Convulsions of newborn

P16_CONVU_NEWBO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P90 Cause of death: ICD-10 — P90 2 out of 7 registries used, show all original rules.	23
4. Check minimum number of events None	23
5. Include endpoints None	23
6. Filter based on genotype QC (FinnGen only)	23

Control definitions (FinnGen only)

Control exclude: P16_OTH_DISORD_ORIGINA_PERINA_PERIOD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P9
Name in latin: Convulsiones neonati (benignae)

NAME	P16_CONVU_NEWBO
CONTROL_EXCLUDE	P16_OTH_DISORD_ORIGINA_PERINA_PERIOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P90
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P90
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Convulsions of newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1496	612	883
Only index persons	914	371	543
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	0.06	0.01	0.01
Only index persons	0.01	0.01	0.01

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	23	10	13
Unadjusted period prevalence (%)	0.00	0.00	0.01
Median age at first event (years)	0.01	0.01	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3009466) Valproate [Moles/volume] in Serum or Plasma

9.61

3.27

6.2

4.9

553.3

454.4

umol/l

—

(3023183) Ammonium ion [Moles/volume] in Plasma

6.33

2.58

2.2

7.9

35.0

47.9

umol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

5.38

2.32

1.3

1.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

3.53

1.95

3.0

2.6

706.0

462.3

u/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

2.75

1.57

11.1

6.0

130.5

133.4

u/l

0.04

(3000991) Gas panel - Venous blood

2.84

1.49

9.2

19.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.45

1.44

2.2

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.45

1.44

2.2

1.9

—

(3002032) Base excess in Venous blood by calculation

2.63

1.31

5.4

10.6

0.5

0.9

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

1.28

0.0

1.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

2.69

1.21

9.6

15.3

0.8

mmol/l

—

(40758558) Short blood count panel - Blood

2.44

1.18

21.5

4.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.61

1.09

11.0

8.2

164.8

158.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.61

1.09

2.2

2.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

1.04

0.0

1.0

—

(3033658) Prothrombin time (PT) actual/Normal

2.28

0.99

13.2

10.4

77.3

85.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

0.43

0.93

3.0

2.8

33.8

35.1

mmol/mol

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

199

0.44

0.92

4.3

3.5

—

(3022313) Gas panel - Capillary blood

2.14

0.91

15.7

10.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.47

0.90

2.2

1.8

—

(3036489) Thrombin time

2.49

0.82

11.0

8.2

23.6

23.5

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.37

0.80

12.0

8.9

3.0

2.8

g/l

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.92

0.68

12.2

9.3

78.4

88.3

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.63

0.0

3.0

—

9265.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.72

0.58

1.2

3.8

—

(3048689) Calprotectin [Mass/mass] in Stool

1.72

0.58

1.5

2.4

65.7

46.6

ug/g

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.70

0.54

3.3

3.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

1.75

0.54

21.5

13.1

1.2

mmol/l

0.58

(3013826) Glucose [Moles/volume] in Serum or Plasma

1.72

0.51

16.2

12.1

5.4

6.0

mmol/l

1.12

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.69

0.51

18.0

10.2

24.5

24.4

mmol/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.58

0.49

21.1

10.5

1.5

1.4

mmol/l

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.43

0.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.43

0.0

2.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.43

0.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3032080) INR in Blood by Coagulation assay

1.67

0.41

2.3

4.5

—

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.58

0.40

3.7

3.1

—

(3044640) Blood type and Crossmatch panel - Blood

1.57

0.37

10.9

3.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.48

0.34

23.9

13.7

25.3

24.7

mmol/l

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.40

0.25

12.4

7.2

35.4

31.9

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.34

0.23

1.7

2.8

2.4

mmol/l

—

(3008898) HLA-B27 [Presence]

0.00

0.22

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.22

0.0

1.1

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.22

0.0

2.3

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

1.7

—

0.1

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.22

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.22

0.0

1.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.22

0.0

1.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

1.38

0.21

11.3

5.5

109.2

112.6

ml/min/173m2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

0.3

—

(3002256) Pathology report gross observation

0.00

0.21

0.0

1.1

—

(3015736) pH of Urine

0.74

0.20

3.2

3.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.35

0.19

28.9

19.3

1.2

mmol/l

0.13

(3007164) IgA [Mass/volume] in Serum or Plasma

1.35

0.19

1.5

1.2

g/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

1.33

0.19

1.9

3.2

38.4

36.2

ug/l

—

(3013707) Erythrocyte sedimentation rate by Westergren method

116

1.28

0.13

1.8

4.1

6.1

8.1

mm/h

0.55

104

(40761511) CBC panel - Blood by Automated count

176

0.87

0.10

11.9

8.8

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

1.12

0.10

1.2

2.3

3.6

2.6

mg/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.79

0.09

1.0

2.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

155

0.91

0.09

6.1

3.3

2.3

2.0

mu/l

0.47

143

(3044889) 12 lead EKG panel

0.84

0.09

2.0

2.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

1.18

0.09

2.9

5.0

—

0.0

—

(3009261) Glucose [Presence] in Urine by Test strip

1.18

0.09

2.1

3.4

—

0.0

—

(3035350) Ketones [Presence] in Urine by Test strip

1.16

0.09

2.1

3.4

—

0.0

—

(42870588) Differential panel, method unspecified - Blood

1.13

0.02

12.1

7.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

109

1.02

0.00

2.6

4.4

—

(3014599) Egg white IgE Ab [Units/volume] in Serum

0.00

0.0

2.0

—

4.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

139.2

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3000492) Spirometry study

0.00

0.0

1.9

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

3.2

—

(3011648) Oxygen content in Venous blood

0.00

0.0

17.5

—

11.9

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

8.5

—

1.7

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3012494) Peanut IgE Ab [Units/volume] in Serum

0.00

0.0

1.6

—

5.5

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

4.0

—

32.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection

0.00

0.0

5.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(4010399)

0.00

0.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

5.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(36304419) Bacteria [Presence] in Urine

0.98

0.00

2.0

4.0

—

(3019225) pH of Specimen

0.00

0.0

13.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

2.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.88

0.00

2.2

3.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

1.8

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.9

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

3.2

—

92.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3003101) Alpha 1 antitrypsin [Mass/mass] in Stool

0.00

0.0

2.6

—

143.4

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

2.2

—

(3003694) ABO and Rh group [Type] in Blood

0.94

0.00

1.5

1.9

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.0

1.0

—

60.2

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.90

0.00

4.5

4.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.0

1.6

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3022229) Phosphate [Moles/volume] in Urine

0.00

0.0

2.0

—

11.9

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

0.1

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

0.0

3.2

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.0

1.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

3.2

—

(3007302) Hemoglobin [Mass/volume] in Mixed venous blood

0.00

0.0

3.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.98

0.00

1.9

4.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.3

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_CONVU_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_CONVU_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_CONVU_NEWBO – Convulsions of newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Convulsions of newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints