info icon

This is a non-core endpoint: only basic statistics are computed.

Intracranial injury with prolonged coma

ST19_INTRACR_INJURY_W_PROLO_COMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 S06.7
  • Cause of death: ICD-10 S06.7

2 out of 7 registries used, show all original rules.

31

4. Check minimum number of events

None

31

5. Include endpoints

None

31

6. Filter based on genotype QC (FinnGen only)

31

Control definitions (FinnGen only)

Control exclude
NEURODIS

Extra metadata

Level in the ICD hierarchy
4
Special
ST19_ICTRAUCOMA
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S06
Name in latin
Laesio intracranialis cum comate prolongato

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 31 9 22
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 61.56 69.12 58.47

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
14
46
4.73
4.16
3.9
1.6
u/l
265.6
262.1
0.01
14
39
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
6
13
5.43
2.40
2.5
6.7
ng/l
142.8
333.8
—
6
13
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
5
9
6.37
2.30
20.2
5.6
%
0.8
0.6
—
5
9
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
5
9
6.37
2.30
20.2
5.6
%
2.3
1.4
—
5
9
(3019060) Gas panel - Arterial blood
6
14
5.03
2.27
16.0
4.7
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
8
30
3.23
1.88
7.4
4.2
ng/l
899.9
287.0
—
8
24
(3000991) Gas panel - Venous blood
6
18
3.87
1.85
15.0
3.9
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
5
13
4.36
1.79
2.6
2.2
mmol/l
25.4
24.0
—
5
13
(3021447) Carbon dioxide [Partial pressure] in Venous blood
6
24
2.85
1.38
2.7
2.9
kpa
5.8
5.5
—
6
24
(3012544) pH of Venous blood
6
25
2.72
1.31
2.7
3.3
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
6
26
2.61
1.25
1.3
2.2
—
—
—
0
0
(4035726)
0
28
0.00
1.04
0.0
1.4
—
—
—
0
0
(3022145) Colonoscopy Study observation
0
28
0.00
1.04
0.0
1.2
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
7
37
2.15
1.01
1.4
2.6
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
12
73
2.05
1.00
3.0
1.9
u/l
93.1
52.6
0.36
12
68
(3003338) MCHC [Mass/volume]
24
194
2.05
0.93
18.7
18.1
g/l
333.1
333.2
0.01
24
194
(3013826) Glucose [Moles/volume] in Serum or Plasma
18
131
1.89
0.88
13.8
3.5
mmol/l
6.8
6.6
0.17
18
123
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
0
24
0.00
0.83
0.0
3.8
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
0
24
0.00
0.83
0.0
1.4
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
0
25
0.00
0.83
0.0
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
26
2.09
0.74
1.4
1.8
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
12
80
1.82
0.74
1.7
2.8
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
10
63
1.87
0.72
1.5
2.7
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
5
27
2.01
0.72
1.4
2.4
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
9
63
1.60
0.59
2.8
2.7
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
22
246
0.64
0.58
14.7
13.4
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
18
145
1.58
0.51
4.1
2.6
u/l
65.7
52.9
0.15
18
135
(3030981) Hyaline casts [#/volume] in Urine by Automated count
0
15
0.00
0.42
0.0
3.1
—
0.0
—
0
15
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
16
0.00
0.42
0.0
1.6
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
18
0.00
0.41
0.0
1.8
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
0
18
0.00
0.41
0.0
3.6
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
25
223
1.62
0.40
13.3
14.5
ml/min/173m2
86.7
79.8
0.61
16
178
(3033658) Prothrombin time (PT) actual/Normal
6
42
1.53
0.38
4.3
4.4
%
92.2
89.8
—
6
42
(3031040) Bacteria [#/volume] in Urine by Automated count
17
141
1.46
0.38
3.0
3.7
—
431.0
—
0
5
(3023368) Bacteria identified in Blood by Culture
8
62
1.39
0.32
2.4
5.4
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
14
116
1.38
0.29
1.6
3.1
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
6
83
0.66
0.28
5.0
3.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
8
102
0.71
0.26
1.5
2.0
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
5
42
1.23
0.22
1.4
3.5
—
—
—
0
0
(3018418) pH of Serum or Plasma
6
47
1.34
0.22
1.5
3.7
—
7.4
—
0
7
(3001019) Free T4 and TSH panel - Serum or Plasma
0
11
0.00
0.22
0.0
1.3
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
0
11
0.00
0.22
0.0
1.5
—
—
—
0
0
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
1.4
—
1.4
—
0
7
(40768443) Skin Pathology biopsy report
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
7
59
1.24
0.20
1.3
1.3
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
5
67
0.70
0.19
2.0
2.6
mmol/l
8.5
8.1
—
5
55
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
13
112
1.28
0.18
3.5
4.5
—
—
—
0
0
(3013512) EKG study
6
76
0.74
0.18
6.8
3.8
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
9
77
1.24
0.18
2.6
3.3
—
—
—
0
0
(3015736) pH of Urine
10
84
1.28
0.16
4.0
3.3
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
20
214
0.82
0.12
19.0
14.2
%
37.6
40.2
—
10
148
(3037467) Urinalysis macro (dipstick) panel - Urine
17
158
1.17
0.08
3.3
3.6
—
—
—
0
0
(3044889) 12 lead EKG panel
15
161
0.87
0.07
1.9
3.6
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
10
98
1.03
0.00
3.1
3.5
—
—
—
0
0
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3000475) Leukocytes [#/volume] in Synovial fluid
0
5
0.00
0.00
0.0
1.6
—
20246.0
—
0
5
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008757) Leukocyte morphology finding [Identifier] in Blood
0
6
0.00
0.00
0.0
5.3
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
7
71
0.98
0.00
2.4
3.9
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
2.2
—
4484.0
—
0
5
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
0
6
0.00
0.00
0.0
4.3
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method
0
7
0.00
0.00
0.0
2.6
—
5.1
—
0
7
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
7
73
0.95
0.00
3.9
3.1
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
222.3
—
0
7
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.1
—
38.0
—
0
9
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
5
50
1.00
0.00
3.4
3.1
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_INTRACR_INJURY_W_PROLO_COMA – Intracranial injury with prolonged coma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).