Intracranial injury with prolonged coma

ST19_INTRACR_INJURY_W_PROLO_COMA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — S06.7 Cause of death: ICD-10 — S06.7 2 out of 7 registries used, show all original rules.	31
4. Check minimum number of events None	31
5. Include endpoints None	31
6. Filter based on genotype QC (FinnGen only)	31

Control definitions (FinnGen only)

Control exclude: NEURODIS

Extra metadata

Level in the ICD hierarchy: 4
Special: ST19_ICTRAUCOMA
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: S06
Name in latin: Laesio intracranialis cum comate prolongato

NAME	ST19_INTRACR_INJURY_W_PROLO_COMA
CONTROL_EXCLUDE	NEURODIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	S067
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	S067
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Intracranial injury with prolonged coma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	9	22
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	61.56	69.12	58.47

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

4.73

4.16

3.9

1.6

265.6

262.1

u/l

0.01

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

5.43

2.40

2.5

6.7

142.8

333.8

ng/l

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

6.37

2.30

20.2

5.6

0.8

0.6

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

6.37

2.30

20.2

5.6

2.3

1.4

—

(3019060) Gas panel - Arterial blood

5.03

2.27

16.0

4.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

3.23

1.88

7.4

4.2

899.9

287.0

ng/l

—

(3000991) Gas panel - Venous blood

3.87

1.85

15.0

3.9

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

4.36

1.79

2.6

2.2

25.4

24.0

mmol/l

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.85

1.38

2.7

2.9

5.8

5.5

kpa

—

(3012544) pH of Venous blood

2.72

1.31

2.7

3.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.61

1.25

1.3

2.2

—

(4035726)

0.00

1.04

0.0

1.4

—

(3022145) Colonoscopy Study observation

0.00

1.04

0.0

1.2

—

(3042936) Bacteria identified in Isolate by Culture

2.15

1.01

1.4

2.6

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

2.05

1.00

3.0

1.9

93.1

52.6

u/l

0.36

(3003338) MCHC [Mass/volume]

194

2.05

0.93

18.7

18.1

333.1

333.2

g/l

0.01

194

(3013826) Glucose [Moles/volume] in Serum or Plasma

131

1.89

0.88

13.8

3.5

6.8

6.6

mmol/l

0.17

123

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.83

0.0

3.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.00

0.83

0.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.83

0.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

2.09

0.74

1.4

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

1.82

0.74

1.7

2.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.87

0.72

1.5

2.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.01

0.72

1.4

2.4

—

(3026008) Bacteria identified in Urine by Culture

1.60

0.59

2.8

2.7

—

(40761511) CBC panel - Blood by Automated count

246

0.64

0.58

14.7

13.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

145

1.58

0.51

4.1

2.6

65.7

52.9

u/l

0.15

135

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.42

0.0

3.1

—

0.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.42

0.0

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.41

0.0

1.8

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.41

0.0

3.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

223

1.62

0.40

13.3

14.5

86.7

79.8

ml/min/173m2

0.61

178

(3033658) Prothrombin time (PT) actual/Normal

1.53

0.38

4.3

4.4

92.2

89.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

141

1.46

0.38

3.0

3.7

—

431.0

—

(3023368) Bacteria identified in Blood by Culture

1.39

0.32

2.4

5.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

116

1.38

0.29

1.6

3.1

—

(1761868) Lipid panel - Serum or Plasma

0.66

0.28

5.0

3.1

—

(40768804) Tissue Pathology biopsy report

102

0.71

0.26

1.5

2.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.23

0.22

1.4

3.5

—

(3018418) pH of Serum or Plasma

1.34

0.22

1.5

3.7

—

7.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.22

0.0

1.5

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

1.4

—

(40768443) Skin Pathology biopsy report

0.00

0.21

0.0

1.0

—

(36660697) Celiac disease serology panel - Serum

0.00

0.21

0.0

1.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3003694) ABO and Rh group [Type] in Blood

1.24

0.20

1.3

—

(3009508) Creatinine [Moles/volume] in Urine

0.70

0.19

2.0

2.6

8.5

8.1

mmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

112

1.28

0.18

3.5

4.5

—

(3013512) EKG study

0.74

0.18

6.8

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.24

0.18

2.6

3.3

—

(3015736) pH of Urine

1.28

0.16

4.0

3.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

214

0.82

0.12

19.0

14.2

37.6

40.2

—

148

(3037467) Urinalysis macro (dipstick) panel - Urine

158

1.17

0.08

3.3

3.6

—

(3044889) 12 lead EKG panel

161

0.87

0.07

1.9

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.03

0.00

3.1

3.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.0

1.6

—

20246.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

5.3

—

(42870588) Differential panel, method unspecified - Blood

0.98

0.00

2.4

3.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.6

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.2

—

4484.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

4.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.6

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.0

2.6

—

5.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.95

0.00

3.9

3.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.5

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

222.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

2.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

38.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

3.7

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

4.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

2.6

—

(36304419) Bacteria [Presence] in Urine

1.00

0.00

3.4

3.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_INTRACR_INJURY_W_PROLO_COMA – Intracranial injury with prolonged coma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Intracranial injury with prolonged coma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Intracranial injury with prolonged coma (ST19_INTRACR_INJURY_W_PROLO_COMA)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints