hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1821 |
4. Check minimum number of eventsNone |
1821 |
5. Include endpoints |
2009 |
6. Filter based on genotype QC (FinnGen only) |
2009 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Hyperfunctio hypophysis
Similar endpoints
↥List of similar endpoints to
Hyperfunction of pituitary gland
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13775 | 10007 | 3602 |
| Only index persons | 12382 | 9265 | 3117 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.29 | 0.10 |
| Only index persons | 0.28 | 0.34 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 36.03 | 32.93 | 44.58 |
| Only index persons | 35.04 | 32.51 | 42.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2009 | 1527 | 482 |
| Unadjusted period prevalence (%) | 0.45 | 0.52 | 0.21 |
| Median age at first event (years) | 37.79 | 34.06 | 49.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1832
- Matched controls
- 18321
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G02CB01
ATC
bromocriptine; systemic
44.5
323.0
473
142
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
310.7
323.0
372
15
E22.1
ICD-10 Finland
Hyperprolactinaemia
10361.8
323.0
1235
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
396.3
323.0
514
18
N04BC06
ATC
cabergoline; oral (dopamine agonists)
792.5
323.0
428
7
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
210.6
198
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
87.3
169.2
188
24
H02AB09
ATC
hydrocortisone; systemic
25.5
162.0
231
103
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
+∞
159.8
151
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
529.7
149.8
147
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
135.1
128
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
99.9
95
*
E22.80
ICD-10 Finland
Central precocious puberty
+∞
94.6
90
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
9.5
74.8
160
183
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
9.9
71.9
150
164
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
249.6
70.8
72
*
G02CB04
ATC
quinagolide; oral
328.1
63.8
64
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.2
61.8
254
669
N05AX08
ATC
risperidone; systemic
4.5
61.3
236
583
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
213.8
60.5
62
*
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
52.3
50
*
H03AA01
ATC
levothyroxine sodium; systemic
2.5
52.2
517
2506
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
7.7
51.1
123
170
H01CB02
ATC
octreotide; parenteral
251.6
48.3
49
*
G03DB01
ATC
dydrogesterone; oral
2.7
47.8
391
1693
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
46.0
44
*
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
45.0
43
*
N05AH03
ATC
olanzapine; systemic
3.9
43.8
195
546
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
71.7
43.2
49
7
102
Kela drug reimbursment
Diabetes insipidus
+∞
42.9
41
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.4
42.6
134
264
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
41.8
40
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
39.7
38
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
107.4
38.9
42
*
H01AC01
ATC
somatropin; parenteral
+∞
38.7
37
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
136.2
37.9
40
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.5
37.7
141
335
N05AH04
ATC
quetiapine; oral
2.3
37.3
395
1935
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
193.9
36.9
38
*
H01CB03
ATC
lanreotide; parenteral
97.0
34.8
38
*
N05AX12
ATC
aripiprazole; systemic
4.0
34.2
144
382
E23.05
ICD-10 Finland
Lack of TSH
332.9
33.0
33
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
31.3
30
*
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
31.3
30
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
31.3
30
*
N04BC01
ATC
bromocriptine; oral
162.8
30.8
32
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
18.1
29.7
46
26
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
28.6
646
4217
2542
FHL
Transasal hypophysectomy
+∞
28.2
27
*
N05AB03
ATC
perphenazine; systemic, rectal
4.4
28.0
104
245
AA1AD
NOMESCO Finland
CT of head and brain
2.1
28.0
350
1825
XCK00
NOMESCO Finland
Perimetry
3.4
27.2
137
422
N05AH02
ATC
clozapine; systemic
5.2
27.2
86
171
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.8
27.1
186
708
ZXC86
NOMESCO Finland
Use of endoscopic device
15.5
26.9
44
29
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
6.4
26.7
71
114
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.8
24.6
84
182
N03AG01
ATC
valproic acid; systemic, rectal
3.0
24.0
149
533
N05AA02
ATC
levomepromazine; systemic
3.8
23.9
104
284
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
11.6
23.2
43
38
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
10.5
23.1
45
44
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
23.0
229
1069
N05BA06
ATC
lorazepam; systemic, sublingual
3.6
22.9
108
316
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
22.9
276
1406
XLA10
NOMESCO Finland
NA
3.0
22.6
139
492
N06AB04
ATC
citalopram; systemic
1.9
22.4
396
2340
UJF32
NOMESCO Finland
Coloscopy
1.9
21.9
385
2268
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
21.9
21
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
6.2
21.7
59
98
N06AX16
ATC
venlafaxine; oral
2.0
21.0
298
1617
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
20.9
20
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.7
20.6
70
152
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
20.4
274
1456
L02AE02
ATC
leuprorelin; implant, parenteral
3.7
20.1
90
253
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
19.8
19
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.8
19
*
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
19.8
19
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
19.7
447
2852
N97.9
ICD-10 Finland
Female infertility, unspecified
2.5
19.6
161
677
N04AA02
ATC
biperiden; systemic
4.9
19.3
63
131
N05CD07
ATC
temazepam; oral
2.4
19.2
173
766
N05BA04
ATC
oxazepam; oral
1.7
19.1
439
2811
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
19.0
598
4186
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.8
18.9
124
459
P72
ICPC
Schizophrenia
5.0
18.8
61
126
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
18.8
18
*
N03AX09
ATC
lamotrigine; oral
2.7
18.4
128
490
N97.0
ICD-10 Finland
Female infertility associated with anovulation
4.1
18.2
71
177
E21.0
ICD-10 Finland
Primary hyperparathyroidism
37.1
17.6
22
6
R51.80
ICD-10 Finland
Headache
1.8
17.2
305
1790
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.0
17.0
68
174
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
17.0
174
821
E23.03
ICD-10 Finland
Lack of ACTH
+∞
16.7
16
*
E23.2
ICD-10 Finland
Diabetes insipidus
90.9
16.6
18
*
C07AA05
ATC
propranolol; systemic
1.7
16.5
370
2337
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
16.5
365
2296
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
16.1
420
2767
N06AX11
ATC
mirtazapine; oral
1.6
15.7
529
3727
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
+∞
15.6
15
*
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
5.5
15.6
46
86
R11
ICD-10 Finland
Nausea and vomiting
2.3
15.5
154
716
R53
ICD-10 Finland
Malaise and fatigue
1.7
15.4
349
2204
N05CF01
ATC
zopiclone; oral
1.6
15.4
469
3220
F20.9
ICD-10 Finland
Schizophrenia, unspecified
3.9
15.4
63
165
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.9
15.4
96
346
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
15.4
221
1198
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
15.3
411
2724
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.7
15.2
103
391
N06AB03
ATC
fluoxetine; oral
1.9
15.2
229
1266
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
4.4
14.9
53
122
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
57.2
14.8
17
*
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
9.2
14.7
30
33
N05AF03
ATC
chlorprothixene; systemic
3.5
14.6
69
204
D352, E221
ICD-10 Finland
NA
+∞
14.6
14
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
14.5
264
1557
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
14.4
232
1309
C03CA01
ATC
furosemide; systemic
1.8
14.4
283
1713
G47.3
ICD-10 Finland
Sleep apnoea
1.8
14.2
290
1773
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
14.0
349
2262
N05AN01
ATC
lithium; oral
3.4
13.8
66
198
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
+∞
13.6
13
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
13.6
13
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.2
13.5
147
711
H02AA02
ATC
fludrocortisone; oral
16.3
13.5
21
13
H53.4
ICD-10 Finland
Visual field defects
4.8
13.4
44
94
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
13.0
118
525
121
Kela drug reimbursment
Severe hypofunction of sexual glands
4.8
12.9
42
89
N05AA01
ATC
chlorpromazine; systemic, rectal
5.5
12.9
37
68
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
5.5
12.6
36
66
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.5
12
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
12.5
12
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
+∞
12.5
12
*
2599X
ICD-9 Finland
Other endocrine disorders, Unspecified endocrine disorder
+∞
12.5
12
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
12.5
12
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
12.5
297
1897
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
12.4
702
5486
A06AD11
ATC
lactulose; oral
1.9
12.4
177
959
N05BA01
ATC
diazepam; systemic, rectal
1.8
12.2
203
1158
188
Kela drug reimbursment
Psychosis requiring demanding treatment
5.3
12.1
36
69
T99
ICPC
Endocr/metab/nutrit disease other
5.3
12.1
36
69
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
11.9
206
1191
XF404
NOMESCO Finland
Ambulatory ECG
2.2
11.9
127
610
R42
ICD-10 Finland
Dizziness and giddiness
1.6
11.8
304
1980
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.3
11.6
58
181
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
65.4
11.6
13
*
R41.0
ICD-10 Finland
Disorientation, unspecified
4.2
11.5
43
105
301
Kela drug reimbursment
Growth hormone
+∞
11.5
11
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
11.5
11
*
P29
ICPC
Psychological sympt/compl other
2.1
11.3
130
644
N03AE01
ATC
clonazepam; systemic
2.4
11.3
96
415
R55
ICD-10 Finland
Syncope and collapse
2.0
11.3
141
724
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
8.9
11.3
23
26
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
11.3
383
2673
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
11.2
173
960
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
11.2
277
1783
E29.1
ICD-10 Finland
Testicular hypofunction
17.1
11.2
17
10
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
11.2
338
2295
A02BC02
ATC
pantoprazole; systemic
1.4
11.0
978
8252
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
10.9
178
1007
N05AE04
ATC
ziprasidone; systemic
5.7
10.9
30
53
F60.9
ICD-10 Finland
Personality disorder, unspecified
4.2
10.8
40
97
T73
ICPC
Neoplasm endocrine other/unspecified
21.6
10.7
15
7
A28
ICPC
Limited function/disability NOS
1.9
10.7
150
806
R06.0
ICD-10 Finland
Dyspnoea
1.6
10.5
334
2290
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
10.5
244
1544
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
110.6
10.4
11
*
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
10.4
10
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
10.4
10
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
+∞
10.4
10
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.4
10.4
90
394
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
32.7
10.3
13
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
10.3
519
3930
N05AE03
ATC
sertindole; oral
8.8
10.3
21
24
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
5.8
10.3
28
49
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
10.2
388
2772
N05AC02
ATC
thioridazine; oral
3.5
10.0
45
130
N06AX21
ATC
duloxetine; oral
1.8
10.0
185
1094
J01DB01
ATC
cefalexin; oral
1.4
10.0
1404
12738
WX402
NOMESCO Finland
General anaesthesia
1.6
9.9
268
1766
H47.2
ICD-10 Finland
Optic atrophy
12.2
9.8
17
14
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.8
9.8
62
228
L02AE04
ATC
triptorelin; parenteral
10.7
9.8
18
17
N05AD01
ATC
haloperidol; systemic
3.1
9.8
51
166
ZXC95
NOMESCO Finland
Use of surgical navigator
5.1
9.6
29
58
F82
ICD-10 Finland
Specific developmental disorder of motor function
11.4
9.6
17
15
N05AL01
ATC
sulpiride; systemic
4.7
9.5
31
67
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
9.5
183
1094
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
9.5
332
2328
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
9.5
144
795
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
100.5
9.4
10
*
E34.35
ICD-10 Finland
Abnormal growth retardation
100.5
9.4
10
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
+∞
9.4
9
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
9.4
9
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
9.4
9
*
N06AB05
ATC
paroxetine; oral
2.0
9.4
114
582
SPAT1263
SPAT
Sampling
1.4
9.3
700
5677
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
9.3
198
1221
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.7
9.2
38
103
N05AX13
ATC
paliperidone; systemic
7.3
9.2
21
29
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
9.1
203
1266
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
3.4
9.1
43
130
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
9.1
122
645
N05AF05
ATC
zuclopenthixol; systemic
4.6
9.1
30
66
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.8
9.0
57
211
L17
ICPC
Foot/toe symptom/complaint
1.5
8.9
368
2665
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
24.1
8.9
12
5
N06AB06
ATC
sertraline; oral
1.7
8.9
201
1262
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.9
8.9
138
771
AA400
NOMESCO Finland
Electroconvulsive therapy
4.8
8.9
28
59
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
4.1
8.9
33
82
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.5
8.9
68
281
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
8.8
211
1342
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
8.8
224
1452
N06AG02
ATC
moclobemide; oral
2.4
8.7
73
315
S10
ICPC
Boil/carbuncle
2.2
8.7
86
401
E28.3
ICD-10 Finland
Primary ovarian failure
50.2
8.7
10
*
SPAT1234
SPAT
Support of social functional capacity
2.4
8.7
70
297
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.2
8.7
86
403
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
3.7
8.6
36
99
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
8.6
292
2028
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.1
8.6
46
153
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
5.3
8.6
25
48
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
5.5
8.6
24
44
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
8.6
526
4111
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.6
8.6
37
105
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.9
8.5
119
638
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
90.5
8.4
9
*
E30.8
ICD-10 Finland
Other disorders of puberty
90.5
8.4
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.4
605
4854
SPAT1254
SPAT
Administration of medicine
1.6
8.4
211
1360
X05
ICPC
Menstruation absent/scanty
3.5
8.4
37
107
J01MA12
ATC
levofloxacin; systemic
1.6
8.4
226
1487
A11CC03
ATC
alfacalcidol; systemic
4.0
8.3
32
82
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.7
8.3
184
1144
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
8.3
8
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
8.3
8
*
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
8.3
8
*
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
8.3
8
*
H01AX01
ATC
pegvisomant; parenteral
+∞
8.3
8
*
2598X
ICD-9 Finland
Other endocrine disorders, Other specified endocrine disorders
+∞
8.3
8
*
D352, E220
ICD-10 Finland
NA
+∞
8.3
8
*
-50
ICPC
Medication/prescr/renewal
2.5
8.3
62
253
C07AB07
ATC
bisoprolol; oral
1.4
8.3
519
4063
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
5.3
8.3
24
46
F23.8
ICD-10 Finland
Other acute and transient psychotic disorders
8.6
8.3
17
20
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.8
8.3
134
758
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
8.2
60
241
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.9
8.1
47
164
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
8.1
79
365
F28
ICD-10 Finland
Other nonorganic psychotic disorders
8.2
8.1
17
21
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.2
8.1
82
389
N03AX16
ATC
pregabalin; oral
1.5
8.1
326
2347
F83
ICD-10 Finland
Mixed specific developmental disorders
6.8
8.1
19
28
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.0
8.1
46
158
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
2.4
8.0
65
275
P01
ICPC
Feeling anxious/nervous/tense
1.6
7.9
232
1556
IGY99
NOMESCO Finland
Other psychiatric treatment contact
2.8
7.9
50
184
A12AA04
ATC
calcium carbonate; oral
4.9
7.9
24
49
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
7.9
83
401
WX110
NOMESCO Finland
Local anesthesy
1.3
7.8
1196
10719
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.5
7.8
57
228
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
7.7
144
855
SPAT1240
SPAT
Therapeutic discussion
1.6
7.7
215
1426
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
5.3
7.7
22
42
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
4.6
7.7
25
55
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
7.5
7.7
17
23
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
7.7
274
1925
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
7.6
96
495
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.4
7.6
35
105
N05BE01
ATC
buspirone; oral
2.7
7.6
49
184
137
Kela drug reimbursment
Uraemia requiring dialysis
6.7
7.6
18
27
J20.8
ICD-10 Finland
Acute bronchitis due to other specified organisms
11.9
7.6
13
11
F22.0
ICD-10 Finland
Delusional disorder
3.6
7.6
32
90
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
3.6
7.6
32
90
N03AX14
ATC
levetiracetam; systemic
2.9
7.6
44
155
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
2.9
7.6
44
155
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
7.5
173
1089
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
7.5
124
706
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.3
7.5
67
299
UKC02
NOMESCO Finland
Cystoscopy
1.7
7.4
161
997
E26.0
ICD-10 Finland
Primary hyperaldosteronism
80.4
7.4
8
*
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
5.3
7.4
21
40
Z50.1
ICD-10 Finland
Other physical therapy
2.2
7.4
72
336
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
7.4
130
756
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.7
7.4
149
907
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
7.3
106
580
H05BX01
ATC
cinacalcet; oral
+∞
7.3
7
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
7.3
7
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
7.3
7
*
E22.8
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
7.3
194
1272
N03AF01
ATC
carbamazepine; oral, rectal
2.2
7.3
71
331
SPAT1153
SPAT
Removal of sutures
1.4
7.3
407
3115
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
6.3
7.2
18
29
WX882
NOMESCO Finland
High dependency care
2.8
7.2
44
161
A02BC01
ATC
omeprazole; systemic
1.4
7.2
378
2858
N30.0
ICD-10 Finland
Acute cystitis
1.5
7.2
215
1449
B05DA
ATC
Isotonic solutions
7.3
7.2
16
22
Y28
ICPC
Limited function/disability (Y)
20.1
7.1
10
5
E86
ICD-10 Finland
Volume depletion
3.4
7.1
32
95
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
7.1
207
1388
P98
ICPC
Psychosis NOS/other
5.6
7.1
19
34
N02AA05
ATC
oxycodone; systemic
1.7
7.0
149
922
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
7.0
114
648
P99
ICPC
Psychological disorders other
2.4
6.9
56
240
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.6
6.9
178
1155
O92.6
ICD-10 Finland
Galactorrhoea
13.8
6.9
11
8
SPAT1243
SPAT
Psychiatric/psychological examination
2.2
6.9
64
294
S18
ICPC
Laceration/cut
1.3
6.9
554
4495
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
3.0
6.9
37
126
A01
ICPC
Pain general/multiple sites
1.8
6.8
111
630
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.0
6.8
86
447
L28
ICPC
Limited function/disability (L)
1.6
6.8
172
1112
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.7
6.8
42
156
F50.9
ICD-10 Finland
Eating disorder, unspecified
3.3
6.8
32
99
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.8
388
2979
D12
ICPC
Constipation
2.7
6.8
44
167
E21.2
ICD-10 Finland
Other hyperparathyroidism
40.2
6.8
8
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
6.7
185
1219
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.7
6.7
135
821
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.5
6.7
51
211
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
6.7
143
885
N05AF01
ATC
flupentixol; systemic
3.2
6.7
32
100
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
7.2
6.7
15
21
A27
ICPC
Fear of other disease NOS
2.2
6.7
65
304
A46
ICD-10 Finland
Erysipelas
1.7
6.7
146
910
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.8
6.7
119
698
P85
ICPC
Mental retardation
22.6
6.7
9
*
TLW00
NOMESCO Finland
Insemination
2.6
6.7
45
176
A55
ICPC
General and Unspecified, Local injection/infiltration
4.9
6.7
20
41
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
5.9
6.6
17
29
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
5.5
6.6
18
33
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
5.5
6.6
18
33
G03GA01
ATC
chorionic gonadotrophin; parenteral
1.9
6.6
90
483
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
6.5
118
696
F45.0
ICD-10 Finland
Somatization disorder
6.9
6.5
15
22
SPAT1216
SPAT
Assessment of functional ability
1.6
6.5
166
1076
N03AX12
ATC
gabapentin; oral
1.5
6.5
210
1439
N03AX11
ATC
topiramate; oral
2.4
6.4
52
222
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
6.4
120
711
D35.30
ICD-10 Finland
Craniopharyngoma
70.1
6.4
7
*
F61.0
ICD-10 Finland
Mixed personality disorders
2.6
6.4
42
161
127
Kela drug reimbursment
Transplant complication
3.8
6.4
25
67
X21
ICPC
Breast sympt/compl female other
2.5
6.4
46
187
U07
ICPC
Urine symptom/complaint other
2.0
6.3
74
375
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
6.6
6.3
15
23
C03DA01
ATC
spironolactone; oral
1.8
6.3
105
601
N06AA09
ATC
amitriptyline; systemic
1.7
6.3
124
747
A06AC51
ATC
ispaghula, combinations; systemic
2.0
6.3
72
362
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
5.5
6.3
17
31
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
5.5
6.3
17
31
X78
ICD-10 Finland
Intentional self-harm by sharp object
4.6
6.3
20
44
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.7
6.3
112
660
2536X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of neurohypophysis
+∞
6.3
6
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
6.3
6
*
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
+∞
6.3
6
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
6.3
6
*
25301
ICD-8 Finland
Diseases of pituitary gland, Gigantismus hypophysarius et hyperpituitarismus alius
+∞
6.3
6
*
BBA20
NOMESCO Finland
Exploration of parathyroid gland
+∞
6.3
6
*
E220, D352
ICD-10 Finland
NA
+∞
6.3
6
*
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
6.2
191
1296
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
6.2
447
3557
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
3.1
6.2
31
101
X07
ICPC
Menstruation irregular/frequent
2.8
6.2
37
135
N06AB10
ATC
escitalopram; oral
1.4
6.2
352
2695
F23.3
ICD-10 Finland
Other acute predominantly delusional psychotic disorders
6.3
6.2
15
24
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
6.1
109
641
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
7.7
6.1
13
17
R33
ICD-10 Finland
Retention of urine
2.0
6.1
72
366
P28
ICPC
Limited function/disability (P)
4.0
6.1
22
55
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.1
6.1
61
291
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
6.1
245
1763
XA800
NOMESCO Finland
Neuropsychological investigation
2.2
6.0
60
283
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
6.0
176
1179
M05BX04
ATC
denosumab; parenteral
2.5
6.0
46
190
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPIT | 1.864 [1.59, 2.18] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.314 |
During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 7880 females with E4_HYPERPIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPIT | 1.915 [1.63, 2.25] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 521 out of 2276 males with E4_HYPERPIT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERPIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.217% | 0.38% |
| 5 | 1.083% | 2.337% |
| 10 | 2.632% | 6.055% |
| 15 | 5.096% | 10.909% |
| 20 | 9.329% | 18.171% |
Relationships between endpoints
↥Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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