No definition available.
Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
AB1_HIV_INFECT_PARASITES
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
90 |
4. Check minimum number of eventsNone |
90 |
5. Include endpointsNone |
90 |
6. Filter based on genotype QC (FinnGen only) |
90 |
Control definitions (FinnGen only)
- Control exclude
- AB1_HIV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
based on the number of shared cases.
Similar with more cases:
- Human immunodeficiency virus [HIV] disease
- Certain infectious and parasitic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 721 | 224 | 457 |
| Only index persons | 565 | 193 | 372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 43.20 | 40.28 | 45.11 |
| Only index persons | 43.37 | 39.02 | 45.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 90 | 22 | 68 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 46.81 | 49.90 | 45.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
+∞
66.2
54
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
+∞
57.4
48
*
WW200
NOMESCO Finland
Immunization
108.4
53.2
56
17
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
+∞
43.9
38
*
B20.6
ICD-10 Finland
HIV disease resulting in Pneumocystis jirovecii pneumonia
+∞
31.3
28
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
34.0
30.7
41
24
B20.9
ICD-10 Finland
HIV disease resulting in unspecified infectious or parasitic disease
+∞
18.4
17
*
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
+∞
16.2
15
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
14.6
12.5
21
19
B20.1
ICD-10 Finland
HIV disease resulting in other bacterial infections
+∞
11.7
11
*
B20.0
ICD-10 Finland
HIV disease resulting in mycobacterial infection
+∞
11.7
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
10.6
53
225
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
9.4
10.4
22
31
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
9.6
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
8.9
34
105
QAJ99
NOMESCO Finland
Other aesthetic operations on skin of head or neck
+∞
8.5
8
*
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
7.3
8.2
20
35
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
50.1
7.9
9
*
B20.3
ICD-10 Finland
HIV disease resulting in other viral infections
+∞
7.4
7
*
B20.4
ICD-10 Finland
HIV disease resulting in candidiasis
+∞
7.4
7
*
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
+∞
6.3
6
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.4
6.2
13
18
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.5
6.2
18
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
76
95
46.00
68.11
14.4
6.5
0.9
1.0
mmol/l
0.96
76
90
50
59
17.82
43.70
2.4
2.5
29.9
27.3
u/l
0.31
50
50
62
186
8.50
22.55
2.3
1.8
1.4
1.5
mmol/l
0.56
62
162
73
263
10.40
21.93
15.5
3.7
31.8
33.1
u/l
0.24
73
252
26
32
11.02
20.77
3.1
2.6
—
—
—
0
0
25
30
11.15
20.31
3.0
2.3
—
—
—
0
0
70
276
7.91
17.95
5.2
5.8
38.1
36.1
g/l
2.14
70
261
74
330
7.99
15.88
4.0
3.2
0.0
0.0
estimate
—
10
58
74
337
7.73
15.29
7.6
4.2
0.0
0.0
estimate
—
10
57
74
343
7.51
14.80
4.3
3.1
0.0
0.0
estimate
—
8
53
34
81
6.14
14.73
3.1
2.2
—
—
—
0
0
32
74
6.16
14.27
2.7
2.0
—
—
—
0
0
11
10
12.39
10.36
2.6
1.3
—
—
—
0
0
13
5
29.97
10.13
1.1
1.0
—
—
—
0
0
75
424
5.61
9.93
6.5
4.9
6.2
6.8
mmol/l
2.05
75
401
12
15
9.08
9.08
1.2
1.4
—
—
—
0
0
45
189
3.76
8.82
5.5
3.0
0.1
0.4
e6/l
1.13
33
146
14
23
7.02
8.46
4.1
2.6
—
—
—
0
0
8
0
+∞
8.46
5.1
0.0
—
—
—
0
0
14
26
6.19
7.51
1.2
1.5
131.2
351.7
miu/ml
—
5
14
11
7
17.64
7.44
5.0
3.4
—
—
—
0
0
29
102
3.72
7.21
5.0
2.7
0.2
1.0
e6/l
1.48
15
53
48
234
3.25
7.07
5.3
3.1
—
—
—
0
0
14
29
5.53
6.70
1.4
1.5
—
—
—
0
0
10
7
15.84
6.57
4.3
3.1
—
—
—
0
0
12
22
6.14
6.48
2.3
1.3
—
—
—
0
0
19
54
4.19
6.28
3.3
2.7
71.8
64.2
ml/min/173m2
—
9
22
12
23
5.87
6.20
1.3
1.2
1.7
0.1
iu/ml
—
6
5
29
112
3.34
6.15
5.0
2.6
0.3
0.9
e6/l
1.37
15
63
12
25
5.38
5.68
1.3
1.2
—
—
—
0
0
10
18
6.13
5.45
4.0
1.4
—
—
—
0
0
54
323
2.68
4.92
5.1
7.6
1.2
1.2
mmol/l
0.15
42
285
14
46
3.42
3.71
1.4
1.7
—
—
—
0
0
6
6
10.59
3.55
1.3
2.0
—
—
—
0
0
24
112
2.56
3.46
1.7
1.9
—
—
—
0
0
19
84
2.60
3.03
1.8
1.8
—
—
—
0
0
5
5
10.48
3.01
1.4
1.6
1557.4
504.8
u/ml
—
5
5
16
66
2.73
2.90
2.3
2.8
—
—
—
0
0
19
86
2.53
2.88
1.8
1.9
—
—
—
0
0
6
11
5.75
2.58
1.0
1.2
—
—
—
0
0
7
16
4.65
2.53
1.1
1.8
—
—
—
0
0
7
16
4.65
2.53
1.1
1.8
—
—
—
0
0
7
18
4.12
2.30
1.0
1.1
—
—
—
0
0
84
750
2.80
2.01
22.3
13.1
20.1
23.7
mg/l
0.70
76
583
6
16
3.94
1.97
1.2
1.3
—
—
—
0
0
36
245
1.78
1.83
1.9
1.9
92.5
87.3
pmol/l
0.38
20
124
33
220
1.79
1.79
2.3
2.1
118.5
226.8
u/l
1.95
33
213
81
719
2.26
1.76
25.5
11.7
83.6
86.8
ml/min/173m2
0.82
74
593
10
42
2.55
1.74
7.4
8.7
24.7
25.0
mmol/l
—
10
42
6
19
3.31
1.69
1.8
2.5
4.0
3.5
g/l
—
6
19
17
267
0.55
1.38
2.6
3.7
17.0
56.3
ng/l
—
8
175
5
18
2.88
1.30
1.0
2.5
271.2
166.8
%
—
5
18
5
18
2.88
1.30
1.4
1.4
—
—
—
0
0
5
20
2.58
1.16
1.2
1.8
—
—
—
0
0
23
156
1.64
1.13
2.3
2.4
—
—
—
0
0
21
140
1.65
1.10
4.2
3.3
11.6
267.2
ng/l
2.05
14
114
5
22
2.34
1.04
1.0
1.8
97.0
86.5
%
—
5
22
11
61
1.92
1.03
2.1
1.3
—
—
—
0
0
17
111
1.66
0.96
1.9
2.2
13.3
14.0
umol/l
0.12
17
102
6
27
2.31
0.95
1.3
1.6
2.1
1.4
mg/l
—
6
21
11
65
1.79
0.87
1.5
2.5
325.5
385.3
nmol/l
0.53
11
57
5
23
2.24
0.77
1.2
2.6
—
—
—
0
0
25
320
0.70
0.76
3.7
3.8
22.5
21.6
%
—
6
123
39
321
1.38
0.73
3.9
4.0
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
9
61
1.53
0.56
1.0
1.8
52.1
40.8
nmol/l
—
9
61
21
260
0.75
0.49
5.7
3.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
7.6
—
0
13
5
35
1.45
0.40
1.0
1.4
—
—
—
0
0
13
102
1.32
0.32
1.8
1.6
965.6
1173.4
nmol/l
0.36
13
78
20
236
0.80
0.32
2.8
2.7
0.5
0.7
ug/l
0.77
12
121
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.9
—
2373.2
—
0
10
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
5
66
0.74
0.17
1.6
4.0
1.6
75.4
ug/l
—
5
52
16
142
1.15
0.14
1.3
1.3
—
1.2
—
0
41
11
126
0.86
0.12
1.5
1.4
—
—
—
0
0
55
530
1.10
0.12
3.5
3.0
—
—
—
0
0
5
45
1.12
0.10
13.2
11.4
1.1
1.8
%
—
5
45
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
13.5
—
0
6
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
14.4
—
0
8
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
3.2
—
0
7
0
5
0.00
0.00
0.0
3.4
—
199.3
—
0
5
0
7
0.00
0.00
0.0
1.3
—
109.9
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
121.0
—
0
5
0
5
0.00
0.00
0.0
3.2
—
232.2
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
3.2
—
97.8
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint AB1_HIV_INFECT_PARASITES and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_HIV_INFECT_PARASITES | 4.062 [2.74, 6.01] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 367 males with AB1_HIV_INFECT_PARASITES died.
Mortality risk
Mortality risk for people of age
years, who have AB1_HIV_INFECT_PARASITES.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.694% |
| 5 | No data | 4.927% |
| 10 | No data | 12.343% |
| 15 | No data | 22.69% |
| 20 | No data | 36.882% |
Relationships between endpoints
↥Index endpoint: AB1_HIV_INFECT_PARASITES – Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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