No definition available.
Slow fetal growth and fetal malnutrition
P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
218 |
4. Check minimum number of eventsNone |
218 |
5. Include endpointsNone |
218 |
6. Filter based on genotype QC (FinnGen only) |
218 |
Control definitions (FinnGen only)
- Control exclude
- P16_DISORD_RELATED_LENGTH_GESTATION_FETAL_GROWTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- P0[5-8]
- Name in latin
- Crescentia tarda et malnutritio fetalis
Similar endpoints
↥List of similar endpoints to
Slow fetal growth and fetal malnutrition
based on the number of shared cases.
Similar with more cases:
- Disorders related to length of gestation and fetal growth
- Certain conditions originating in the perinatal period
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12946 | 6759 | 6182 |
| Only index persons | 6781 | 3568 | 3213 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.19 | 0.17 |
| Only index persons | 0.13 | 0.13 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 0.01 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 218 | 135 | 83 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | 0.00 | 0.00 | 0.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 191
- Matched controls
- 1910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P05.1
ICD-10 Finland
Small for gestational age
+∞
140.5
117
*
P07.3
ICD-10 Finland
Other preterm infants
+∞
92.4
81
*
P05.0
ICD-10 Finland
Light for gestational age
+∞
86.1
76
*
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
48.5
77.8
95
38
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
+∞
35.5
33
*
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
+∞
35.5
33
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
30.4
25.0
33
13
602
Kela drug reimbursment
Children's severe malnutrition
12.5
24.8
46
47
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
34.0
18.8
24
8
P07.2
ICD-10 Finland
Extreme immaturity
+∞
16.9
16
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
+∞
16.9
16
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
13.5
16.2
28
24
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
12.9
13.7
24
21
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
+∞
13.7
13
*
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
150.2
13.6
14
*
WX722
NOMESCO Finland
PEEP
11.7
12.1
22
21
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
11.1
11.9
22
22
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
24.8
11.8
16
7
P07.1
ICD-10 Finland
Other low birth weight
+∞
11.6
11
*
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
11.6
11
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
5.5
11.3
34
72
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
+∞
10.5
10
*
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
52.4
8.8
10
*
P07.01
ICD-10 Finland
Extremely low birth weight 500-749 g
+∞
8.4
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.9
8.2
34
100
RK312
NOMESCO Finland
NA
23.2
8.1
11
5
Z38.3
ICD-10 Finland
Twin, born in hospital
46.9
7.8
9
*
R62.0
ICD-10 Finland
Delayed milestone
3.9
7.6
31
90
H01AC01
ATC
somatropin; parenteral
5.4
7.6
22
45
WX730
NOMESCO Finland
Conventional respirator
14.1
7.5
12
9
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
11.5
7.4
13
12
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.6
7.3
58
270
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.3
7.2
39
139
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
6.9
64
320
R4110
NOMESCO Finland
Physiotherapy
2.5
6.8
65
329
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
6.4
55
262
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
6.3
57
281
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
+∞
6.3
6
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
6.1
76
437
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
6.1
39
159
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
50
3.34
4.37
5.3
6.5
2.1
2.5
ug/l
0.26
16
50
35
167
2.28
4.34
2.8
2.5
4.6
5.5
u/l
0.45
20
98
9
16
5.77
3.67
2.3
1.7
2.0
6.2
mg/l
—
9
11
41
233
1.92
3.21
1.7
1.5
99.4
366.7
u/ml
1.79
34
222
32
171
2.00
2.99
1.5
1.3
21.3
19.3
nmol/l
0.23
27
146
28
149
1.99
2.65
3.2
2.5
9.0
6.4
iu/l
0.34
19
94
28
150
1.98
2.60
23.6
14.9
106.1
105.6
mmol/l
0.32
28
150
163
1396
1.63
2.50
4.2
3.7
2.4
2.0
mu/l
2.20
154
1302
9
28
3.28
2.31
2.0
2.8
18.0
17.1
%
—
9
16
17
81
2.17
2.14
1.2
1.4
—
—
—
0
0
17
81
2.17
2.14
1.2
1.4
—
—
—
0
0
6
15
4.05
2.03
6.3
8.0
—
—
—
0
0
109
885
1.44
1.92
4.9
5.0
137.2
134.1
u/l
0.13
103
831
189
1716
1.71
1.91
10.4
11.7
22.6
23.8
mg/l
0.18
124
1139
15
73
2.11
1.81
1.1
1.2
—
—
—
0
0
5
13
3.87
1.71
1.8
1.2
—
—
—
0
0
5
13
3.87
1.71
1.8
1.2
—
—
—
0
0
5
13
3.87
1.71
1.8
1.2
—
—
—
0
0
6
19
3.19
1.65
1.3
1.5
—
15.9
—
0
7
14
69
2.08
1.65
16.3
19.8
0.7
0.7
%
0.05
14
69
14
70
2.05
1.59
16.3
19.5
1.0
1.0
%
0.11
14
70
14
70
2.05
1.59
16.3
19.5
96.0
95.4
%
0.16
14
70
14
70
2.05
1.59
11.1
11.8
23.3
22.7
mmol/l
0.33
14
65
14
71
2.02
1.54
16.3
18.9
22.8
24.2
mmol/l
0.92
14
71
6
21
2.88
1.50
5.0
6.6
—
—
—
0
0
6
21
2.88
1.50
3.7
6.5
—
—
—
0
0
99
820
1.36
1.43
16.1
15.0
1.2
1.2
mmol/l
0.01
93
782
5
16
3.14
1.43
1.4
1.9
—
—
—
0
0
145
1276
1.38
1.42
3.8
3.3
14.5
14.4
pmol/l
0.13
134
1139
101
842
1.35
1.39
14.3
13.5
1.2
1.2
mmol/l
0.08
92
781
46
336
1.45
1.38
5.1
2.8
1.0
1.0
kg/l
0.46
11
61
6
23
2.63
1.36
10.7
11.6
—
—
—
0
0
42
303
1.46
1.34
1.5
1.4
97.2
99.0
pmol/l
0.09
16
153
63
493
1.38
1.28
7.8
9.8
38.7
37.6
g/l
0.98
63
471
44
324
1.43
1.26
5.8
3.4
0.0
0.0
estimate
—
8
114
13
72
1.84
1.15
1.7
2.0
—
—
—
0
0
79
924
0.76
1.13
1.8
2.1
—
—
—
0
0
72
851
0.76
1.11
2.0
1.9
11.9
3.6
u/ml
0.78
15
140
9
46
1.98
1.04
2.8
4.0
26.9
24.3
umol/l
—
9
46
192
1805
1.47
1.02
16.2
17.0
39.6
38.7
%
1.56
174
1637
0
28
0.00
0.98
0.0
1.0
—
—
—
0
0
131
1171
1.27
0.96
9.1
13.1
3.5
3.4
e9/l
0.23
109
947
10
54
1.88
0.96
1.4
1.4
4.2
3.5
umol/l
—
10
48
87
741
1.27
0.95
3.5
2.9
35.3
36.3
mmol/mol
0.40
80
695
6
28
2.16
0.91
1.2
1.1
—
—
—
0
0
8
44
1.83
0.86
2.0
1.7
—
—
—
0
0
78
666
1.25
0.82
4.4
3.5
74.5
68.2
nmol/l
0.93
70
627
0
24
0.00
0.79
0.0
1.2
—
36.9
—
0
24
0
25
0.00
0.79
0.0
1.1
—
4.2
—
0
15
54
443
1.28
0.78
5.2
3.0
—
—
—
0
0
8
48
1.68
0.78
17.9
5.9
61.9
61.6
%
—
8
48
29
217
1.37
0.78
2.4
2.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
12.1
—
0
17
163
1515
1.27
0.77
14.2
14.3
4.0
3.9
mmol/l
0.29
158
1451
5
23
2.18
0.76
1.2
1.2
—
—
—
0
0
45
363
1.29
0.75
2.4
3.9
—
—
—
0
0
5
24
2.09
0.74
1.2
1.2
—
—
—
0
0
66
561
1.24
0.71
3.8
4.5
—
—
—
0
0
14
93
1.53
0.69
2.1
2.7
5.2
5.3
pmol/l
0.11
14
84
5
28
1.79
0.66
2.8
2.3
—
—
—
0
0
78
681
1.21
0.65
4.9
3.4
0.0
0.0
estimate
—
6
112
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
19
0.00
0.60
0.0
1.2
—
—
—
0
0
0
19
0.00
0.60
0.0
1.1
—
1.8
—
0
10
0
22
0.00
0.59
0.0
2.8
—
53.7
—
0
22
0
22
0.00
0.59
0.0
1.0
—
21.0
—
0
14
56
479
1.21
0.57
9.4
9.6
0.9
0.9
mmol/l
0.02
39
348
10
65
1.55
0.54
1.9
4.7
—
—
—
0
0
11
156
0.68
0.54
1.1
1.2
—
—
—
0
0
9
133
0.66
0.53
1.8
1.8
—
—
—
0
0
77
683
1.18
0.53
6.5
5.0
0.0
0.0
estimate
—
8
119
23
180
1.30
0.49
2.5
2.3
—
—
—
0
0
11
153
0.70
0.49
2.5
1.8
—
—
—
0
0
10
67
1.50
0.49
2.8
3.0
—
—
—
0
0
10
67
1.50
0.49
1.3
1.3
—
—
—
0
0
77
688
1.17
0.48
4.9
3.4
0.0
0.0
estimate
—
8
117
11
152
0.70
0.48
2.7
1.8
133.0
153.4
u/ml
—
6
65
87
789
1.16
0.45
6.7
5.9
114.1
114.9
ml/min/173m2
0.12
54
473
6
93
0.63
0.43
1.0
1.1
—
—
—
0
0
5
32
1.56
0.42
2.0
1.8
—
—
—
0
0
8
58
1.38
0.41
2.0
1.6
—
—
—
0
0
23
185
1.26
0.41
2.3
2.1
13.2
15.6
ng/l
—
10
59
12
87
1.39
0.41
2.2
1.3
1.2
1.2
g/l
0.05
12
82
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
161
1533
1.16
0.39
8.5
9.5
25.6
24.1
u/l
0.39
155
1470
96
885
1.13
0.38
2.8
2.0
5.3
5.3
mmol/l
0.19
85
799
25
206
1.23
0.37
3.8
3.6
24.5
21.3
%
0.53
25
198
188
1814
1.20
0.37
4.4
4.0
—
—
—
0
0
13
166
0.76
0.36
1.2
1.2
—
—
—
0
0
10
133
0.73
0.36
1.1
1.3
—
—
—
0
0
6
42
1.43
0.35
3.0
4.8
451.3
440.2
umol/l
—
6
42
10
73
1.38
0.33
8.0
4.6
26.7
27.2
%
—
10
73
7
54
1.29
0.30
2.3
1.1
—
233.4
—
0
17
21
175
1.21
0.29
4.8
2.5
5285.0
4684.5
u/l
—
7
47
8
65
1.23
0.27
1.4
1.6
—
—
—
0
0
10
76
1.32
0.27
1.1
1.2
—
—
—
0
0
25
285
0.85
0.27
1.0
1.0
—
—
—
0
0
8
66
1.21
0.27
5.1
3.7
1.3
1.2
mmol/l
—
8
56
11
86
1.28
0.25
2.5
2.2
—
—
—
0
0
10
77
1.30
0.25
8.0
4.8
—
—
—
0
0
6
80
0.74
0.24
1.0
1.3
—
—
—
0
0
25
282
0.86
0.24
1.7
2.1
—
—
—
0
0
53
485
1.11
0.23
2.3
3.5
2.6
2.6
mg/l
0.02
47
428
5
38
1.31
0.23
1.2
1.1
80.6
75.1
%
—
5
38
5
38
1.31
0.23
1.2
1.2
—
—
—
0
0
5
39
1.28
0.23
2.4
1.7
—
—
—
0
0
21
181
1.17
0.21
2.2
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
5.6
—
0
10
0
10
0.00
0.21
0.0
1.5
—
0.4
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
29
257
1.14
0.21
2.4
6.9
5.5
2.5
mg/l
0.42
20
185
0
13
0.00
0.21
0.0
1.3
—
102.3
—
0
13
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
9
112
0.79
0.20
2.4
2.0
—
—
—
0
0
11
89
1.24
0.20
2.6
2.4
—
—
—
0
0
17
188
0.89
0.13
2.0
4.2
3337.0
1222.7
ng/l
—
10
116
10
84
1.19
0.13
1.4
2.0
—
—
—
0
0
50
471
1.07
0.12
13.9
11.8
0.5
0.9
mmol/l
0.42
39
373
95
970
0.95
0.12
5.1
3.8
35.8
132.5
e6/l
—
5
13
34
356
0.94
0.09
3.3
4.2
2.9
2.4
e6/l
0.20
20
210
5
48
1.03
0.09
1.0
1.2
—
—
—
0
0
6
53
1.13
0.09
1.3
1.3
—
—
—
0
0
6
53
1.13
0.09
1.3
1.3
—
—
—
0
0
6
53
1.13
0.09
1.3
1.3
—
—
—
0
0
6
55
1.08
0.09
1.2
1.5
—
—
—
0
0
91
880
1.04
0.08
3.4
3.4
51.4
52.2
ug/l
0.03
85
829
48
457
1.05
0.08
2.2
2.5
—
—
—
0
0
7
63
1.10
0.08
2.1
2.1
—
—
—
0
0
7
63
1.10
0.08
1.6
1.4
—
—
—
0
0
112
1089
1.04
0.08
4.6
4.4
7.0
7.4
mm/h
0.22
104
1008
7
68
1.02
0.08
1.6
2.3
—
—
—
0
0
8
75
1.06
0.07
2.5
2.4
—
—
—
0
0
81
822
0.96
0.07
3.3
2.6
2.7
2.6
mmol/l
0.63
75
772
9
86
1.04
0.07
1.4
2.2
—
—
—
0
0
81
818
0.97
0.05
3.2
2.6
1.3
1.4
mmol/l
1.05
76
771
47
478
0.97
0.04
2.4
2.7
—
—
—
0
0
15
157
0.94
0.03
1.0
1.1
2.6
11.1
u/ml
—
6
47
55
535
1.03
0.03
15.9
15.1
24.7
24.9
mmol/l
0.23
55
535
54
545
0.98
0.02
4.1
4.6
0.2
0.3
e6/l
0.37
41
407
34
346
0.97
0.02
3.7
4.2
2.3
0.9
e6/l
0.55
20
199
84
840
0.99
0.01
3.7
2.8
4.3
4.3
mmol/l
0.16
79
800
20
192
1.04
0.01
1.1
1.3
0.1
3.5
u/ml
3.55
14
128
14
140
0.99
0.00
1.1
1.9
—
—
—
0
0
13
130
0.99
0.00
1.5
1.4
—
—
—
0
0
33
327
1.00
0.00
2.0
2.2
—
—
—
0
0
14
144
0.96
0.00
2.3
2.8
24.6
31.6
u/l
0.54
14
118
13
125
1.03
0.00
1.4
1.4
—
—
—
0
0
15
150
0.99
0.00
1.5
1.4
—
—
—
0
0
19
188
1.00
0.00
3.4
12.6
87.3
91.4
%
0.35
19
188
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.96
0.00
1.0
6.5
294.3
418.2
mg/l
—
7
72
61
605
1.00
0.00
5.7
4.9
—
—
—
0
0
0
5
0.00
0.00
0.0
20.2
—
30.6
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
4.1
—
0
5
0
7
0.00
0.00
0.0
1.4
—
12.8
—
0
7
0
8
0.00
0.00
0.0
1.3
—
61.9
—
0
8
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
9
98
0.91
0.00
1.3
1.9
—
—
—
0
0
5
50
0.99
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
54.6
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
11.5
—
0
8
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
88.3
—
0
8
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
25.0
—
0
6
0
5
0.00
0.00
0.0
20.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION | 6.474 [4.98, 8.41] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.407 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 6317 females with P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION | 3.741 [2.92, 4.79] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 5727 males with P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION died.
Mortality risk
Mortality risk for people of age
years, who have P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.569% | 0.49% |
| 5 | 3.842% | 3.819% |
| 10 | 8.574% | 10.069% |
| 15 | 17.236% | 18.695% |
| 20 | 30.123% | 31.154% |
Relationships between endpoints
↥Index endpoint: P16_SLOW_FETAL_GROWTH_FETAL_MALNUTRITION – Slow fetal growth and fetal malnutrition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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