mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
587 |
4. Check minimum number of eventsNone |
587 |
5. Include endpointsNone |
587 |
6. Filter based on genotype QC (FinnGen only) |
587 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified mental retardation
based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation, excluding more controls
- Mental retardation, wide definition
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16429 | 6793 | 9614 |
| Only index persons | 12801 | 5334 | 7467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.19 | 0.27 |
| Only index persons | 0.25 | 0.20 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 7.92 | 9.25 | 6.90 |
| Only index persons | 9.82 | 11.70 | 8.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 587 | 266 | 321 |
| Unadjusted period prevalence (%) | 0.12 | 0.09 | 0.14 |
| Median age at first event (years) | 10.49 | 13.30 | 8.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 534
- Matched controls
- 5330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
1186.5
285.4
254
*
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
1207.8
104.9
99
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
15.5
96.9
170
156
N03AG01
ATC
valproic acid; systemic, rectal
14.9
95.8
171
163
P85
ICPC
Mental retardation
129.4
91.3
96
9
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
513.1
90.0
87
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
8.6
73.2
180
299
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
69.3
65
*
N05AX08
ATC
risperidone; systemic
10.7
66.1
137
166
G40.9
ICD-10 Finland
Epilepsy, unspecified
16.6
65.2
108
80
N05BA09
ATC
clobazam; oral
31.8
63.2
84
31
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
61.6
58
*
183
Kela drug reimbursment
Lamotrigin and topiramate
32.8
56.2
74
26
N05BA01
ATC
diazepam; systemic, rectal
7.3
55.9
149
267
F83
ICD-10 Finland
Mixed specific developmental disorders
13.4
55.8
101
91
3199A
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS,EI KÄYTTÄYTYMIHÄIRI]
+∞
55.1
52
*
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
583.3
54.5
53
*
N03AX14
ATC
levetiracetam; systemic
16.1
54.1
90
66
F78.0
ICD-10 Finland
Other mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
54.0
51
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
18.6
53.5
84
53
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
71.9
51.3
58
9
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
+∞
48.7
46
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
8.4
48.4
114
166
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.2
47.2
125
217
31599
ICD-8 Finland
Unspecified mental retardation, Other and unspecified
+∞
46.5
44
*
N03AG04
ATC
vigabatrin; oral
167.1
44.5
46
*
N03AX09
ATC
lamotrigine; oral
9.1
44.2
98
128
R62.0
ICD-10 Finland
Delayed milestone
9.3
43.2
94
119
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
+∞
42.2
40
*
N05CD08
ATC
midazolam; nasal, systemic
12.0
40.8
77
74
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.7
39.9
127
276
N03AX11
ATC
topiramate; oral
14.5
39.0
67
52
N05AA02
ATC
levomepromazine; systemic
10.8
36.8
73
77
181
Kela drug reimbursment
Retigabine and vigabatrin
135.8
36.2
38
*
F79
ICD-10 Finland
Unspecified mental retardation
346.9
33.2
33
*
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
32.6
31
*
N05AH03
ATC
olanzapine; systemic
6.5
32.2
89
159
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.3
31.0
102
226
A06AD11
ATC
lactulose; oral
5.7
30.6
94
192
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.6
29.7
160
563
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.4
29.3
50
38
N03AF01
ATC
carbamazepine; oral, rectal
9.6
28.8
60
69
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.1
28.8
126
372
G40.89
ICD-10 Finland
Other epilepsy
38.4
28.7
36
10
XA800
NOMESCO Finland
Neuropsychological investigation
5.1
28.6
98
226
EBA15
NOMESCO Finland
Extraction of large number of teeth
7.1
28.1
72
115
F29
ICD-10 Finland
Unspecified nonorganic psychosis
7.6
27.6
67
99
Z2446
NOMESCO Finland
Social worker
3.7
27.0
137
458
RL140
NOMESCO Finland
NA
16.0
26.5
43
29
N05BA06
ATC
lorazepam; systemic, sublingual
9.2
26.3
56
67
N03AF02
ATC
oxcarbazepine; oral
6.9
26.1
68
111
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.1
25.6
47
42
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
25.2
24
*
Z31.5
ICD-10 Finland
Genetic counselling
5.3
25.2
81
173
N05AC02
ATC
thioridazine; oral
14.6
24.9
42
31
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.5
24.5
94
242
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
11.9
24.3
45
41
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.3
23.7
144
543
A28
ICPC
Limited function/disability NOS
4.3
23.1
92
245
L28
ICPC
Limited function/disability (L)
4.4
22.6
87
224
N05AH04
ATC
quetiapine; oral
3.3
22.4
127
455
RT490
NOMESCO Finland
NA
25.2
22.4
31
13
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
21.8
177
807
N03AE01
ATC
clonazepam; systemic
6.9
21.6
55
87
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
24.3
21.5
30
13
Z2445
NOMESCO Finland
Psychologist
3.8
21.4
99
301
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
62.5
21.0
24
*
N05AB03
ATC
perphenazine; systemic, rectal
9.6
21.0
43
48
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
19.2
20.6
31
17
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.5
20.4
77
194
RT274
NOMESCO Finland
NA
59.8
20.0
23
*
H50.30
ICD-10 Finland
Intermittent esotropy
9.5
20.0
41
46
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
19.7
98
315
H52.2
ICD-10 Finland
Astigmatism
7.2
19.2
47
70
F78.1
ICD-10 Finland
Other mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
18.8
18
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
12.0
18.7
34
30
F84.0
ICD-10 Finland
Childhood autism
39.9
18.7
23
6
N03AF03
ATC
rufinamide; oral
103.5
18.7
20
*
F71.9
ICD-10 Finland
Moderate mental retardation, without mention of impairment of behaviour
196.3
18.6
19
*
SPAT1262
SPAT
Handing over of treatment supplies
3.3
18.4
105
372
RT150
NOMESCO Finland
NA
10.9
18.4
35
34
M41.4
ICD-10 Finland
Neuromuscular scoliosis
45.6
18.4
22
5
M79.0
ICD-10 Finland
Rheumatism, unspecified
12.0
18.2
33
29
N05AH02
ATC
clozapine; systemic
8.4
18.1
40
51
N03AB02
ATC
phenytoin; systemic
38.1
17.7
22
6
N05AF03
ATC
chlorprothixene; systemic
7.8
17.3
40
55
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
12.1
17.2
31
27
Z3226
NOMESCO Finland
Physiotherapist
2.5
17.2
160
770
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
10.0
17.1
34
36
RS222
NOMESCO Finland
NA
9.3
16.9
35
40
SAA03
NOMESCO Finland
Extended examination of mouth
2.2
16.9
285
1829
7834D
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[LAPSEN NORMAALIN KEHITTYMISEN HIDASTUMINEN]
+∞
16.7
16
*
N04AA02
ATC
biperiden; systemic
10.5
16.6
32
32
SPAT1229
SPAT
Assessment of need for aid
5.7
16.6
48
90
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
16.5
75
223
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
10.2
16.4
32
33
RT190
NOMESCO Finland
NA
25.4
16.1
22
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
16.0
128
562
P72
ICPC
Schizophrenia
10.9
15.9
30
29
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
34.5
15.8
20
6
3459X
ICD-9 Finland
Epilepsy, unspecified
87.6
15.6
17
*
N05AD01
ATC
haloperidol; systemic
8.1
15.6
35
46
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
39.2
15.5
19
5
R1260
NOMESCO Finland
Evaluation of communicative skills
8.7
15.5
33
40
R11
ICD-10 Finland
Nausea and vomiting
3.4
15.4
80
265
G40.10
ICD-10 Finland
Simple partial seizures
16.7
15.4
24
15
N06AB04
ATC
citalopram; systemic
2.8
14.9
106
434
RL130
NOMESCO Finland
NA
8.8
14.7
31
37
F71
ICD-10 Finland
Moderate mental retardation
+∞
14.6
14
*
31199
ICD-8 Finland
Mild mental retardation, Other and unspecified
+∞
14.6
14
*
SDA02
NOMESCO Finland
Parodonthologic therapy
2.2
14.6
200
1145
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
82.3
14.6
16
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
10.5
14.6
28
28
Q99.8
ICD-10 Finland
Other specified chromosome abnormalities
15.9
14.5
23
15
N03AX15
ATC
zonisamide; oral
19.8
14.3
21
11
199
Kela drug reimbursment
Rufinamide
77.0
13.6
15
*
3170A
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,EI KÄYTÄYTYM.HÄIRIÖTÄ]
+∞
13.6
13
*
3199B
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS JA KÄYTTÄYTYMIHÄIRI]
+∞
13.6
13
*
N88
ICPC
Epilepsy
16.7
13.5
21
13
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
16.7
13.5
21
13
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
143.2
13.5
14
*
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
26.5
13.4
18
7
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.8
13.3
95
388
N05AX12
ATC
aripiprazole; systemic
4.3
13.2
50
126
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
13.2
200
1185
JDB10
NOMESCO Finland
Percutaneous gastrostomy
11.3
13.1
24
22
G40.39
ICD-10 Finland
Other or unspecified generalized epileptic syndromes with atonic, clonic, myoclonic or tonic-clonic seizures
11.3
13.1
24
22
R4110
NOMESCO Finland
Physiotherapy
2.2
12.8
162
888
K03.66
ICD-10 Finland
Tooth plaque
2.8
12.8
87
343
N03AX18
ATC
lacosamide; systemic
12.7
12.7
22
18
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
3.0
12.6
79
294
3046
Kela drug reimbursment
NA
+∞
12.5
12
*
N03AX17
ATC
stiripentol; oral
+∞
12.5
12
*
V628A
ICD-9 Finland
Other psychosocial circumstances, Other psychological or physical stress, not elsewhere classified
+∞
12.5
12
*
3153A
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[KIELENKEHITYKSEN ERITYISVAIKEUS]
132.8
12.5
13
*
N05AC01
ATC
periciazine; systemic
132.8
12.5
13
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
8.3
12.5
27
34
G03DC03
ATC
lynestrenol; oral
8.3
12.5
27
34
SPAT1234
SPAT
Support of social functional capacity
6.2
12.4
33
56
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
12.3
97
419
N05BA04
ATC
oxazepam; oral
2.4
12.2
118
567
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
5.4
12.2
36
70
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.6
12.0
98
430
SAA02
NOMESCO Finland
Basic examination of mouth
2.0
12.0
397
3136
N06AA09
ATC
amitriptyline; systemic
4.0
12.0
48
128
34599
ICD-8 Finland
Epilepsy, Other and unspecified
47.7
11.9
14
*
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
47.7
11.9
14
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
11.8
50
140
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
16.8
11.7
18
11
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
30.7
11.7
15
5
T90
ICPC
Diabetes non-insulin dependent
2.7
11.6
84
343
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
8.9
11.6
24
28
EBA00
NOMESCO Finland
Extraction of tooth
2.0
11.6
209
1314
N05AA01
ATC
chlorpromazine; systemic, rectal
14.0
11.5
19
14
F78.9
ICD-10 Finland
Other mental retardation, without mention of impairment of behaviour
+∞
11.5
11
*
F72.1
ICD-10 Finland
Severe mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
11.5
11
*
OAB43
SPAT
NA
0.2
11.4
14
585
A10BA02
ATC
metformin; oral
2.5
11.4
97
437
U04
ICPC
Incontinence urine
5.9
11.3
31
55
ZXE00
NOMESCO Finland
One hour or less
1.9
11.3
235
1550
L17
ICPC
Foot/toe symptom/complaint
2.2
11.2
136
725
WYA30
SPAT
NA
13.1
11.2
19
15
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.3
11.2
24
30
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.1
11.1
64
227
Q04.8
ICD-10 Finland
Other specified congenital malformations of brain
44.2
11.0
13
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.2
10.9
9
483
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
10.7
174
1044
N05AF05
ATC
zuclopenthixol; systemic
13.2
10.7
18
14
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
61.1
10.7
12
*
M03BX01
ATC
baclofen; systemic
11.5
10.6
19
17
P99
ICPC
Psychological disorders other
5.8
10.6
29
52
H50.31
ICD-10 Finland
Intermittent exotropia
6.1
10.6
28
48
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.6
10.5
78
325
G80.3
ICD-10 Finland
Dyskinetic cerebral palsy
111.9
10.4
11
*
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
+∞
10.4
10
*
3170B
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,JOSSA KÄYTÄYTYM.HÄIRI]
+∞
10.4
10
*
31509
ICD-8 Finland
Unspecified mental retardation, Following infections and intoxications, Unspecified
+∞
10.4
10
*
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
33.2
10.4
13
*
K02.1
ICD-10 Finland
Caries of dentine
1.8
10.4
319
2387
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
19.2
10.3
15
8
RS142
NOMESCO Finland
NA
23.9
10.3
14
6
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.2
10.3
14
555
G41.9
ICD-10 Finland
Status epilepticus, unspecified
13.4
10.2
17
13
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
10.1
65
247
4122
FHL
Tympanostomy (tympanic tube)
6.5
9.9
25
40
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
7.2
9.9
23
33
AA1AD
NOMESCO Finland
CT of head and brain
2.4
9.8
87
398
N05CD07
ATC
temazepam; oral
3.4
9.8
47
147
N03AA02
ATC
phenobarbital; systemic
55.9
9.7
11
*
Q93.5
ICD-10 Finland
Other deletions of part of a chromosome
55.9
9.7
11
*
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
55.9
9.7
11
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
9.3
9.6
19
21
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
10.3
9.6
18
18
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
9.5
210
1394
AA10D
NOMESCO Finland
NA
101.6
9.4
10
*
4451
FHL
Guitar cutting
3.8
9.4
39
108
7803A
ICD-9 Finland
General symptoms, Convulsions
8.3
9.4
20
25
F73.0
ICD-10 Finland
Profound mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
9.4
9
*
F70
ICD-10 Finland
Mild mental retardation
+∞
9.4
9
*
3AX01
NOMESCO Finland
NA
22.1
9.4
13
6
UDC00
NOMESCO Finland
Ear microscopy
2.9
9.4
58
216
F22.0
ICD-10 Finland
Delusional disorder
9.7
9.3
18
19
Z2221
NOMESCO Finland
Medical doctor
1.9
9.3
159
963
R32
ICD-10 Finland
Unspecified urinary incontinence
6.2
9.3
24
40
C03CA01
ATC
furosemide; systemic
2.5
9.3
76
332
RT160
NOMESCO Finland
NA
7.9
9.2
20
26
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
9.1
101
513
K59.0
ICD-10 Finland
Constipation
3.7
9.1
39
111
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
9.1
67
276
F20.5
ICD-10 Finland
Residual schizophrenia
15.9
9.1
14
9
Z93.1
ICD-10 Finland
Gastrostomy status
37.3
9.0
11
*
K02.9
ICD-10 Finland
Dental caries, unspecified
6.3
9.0
23
38
H52.0
ICD-10 Finland
Hypermetropia
3.9
9.0
36
97
G91.1
ICD-10 Finland
Obstructive hydrocephalus
19.0
9.0
13
7
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
24.4
8.9
12
5
R60.0
ICD-10 Finland
Localized oedema
3.2
8.9
46
152
K59.09
ICD-10 Finland
Constipation, unspecified
3.0
8.8
50
175
R50.9
ICD-10 Finland
Fever, unspecified
2.1
8.8
114
620
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
4.8
8.7
28
61
G80.8
ICD-10 Finland
Other cerebral palsy
50.7
8.7
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
8.6
109
585
P28
ICPC
Limited function/disability (P)
16.6
8.6
13
8
Z01.2
ICD-10 Finland
Dental examination
1.7
8.6
262
1908
RS312
NOMESCO Finland
NA
28.0
8.5
11
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
28.0
8.5
11
*
F20.8
ICD-10 Finland
Other schizophrenia
28.0
8.5
11
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
8.4
81
384
Q04.3
ICD-10 Finland
Other reduction deformities of brain
91.3
8.4
9
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
8.4
60
244
RF311
NOMESCO Finland
NA
+∞
8.3
8
*
31500
ICD-8 Finland
Unspecified mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
8.3
8
*
F72.9
ICD-10 Finland
Severe mental retardation, without mention of impairment of behaviour
+∞
8.3
8
*
H47.6
ICD-10 Finland
Disorders of visual cortex
+∞
8.3
8
*
G40
ICD-10 Finland
Epilepsy
11.0
8.3
15
14
N05AD03
ATC
melperone; systemic
9.6
8.3
16
17
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.5
8.2
64
272
H13
ICPC
Plugged feeling ear
2.3
8.2
75
349
Z3231
NOMESCO Finland
Registered nurse
1.8
8.1
184
1216
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
33.8
8.1
10
*
5210A
ICD-9 Finland
Diseases of hard tissues of teeth, Dental caries
33.8
8.1
10
*
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
9.1
8.1
16
18
30180
ICD-8 Finland
Personality disorders, Immatura
22.4
8.0
11
5
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.8
8.0
32
87
RS211
NOMESCO Finland
NA
6.7
7.9
19
29
R4130
NOMESCO Finland
Speech therapy
3.6
7.9
34
98
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
7.9
76
362
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
6.2
7.9
20
33
DFF20
NOMESCO Finland
Audiometry for children
4.1
7.9
29
73
WYA20
NOMESCO Finland
Home visit
7.1
7.8
18
26
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.3
7.8
37
116
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.3
7.8
37
116
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
15.3
7.7
12
8
Q89.7
ICD-10 Finland
Multiple congenital malformations, not elsewhere classified
15.3
7.7
12
8
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.8
7.7
164
1060
Z02.7
ICD-10 Finland
Issue of medical certificate
3.5
7.7
35
106
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
18.6
7.6
11
6
N03AD01
ATC
ethosuximide; oral
18.6
7.6
11
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.6
185
1247
U07.2
ICD-10 Finland
COVID-19, virus not identified
0.4
7.6
26
657
M03BX02
ATC
tizanidine; oral
0.6
7.6
120
1818
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.6
114
653
G40.1
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
25.4
7.6
10
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.5
7.6
34
102
R13
ICD-10 Finland
Dysphagia
4.0
7.6
29
76
R4120
NOMESCO Finland
Occupational therapy
2.7
7.6
51
200
XX4AW
NOMESCO Finland
NA
4.5
7.5
25
57
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
7.5
60
259
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
4.7
7.5
24
53
H61.2
ICD-10 Finland
Impacted cerumen
3.4
7.4
35
109
Q02
ICD-10 Finland
Microcephaly
81.0
7.4
8
*
Z50.5
ICD-10 Finland
Speech therapy
2.9
7.4
44
161
Z39.2
ICD-10 Finland
Routine postpartum follow-up
0.1
7.4
*
283
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
2.1
7.4
83
425
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
8.5
7.3
15
18
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.1
7.3
39
133
N03AX22
ATC
perampanel; oral
11.0
7.3
13
12
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
7.3
94
506
31109
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Unspecified
+∞
7.3
7
*
R45.1
ICD-10 Finland
Restlessness and agitation
+∞
7.3
7
*
G40.0
ICD-10 Finland
Localization-related (focal)(partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset
+∞
7.3
7
*
31299
ICD-8 Finland
Moderate mental retardation, Other and unspecified
+∞
7.3
7
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
7.3
101
561
S01.3
ICD-10 Finland
Open wound of ear
16.0
7.2
11
7
SPAT1301
SPAT
No procedures
1.8
7.2
157
1018
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
7.2
141
886
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
7.2
109
624
R33
ICD-10 Finland
Retention of urine
3.7
7.2
30
85
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
20.3
7.1
10
5
F21
ICD-10 Finland
Schizotypal disorder
8.1
7.1
15
19
ZXA10
NOMESCO Finland
Bilateral
2.0
7.1
100
559
U07
ICPC
Urine symptom/complaint other
3.3
7.1
34
108
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
7.0
96
532
SCF02
NOMESCO Finland
Preventive oral care by dental hygienist
3.0
7.0
40
142
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.0
7.0
88
470
KMAK
NOMESCO Finland
NA
1.7
6.9
217
1562
R4190
NOMESCO Finland
Nutritional therapy
2.3
6.9
64
297
RS314
NOMESCO Finland
NA
14.0
6.9
11
8
F20
ICD-10 Finland
Schizophrenia
14.0
6.9
11
8
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
6.9
42
157
-31
ICPC
Medical examin/health eval partial
2.9
6.9
41
151
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.7
6.9
28
78
H54.7
ICD-10 Finland
Unspecified visual loss
8.4
6.9
14
17
F61.0
ICD-10 Finland
Mixed personality disorders
5.1
6.9
20
40
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
6.8
47
187
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
6.8
47
187
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.2
6.8
34
111
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
11.1
6.8
12
11
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.2
6.8
6
306
R53
ICD-10 Finland
Malaise and fatigue
2.0
6.8
87
470
H51.9
ICD-10 Finland
Disorder of binocular movement, unspecified
40.5
6.8
8
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
40.5
6.8
8
*
M01AB05
ATC
diclofenac; systemic, rectal
0.6
6.8
130
1885
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.6
6.7
48
197
WX402
NOMESCO Finland
General anaesthesia
1.9
6.7
115
687
A10BH01
ATC
sitagliptin; oral
3.3
6.7
32
102
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
5.6
6.6
18
33
NF1DA
NOMESCO Finland
X-ray of hips
6.0
6.6
17
29
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
12.4
6.6
11
9
H26.02
ICD-10 Finland
Presenil cataract
7.0
6.5
15
22
N05AN01
ATC
lithium; oral
4.6
6.5
21
47
F99
ICD-10 Finland
Mental disorder, not otherwise specified
5.4
6.5
18
34
M79.7
ICD-10 Finland
Fibromyalgia
5.8
6.5
17
30
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
70.5
6.4
7
*
Q85.1
ICD-10 Finland
Tuberous sclerosis
70.5
6.4
7
*
2988A
ICD-9 Finland
Other nonorganic psychoses, Other and unspecified reactive psychosis
70.5
6.4
7
*
A03FA02
ATC
cisapride; oral, rectal
3.2
6.4
32
105
T82
ICPC
Obesity
3.5
6.4
28
83
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
14.5
6.4
10
7
Q90.9
ICD-10 Finland
Down syndrome, unspecified
14.5
6.4
10
7
K05.18
ICD-10 Finland
Chronic gingivitis
3.0
6.4
36
126
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.8
6.4
122
757
F60.9
ICD-10 Finland
Personality disorder, unspecified
6.7
6.4
15
23
K07.24
ICD-10 Finland
Open bite
4.1
6.3
23
58
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
6.3
47
194
S22
ICPC
Nail symptom/complaint
3.0
6.3
36
127
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
6.3
94
533
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
4.7
6.3
20
44
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.1
6.3
33
112
RS230
NOMESCO Finland
NA
9.4
6.3
12
13
N05CD02
ATC
nitrazepam; oral
9.4
6.3
12
13
RT130
NOMESCO Finland
NA
18.2
6.3
9
5
Q93.8
ICD-10 Finland
Other deletions from the autosomes
18.2
6.3
9
5
WX730
NOMESCO Finland
Conventional respirator
4.9
6.3
19
40
NEK20
NOMESCO Finland
Fenestration or forage of bone of pelvis
+∞
6.3
6
*
G40.59
ICD-10 Finland
Other special epileptic syndromes
+∞
6.3
6
*
3180A
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS,EI KÄYTÄYT.HÄIR]
+∞
6.3
6
*
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
6.3
6
*
N03AX24
ATC
cannabidiol; oral
+∞
6.3
6
*
31550
ICD-8 Finland
Unspecified mental retardation, With chromosomal abnormalities, Morbus Down (mongolismi)
+∞
6.3
6
*
WX110
NOMESCO Finland
Local anesthesy
1.6
6.3
356
2955
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
6.3
73
378
H60.9
ICD-10 Finland
Otitis externa, unspecified
2.6
6.2
44
179
SPAT1364
SPAT
Health check-up performed during second study year in students of upper secondary schools, vocational schools etc.
0.1
6.2
*
230
R1250
NOMESCO Finland
Evaluation of functional capability
4.6
6.2
20
45
TJF80
NOMESCO Finland
Ostomy education
6.4
6.2
15
24
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.2
108
650
N99
ICPC
Neurological disease other
7.8
6.1
13
17
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
6.1
117
727
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
6.1
46
195
N28
ICPC
Limited function/disability (N)
6.8
6.1
14
21
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
6.8
6.1
14
21
H53.0
ICD-10 Finland
Amblyopia ex anopsia
4.2
6.1
21
51
N06AX03
ATC
mianserin; oral
3.9
6.0
23
61
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
3.2
6.0
29
93
Mortality – FinRegistry
↥Association
Association between endpoint F5_OTHRET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_OTHRET | 5.514 [4.46, 6.81] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 447 out of 3621 females with F5_OTHRET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_OTHRET | 4.418 [3.68, 5.31] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 509 out of 5439 males with F5_OTHRET died.
Mortality risk
Mortality risk for people of age
years, who have F5_OTHRET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.518% | 1.017% |
| 5 | 2.797% | 5.521% |
| 10 | 7.457% | 12.32% |
| 15 | 14.119% | 20.931% |
| 20 | 23.79% | 32.784% |
Relationships between endpoints
↥Index endpoint: F5_OTHRET – Other and unspecified mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data