Feeding problems of newborn

P16_FEEDI_PROBL_NEWBO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P92 Cause of death: ICD-10 — P92 2 out of 7 registries used, show all original rules.	163
4. Check minimum number of events None	163
5. Include endpoints None	163
6. Filter based on genotype QC (FinnGen only)	163

Control definitions (FinnGen only)

Control exclude: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P9
Name in latin: Perturbationes nutriendi neonati

NAME	P16_FEEDI_PROBL_NEWBO
CONTROL_EXCLUDE	P16_OTH_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P92
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P92
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Feeding problems of newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	11115	5468	5644
Only index persons	3886	2007	1879
Unadjusted period prevalence (%)
Whole population	0.16	0.16	0.16
Only index persons	0.07	0.07	0.07
Median age at first event (years)
Whole population	0.05	0.04	0.04
Only index persons	0.05	0.05	0.04

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	163	107	56
Unadjusted period prevalence (%)	0.03	0.04	0.02
Median age at first event (years)	0.11	0.14	0.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
149: Matched controls
1491

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P92.5

ICD-10 Finland

Neonatal difficulty in feeding at breast

+∞

54.6

P92.9

ICD-10 Finland

Feeding problem of newborn, unspecified

+∞

26.9

P92.3

ICD-10 Finland

Underfeeding of newborn

+∞

24.7

P92.1

ICD-10 Finland

Regurgitation and rumination in newborn

+∞

23.6

P92.0

ICD-10 Finland

Vomiting in newborn

242.5

21.1

P92.2

ICD-10 Finland

Slow feeding of newborn

+∞

13.8

MA3AE

NOMESCO Finland

Combined first trimester screening

6.2

8.9

Z37.0

ICD-10 Finland

Single live birth

5.8

8.3

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

5.8

7.9

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3047352) Trisomy 18 risk [Likelihood] in Fetus

5.05

12.27

1.4

—

(3005033) Fetal Nuchal fold Thickness US

5.05

12.27

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

4.82

11.63

1.6

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

4.14

9.62

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

4.14

9.62

1.4

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

4.14

9.62

1.4

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

4.14

9.62

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

3.62

8.00

1.6

1.5

—

(3022621) pH of Urine by Test strip

3.96

7.45

2.8

1.9

—

(3014051) Protein [Presence] in Urine by Test strip

5.23

7.08

2.1

1.7

—

(3006462) Nitrate [Presence] in Urine

15.76

5.97

1.8

1.7

—

(4211845)

15.76

5.97

1.8

1.7

—

(3000330) Specific gravity of Urine by Test strip

3.59

4.74

2.4

2.0

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

8.58

4.62

1.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.79

4.55

2.2

2.3

—

(3030467) Casts [#/volume] in Urine by Automated count

444

1.96

4.15

4.9

4.7

0.1

0.3

e6/l

1.62

339

(36304419) Bacteria [Presence] in Urine

447

1.94

4.05

4.8

4.7

—

(3045414) Leukocytes [Presence] in Urine

3.27

3.92

2.1

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

471

1.90

3.83

4.9

5.1

26.5

31.2

e6/l

0.09

363

(3044640) Blood type and Crossmatch panel - Blood

352

1.95

3.81

2.5

3.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

3.44

3.71

1.1

—

(3018095) Leukocytes [#/volume] in Urine

560

1.84

3.59

5.5

5.8

91.3

44.2

e6/l

0.27

375

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

305

1.92

3.42

2.4

3.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

485

1.82

3.40

5.3

5.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

168

2.13

3.29

1.6

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

284

1.92

3.29

3.2

4.2

0.5

e6/l

0.04

172

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

291

1.86

3.03

3.1

4.4

1.0

1.5

e6/l

0.33

178

(3019832) Treponema pallidum Ab [Presence] in Serum

295

1.83

2.90

1.7

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

480

1.63

2.33

5.0

4.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

726

1.61

2.33

5.9

8.6

6.2

5.9

mmol/l

0.24

671

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

668

1.61

2.32

10.9

14.4

1.2

mmol/l

0.06

615

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

255

1.75

2.30

1.8

2.1

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

119

1.98

2.09

1.6

2.2

8.4

8.0

iu/l

0.04

(3000850) Epithelial cells [#/volume] in Urine

315

1.64

2.03

4.4

3.8

4.5

7.8

e6/l

1.92

274

(3026782) Osmolality of Urine

308

1.64

1.98

4.5

3.6

588.8

577.9

mosm/kgh2o

0.10

262

(3018418) pH of Serum or Plasma

254

1.65

1.83

5.5

5.1

7.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.59

1.77

1.3

—

(3003694) ABO and Rh group [Type] in Blood

460

1.52

1.76

2.0

1.7

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

3.93

1.73

2.0

1.1

—

(40768804) Tissue Pathology biopsy report

284

1.59

1.71

1.8

1.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.24

1.67

8.7

8.2

—

(40768797) Stomach Pathology biopsy report

2.00

1.66

1.7

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

210

1.65

1.8

1.9

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.07

1.59

6.7

5.0

2.8

2.9

e9/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

345

1.51

3.5

3.1

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

372

1.50

1.51

7.8

12.0

0.6

1.1

mmol/l

0.97

268

(3001019) Free T4 and TSH panel - Serum or Plasma

2.51

1.50

1.6

1.9

—

(1761868) Lipid panel - Serum or Plasma

207

1.61

1.50

1.4

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

428

1.47

1.48

2.8

2.1

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

135

1.73

1.45

1.6

2.1

5.8

6.6

u/l

0.24

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.79

1.45

12.0

4.7

49.7

49.4

—

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

2.79

1.45

1.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.08

1.42

1.8

1.6

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

3.00

1.37

2.8

2.5

72.0

59.5

umol/l

—

(40761511) CBC panel - Blood by Automated count

142

1309

1.66

1.35

8.6

8.9

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

122

1.73

1.35

2.3

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.80

1.33

1.7

1.9

—

(3026008) Bacteria identified in Urine by Culture

322

1.46

1.24

3.1

2.5

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

2.36

1.20

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

831

1.38

1.19

5.0

4.7

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.10

1.17

1.6

1.5

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.78

1.16

1.5

1.3

—

(3022313) Gas panel - Capillary blood

336

1.42

1.14

8.3

11.6

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

1.75

1.12

1.1

5.4

6.5

u/ml

—

(3009261) Glucose [Presence] in Urine by Test strip

572

1.36

1.10

4.8

3.6

0.0

estimate

0.00

(3021601) Nitrite [Presence] in Urine by Test strip

565

1.35

1.06

6.3

5.3

0.0

estimate

0.00

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.01

1.05

1.7

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

566

1.35

1.05

4.5

3.5

0.0

estimate

0.00

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

406

1.37

1.04

9.7

15.5

24.6

24.7

mmol/l

0.10

406

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

445

1.36

1.01

2.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.88

1.00

1.3

1.6

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

150

1.54

0.99

2.3

2.8

12003.7

3761.8

u/l

—

(3022145) Colonoscopy Study observation

1.91

0.99

2.1

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

126

1.57

0.96

1.9

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

126

1.57

0.96

1.9

2.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.96

0.0

1.2

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

127

1171

1.38

0.93

14.5

14.8

4.0

3.9

mmol/l

0.15

121

1127

(3019550) Sodium [Moles/volume] in Serum or Plasma

127

1172

1.38

0.91

14.6

14.9

139.3

mmol/l

0.01

122

1138

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

205

1.44

0.91

1.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

120

1.56

0.90

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.97

0.85

2.2

1.4

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

1.66

0.84

1.1

1.2

36.8

9.2

u/ml

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.78

0.84

1.3

—

(21494815) CD4 cells/100 lymphocytes in Specimen

1.70

0.80

3.0

3.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

339

1.32

0.77

2.5

1.7

—

(3015736) pH of Urine

452

1.29

0.77

3.4

3.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.71

0.76

1.0

1.2

—

(3002032) Base excess in Venous blood by calculation

368

1.31

0.76

6.3

10.4

1.5

1.0

mmol/l

0.82

282

(3009542) Hematocrit [Volume Fraction] of Blood

148

1414

1.51

0.75

13.3

16.2

37.6

38.5

1.20

139

1311

(3002523) Influenza virus A Ag [Presence] in Specimen

1.67

0.75

1.0

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

360

1.30

0.74

4.4

3.3

—

(3028271) Lactate [Moles/volume] in Capillary blood

1.95

0.71

1.8

2.9

1.7

1.6

mmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

243

1.34

0.70

1.5

1.6

89.6

95.3

pmol/l

0.27

124

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

1.88

0.69

1.0

1.1

—

1.5

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

1.56

0.64

1.1

0.0

0.5

u/ml

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

1.75

0.64

1.0

—

(3008295) Osmolality of Serum or Plasma

1.75

0.64

2.2

1.7

300.4

294.0

mosm/kgh2o

—

(3023520) Reticulocytes [#/volume] in Blood

139

1.42

0.64

2.9

4.7

96.8

60.1

e9/l

0.60

(3023368) Bacteria identified in Blood by Culture

220

1.33

0.62

6.6

4.4

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.60

0.61

1.1

1.2

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

1.57

0.60

3.0

3.3

—

(1175426) CD3 cells/100 lymphocytes in Blood

1.57

0.60

3.0

3.3

72.4

63.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

258

1.30

0.60

4.4

3.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

160

1.36

0.57

2.1

2.0

—

(3002256) Pathology report gross observation

1.45

0.56

1.1

1.2

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

1.64

0.56

1.7

1.3

—

(3021901) Oxygen saturation in Capillary blood

1.64

0.56

1.3

13.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

1.56

0.56

1.4

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.48

0.54

2.7

2.1

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

1.46

0.51

1.9

5.1

4.5

14.2

umol/l

2.18

(3027945) Reticulocytes/100 erythrocytes in Blood

211

1.28

0.47

3.7

6.8

1.4

1.3

0.14

201

(3021879) Hepatitis B virus core Ab [Presence] in Serum

103

1.39

0.47

2.0

1.4

—

(42870560) Thyrotropin [Units/volume] in Cord blood

1.40

0.45

1.0

10.7

8.6

mu/l

0.50

(3005719) IgG [Mass/volume] in Serum or Plasma

167

1.30

0.44

3.3

4.1

8.3

g/l

0.03

161

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

139

1338

1.26

0.44

13.3

11.9

25.2

22.3

mg/l

0.48

927

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

364

1.21

0.43

3.4

2.6

—

(3011288) Drugs identified in Urine by Screen method

105

1.36

0.42

1.7

2.1

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

1.58

0.42

1.0

1.2

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

1.58

0.42

1.0

1.2

80.8

72.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

628

1.17

0.41

1.9

1.6

1.4

1.5

g/l

0.30

299

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.5

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.41

0.0

1.1

—

(3019060) Gas panel - Arterial blood

0.00

0.41

0.0

3.4

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.41

0.0

1.6

—

(3004409) Coagulation factor X activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.41

0.0

1.2

—

87.4

—

(3005353) Prothrombin activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.41

0.0

1.0

—

90.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

1.49

0.40

6.2

5.1

26.4

26.6

umol/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

338

1.20

0.40

12.2

12.3

1.4

mmol/l

0.03

324

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.44

0.40

1.1

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.33

0.40

7.5

2.5

—

(3016879) Cocaine [Presence] in Urine

143

1.29

0.39

1.7

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

1.36

0.39

1.3

1.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.32

0.38

1.4

1.6

1.2

g/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.30

0.37

2.0

—

(3013512) EKG study

122

0.72

0.37

2.3

3.0

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

1.38

0.35

1.3

2.6

121.2

127.9

g/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

679

1.14

0.31

7.4

5.5

139.5

134.5

u/l

0.16

634

(3010813) Leukocytes [#/volume] in Blood

155

1522

1.37

0.30

18.2

17.6

7.4

7.1

e9/l

1.01

150

1446

(3026361) Erythrocytes [#/volume] in Blood

155

1521

1.39

0.30

18.2

17.6

4.5

e12/l

0.54

148

1444

(3006245) CD3-CD19+ cells/100 cells in Blood

1.26

0.30

2.0

3.9

14.9

16.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

172

0.80

0.29

1.9

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

120

0.74

0.28

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

122

1.25

0.28

1.3

1.5

—

(3032080) INR in Blood by Coagulation assay

245

0.84

0.27

5.0

4.5

1.0

1.1

inr

—

(21494755) Public health laboratory ask at order entry panel

1.26

0.26

1.0

1.2

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.25

0.26

1.1

—

(4035726)

1.30

0.25

2.8

1.8

—

(1616796) Gas panel - Central venous blood

1.36

0.24

9.8

5.1

—

(40761536) Microorganisms panel - Urine sediment

1.27

0.23

9.4

3.8

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.29

0.23

1.8

—

(3000991) Gas panel - Venous blood

326

1.13

0.22

9.3

13.0

—

(3027008) Opiates [Presence] in Urine

154

1.19

0.22

1.7

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

154

1.19

0.22

1.9

1.6

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

1.23

0.22

1.0

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

621

1.11

0.22

13.5

6.8

113.3

111.3

ml/min/173m2

0.26

395

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

641

1.10

0.22

2.0

1.8

4.3

4.6

u/ml

0.05

(3021578) Parainfluenza virus 2 Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(4094501)

0.00

0.21

0.0

1.0

—

(3010464) Parainfluenza virus 1 Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3005880) Parainfluenza virus 3 Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.3

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.21

0.0

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

0.21

0.0

1.8

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

0.00

0.21

0.0

1.7

—

(3035637) Corticotropin [Mass/volume] in Plasma

1.27

0.21

1.8

2.0

—

(3028300) Cannabinoids [Presence] in Urine

155

1.18

0.21

1.7

1.6

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

1.26

0.20

1.7

3.2

21.8

23.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.26

0.20

1.2

2.3

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.20

0.0

1.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.20

0.0

1.7

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.21

0.20

2.2

2.0

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

137

1.19

0.19

2.0

1.4

1.3

1.4

0.20

124

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

205

0.86

0.18

1.3

2.0

1.1

1.2

mmol/l

0.34

188

(3012494) Peanut IgE Ab [Units/volume] in Serum

1.19

0.18

1.3

2.2

55.7

u/ml

—

(3021589) Normoblasts [#/volume] in Blood

846

1.09

0.17

9.4

11.8

0.0

e9/l

0.00

648

(3042936) Bacteria identified in Isolate by Culture

130

1.17

0.16

2.0

2.2

—

(3016244) Insulin [Units/volume] in Serum or Plasma

1.12

0.16

2.4

3.3

18.7

14.7

mu/l

—

(3021706) Oxygen [Partial pressure] in Arterial cord blood

1.13

0.15

1.0

3.7

3.4

kpa

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

1.13

0.15

1.0

19.6

19.7

mmol/l

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

1.12

0.15

1.0

6.4

7.1

kpa

—

(3006598) pH of Arterial cord blood

1.12

0.15

1.0

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

150

1.15

0.15

1.2

0.6

4.4

u/ml

—

(3028026) IgM [Mass/volume] in Serum or Plasma

131

1.16

0.15

2.3

2.1

1.0

g/l

0.06

123

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.81

0.15

1.1

—

(42870588) Differential panel, method unspecified - Blood

681

1.08

0.14

7.1

10.3

—

(3029937) Albumin [Presence] in Urine by Test strip

267

1.10

0.14

5.3

3.7

0.0

estimate

0.00

(3019198) Lymphocytes [#/volume] in Blood

893

1.07

0.13

7.6

9.7

2.6

2.5

e9/l

0.55

765

(3027944) Amphetamines [Presence] in Urine

152

1.13

0.13

1.9

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

924

1.07

0.12

8.4

11.4

3.6

3.4

e9/l

0.23

776

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

116

0.85

0.12

1.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

1.14

0.10

2.4

2.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

262

1.08

0.10

12.2

5.2

—

(3000494) Fungus identified in Specimen by Culture

114

0.87

0.10

1.6

1.5

—

(3006315) Basophils [#/volume] in Blood

868

1.06

0.09

7.8

9.9

0.0

e9/l

0.07

719

(3014007) Fractional oxyhemoglobin in Arterial blood

1.07

0.09

17.4

26.4

95.6

95.0

—

(3045462) Protein/Creatinine [Ratio] in Urine

1.04

0.09

11.8

8.9

30.2

1161.1

g/mol

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.04

0.09

1.2

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.14

0.09

1.1

1.4

—

(3019150) Specific gravity of Urine by Refractometry

267

0.92

0.09

3.0

2.9

1.0

kg/l

0.13

(3001604) Monocytes [#/volume] in Blood

869

1.05

0.09

7.7

9.8

0.6

e9/l

0.18

720

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.05

0.08

1.0

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.04

0.08

2.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.81

0.08

1.2

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.81

0.08

1.2

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

721

1.05

0.08

2.3

2.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.09

0.07

1.3

1.1

—

(3000492) Spirometry study

1.03

0.07

1.0

1.5

—

(3028707) Methadone [Presence] in Urine by Screen method

1.09

0.07

1.8

1.9

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.09

0.07

3.0

5.1

5.2

pmol/l

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

128

1.10

0.07

1.9

8.5

3.5

2.8

g/l

0.47

123

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.85

0.07

3.4

2.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.84

0.07

3.4

2.2

—

(3013115) Eosinophils [#/volume] in Blood

883

1.04

0.06

8.2

10.8

0.2

e9/l

0.43

755

(3008401) Mugwort IgE Ab [Units/volume] in Serum

149

1.08

0.05

1.2

0.1

1.0

u/ml

1.25

122

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

110

1.10

0.05

2.0

2.2

—

(3044889) 12 lead EKG panel

483

0.96

0.04

3.0

2.2

—

(40758558) Short blood count panel - Blood

547

1.04

0.04

5.0

10.0

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

150

1.07

0.04

1.2

0.4

6.4

u/ml

4.41

126

(36660697) Celiac disease serology panel - Serum

279

1.05

0.04

1.4

1.2

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

109

0.91

0.04

5.3

4.7

27.1

23.0

nmol/l

—

109

(3050129) First trimester maternal screen panel - Serum or Plasma

111

1.09

0.04

1.0

1.4

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

161

1.06

0.03

1.2

1.3

0.3

3.0

u/ml

1.72

116

(3017143) Hepatitis C virus Ab [Presence] in Serum

199

0.95

0.03

2.5

1.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

108

0.92

0.03

1.2

1.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

143

1.05

0.01

2.0

10.4

97.1

90.3

0.71

143

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

141

1403

1.04

0.01

4.6

4.1

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

136

1.03

0.00

10.4

16.7

1.5

1.4

mmol/l

0.02

120

(3048929) Epstein Barr virus Ab [Presence] in Serum

189

1.01

0.00

1.8

1.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

219

1.01

0.00

1.5

5.8

1.4

1.5

mg/l

0.10

153

(3017732) Neutrophils [#/volume] in Blood

1.03

0.00

1.5

1.8

3.6

4.2

e9/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

195

1.03

0.00

2.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

338

1.01

0.00

3.3

2.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

142

0.98

0.00

2.4

2.8

8.8

12.5

ng/l

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3003396) Base excess in Arterial blood by calculation

0.92

0.00

14.7

19.7

1.7

0.6

mmol/l

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.0

—

(43055222) Platelet function.collagen + Adenosine diphosphate induced and EPINEPHrine induced panel - Blood

0.00

0.0

1.9

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

3.7

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3032868) Hemoglobin electrophoresis panel in Blood

0.00

0.0

1.7

—

(3045209) Lutropin/Follitropin [Ratio] in Serum or Plasma

0.00

0.0

1.2

—

(40757578) FLT3 gene targeted mutation analysis in Bone marrow by Molecular genetics method

0.00

0.0

1.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3017461) Flecainide [Moles/volume] in Serum or Plasma

0.00

0.0

6.2

—

0.5

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

87.3

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.00

0.00

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3013931) Oligosaccharides [Presence] in Urine

0.00

0.0

1.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

0.7

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

120

1.00

0.00

1.9

7.2

167.4

163.9

0.04

120

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.96

0.00

17.4

23.5

24.6

24.5

mmol/l

—

(3009871) Measles virus Ab [Titer] in Serum

0.00

0.0

3.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.98

0.00

2.2

2.4

—

(3041082) Glomerular basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.91

0.00

4.6

2.2

0.2

0.5

nmol/l

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

2.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.84

0.00

1.4

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

82.4

—

(4024509)

0.00

0.0

1.4

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3035401) Herpes virus 6 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.7

—

132.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_FEEDI_PROBL_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FEEDI_PROBL_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_FEEDI_PROBL_NEWBO – Feeding problems of newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Feeding problems of newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints