Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms

AB1_HIV_MALIGNANT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B21 Cause of death: ICD-10 — B21 2 out of 7 registries used, show all original rules.	23
4. Check minimum number of events None	23
5. Include endpoints None	23
6. Filter based on genotype QC (FinnGen only)	23

Control definitions (FinnGen only)

Control exclude: AB1_HIV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_HIV_MALIGNANT
CONTROL_EXCLUDE	AB1_HIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B21
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B21
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	198	56	133
Only index persons	156	54	102
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	41.73	36.98	44.02
Only index persons	41.45	36.98	43.82

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	23	5	18
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	42.00	43.18	41.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

+∞

22.65

4.1

0.0

20.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

12.15

6.97

3.1

3.2

—

(40758558) Short blood count panel - Blood

10.80

6.24

15.9

8.0

—

(3045462) Protein/Creatinine [Ratio] in Urine

+∞

5.39

4.8

0.0

19.2

—

g/mol

—

(3013762) Body weight Measured

+∞

5.39

1.0

0.0

—

(3015736) pH of Urine

8.50

5.17

3.4

3.0

—

(3018095) Leukocytes [#/volume] in Urine

7.83

4.82

4.4

3.2

4.9

17.3

e6/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

10.53

4.70

2.0

1.5

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

13.61

4.34

2.6

1.9

1.3

1.6

mg/l

—

(3052851) Hemolysis interference index of Serum or Plasma

13.61

4.34

3.4

2.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

15.48

4.00

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.42

2.58

1.1

1.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

3.81

2.25

1.0

1.4

21.7

22.0

nmol/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

4.32

2.17

3.1

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

5.47

2.05

1.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

4.12

1.89

3.2

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

3.14

1.80

1.5

1.8

99.7

103.5

pmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.41

1.75

1.1

2.1

—

(40761511) CBC panel - Blood by Automated count

209

0.29

1.63

16.0

12.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.45

1.44

1.4

1.9

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

0.00

1.28

0.0

1.2

—

6.4

—

(3026008) Bacteria identified in Urine by Culture

2.90

1.26

1.7

2.1

—

(3042936) Bacteria identified in Isolate by Culture

2.60

1.18

2.7

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.35

1.09

2.8

3.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.61

1.09

1.2

2.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.61

1.09

1.2

2.2

—

(3000494) Fungus identified in Specimen by Culture

2.64

1.02

1.8

1.3

—

(36304419) Bacteria [Presence] in Urine

2.13

0.86

2.8

2.6

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.00

0.85

0.0

8.8

—

103.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.49

0.82

2.2

1.7

—

(3002256) Pathology report gross observation

2.27

0.78

1.6

1.2

—

(40768804) Tissue Pathology biopsy report

1.97

0.74

1.4

1.7

—

(4010399)

0.00

0.63

0.0

1.4

—

(3044889) 12 lead EKG panel

141

1.78

0.57

3.2

3.6

—

(3023368) Bacteria identified in Blood by Culture

1.70

0.54

2.7

7.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

141

0.58

0.52

4.2

3.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.63

0.47

1.2

2.8

59.1

74.3

nmol/l

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.43

0.0

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

159

0.70

0.32

4.5

3.3

82.5

56.7

u/l

0.68

152

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.22

0.0

1.7

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.22

0.0

12.4

—

0.6

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.22

0.0

12.4

—

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

2.8

—

2.3

—

(3020891) Body temperature

0.00

0.22

0.0

4.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.0

—

0.8

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.22

0.0

2.7

—

50.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

1.8

—

(3018418) pH of Serum or Plasma

1.36

0.21

1.4

5.8

—

7.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.21

0.0

2.5

—

0.1

—

(1002224) Polysomnography panel

0.00

0.21

0.0

1.1

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.68

0.20

3.8

3.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

1.25

0.19

6.6

9.3

1.2

mmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.75

0.19

3.6

4.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.10

0.09

3.5

6.0

2.6

2.3

mmol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

1.16

0.09

1.9

1.7

89.7

128.5

u/l

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.2

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

3.8

—

4.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

0.94

0.00

2.2

2.6

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.7

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.3

—

0.0

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.00

0.00

3.8

2.4

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

10.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(4034850)

0.00

0.0

9.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.1

—

(4062490)

0.00

0.0

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

1.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

11.0

—

18.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.8

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.2

—

(4268621)

0.00

0.0

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HIV_MALIGNANT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_HIV_MALIGNANT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_HIV_MALIGNANT – Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints