This is a non-core endpoint: only basic statistics are computed.

Fracture of lower limb, level unspecified

EFO Endpoint Browser

ST19_FRACT_LOWER_LIMB_LEVEL_UNSPE

No definition available.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T12 Cause of death: ICD-10 — T12 2 out of 7 registries used, show all original rules.	18
4. Check minimum number of events None	18
5. Include endpoints None	18
6. Filter based on genotype QC (FinnGen only)	18

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T0[8-9]|T1[0-4]
Name in latin: Fractura membri inferioris, regione non specificata

NAME	ST19_FRACT_LOWER_LIMB_LEVEL_UNSPE
CONTROL_EXCLUDE	ST19_INJURI_UNSPE_PART_TRUNK_LIMB_BODY_REGION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T12
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T12
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Fracture of lower limb, level unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	233	102	129
Only index persons	209	92	117
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	43.84	53.11	36.34
Only index persons	43.66	53.11	36.23

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	18	7	11
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	39.20	41.77	37.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

7.14

3.83

4.3

3.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

5.80

3.21

3.5

2.9

15.80

30.55

ng/l

—

(36304419) Bacteria [Presence] in Urine

4.58

2.45

5.3

2.9

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

5.84

2.37

3.7

1.9

31.67

28.39

—

(40758558) Short blood count panel - Blood

4.12

2.12

5.8

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

3.87

2.04

4.5

3.7

6.21

6.80

mmol/l

0.64

(3023368) Bacteria identified in Blood by Culture

3.83

1.82

5.9

4.0

—

(3013512) EKG study

3.73

1.81

5.3

5.5

—

(3032080) INR in Blood by Coagulation assay

3.59

1.77

4.8

3.4

—

1.17

—

(3015736) pH of Urine

3.59

1.77

8.3

3.5

—

(3026782) Osmolality of Urine

3.43

1.66

5.1

3.0

521.14

532.39

mosm/kgh2o

—

(3033658) Prothrombin time (PT) actual/Normal

3.43

1.66

9.7

2.9

105.29

98.39

—

(3044640) Blood type and Crossmatch panel - Blood

3.07

1.46

1.8

2.4

—

(3042936) Bacteria identified in Isolate by Culture

3.43

1.38

1.8

2.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

3.04

1.28

1.6

2.0

—

(3026008) Bacteria identified in Urine by Culture

2.53

1.12

4.1

3.9

—

(42870588) Differential panel, method unspecified - Blood

2.59

1.01

5.2

6.6

—

(3009508) Creatinine [Moles/volume] in Urine

2.39

0.95

7.5

2.7

10.67

9.97

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.17

0.75

2.0

2.8

—

(40768804) Tissue Pathology biopsy report

1.79

0.57

1.7

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.87

0.49

3.3

4.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.74

0.42

5.3

4.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.42

0.0

1.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

1.56

0.38

9.6

6.1

—

0.00

—

(3035350) Ketones [Presence] in Urine by Test strip

1.52

0.37

5.3

3.9

—

0.00

—

(3009261) Glucose [Presence] in Urine by Test strip

1.52

0.37

5.3

4.1

—

0.00

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.59

0.34

5.5

5.1

—

(3044889) 12 lead EKG panel

1.49

0.33

4.0

2.6

—

(3019225) pH of Specimen

0.00

0.22

0.0

10.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.2

—

(3017181) Myelocytes/100 leukocytes in Blood

0.00

0.22

0.0

3.8

—

1.80

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.30

0.22

3.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.21

0.0

1.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

125

0.88

0.10

3.7

4.0

5.78

5.85

mmol/l

0.11

114

(3013707) Erythrocyte sedimentation rate by Westergren method

1.17

0.09

3.2

3.3

18.60

10.68

mm/h

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

132

0.95

0.00

3.4

3.1

1.26

1.50

mmol/l

0.73

123

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

1.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

3.9

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.1

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

3.0

—

1.18

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.0

5.6

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.0

3.4

—

23.70

—

(3023520) Reticulocytes [#/volume] in Blood

0.00

0.0

2.4

—

75.20

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.0

—

Mortality – FinRegistry

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Association

Association between endpoint ST19_FRACT_LOWER_LIMB_LEVEL_UNSPE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_LOWER_LIMB_LEVEL_UNSPE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: ST19_FRACT_LOWER_LIMB_LEVEL_UNSPE – Fracture of lower limb, level unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fracture of lower limb, level unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints