Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

AB1_HIV_INFECT_PARASITES

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B20 Cause of death: ICD-10 — B20 2 out of 7 registries used, show all original rules.	90
4. Check minimum number of events None	90
5. Include endpoints None	90
6. Filter based on genotype QC (FinnGen only)	90

Control definitions (FinnGen only)

Control exclude: AB1_HIV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_HIV_INFECT_PARASITES
CONTROL_EXCLUDE	AB1_HIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B20
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B20
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	721	224	457
Only index persons	565	193	372
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	43.20	40.28	45.11
Only index persons	43.37	39.02	45.63

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	90	22	68
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	46.81	49.90	45.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
79: Matched controls
789

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B23.1

ICD-10 Finland

HIV disease resulting in (persistent) generalized lymphadenopathy

+∞

66.2

B24

ICD-10 Finland

Unspecified human immunodeficiency virus [HIV] disease

+∞

57.4

WW200

NOMESCO Finland

Immunization

108.4

53.2

B23.8

ICD-10 Finland

HIV disease resulting in other specified conditions

+∞

43.9

B20.6

ICD-10 Finland

HIV disease resulting in Pneumocystis jirovecii pneumonia

+∞

31.3

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

34.0

30.7

B20.9

ICD-10 Finland

HIV disease resulting in unspecified infectious or parasitic disease

+∞

18.4

Z21

ICD-10 Finland

Asymptomatic human immunodeficiency virus [HIV] infection status

+∞

16.2

Z25.1

ICD-10 Finland

Need for immunization against influenza

14.6

12.5

B20.1

ICD-10 Finland

HIV disease resulting in other bacterial infections

+∞

11.7

B20.0

ICD-10 Finland

HIV disease resulting in mycobacterial infection

+∞

11.7

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.1

10.6

225

Z11.3

ICD-10 Finland

Special screening examination for infections with a predominantly sexual mode of transmission

9.4

10.4

B23.0

ICD-10 Finland

Acute HIV infection syndrome

+∞

9.6

J18.9

ICD-10 Finland

Pneumonia, unspecified

4.9

8.9

105

QAJ99

NOMESCO Finland

Other aesthetic operations on skin of head or neck

+∞

8.5

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

7.3

8.2

Z73.3

ICD-10 Finland

Stress, not elsewhere classified

50.1

7.9

B20.3

ICD-10 Finland

HIV disease resulting in other viral infections

+∞

7.4

B20.4

ICD-10 Finland

HIV disease resulting in candidiasis

+∞

7.4

A56.3

ICD-10 Finland

Chlamydial infection of anus and rectum

+∞

6.3

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

8.4

6.2

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

5.5

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(21494815) CD4 cells/100 lymphocytes in Specimen

576.11

83.81

4.0

1.2

23.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

46.00

68.11

14.4

6.5

mmol/l

0.9

1.0

0.96

(3021879) Hepatitis B virus core Ab [Presence] in Serum

32.67

65.57

4.6

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

33.50

60.87

5.4

1.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

17.82

43.70

2.4

2.5

u/l

29.9

27.3

0.31

(42870588) Differential panel, method unspecified - Blood

236

25.24

32.79

16.0

5.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

10.71

26.80

3.2

2.0

—

(3022096) Basophils/100 leukocytes in Blood

322

21.23

26.05

20.9

6.1

0.8

0.7

0.40

303

(3006504) Eosinophils/100 leukocytes in Blood

330

20.43

25.31

21.0

6.2

2.8

0.04

312

(3019069) Monocytes/100 leukocytes in Blood

334

20.04

24.94

21.1

6.5

9.2

8.6

1.86

319

(3018010) Neutrophils/100 leukocytes in Blood

338

19.67

24.58

20.6

6.0

51.5

57.6

5.93

322

(3002030) Lymphocytes/100 leukocytes in Blood

343

19.21

24.13

21.0

6.2

34.9

27.1

9.26

327

(3011397) Hemoglobin [Presence] in Urine by Test strip

151

8.17

22.70

3.6

3.3

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

186

8.50

22.55

2.3

1.8

mmol/l

1.4

1.5

0.56

162

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

263

10.40

21.93

15.5

3.7

u/l

31.8

33.1

0.24

252

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

11.02

20.77

3.1

2.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

11.15

20.31

3.0

2.3

—

(3018095) Leukocytes [#/volume] in Urine

237

8.15

19.91

6.6

3.4

e6/l

36.2

38.5

0.02

176

(40758558) Short blood count panel - Blood

188

6.86

18.60

17.7

6.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

276

7.91

17.95

5.2

5.8

g/l

38.1

36.1

2.14

261

(3035350) Ketones [Presence] in Urine by Test strip

330

7.99

15.88

4.0

3.2

estimate

0.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

463

13.19

15.84

9.7

3.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

13.68

15.76

1.2

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

337

7.73

15.29

7.6

4.2

estimate

0.0

—

(3021589) Normoblasts [#/volume] in Blood

323

7.15

15.03

21.6

9.2

e9/l

0.0

0.62

262

(3009261) Glucose [Presence] in Urine by Test strip

343

7.51

14.80

4.3

3.1

estimate

0.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

6.14

14.73

3.1

2.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

6.16

14.27

2.7

2.0

—

(3010503) CD19 cells [#/volume] in Blood

41.27

14.08

6.2

1.4

e9/l

0.2

—

(3013762) Body weight Measured

+∞

12.80

1.2

0.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

107

4.94

11.83

1.3

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

12.39

10.36

2.6

1.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

19.65

10.29

1.1

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

29.97

10.13

1.1

1.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

424

5.61

9.93

6.5

4.9

mmol/l

6.2

6.8

2.05

401

(3052851) Hemolysis interference index of Serum or Plasma

7.71

9.18

2.9

2.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

9.08

1.2

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

189

3.76

8.82

5.5

3.0

e6/l

0.1

0.4

1.13

146

(36304419) Bacteria [Presence] in Urine

191

3.71

8.65

5.3

3.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

7.02

8.46

4.1

2.6

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

+∞

8.46

5.1

0.0

—

(3002582) Erythrocytes [#/volume] in Urine

205

3.54

8.09

5.4

3.1

e6/l

42.3

50.9

0.10

164

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

6.19

7.51

1.2

1.5

miu/ml

131.2

351.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

17.64

7.44

5.0

3.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

102

3.72

7.21

5.0

2.7

e6/l

0.2

1.0

1.48

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

234

3.25

7.07

5.3

3.1

—

(3023368) Bacteria identified in Blood by Culture

182

3.30

7.06

5.8

5.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.53

6.70

1.4

1.5

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

15.84

6.57

4.3

3.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

6.14

6.48

2.3

1.3

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

4.19

6.28

3.3

2.7

ml/min/173m2

71.8

64.2

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

5.87

6.20

1.3

1.2

iu/ml

1.7

0.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

112

3.34

6.15

5.0

2.6

e6/l

0.3

0.9

1.37

(3009508) Creatinine [Moles/volume] in Urine

210

3.01

6.11

6.9

3.2

mmol/l

7.3

8.8

1.21

189

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

6.91

6.09

1.2

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.38

5.68

1.3

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

6.13

5.45

4.0

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

323

2.68

4.92

5.1

7.6

mmol/l

1.2

0.15

285

(3025130) Human papilloma virus identified in Specimen

15.00

4.65

2.4

1.8

—

(3018418) pH of Serum or Plasma

199

2.57

4.45

3.8

4.0

7.4

—

(1761868) Lipid panel - Serum or Plasma

342

0.30

4.41

4.3

2.7

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.56

4.00

1.6

1.7

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

6.12

3.76

1.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

419

2.41

3.72

5.9

3.8

—

20.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.42

3.71

1.4

1.7

—

(3042936) Bacteria identified in Isolate by Culture

109

2.64

3.66

2.7

1.8

—

(3009871) Measles virus Ab [Titer] in Serum

10.59

3.55

1.3

1.7

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

10.59

3.55

1.3

2.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

112

2.56

3.46

1.7

1.9

—

(3026008) Bacteria identified in Urine by Culture

142

2.41

3.38

3.1

2.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

6.79

3.25

5.3

5.2

47.6

53.8

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

6.79

3.25

5.3

4.3

e9/l

3.0

3.7

—

(3002385) Erythrocyte distribution width [Ratio]

636

2.98

3.06

33.9

17.0

13.5

13.7

0.67

628

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.60

3.03

1.8

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

10.48

3.01

1.4

1.6

u/ml

1557.4

504.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.73

2.90

2.3

2.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.53

2.88

1.8

1.9

—

(3012544) pH of Venous blood

2.80

2.88

2.7

3.5

—

(3051651) Icteric interference index of Serum or Plasma

8.72

2.78

2.4

1.3

—

(3011288) Drugs identified in Urine by Screen method

4.05

2.75

15.4

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.75

2.58

1.0

1.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

7.47

2.58

1.0

1.6

—

(3021788) Differential panel - Synovial fluid

7.47

2.58

1.4

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.65

2.53

1.1

1.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.65

2.53

1.1

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

734

3.16

2.49

31.9

13.7

40.5

42.1

1.21

589

(3023520) Reticulocytes [#/volume] in Blood

2.86

2.47

1.7

3.3

e9/l

50.6

78.5

—

(3000991) Gas panel - Venous blood

2.58

2.36

7.0

8.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

4.12

2.30

1.0

1.1

—

(3000494) Fungus identified in Specimen by Culture

2.24

2.26

1.6

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

5.81

2.24

2.6

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

142

2.05

2.23

1.6

2.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

750

2.80

2.01

22.3

13.1

mg/l

20.1

23.7

0.70

583

(3034770) Mitochondria Ab [Titer] in Serum

3.94

1.97

1.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.94

1.97

1.2

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

3.36

1.92

1.1

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

4.34

1.85

1.0

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

245

1.78

1.83

1.9

pmol/l

92.5

87.3

0.38

124

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

220

1.79

2.3

2.1

u/l

118.5

226.8

1.95

213

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

719

2.26

1.76

25.5

11.7

ml/min/173m2

83.6

86.8

0.82

593

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.55

1.74

7.4

8.7

mmol/l

24.7

25.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.31

1.69

1.8

2.5

g/l

4.0

3.5

—

(3032080) INR in Blood by Coagulation assay

287

1.71

1.67

6.3

8.5

inr

1.2

—

(40761511) CBC panel - Blood by Automated count

807

0.49

1.65

15.5

12.1

—

(3037756) Immunofixation for Serum or Plasma

3.71

1.64

1.0

1.4

—

(3012516) Albumin [Mass/volume] in Urine

183

1.77

1.61

3.8

3.5

mg/l

91.9

71.2

0.16

128

(3027945) Reticulocytes/100 erythrocytes in Blood

2.12

1.59

2.0

3.2

1.4

1.8

1.10

(3008898) HLA-B27 [Presence]

0.00

1.57

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

3.46

1.54

1.0

2.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.46

1.54

1.0

—

(1616796) Gas panel - Central venous blood

3.46

1.54

1.8

3.8

—

(3000330) Specific gravity of Urine by Test strip

2.85

1.46

2.7

2.1

—

(40761536) Microorganisms panel - Urine sediment

2.32

1.46

6.4

4.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.53

1.42

9.7

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

267

0.55

1.38

2.6

3.7

ng/l

17.0

56.3

—

175

(3028707) Methadone [Presence] in Urine by Screen method

3.05

1.37

10.6

1.4

—

(3016879) Cocaine [Presence] in Urine

2.48

1.33

8.8

1.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.88

1.30

1.0

2.5

271.2

166.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.88

1.30

1.2

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.88

1.30

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

2.34

1.28

8.8

1.3

—

(3027944) Amphetamines [Presence] in Urine

2.34

1.28

8.9

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.50

1.26

1.2

1.1

—

(3027008) Opiates [Presence] in Urine

2.27

1.25

8.8

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.27

1.25

9.2

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.58

1.16

1.2

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

156

1.64

1.13

2.3

2.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

140

1.65

1.10

4.2

3.3

ng/l

11.6

267.2

2.05

114

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.21

1.08

1.1

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

211

1.55

1.07

2.7

2.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.34

1.04

1.0

1.8

97.0

86.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.92

1.03

2.1

1.3

—

(3022621) pH of Urine by Test strip

2.02

0.99

4.1

1.7

—

(36660697) Celiac disease serology panel - Serum

1.92

0.96

1.2

—

(3022948) Iron [Moles/volume] in Serum or Plasma

111

1.66

0.96

1.9

2.2

umol/l

13.3

14.0

0.12

102

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

2.31

0.95

1.3

1.6

mg/l

2.1

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.07

0.89

1.0

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.79

0.87

1.5

2.5

nmol/l

325.5

385.3

0.53

(3007164) IgA [Mass/volume] in Serum or Plasma

141

1.54

0.84

1.2

1.3

g/l

6.1

2.5

—

(3013512) EKG study

183

0.60

0.84

3.2

3.6

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.69

0.79

39.3

21.2

—

1.3

—

(4094501)

0.00

0.79

0.0

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.24

0.77

1.2

2.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

320

0.70

0.76

3.7

3.8

22.5

21.6

—

123

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

321

1.38

0.73

3.9

4.0

—

(3045414) Leukocytes [Presence] in Urine

1.98

0.72

1.0

1.6

—

(3002256) Pathology report gross observation

1.62

0.69

1.4

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

193

1.41

0.67

4.6

4.2

mg/mmol

9.9

9.7

0.01

137

(3020891) Body temperature

0.00

0.60

0.0

5.9

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.53

0.59

1.5

2.7

g/l

0.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.59

0.0

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.53

0.56

1.0

1.8

nmol/l

52.1

40.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.60

0.50

1.1

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

260

0.75

0.49

5.7

3.1

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.46

0.47

1.1

3.3

g/l

64.4

68.4

—

(3003694) ABO and Rh group [Type] in Blood

205

1.30

0.46

1.3

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.40

0.0

1.3

—

7.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.40

1.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.39

0.0

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

164

0.76

0.34

7.8

6.2

—

(3000492) Spirometry study

0.70

0.33

1.9

1.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

102

1.32

0.32

1.8

1.6

nmol/l

965.6

1173.4

0.36

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

236

0.80

0.32

2.8

2.7

ug/l

0.5

0.7

0.77

121

(40768797) Stomach Pathology biopsy report

1.30

0.25

1.1

1.4

—

(3022145) Colonoscopy Study observation

0.69

0.25

1.0

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.27

0.24

1.3

1.6

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.1

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.9

—

2373.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.1

—

2.8

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

2.2

—

12.7

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.74

0.17

1.6

4.0

ug/l

1.6

75.4

—

(40768804) Tissue Pathology biopsy report

256

1.14

0.17

1.6

1.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

142

1.15

0.14

1.3

—

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

126

0.86

0.12

1.5

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

530

1.10

0.12

3.5

3.0

—

(3019150) Specific gravity of Urine by Refractometry

145

0.88

0.10

12.1

3.7

—

1.0

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.12

0.10

13.2

11.4

1.1

1.8

—

(4035726)

1.06

0.09

1.7

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

193

0.92

0.07

6.5

2.6

—

(3044889) 12 lead EKG panel

532

0.99

0.00

3.0

3.6

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

3.9

—

24.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.95

0.00

1.6

1.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.8

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.5

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.8

—

0.5

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.5

—

13.5

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

2.1

—

1.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.1

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.6

—

88.3

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

14.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.5

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.1

—

(4281824)

0.00

0.0

1.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.4

—

(3019225) pH of Specimen

1.00

0.00

2.2

3.3

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(4133840)

0.00

0.0

1.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

3.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

23.3

—

1718.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.4

—

199.3

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

1.6

—

1.0

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

109.9

—

(3004451) EKG impression Narrative

0.00

0.0

1.6

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

18.2

—

1032.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.4

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

1.6

—

1.2

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.4

—

106.2

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.4

—

121.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.6

—

55.2

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.4

—

4.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

3.2

—

232.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.1

—

6.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

97.8

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.4

—

(4024509)

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HIV_INFECT_PARASITES and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
AB1_HIV_INFECT_PARASITES	4.062 [2.74, 6.01]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.052

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 367 males with AB1_HIV_INFECT_PARASITES died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HIV_INFECT_PARASITES.

N-year risk	Females	Males
1	No data	0.694%
5	No data	4.927%
10	No data	12.343%
15	No data	22.69%
20	No data	36.882%

Relationships between endpoints

↥

Index endpoint: AB1_HIV_INFECT_PARASITES – Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints