.0
ICD-10 Finland
Delayed milestone
3.2
16.6
93
301
P07.0
ICD-10 Finland
Extremely low birth weight
+∞
16.4
16
*
A11JC
ATC
Vitamins, other combinations
34.0
16.3
21
6
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
26.8
16.1
22
8
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
16.1
281
1625
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
9.0
15.7
33
36
FDE00
NOMESCO Finland
Closure of patent ductus arteriosus
154.7
15.2
16
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
3.9
14.7
62
160
P22.8
ICD-10 Finland
Other respiratory distress of newborn
13.5
14.6
25
18
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
14.5
148
678
RK520
NOMESCO Finland
NA
24.3
14.3
20
8
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
14.0
100
378
WX730
NOMESCO Finland
Conventional respirator
7.4
13.9
33
44
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
12.9
190
1015
Z3231
NOMESCO Finland
Registered nurse
1.7
12.3
320
2077
P08.2
ICD-10 Finland
Post-term infant, not heavy for gestational age
+∞
12.3
12
*
Z2221
NOMESCO Finland
Medical doctor
1.9
12.3
220
1265
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
12.0
225
1311
ZXE00
NOMESCO Finland
One hour or less
1.7
11.8
335
2223
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
17.4
11.7
18
10
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
11.6
177
958
WX732
NOMESCO Finland
High frequency respirator
115.5
11.2
12
*
XA800
NOMESCO Finland
Neuropsychological investigation
2.4
10.9
96
408
6BB16
NOMESCO Finland
NA
24.1
10.9
15
6
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.0
10.8
157
830
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
7.2
10.6
25
34
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
10.5
224
1354
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.2
10.4
20
19
P52.0
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn
57.7
10.4
12
*
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
12.4
10.3
18
14
137
Kela drug reimbursment
Uraemia requiring dialysis
7.7
10.2
23
29
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
8.9
10.2
21
23
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
15.5
10.1
16
10
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
5.0
9.9
31
61
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
2.8
9.9
62
218
P21.1
ICD-10 Finland
Mild and moderate birth asphyxia
6.4
9.8
25
38
Z94.0
ICD-10 Finland
Kidney transplant status
5.2
9.7
29
54
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
9.6
146
783
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
9.5
212
1293
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.2
9.5
96
435
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
9.4
98
452
R03AC02
ATC
salbutamol; inhalant
1.6
9.4
436
3235
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
2.1
9.3
104
494
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.2
9.3
28
53
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.6
9.1
299
2033
RT150
NOMESCO Finland
NA
4.1
9.0
34
81
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.7
8.9
29
60
KAC00
NOMESCO Finland
Nephrectomy
6.8
8.7
21
30
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.4
8.7
25
45
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
8.7
144
795
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
3.8
8.6
35
90
RS220
NOMESCO Finland
NA
3.7
8.6
36
95
A11CC03
ATC
alfacalcidol; systemic
4.2
8.5
31
72
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
48.0
8.5
10
*
Z00.6
ICD-10 Finland
Examination for normal comparison and control in clinical research programme
9.1
8.5
17
18
ZXA10
NOMESCO Finland
Bilateral
1.8
8.3
148
837
P28.4
ICD-10 Finland
Other apnoea of newborn
19.2
8.3
12
6
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
8.6
8.2
17
19
P61.2
ICD-10 Finland
Anaemia of prematurity
+∞
8.2
8
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
8.1
162
951
ZXD05
NOMESCO Finland
Urgent procedure
1.7
8.1
180
1093
Z99.2
ICD-10 Finland
Dependence on renal dialysis
7.8
7.8
17
21
ZX114
NOMESCO Finland
Intramuscular
4.0
7.8
30
74
R03BA02
ATC
budesonide; inhalant
1.8
7.8
142
811
P59.9
ICD-10 Finland
Neonatal jaundice, unspecified
2.9
7.7
45
152
B03XA01
ATC
erythropoietin; parenteral
6.3
7.6
19
29
UDC00
NOMESCO Finland
Ear microscopy
2.1
7.6
90
439
J21.90
ICD-10 Finland
Acute obstructive bronchitis in children
2.3
7.5
70
307
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
7.5
85
403
H66.9
ICD-10 Finland
Otitis media, unspecified
1.6
7.5
236
1570
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.5
126
698
R03BA05
ATC
fluticasone; inhalant
1.6
7.5
210
1357
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.1
7.4
82
387
P21.0
ICD-10 Finland
Severe birth asphyxia
7.1
7.4
17
23
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
5.7
7.4
20
34
A03FA02
ATC
cisapride; oral, rectal
3.0
7.3
40
130
Z2445
NOMESCO Finland
Psychologist
1.8
7.3
125
699
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.9
7.3
42
141
P77
ICD-10 Finland
Necrotizing enterocolitis of fetus and newborn
76.7
7.3
8
*
P36.3
ICD-10 Finland
Sepsis of newborn due to other and unspecified staphylococci
76.7
7.3
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
7.2
62
260
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
1.9
7.2
101
523
H50.31
ICD-10 Finland
Intermittent exotropia
3.0
7.2
39
126
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
1.7
7.2
168
1032
H53.0
ICD-10 Finland
Amblyopia ex anopsia
2.9
7.2
42
143
127
Kela drug reimbursment
Transplant complication
3.5
7.1
31
86
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
15.1
7.0
11
7
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.0
7.0
86
425
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
7.0
86
426
7AA02
NOMESCO Finland
NA
28.8
7.0
9
*
C08CA01
ATC
amlodipine; oral
3.2
6.9
34
103
B05DA
ATC
Isotonic solutions
7.0
6.9
16
22
RK310
NOMESCO Finland
NA
7.0
6.9
16
22
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.3
6.9
33
98
J12.1
ICD-10 Finland
Respiratory syncytial virus pneumonia
11.5
6.9
12
10
RL140
NOMESCO Finland
NA
3.5
6.8
30
84
EMB30
NOMESCO Finland
Adenotomy
1.6
6.7
185
1186
P00.8
ICD-10 Finland
Fetus and newborn affected by other maternal conditions
13.2
6.7
11
8
FM2CE
NOMESCO Finland
NA
2.0
6.7
85
426
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
6.6
81
399
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.2
6.6
63
279
WW500
NOMESCO Finland
Blood transfusion
2.8
6.6
39
134
WX725
NOMESCO Finland
Noninvasive ventilation
3.6
6.6
28
76
Z49.1
ICD-10 Finland
Extracorporeal dialysis
7.9
6.6
14
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
6.5
126
732
A12AA04
ATC
calcium carbonate; oral
5.1
6.5
19
36
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
6.9
6.5
15
21
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
6.4
102
556
UGC02
NOMESCO Finland
Rigid bronchoscopy
4.1
6.4
23
54
RK410
NOMESCO Finland
NA
11.7
6.4
11
9
TJF80
NOMESCO Finland
Ostomy education
4.7
6.4
20
41
ZX106
NOMESCO Finland
Intranasal
9.6
6.3
12
12
TJD20
NOMESCO Finland
Change of gastrostomy tube
4.1
6.3
23
55
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.2
6.3
63
286
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
2.3
6.3
54
230
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
1.8
6.2
102
559
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
5.9
6.2
16
26
H01AC01
ATC
somatropin; parenteral
2.6
6.2
43
161
P01.11
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes more than 7 days before delivery
+∞
6.1
6
*
Z49.2
ICD-10 Finland
Other dialysis
6.3
6.1
15
23
XKC03
NOMESCO Finland
Water cystometry
4.7
6.1
19
39
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
3.5
6.0
26
72

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: P16_DISORD_RELATED_LENGTH_GESTATION_FETAL_GROWTH – Disorders related to length of gestation and fetal growth

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).