Disorders of muscle tone of newborn

P16_DISORD_MUSCLE_TONE_NEWBO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P94 Cause of death: ICD-10 — P94 2 out of 7 registries used, show all original rules.	62
4. Check minimum number of events None	62
5. Include endpoints None	62
6. Filter based on genotype QC (FinnGen only)	62

Control definitions (FinnGen only)

Control exclude: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P9
Name in latin: Dystonia muscularis neonati

NAME	P16_DISORD_MUSCLE_TONE_NEWBO
CONTROL_EXCLUDE	P16_OTH_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P94
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P94
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Disorders of muscle tone of newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2823	1183	1638
Only index persons	1569	650	919
Unadjusted period prevalence (%)
Whole population	0.04	0.03	0.05
Only index persons	0.03	0.02	0.04
Median age at first event (years)
Whole population	0.24	0.19	0.19
Only index persons	0.33	0.36	0.31

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	62	29	33
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	0.43	0.51	0.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
56: Matched controls
558

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

P94.2

ICD-10 Finland

Congenital hypotonia

+∞

36.5

P94.1

ICD-10 Finland

Congenital hypertonia

+∞

13.0

R62.0

ICD-10 Finland

Delayed milestone

9.4

9.3

F79.0

ICD-10 Finland

Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour

33.5

8.9

P94.9

ICD-10 Finland

Disorder of muscle tone of newborn, unspecified

+∞

8.5

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

9.3

7.3

P85

ICPC

Mental retardation

26.2

6.9

R62.8

ICD-10 Finland

Other lack of expected normal physiological development

17.0

6.7

F79.9

ICD-10 Finland

Unspecified mental retardation, without mention of impairment of behaviour

+∞

6.4

P94.8

ICD-10 Finland

Other disorders of muscle tone of newborn

+∞

6.4

R4110

NOMESCO Finland

Physiotherapy

4.4

6.3

103

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044640) Blood type and Crossmatch panel - Blood

142

2.77

3.68

5.6

3.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

8.92

2.80

2.8

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

191

2.25

2.47

6.6

4.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.50

2.44

3.3

1.8

—

(3023368) Bacteria identified in Blood by Culture

105

2.34

2.29

4.5

3.2

—

(1616796) Gas panel - Central venous blood

5.93

2.25

5.6

3.6

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

442

2.72

2.17

25.5

16.7

4.0

mmol/l

0.14

425

(3019550) Sodium [Moles/volume] in Serum or Plasma

443

2.69

2.16

23.4

16.8

139.2

139.3

mmol/l

0.14

430

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

141

2.15

2.09

9.2

15.5

0.0

0.9

mmol/l

0.67

105

(3015736) pH of Urine

160

2.08

1.99

5.3

4.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.03

1.98

1.3

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.03

1.98

1.3

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

163

2.02

1.88

5.7

4.8

11.5

37.8

e6/l

0.80

127

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

244

2.00

1.88

13.5

19.2

1.2

mmol/l

0.03

229

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

122

2.09

1.85

7.0

3.3

—

(3019060) Gas panel - Arterial blood

4.08

1.75

1.6

4.6

—

(3012544) pH of Venous blood

125

2.03

1.72

9.2

13.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

259

1.93

1.71

20.5

7.3

108.7

106.8

ml/min/173m2

0.12

177

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

143

1.97

1.67

10.9

21.1

24.2

24.6

mmol/l

0.32

143

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

280

1.92

1.66

11.0

5.5

129.6

128.7

u/l

0.02

262

(40758558) Short blood count panel - Blood

178

1.92

1.65

8.5

8.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

341

2.00

1.65

4.0

3.1

14.4

14.5

pmol/l

0.07

311

(3041096) Erythrocytes [Presence] in Urine by Automated

103

2.05

1.63

4.7

4.0

—

(3042936) Bacteria identified in Isolate by Culture

2.41

1.62

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

121

0.36

1.60

2.2

2.4

—

(3030467) Casts [#/volume] in Urine by Automated count

146

1.91

1.56

5.3

4.3

0.1

e6/l

0.23

110

(36304419) Bacteria [Presence] in Urine

148

1.88

1.49

4.7

4.3

—

(3052851) Hemolysis interference index of Serum or Plasma

2.91

1.47

2.5

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.15

1.46

1.8

2.2

—

(3022313) Gas panel - Capillary blood

126

1.87

1.36

9.4

14.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.29

1.36

3.1

6.8

150.3

160.2

—

(3000991) Gas panel - Venous blood

118

1.88

1.35

10.3

14.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

206

1.77

1.34

8.8

5.7

0.0

estimate

—

(3037467) Urinalysis macro (dipstick) panel - Urine

293

1.77

1.32

5.9

4.5

—

(3020630) Protein [Mass/volume] in Serum or Plasma

2.93

1.31

1.2

1.9

63.9

59.4

g/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

171

1.77

1.31

6.2

4.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

137

1.81

1.28

4.4

4.2

—

(3018095) Leukocytes [#/volume] in Urine

191

1.73

1.25

8.0

5.7

19.8

29.8

e6/l

0.38

129

(40761511) CBC panel - Blood by Automated count

471

2.13

1.25

14.1

9.7

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.77

1.24

17.8

11.0

60.5

54.3

—

(3021901) Oxygen saturation in Capillary blood

2.77

1.24

3.8

17.0

—

(3009261) Glucose [Presence] in Urine by Test strip

210

1.72

1.23

5.3

4.1

0.0

estimate

—

(3012516) Albumin [Mass/volume] in Urine

2.20

1.20

5.5

2.9

64.0

95.5

mg/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.50

1.16

1.3

1.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.33

1.12

2.4

2.0

—

(3037121) Protein [Mass/volume] in Urine

2.33

1.12

21.6

6.0

0.4

0.3

g/l

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

171

1.66

1.05

6.8

3.9

66.7

69.6

nmol/l

0.27

160

(40761536) Microorganisms panel - Urine sediment

2.12

1.04

3.3

—

(42870588) Differential panel, method unspecified - Blood

237

1.62

1.03

10.7

11.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

130

0.48

1.02

2.1

2.5

—

(3013512) EKG study

1.89

1.00

3.6

2.7

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.98

0.0

1.3

—

(3002256) Pathology report gross observation

2.00

0.97

1.3

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.86

0.97

1.3

2.3

—

(3000492) Spirometry study

2.18

0.92

2.2

1.3

—

(4035726)

2.18

0.92

1.5

1.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

459

1.82

0.92

12.2

8.9

27.0

24.9

u/l

0.32

442

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

132

1.63

0.90

10.4

13.0

23.4

24.2

mmol/l

1.42

132

(3026008) Bacteria identified in Urine by Culture

116

1.64

0.86

1.8

2.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

142

0.57

0.82

2.3

2.0

—

(3037522) Nuclear Ab [Titer] in Serum

1.85

0.81

1.3

1.8

—

462.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.78

0.79

1.9

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.74

0.78

1.9

2.2

—

(3013115) Eosinophils [#/volume] in Blood

308

1.50

0.77

11.1

0.2

e9/l

0.56

254

(3001604) Monocytes [#/volume] in Blood

299

1.49

0.75

10.9

10.3

0.6

e9/l

0.14

245

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

490

1.79

0.74

21.3

13.0

22.3

22.6

mg/l

0.02

357

(3006315) Basophils [#/volume] in Blood

300

1.48

0.73

10.9

10.2

0.0

e9/l

0.36

246

(3022145) Colonoscopy Study observation

2.00

0.72

1.4

1.7

—

(3019198) Lymphocytes [#/volume] in Blood

312

1.46

0.69

10.9

10.0

3.4

2.4

e9/l

0.45

261

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.59

0.69

4.9

3.8

1.0

0.4

e6/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

224

1.46

0.69

3.5

4.7

50.6

31.6

u/l

0.48

211

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.85

0.67

1.0

1.2

—

(3006504) Eosinophils/100 leukocytes in Blood

293

1.45

0.67

11.5

10.4

2.4

3.2

1.42

281

(3007164) IgA [Mass/volume] in Serum or Plasma

206

1.45

0.67

1.7

1.6

1.5

g/l

0.08

107

(3026782) Osmolality of Urine

1.57

0.66

4.6

3.6

557.1

580.4

mosm/kgh2o

0.17

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

234

0.67

0.65

2.1

—

(36660697) Celiac disease serology panel - Serum

1.55

0.63

1.3

1.2

—

(3019069) Monocytes/100 leukocytes in Blood

296

1.42

0.62

11.7

10.4

7.4

8.4

1.21

287

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.55

0.62

2.6

2.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.4

—

(3014599) Egg white IgE Ab [Units/volume] in Serum

0.00

0.61

0.0

1.7

—

5.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.61

0.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.60

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.60

0.0

1.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.60

0.0

1.0

—

(40761535) Cells panel - Urine sediment

0.00

0.59

0.0

3.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.59

0.0

1.9

—

(3044889) 12 lead EKG panel

191

1.42

0.59

2.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

100

1.52

0.58

5.1

4.0

0.7

2.5

e6/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

484

0.69

0.58

3.3

3.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

329

1.40

0.57

13.7

11.9

4.3

3.7

e9/l

0.75

272

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.55

0.57

3.1

12.5

94.1

89.7

—

(3003694) ABO and Rh group [Type] in Blood

165

1.41

0.55

1.7

—

(40768797) Stomach Pathology biopsy report

1.55

0.53

2.0

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.51

0.45

1.0

1.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.51

0.45

5.5

6.8

6.0

5.8

umol/l

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.42

0.0

4.5

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.6

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.46

0.40

3.8

21.8

1.8

1.3

mmol/l

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.63

0.38

1.0

2.1

—

(3000494) Fungus identified in Specimen by Culture

1.42

0.33

1.3

1.4

—

(3019150) Specific gravity of Urine by Refractometry

103

1.33

0.31

3.5

4.1

1.0

kg/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.36

0.30

1.8

1.5

97.5

94.9

pmol/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.66

0.28

2.6

1.8

—

(1761868) Lipid panel - Serum or Plasma

1.22

0.26

2.8

2.0

—

(3021589) Normoblasts [#/volume] in Blood

301

1.21

0.24

16.7

11.4

0.4

0.0

e9/l

0.49

229

(40768804) Tissue Pathology biopsy report

117

1.25

0.23

1.9

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.24

0.22

1.4

1.3

—

7.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

110

0.79

0.22

1.6

1.7

—

(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection

0.00

0.21

0.0

4.9

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

1.4

—

5.7

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3041672) Baker's yeast Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

30.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.21

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.5

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.20

0.0

2.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

484

1.17

0.12

25.0

18.4

38.5

38.6

0.06

432

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

1.15

0.10

1.0

20.6

19.3

mmol/l

—

(3006598) pH of Arterial cord blood

1.15

0.10

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.87

0.07

1.7

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

100

1.12

0.05

5.8

5.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

120

1.11

0.05

5.3

3.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

143

0.97

0.00

1.5

2.1

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3042733) HLA Ab [Presence] in Serum

0.00

0.0

2.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.1

—

205.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.3

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

4.4

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(42528717) Cashew nut recombinant (rAna o) 3 IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

7.8

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.0

34.4

—

0.7

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.3

—

(3001820) Epstein Barr virus nuclear Ab [Presence] in Serum

0.00

0.0

2.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.0

—

12.6

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

0.0

1.1

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.0

5.8

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3017461) Flecainide [Moles/volume] in Serum or Plasma

0.00

0.0

5.2

—

0.5

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

96.8

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

12.8

—

(3040893) Potassium [Moles/volume] in Capillary blood

0.00

0.0

5.4

—

4.4

—

(3007302) Hemoglobin [Mass/volume] in Mixed venous blood

0.00

0.0

2.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

8.2

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

6.7

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.6

—

(4198724)

0.00

0.0

3.1

—

(3042299) inFLIXimab [Mass/volume] in Serum or Plasma

0.00

0.0

14.3

—

9.5

—

(4094501)

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

0.0

12.8

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.2

—

0.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_DISORD_MUSCLE_TONE_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_DISORD_MUSCLE_TONE_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_DISORD_MUSCLE_TONE_NEWBO – Disorders of muscle tone of newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Disorders of muscle tone of newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints