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Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms

AB1_HIV_MALIGNANT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B21
  • Cause of death: ICD-10 B21

2 out of 7 registries used, show all original rules.

23

4. Check minimum number of events

None

23

5. Include endpoints

None

23

6. Filter based on genotype QC (FinnGen only)

23

Control definitions (FinnGen only)

Control exclude
AB1_HIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 198 56 133
Only index persons 156 54 102
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 41.73 36.98 44.02
Only index persons 41.45 36.98 43.82

-FinnGen-

Key figures

All Female Male
Number of individuals 23 5 18
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 42.00 43.18 41.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood
18
0
+∞
22.65
4.1
0.0
%
20.4
—
—
5
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
17
43
12.15
6.97
3.1
3.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
18
57
10.80
6.24
15.9
8.0
—
—
—
0
0
(3045462) Protein/Creatinine [Ratio] in Urine
5
0
+∞
5.39
4.8
0.0
g/mol
19.2
—
—
5
0
(3013762) Body weight Measured
5
0
+∞
5.39
1.0
0.0
—
—
—
0
0
(3015736) pH of Urine
18
68
8.50
5.17
3.4
3.0
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
18
72
7.83
4.82
4.4
3.2
e6/l
4.9
17.3
—
8
59
(3019832) Treponema pallidum Ab [Presence] in Serum
9
13
10.53
4.70
2.0
1.5
—
—
—
0
0
(3030366) Cystatin C [Mass/volume] in Serum or Plasma
7
7
13.61
4.34
2.6
1.9
mg/l
1.3
1.6
—
7
7
(3052851) Hemolysis interference index of Serum or Plasma
7
7
13.61
4.34
3.4
2.0
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
6
5
15.48
4.00
1.0
1.0
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
9
29
4.42
2.58
1.1
1.4
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
9
33
3.81
2.25
1.0
1.4
nmol/l
21.7
22.0
—
9
26
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
7
21
4.32
2.17
3.1
1.3
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
5
11
5.47
2.05
1.0
1.1
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
6
18
4.12
1.89
3.2
1.3
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
11
52
3.14
1.80
1.5
1.8
pmol/l
99.7
103.5
—
6
28
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
7
26
3.41
1.75
1.1
2.1
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
17
209
0.29
1.63
16.0
12.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
17
3.45
1.44
1.4
1.9
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
0
33
0.00
1.28
0.0
1.2
—
6.4
—
0
14
(3026008) Bacteria identified in Urine by Culture
7
30
2.90
1.26
1.7
2.1
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
7
33
2.60
1.18
2.7
1.7
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
12
73
2.35
1.09
2.8
3.2
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
22
2.61
1.09
1.2
2.3
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
22
2.61
1.09
1.2
2.2
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
6
27
2.64
1.02
1.8
1.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
10
61
2.13
0.86
2.8
2.6
—
—
—
0
0
(3014576) Chloride [Moles/volume] in Serum or Plasma
0
25
0.00
0.85
0.0
8.8
—
103.4
—
0
25
(3007853) Bacteria identified in Skin by Aerobe culture
5
23
2.49
0.82
2.2
1.7
—
—
—
0
0
(3002256) Pathology report gross observation
5
25
2.27
0.78
1.6
1.2
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
11
73
1.97
0.74
1.4
1.7
—
—
—
0
0
(4010399)
0
21
0.00
0.63
0.0
1.4
—
—
—
0
0
(3044889) 12 lead EKG panel
17
141
1.78
0.57
3.2
3.6
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
7
47
1.70
0.54
2.7
7.0
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
11
141
0.58
0.52
4.2
3.3
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
9
65
1.63
0.47
1.2
2.8
nmol/l
59.1
74.3
—
9
59
(3039443) Prostate specific Ag panel - Serum or Plasma
0
15
0.00
0.43
0.0
1.5
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
14
159
0.70
0.32
4.5
3.3
u/l
82.5
56.7
0.68
14
152
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
11
0.00
0.22
0.0
1.7
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
0
11
0.00
0.22
0.0
12.4
—
0.6
—
0
11
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
0
11
0.00
0.22
0.0
12.4
—
1.3
—
0
11
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
0
11
0.00
0.22
0.0
2.8
—
2.3
—
0
11
(3020891) Body temperature
0
11
0.00
0.22
0.0
4.4
—
—
—
0
0
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
0
10
0.00
0.22
0.0
3.0
—
0.8
—
0
10
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
0
10
0.00
0.22
0.0
2.7
—
50.0
—
0
10
(3001019) Free T4 and TSH panel - Serum or Plasma
0
10
0.00
0.22
0.0
1.8
—
—
—
0
0
(3018418) pH of Serum or Plasma
7
56
1.36
0.21
1.4
5.8
—
7.4
—
0
12
(3030981) Hyaline casts [#/volume] in Urine by Automated count
0
13
0.00
0.21
0.0
2.5
—
0.1
—
0
13
(1002224) Polysomnography panel
0
14
0.00
0.21
0.0
1.1
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
0
14
0.00
0.21
0.0
1.4
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
5
67
0.68
0.20
3.8
3.4
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
9
78
1.25
0.19
6.6
9.3
mmol/l
1.2
1.2
—
9
67
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
7
85
0.75
0.19
3.6
4.2
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
6
56
1.10
0.09
3.5
6.0
mmol/l
2.6
2.3
—
6
51
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
7
63
1.16
0.09
1.9
1.7
u/l
89.7
128.5
—
7
58
(40768443) Skin Pathology biopsy report
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043409) Potassium [Moles/volume] in Arterial blood
0
5
0.00
0.00
0.0
3.8
—
4.2
—
0
5
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
6
63
0.94
0.00
2.2
2.6
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.3
—
0.0
—
0
6
(3010726) Horse dander IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
5
50
1.00
0.00
3.8
2.4
—
—
—
0
0
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
10.9
—
0
6
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(4034850)
0
8
0.00
0.00
0.0
9.3
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(4062490)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
11.0
—
18.4
—
0
5
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(4268621)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_HIV_MALIGNANT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_HIV_MALIGNANT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_HIV_MALIGNANT – Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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