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Syndrome of inappropriate secretion of antidiuretic hormone

DOID EFO Endpoint Browser PheWeb

E4_ANTIDIU

inappropriate ADH syndrome: A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E22.2
  • Hospital discharge: ICD-9 — 2536X
  • Cause of death: ICD-10 — E22.2
  • Cause of death: ICD-9 — 2536X

2 out of 7 registries used, show all original rules.

176

4. Check minimum number of events

None

176

5. Include endpoints

None

176

6. Filter based on genotype QC (FinnGen only)

176

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E22
Name in latin
Syndroma secretionis impropriae hormonis antidiuretici

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1631 971 648
Only index persons 1405 854 551
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 71.56 74.37 67.48
Only index persons 72.04 74.92 67.57

-FinnGen-

Key figures

All Female Male
Number of individuals 176 93 83
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 69.29 69.51 69.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
157
Matched controls
1570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
+∞
210.6
151
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
101.6
101.1
108
33
H02AB09
ATC
hydrocortisone; systemic
23.7
13.7
19
9
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
9.3
10.7
22
27
N03AX14
ATC
levetiracetam; systemic
14.7
9.9
16
12
G40.9
ICD-10 Finland
Epilepsy, unspecified
13.5
9.6
16
13
AA1AD
NOMESCO Finland
CT of head and brain
3.1
9.4
64
283
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
25.8
9.0
12
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.5
9.0
23
40
S06.3
ICD-10 Finland
Focal brain injury
29.3
8.6
11
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
8.5
50
197
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
8.4
8
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
18.4
8.2
12
7
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
23.5
8.1
11
5
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
12.7
7.7
13
11
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
83.8
7.5
8
*
N05BA04
ATC
oxazepam; oral
2.8
7.3
56
258
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
7.1
38
137
R11
ICD-10 Finland
Nausea and vomiting
4.3
7.1
26
69
N03AG01
ATC
valproic acid; systemic, rectal
6.2
7.0
18
32
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.4
7.0
37
132
D64.9
ICD-10 Finland
Anaemia, unspecified
3.8
6.9
29
88
S02.11
ICD-10 Finland
Fracture of base of skull, open
41.9
6.8
8
*
N06AX11
ATC
mirtazapine; oral
2.6
6.8
65
339
N05CF01
ATC
zopiclone; oral
2.5
6.6
68
369
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
6.6
66
351
A06AD11
ATC
lactulose; oral
3.1
6.4
38
147
2536X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of neurohypophysis
+∞
6.3
6
*
R53
ICD-10 Finland
Malaise and fatigue
2.6
6.1
48
224
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
6.0
27
86

Mortality – FinRegistry

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Association

Association between endpoint E4_ANTIDIU and mortality.

Females

Parameter HR [95% CI] p-value
E4_ANTIDIU 2.117 [1.65, 2.72] < 0.001
Birth year 0.994 [0.98, 1.0] 0.177

During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 767 females with E4_ANTIDIU died.

Males

Parameter HR [95% CI] p-value
E4_ANTIDIU 3.366 [2.32, 4.88] < 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 270 out of 507 males with E4_ANTIDIU died.

Mortality risk

Mortality risk for people of age

years, who have E4_ANTIDIU.

N-year risk Females Males
1 0.198% 0.597%
5 1.064% 3.778%
10 2.882% 8.794%
15 5.999% 16.438%
20 10.228% 26.295%

Relationships between endpoints

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Index endpoint: E4_ANTIDIU – Syndrome of inappropriate secretion of antidiuretic hormone

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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