Feeding problems of newborn

P16_FEEDI_PROBL_NEWBO

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P92 Cause of death: ICD-10 — P92 2 out of 7 registries used, show all original rules.	170
4. Check minimum number of events None	170
5. Include endpoints None	170
6. Filter based on genotype QC (FinnGen only)	156

Control definitions (FinnGen only)

Control exclude: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P9
Name in latin: Perturbationes nutriendi neonati

NAME	P16_FEEDI_PROBL_NEWBO
CONTROL_EXCLUDE	P16_OTH_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P92
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P92
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Feeding problems of newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	11115	5468	5644
Only index persons	3886	2007	1879
Unadjusted period prevalence (%)
Whole population	0.16	0.16	0.16
Only index persons	0.07	0.07	0.07
Median age at first event (years)
Whole population	0.05	0.04	0.04
Only index persons	0.05	0.05	0.04

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	156	106	50
Unadjusted period prevalence (%)	0.03	0.04	0.02
Median age at first event (years)	0.16	0.21	0.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
170: Matched controls
1700

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P92.5

ICD-10 Finland

Neonatal difficulty in feeding at breast

887.1

64.3

P92.9

ICD-10 Finland

Feeding problem of newborn, unspecified

+∞

27.9

P92.3

ICD-10 Finland

Underfeeding of newborn

+∞

25.7

P92.0

ICD-10 Finland

Vomiting in newborn

145.5

24.3

P92.1

ICD-10 Finland

Regurgitation and rumination in newborn

97.2

23.4

P92.2

ICD-10 Finland

Slow feeding of newborn

+∞

15.9

Z37.0

ICD-10 Finland

Single live birth

4.4

11.1

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

3.4

8.2

112

MA3AE

NOMESCO Finland

Combined first trimester screening

3.4

8.0

114

A03FA02

ATC

cisapride; oral, rectal

7.6

7.2

P07.3

ICD-10 Finland

Other preterm infants

3.9

6.5

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3047352) Trisomy 18 risk [Likelihood] in Fetus

4.82

12.70

1.4

—

(3005033) Fetal Nuchal fold Thickness US

4.82

12.70

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

4.63

12.11

1.6

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

4.05

10.21

1.4

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

4.05

10.21

1.4

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

4.05

10.21

1.4

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

4.05

10.21

1.4

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

105

3.52

8.39

1.6

1.5

—

(3022621) pH of Urine by Test strip

4.01

8.21

3.1

2.0

—

(3006462) Nitrate [Presence] in Urine

17.58

6.83

1.8

1.7

—

(3000330) Specific gravity of Urine by Test strip

3.99

6.40

2.6

2.1

—

(3014051) Protein [Presence] in Urine by Test strip

5.46

6.40

3.2

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

109

2.88

5.47

2.1

2.2

—

(3045414) Leukocytes [Presence] in Urine

3.59

5.03

2.4

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

191

2.35

4.78

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

459

2.03

4.77

4.8

4.7

0.10

0.27

e6/l

1.20

351

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

3.58

4.74

1.1

—

(36304419) Bacteria [Presence] in Urine

462

2.02

4.67

4.7

4.6

—

(3002582) Erythrocytes [#/volume] in Urine

488

1.96

4.36

4.8

5.0

25.97

30.42

e6/l

0.09

375

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

7.24

4.22

1.0

—

(3044640) Blood type and Crossmatch panel - Blood

367

1.98

4.13

2.4

3.6

—

(3018095) Leukocytes [#/volume] in Urine

579

1.89

4.03

5.4

5.7

88.22

44.01

e6/l

0.26

388

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

318

1.97

3.82

2.3

3.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

295

1.98

3.77

3.2

4.1

0.49

0.50

e6/l

0.02

178

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

502

1.84

3.64

5.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

301

1.94

3.54

3.1

4.3

0.98

1.68

e6/l

0.59

183

(3019832) Treponema pallidum Ab [Presence] in Serum

334

1.90

3.52

1.7

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

511

1.67

2.65

3.3

3.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

742

1.64

2.54

5.8

8.4

6.15

5.89

mmol/l

0.21

685

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

685

1.63

2.51

10.5

14.1

1.23

mmol/l

0.15

631

(3023323) Follitropin [Units/volume] in Serum or Plasma

122

2.02

2.30

1.6

2.2

8.38

7.93

iu/l

0.04

(3015736) pH of Urine

511

1.59

2.22

3.3

5.88

6.30

1.50

(3003694) ABO and Rh group [Type] in Blood

494

1.59

2.19

1.9

1.8

—

(3000850) Epithelial cells [#/volume] in Urine

326

1.66

2.18

4.3

3.7

5.42

7.56

e6/l

0.83

287

(3026782) Osmolality of Urine

319

1.65

2.14

4.4

3.6

599.41

575.32

mosm/kgh2o

0.27

271

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.73

2.04

1.3

—

(1761868) Lipid panel - Serum or Plasma

225

1.70

1.94

1.4

2.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

286

1.62

1.87

1.8

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

472

1.53

1.87

2.8

2.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

171

1.76

1.85

3.0

8.8

6.40

8.26

umol/l

0.25

137

(3018418) pH of Serum or Plasma

262

1.63

1.83

5.4

4.9

7.39

7.40

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

358

1.56

1.81

3.5

3.1

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

3.93

1.72

2.0

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

602

1.47

1.69

4.8

3.6

0.00

estimate

-0.00

103

(3001019) Free T4 and TSH panel - Serum or Plasma

2.47

1.65

1.5

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

595

1.47

1.65

6.1

5.3

0.00

estimate

-0.00

103

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.07

1.59

8.7

7.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

103

872

1.46

1.59

4.9

4.6

—

(3035350) Ketones [Presence] in Urine by Test strip

598

1.45

1.59

4.4

3.5

0.00

estimate

-0.00

103

(3009214) Lutropin [Units/volume] in Serum or Plasma

139

1.76

1.58

1.6

2.1

5.81

6.53

u/l

0.23

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.92

1.52

6.7

5.0

2.76

2.84

e9/l

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

133

1.75

1.51

2.1

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

232

1.58

1.50

1.9

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

372

1.49

7.8

12.0

0.60

1.14

mmol/l

0.97

268

(40768797) Stomach Pathology biopsy report

1.90

1.47

1.7

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.86

1.45

1.5

1.3

—

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

2.79

1.44

1.0

—

(3020874) Milk IgE Ab [Units/volume] in Serum

2.02

1.42

1.4

1.6

0.35

3.92

u/ml

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.08

1.42

1.8

1.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.26

1.39

1.6

1.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.67

1.38

12.0

4.8

49.67

49.70

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

3.00

1.37

2.8

2.5

72.00

59.47

umol/l

—

(40761511) CBC panel - Blood by Automated count

148

1368

1.63

1.33

8.5

8.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

372

1.45

1.31

2.3

1.7

—

(40768804) Tissue Pathology biopsy report

301

1.48

1.30

1.8

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

422

1.41

1.23

7.4

9.7

26.64

28.75

umol/l

0.11

391

(3023103) Potassium [Moles/volume] in Serum or Plasma

134

1219

1.47

1.23

13.9

14.4

3.94

mmol/l

0.05

128

1175

(3019550) Sodium [Moles/volume] in Serum or Plasma

134

1220

1.46

1.21

13.9

14.5

139.24

139.31

mmol/l

0.12

129

1186

(3003327) Ova and parasites identified in Stool by Light microscopy

102

1.74

1.21

1.7

1.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

461

1.39

1.20

2.0

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

2.35

1.19

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

1.15

0.0

1.2

—

(3022313) Gas panel - Capillary blood

336

1.42

1.13

8.3

11.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.98

1.08

1.6

1.4

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

164

1.54

1.06

2.2

2.8

12003.75

3294.33

u/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

386

1.38

1.05

4.2

3.3

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

1.71

1.04

1.1

5.09

6.20

u/ml

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.97

1.04

1.2

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

406

1.37

1.03

9.7

15.5

24.60

24.69

mmol/l

0.10

406

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.81

0.96

1.3

1.6

—

(3026008) Bacteria identified in Urine by Culture

346

1.37

0.95

3.2

2.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

212

1.44

0.94

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.87

0.94

1.0

1.2

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.77

0.94

1.1

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.83

0.90

1.0

1.2

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

1.64

0.87

2.5

4.9

4.65

13.59

umol/l

2.08

(3022145) Colonoscopy Study observation

1.80

0.85

2.1

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

130

1.52

0.85

1.9

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

130

1.52

0.85

1.9

2.0

—

(3023520) Reticulocytes [#/volume] in Blood

139

1.50

0.84

2.9

4.7

96.82

60.13

e9/l

0.60

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.91

0.82

2.2

1.4

—

(21494815) CD4 cells/100 lymphocytes in Specimen

1.70

0.80

3.0

3.5

39.45

36.69

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

1.61

0.77

1.1

1.2

36.84

9.16

u/ml

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

257

1.35

0.76

1.5

1.6

88.91

93.52

pmol/l

0.24

134

(3002032) Base excess in Venous blood by calculation

369

1.30

0.74

6.3

10.4

1.43

1.00

mmol/l

0.70

284

(3028271) Lactate [Moles/volume] in Capillary blood

1.95

0.71

1.8

2.9

1.74

1.58

mmol/l

—

(3002256) Pathology report gross observation

102

1.52

0.70

1.1

1.2

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

1.88

0.69

1.0

1.1

—

1.53

—

(3023368) Bacteria identified in Blood by Culture

226

1.34

0.67

6.5

4.3

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

1.75

0.64

1.0

—

(3008295) Osmolality of Serum or Plasma

1.75

0.64

2.2

1.7

300.40

293.95

mosm/kgh2o

—

(3041096) Erythrocytes [Presence] in Urine by Automated

283

1.30

0.64

4.3

3.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.54

0.61

1.1

1.2

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

1.54

0.61

1.1

0.04

0.47

u/ml

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.61

0.0

1.6

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

1.56

0.60

3.0

3.3

—

(1175426) CD3 cells/100 lymphocytes in Blood

1.56

0.60

3.0

3.3

72.38

63.83

—

(3027831) CD3-CD16+CD56+ (Natural killer) cells/100 cells in Blood

1.56

0.60

3.0

3.3

10.38

10.23

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

132

1.41

0.60

1.7

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

710

1.21

0.57

7.0

5.4

134.73

131.35

u/l

0.11

665

(3021901) Oxygen saturation in Capillary blood

1.64

0.56

1.3

13.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

146

1398

1.31

0.56

13.0

11.7

24.51

22.13

mg/l

0.40

106

965

(3025018) Bordetella pertussis Ab [Titer] in Serum

1.53

0.55

1.4

1.2

—

(3013512) EKG study

131

0.67

0.54

2.3

2.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.43

0.52

2.7

2.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

1.50

0.48

1.3

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

165

1.31

0.48

2.1

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

399

1.21

0.47

3.3

2.6

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

121

1.36

0.46

7.2

11.0

106.88

105.59

mmol/l

0.71

121

(40761536) Microorganisms panel - Urine sediment

1.40

0.45

8.3

3.6

—

(42870560) Thyrotropin [Units/volume] in Cord blood

1.40

0.45

1.0

10.75

8.59

mu/l

0.50

(3021879) Hepatitis B virus core Ab [Presence] in Serum

113

1.36

0.44

1.9

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

1.63

0.43

1.2

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

645

1.17

0.43

1.9

1.6

1.39

1.49

g/l

0.31

309

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

1.58

0.42

1.0

1.2

80.80

71.97

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

123

1.33

0.42

1.4

1.5

—

(3019060) Gas panel - Arterial blood

0.00

0.41

0.0

3.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.41

0.0

1.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

1.48

0.40

6.2

5.1

26.40

26.62

umol/l

—

(3005353) Prothrombin activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.39

0.0

1.0

—

91.08

—

(3004409) Coagulation factor X activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.39

0.0

1.2

—

89.25

—

(3026361) Erythrocytes [#/volume] in Blood

162

1589

1.41

0.38

17.8

17.2

4.50

4.54

e12/l

0.43

155

1510

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.30

0.37

1.4

1.6

1.16

1.17

g/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

341

1.19

0.37

12.2

1.36

mmol/l

0.04

326

(3022217) INR in Platelet poor plasma by Coagulation assay

275

0.81

0.37

8.3

5.2

1.01

1.13

inr

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

1.35

0.34

1.3

2.6

121.17

127.89

g/l

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.69

0.34

1.5

1.7

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.35

0.31

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

749

1.13

0.30

2.2

2.1

—

(3010813) Leukocytes [#/volume] in Blood

162

1591

1.39

0.30

17.8

17.3

7.40

7.05

e9/l

1.05

157

1512

(3006245) CD3-CD19+ cells/100 cells in Blood

1.26

0.30

2.0

3.9

14.86

16.27

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

661

1.13

0.29

2.0

1.7

3.92

4.32

u/ml

0.07

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.34

0.29

1.8

2.0

5.35

6.13

nmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.28

0.28

7.5

2.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.24

0.27

1.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

114

1.25

0.26

1.7

2.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.23

0.25

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

126

0.78

0.25

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

285

1.15

0.25

5.0

3.6

0.00

estimate

-0.00

(1616796) Gas panel - Central venous blood

1.36

0.23

9.8

5.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

669

1.11

0.23

12.8

6.7

113.21

110.85

ml/min/173m2

0.33

432

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

1.23

0.22

1.0

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

126

1.21

0.22

1.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

1.20

0.21

1.2

1.1

—

(3021578) Parainfluenza virus 2 Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3005880) Parainfluenza virus 3 Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3010464) Parainfluenza virus 1 Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.3

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.21

0.0

1.5

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

0.00

0.21

0.0

1.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

0.00

0.21

0.0

1.8

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

36000.00

—

(3035637) Corticotropin [Mass/volume] in Plasma

1.27

0.21

1.8

2.0

—

(4035726) Immunohistochemistry procedure

1.27

0.21

2.8

1.8

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.4

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3000991) Gas panel - Venous blood

328

1.12

0.20

9.3

12.9

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

1.26

0.20

1.7

3.2

21.83

23.13

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.26

0.20

1.2

2.3

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.20

0.0

1.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

146

1.18

0.20

1.9

1.5

1.29

1.37

0.38

133

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.21

0.20

2.2

2.0

—

(3016879) Cocaine [Presence] in Urine

156

1.17

0.19

1.7

—

(3006315) Basophils [#/volume] in Blood

893

1.09

0.19

7.5

9.7

0.04

e9/l

0.04

743

(3019198) Lymphocytes [#/volume] in Blood

924

1.09

0.18

7.5

9.5

2.63

2.45

e9/l

0.70

798

(3001604) Monocytes [#/volume] in Blood

895

1.09

0.18

7.5

9.6

0.58

0.57

e9/l

0.13

745

(3023183) Ammonium ion [Moles/volume] in Plasma

1.13

0.17

2.4

4.6

35.57

36.90

umol/l

—

(4200892) Spirometry reversibility

0.76

0.17

2.2

1.6

—

(3016244) Insulin [Units/volume] in Serum or Plasma

1.12

0.16

2.4

3.3

18.75

14.69

mu/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

958

1.08

0.16

8.1

11.1

3.57

3.44

e9/l

0.18

804

(3000494) Fungus identified in Specimen by Culture

119

0.83

0.16

1.6

1.4

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

1.13

0.15

1.0

19.56

19.74

mmol/l

—

(3021706) Oxygen [Partial pressure] in Arterial cord blood

1.13

0.15

1.0

3.70

3.41

kpa

—

(3006598) pH of Arterial cord blood

1.12

0.15

1.0

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

1.12

0.15

1.0

6.44

7.13

kpa

—

(3013115) Eosinophils [#/volume] in Blood

909

1.08

0.15

7.9

10.6

0.21

0.22

e9/l

0.31

778

(21494755) Public health laboratory ask at order entry panel

1.10

0.15

1.0

1.2

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

151

1.14

0.14

1.2

0.48

2.47

u/ml

1.90

125

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

113

1.16

0.13

1.9

2.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

148

1461

1.10

0.11

4.6

4.1

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

163

1.12

0.11

1.2

1.3

0.26

3.37

u/ml

2.32

131

(3042936) Bacteria identified in Isolate by Culture

134

1.13

0.11

2.0

2.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.17

0.10

1.8

—

(3021589) Normoblasts [#/volume] in Blood

877

1.06

0.10

9.3

11.5

0.00

e9/l

-0.00

675

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

1.14

0.10

2.4

2.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.07

0.09

17.4

26.4

95.62

95.04

—

(3045462) Protein/Creatinine [Ratio] in Urine

1.04

0.09

11.8

8.9

30.24

1161.10

g/mol

—

(3044889) 12 lead EKG panel

510

0.94

0.09

2.9

2.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

195

0.91

0.08

1.7

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.81

0.08

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.80

0.08

1.2

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.80

0.08

1.2

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

147

1.10

0.07

2.3

2.7

8.78

12.65

ng/l

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

196

1.08

0.07

1.8

1.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.84

0.07

1.3

1.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.04

0.07

3.0

3.1

5.13

5.19

pmol/l

—

(3028707) Methadone [Presence] in Urine by Screen method

1.04

0.07

1.8

2.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.12

0.06

1.1

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

141

0.92

0.05

4.2

7.1

251.00

2747.57

umol/l

0.50

132

(3000764) Benzodiazepines [Presence] in Urine

169

1.07

0.05

1.9

1.7

—

(3027008) Opiates [Presence] in Urine

169

1.07

0.05

1.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

211

0.94

0.04

1.3

1.9

1.07

1.21

mmol/l

0.57

192

(3017143) Hepatitis C virus Ab [Presence] in Serum

209

1.06

0.04

2.3

1.6

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

150

1.07

0.04

1.2

0.14

0.96

u/ml

1.25

122

(3028300) Cannabinoids [Presence] in Urine

170

1.07

0.04

1.7

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

109

0.91

0.04

5.3

4.7

27.13

23.01

nmol/l

—

109

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

131

1.07

0.03

1.9

8.3

3.51

2.79

g/l

0.47

125

(3003888) Timothy IgE Ab [Units/volume] in Serum

151

1.07

0.03

1.2

0.43

6.37

u/ml

4.41

126

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

118

0.93

0.03

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

371

1.03

0.02

3.1

2.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

202

1.05

0.02

2.0

—

(40758558) Short blood count panel - Blood

561

1.02

0.02

4.9

9.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

831

1.02

0.02

10.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

143

1.05

0.01

2.0

10.4

97.13

90.30

0.71

143

(36660697) Celiac disease serology panel - Serum

283

1.03

0.01

1.4

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

111

0.99

0.00

1.2

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

234

0.98

0.00

1.5

5.5

1.42

1.46

mg/l

0.03

163

(3014111) Lactate [Moles/volume] in Serum or Plasma

137

1.02

0.00

10.4

16.6

1.46

1.48

mmol/l

0.03

131

(3027944) Amphetamines [Presence] in Urine

167

1.02

0.00

1.9

1.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.01

0.00

1.3

1.1

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.0

—

(3017461) Flecainide [Moles/volume] in Serum or Plasma

0.00

0.0

6.2

—

0.50

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(43055222) Platelet function.collagen + Adenosine diphosphate induced and EPINEPHrine induced panel - Blood

0.00

0.0

1.9

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.7

—

132.83

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

3.71

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3032868) Hemoglobin electrophoresis panel in Blood

0.00

0.0

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.97

-0.00

2.2

2.4

—

(40757578) FLT3 gene targeted mutation analysis in Bone marrow by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.96

-0.00

1.2

—

(3041082) Glomerular basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

-0.00

0.0

4.6

—

3.79

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3009871) Measles virus Ab [Titer] in Serum

0.00

-0.00

0.0

3.0

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

82.40

—

(3000492) Spirometry study

0.97

-0.00

1.0

1.4

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.96

-0.00

1.8

8.61

5.48

u/ml

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.02

-0.00

2.2

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

87.29

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

(3035401) Herpes virus 6 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3045209) Lutropin/Follitropin [Ratio] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

2.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3013931) Oligosaccharides [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.93

-0.00

3.2

2.2

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.1

—

(3003396) Base excess in Arterial blood by calculation

0.91

-0.00

14.7

19.4

1.65

0.56

mmol/l

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.96

-0.00

17.4

23.5

24.60

24.47

mmol/l

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.00

-0.00

1.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.1

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

2.0

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

0.70

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3019150) Specific gravity of Urine by Refractometry

280

1.00

-0.00

2.8

3.0

1.02

kg/l

0.17

Mortality – FinRegistry

↥

Association

Association between endpoint P16_FEEDI_PROBL_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_FEEDI_PROBL_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_FEEDI_PROBL_NEWBO – Feeding problems of newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Feeding problems of newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints