Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

AB1_HIV_INFECT_PARASITES_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 B20
  • Hospital discharge: ICD-10 B20
  • Cause of death: ICD-10 B20

3 out of 7 registries used, show all original rules.

107

4. Check minimum number of events

None

107

5. Include endpoints

None

107

6. Filter based on genotype QC (FinnGen only)

92

Control definitions (FinnGen only)

Control exclude
AB1_HIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 92 25 67
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 49.31 57.48 46.26

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
107
Matched controls
1070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
WW200
NOMESCO Finland
Immunization
160.1
131.7
69
12
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
+∞
88.1
72
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
30.7
69.2
56
37
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
+∞
66.8
57
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
+∞
55.0
48
*
B20.6
ICD-10 Finland
HIV disease resulting in Pneumocystis jirovecii pneumonia
+∞
35.4
32
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
12.2
26.0
30
33
B20.9
ICD-10 Finland
HIV disease resulting in unspecified infectious or parasitic disease
+∞
23.8
22
*
Z3231
NOMESCO Finland
Registered nurse
6.7
22.0
63
188
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
+∞
21.6
20
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
20.4
19.4
29
19
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.0
17.5
76
311
Z2221
NOMESCO Finland
Medical doctor
5.3
16.8
58
195
B20.4
ICD-10 Finland
HIV disease resulting in candidiasis
+∞
14.9
14
*
B20.1
ICD-10 Finland
HIV disease resulting in other bacterial infections
+∞
14.9
14
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.0
14.7
46
140
B20.0
ICD-10 Finland
HIV disease resulting in mycobacterial infection
+∞
13.8
13
*
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
11.7
11
*
B20.3
ICD-10 Finland
HIV disease resulting in other viral infections
+∞
11.7
11
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.9
11.6
24
50
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
24.6
11.0
15
7
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
22.7
10.1
14
7
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.9
10.0
26
66
Z2446
NOMESCO Finland
Social worker
5.8
9.8
20
41
R4110
NOMESCO Finland
Physiotherapy
3.4
8.8
47
198
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
5.4
8.7
19
41
J05AB11
ATC
valaciclovir; oral
4.4
8.6
25
69
N06AB04
ATC
citalopram; systemic
3.7
8.5
34
119
QAJ99
NOMESCO Finland
Other aesthetic operations on skin of head or neck
+∞
8.4
8
*
B20.7
ICD-10 Finland
HIV disease resulting in multiple infections
+∞
8.4
8
*
JN4BD
NOMESCO Finland
Extensive body CT
4.8
8.3
21
52
WX110, ,
SPAT
5.0
7.6
18
42
EB1AA, ,
SPAT
5.0
7.3
17
39
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
7.2
22
63
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.7
7.1
18
44
XF400
NOMESCO Finland
ECG with 12 standard connections
3.5
7.1
29
102
Z3226
NOMESCO Finland
Physiotherapist
3.4
6.9
31
115
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.4
6.9
19
50
WYA30, ,
SPAT
42.9
6.9
8
*
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
74.1
6.5
7
*
TLC02
NOMESCO Finland
Simple extraction of IUD
28.5
6.3
8
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
6.3
6
*
B20.2
ICD-10 Finland
HIV disease resulting in cytomegaloviral disease
+∞
6.3
6
*
OAB43, ,
SPAT
0.2
6.3
6
269
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
8.9
6.0
12
15

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
79
6
487.43
90.25
3.9
1.2
28.09
40.33
%
—
79
6
73
68
31.64
76.78
4.5
1.4
—
—
—
0
0
83
107
31.13
71.52
5.3
1.7
—
—
—
0
0
60
71
17.96
52.40
2.5
2.6
30.20
26.42
u/l
0.61
60
59
98
387
19.18
29.67
19.5
6.6
0.72
0.71
%
0.09
98
364
98
396
18.49
28.85
19.6
6.7
2.69
2.89
%
0.45
98
375
42
64
10.16
28.81
3.3
1.9
—
—
—
0
0
98
399
18.27
28.58
19.8
7.0
9.05
8.53
%
1.33
98
380
98
401
18.13
28.40
15.7
7.4
—
—
—
0
0
68
181
8.56
28.09
3.6
3.3
—
—
—
0
0
98
406
17.77
27.96
19.3
6.5
52.10
57.27
%
5.02
98
387
99
419
19.19
27.91
19.4
6.9
0.57
0.59
e9/l
0.42
94
368
99
420
19.11
27.85
19.4
6.9
0.04
0.04
e9/l
0.34
94
370
98
409
17.56
27.49
19.7
6.7
34.21
27.61
%
7.71
98
389
99
430
18.38
26.93
19.4
6.9
2.12
1.83
e9/l
3.46
94
386
99
436
17.96
26.52
19.7
7.1
0.16
0.19
e9/l
1.71
94
388
81
276
8.96
25.51
6.2
3.6
147.14
34.84
e6/l
0.61
40
199
72
223
7.81
24.85
2.2
1.8
1.34
1.51
mmol/l
0.87
72
194
71
221
7.58
24.24
16.0
6.6
—
—
—
0
0
99
496
14.30
21.80
20.8
10.7
3.26
4.20
e9/l
6.32
94
431
84
336
7.98
21.06
5.5
5.7
37.93
36.32
g/l
1.87
84
318
86
382
7.38
18.25
20.2
9.2
0.00
0.00
e9/l
0.62
79
313
99
557
11.38
17.56
9.3
3.8
—
—
—
0
0
86
408
6.64
16.13
4.2
3.2
0.00
0.01
estimate
0.49
11
71
86
414
6.49
15.67
7.5
4.2
0.00
0.00
estimate
—
10
68
86
422
6.29
15.08
4.2
3.1
0.00
0.00
estimate
—
8
64
14
0
+∞
14.93
1.1
0.0
—
—
—
0
0
42
122
5.02
14.16
1.3
1.6
—
—
—
0
0
17
5
39.91
13.98
6.2
1.4
0.24
0.20
e9/l
—
17
5
56
221
4.22
12.37
4.7
2.9
—
—
—
0
0
56
222
4.19
12.27
4.8
2.9
0.12
0.34
e6/l
1.22
38
166
17
10
19.90
11.64
1.1
1.1
—
—
—
0
0
88
496
5.36
11.52
6.4
4.9
6.34
6.80
mmol/l
1.35
88
468
57
240
3.94
11.24
4.7
3.2
39.07
45.81
e6/l
0.09
38
186
18
15
14.15
10.82
1.2
1.1
—
—
—
0
0
37
122
4.11
10.21
4.3
2.7
0.82
1.01
e6/l
0.10
17
64
47
204
3.33
8.34
5.7
5.3
—
—
—
0
0
49
222
3.23
8.04
4.6
3.6
92.53
91.52
%
0.09
49
217
12
8
16.67
7.92
2.4
1.6
—
—
—
0
0
17
25
7.87
7.66
2.7
2.4
—
—
—
0
0
11
7
17.30
7.40
1.1
1.1
—
—
—
0
0
11
8
15.13
7.06
2.2
2.1
—
—
—
0
0
14
416
0.24
6.65
4.3
2.8
—
—
—
0
0
17
32
6.11
6.49
1.2
1.4
179.00
279.62
miu/ml
—
6
19
12
17
7.80
5.61
1.1
1.1
—
—
—
0
0
63
382
2.58
5.39
5.3
7.5
1.20
1.21
mmol/l
0.30
51
336
45
237
2.55
5.13
3.9
4.4
7.42
7.40
ph
—
6
36
34
157
2.71
5.04
4.3
2.5
616.24
569.50
mosm/kgh2o
0.68
29
136
13
26
5.54
4.81
1.6
1.7
—
—
—
0
0
35
171
2.56
4.59
3.7
2.7
3.64
4.08
e6/l
0.16
30
153
72
493
2.41
4.36
5.7
3.9
—
24.17
—
0
12
7
6
12.35
4.34
1.4
1.7
—
—
—
0
0
49
288
2.29
4.21
1.8
1.8
88.96
89.60
pmol/l
0.04
28
149
10
18
6.01
4.08
1.2
1.4
—
—
—
0
0
18
66
3.08
3.99
7.3
8.4
—
—
—
0
0
34
174
2.40
3.98
2.9
2.6
—
—
—
0
0
26
118
2.59
3.91
2.6
2.2
—
—
—
0
0
15
51
3.26
3.75
1.9
3.1
57.38
77.24
e9/l
—
9
34
7
9
8.22
3.61
1.6
1.1
—
—
—
0
0
96
784
3.18
3.53
33.3
16.6
13.54
14.93
%
6.94
96
775
24
113
2.45
3.32
1.7
1.4
—
—
—
0
0
6
7
8.99
3.30
1.0
1.6
—
—
—
0
0
30
160
2.22
3.12
1.6
2.0
—
—
—
0
0
6
8
7.86
3.09
2.2
2.0
—
—
—
0
0
5
5
10.40
3.01
1.4
1.6
1557.40
504.80
u/ml
—
5
5
7
13
5.68
2.92
5.3
4.6
47.57
55.23
%
—
7
13
7
13
5.68
2.92
5.3
3.8
3.02
3.75
e9/l
—
7
13
10
28
3.83
2.87
14.0
1.4
—
—
—
0
0
101
894
3.31
2.74
21.6
12.9
20.33
22.00
mg/l
0.27
90
689
6
11
5.70
2.58
2.2
2.1
—
—
—
0
0
12
45
2.88
2.55
6.5
8.5
25.33
25.06
mmol/l
0.09
12
45
7
16
4.60
2.52
2.4
1.9
—
—
—
0
0
5
149
0.30
2.39
1.2
1.5
—
—
—
0
0
7
19
3.86
2.19
1.1
1.2
—
—
—
0
0
38
248
1.83
2.18
2.5
2.3
—
—
—
0
0
18
317
0.48
2.14
2.5
3.6
15.89
54.05
ng/l
—
9
201
27
159
1.93
2.11
3.7
3.3
16.65
252.36
ng/l
2.05
17
124
15
70
2.33
2.10
1.2
1.2
—
—
—
0
0
6
15
4.17
2.07
1.2
1.0
—
—
—
0
0
6
17
3.67
1.86
1.0
1.1
—
—
—
0
0
5
12
4.31
1.84
2.2
1.1
—
—
—
0
0
18
96
2.05
1.84
1.4
1.2
—
—
—
0
0
6
18
3.47
1.77
1.0
1.7
—
—
—
0
0
88
965
0.50
1.77
14.5
11.8
—
—
—
0
0
5
14
3.69
1.63
1.0
1.4
—
—
—
0
0
7
28
2.60
1.48
2.4
2.3
—
—
—
0
0
21
128
1.80
1.47
2.3
2.2
12.31
14.40
umol/l
0.60
21
119
5
16
3.22
1.45
1.8
3.6
—
—
—
0
0
13
225
0.52
1.40
3.0
3.6
—
—
—
0
0
19
115
1.79
1.36
1.4
1.5
—
—
—
0
0
36
260
1.58
1.35
2.3
2.2
118.11
208.79
u/l
1.85
36
252
5
18
2.86
1.30
1.0
1.1
—
—
—
0
0
26
175
1.64
1.29
1.2
1.3
5.92
2.43
g/l
—
9
116
6
25
2.48
1.26
1.2
1.1
—
—
—
0
0
48
375
1.51
1.25
15.5
12.8
1.22
1.28
inr
—
10
108
31
220
1.58
1.24
3.7
3.6
126.26
62.55
mg/l
0.52
25
153
0
33
0.00
1.18
0.0
1.1
—
—
—
0
0
5
20
2.57
1.16
10.6
1.5
—
—
—
0
0
8
40
2.08
1.15
8.8
1.4
—
—
—
0
0
8
41
2.03
1.11
1.3
1.1
—
—
—
0
0
7
32
2.27
1.10
9.7
1.3
—
—
—
0
0
5
21
2.45
1.10
1.2
1.3
—
—
—
0
0
11
63
1.83
0.94
1.7
2.7
0.20
0.22
g/l
0.29
11
55
8
42
1.98
0.91
8.9
1.3
—
—
—
0
0
8
42
1.98
0.91
8.8
1.3
—
—
—
0
0
6
29
2.13
0.91
1.0
2.1
20.83
21.75
s
—
6
24
8
43
1.93
0.89
9.3
1.3
—
—
—
0
0
8
43
1.93
0.89
8.8
1.3
—
—
—
0
0
6
30
2.06
0.88
1.0
1.6
—
—
—
0
0
8
47
1.76
0.83
3.8
1.8
—
—
—
0
0
0
26
0.00
0.79
0.0
5.3
—
—
—
0
0
10
59
1.77
0.79
6.4
3.7
—
—
—
0
0
6
34
1.81
0.77
1.0
1.3
—
—
—
0
0
15
101
1.56
0.75
8.3
7.9
105.33
104.29
mmol/l
0.49
15
101
15
102
1.55
0.72
1.4
1.3
—
—
—
0
0
5
26
1.97
0.71
1.6
1.1
—
—
—
0
0
30
238
1.36
0.67
1.3
1.3
—
—
—
0
0
18
240
0.70
0.65
6.5
2.6
—
—
—
0
0
8
50
1.65
0.63
9.3
10.7
1.37
1.82
%
—
8
50
8
50
1.65
0.63
1.3
2.6
—
—
—
0
0
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
0
22
0.00
0.60
0.0
5.7
—
3.99
—
0
22
38
320
1.29
0.56
1.7
1.7
—
—
—
0
0
7
49
1.46
0.47
10.4
10.9
0.69
0.65
%
—
7
49
28
233
1.27
0.45
4.5
4.2
18.76
8.39
mg/mmol
0.47
22
167
14
181
0.74
0.42
11.6
3.7
—
1.02
—
0
17
12
88
1.41
0.42
1.6
2.8
321.42
390.43
nmol/l
0.74
12
79
5
33
1.54
0.42
1.0
1.1
—
—
—
0
0
9
66
1.40
0.39
1.0
1.9
52.11
39.39
nmol/l
—
9
66
9
67
1.37
0.39
1.6
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
6
46
1.32
0.33
3.5
3.6
123.00
132.72
g/l
—
6
46
9
120
0.73
0.29
1.8
1.4
—
—
—
0
0
23
260
0.85
0.22
2.6
2.6
0.58
0.70
ug/l
0.55
15
132
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
88.56
—
0
10
0
10
0.00
0.21
0.0
2.1
—
4.02
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
1.50
—
0
10
0
10
0.00
0.21
0.0
2.1
—
106.80
—
0
10
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
18.5
—
1455.42
—
0
12
0
12
0.00
0.21
0.0
14.5
—
891.08
—
0
12
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
9
112
0.79
0.21
1.6
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
269.85
—
0
13
6
48
1.26
0.20
1.3
1.2
—
—
—
0
0
14
121
1.18
0.16
1.1
1.4
80.00
374.81
titre
—
5
27
5
61
0.81
0.08
2.2
3.5
—
—
—
0
0
9
104
0.85
0.06
1.1
1.3
—
—
—
0
0
66
646
1.06
0.06
3.0
3.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1.67
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
14.22
—
0
5
6
65
0.92
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
3.30
—
0
6
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.9
—
0.52
—
0
7
0
9
0.00
-0.00
0.0
3.7
—
22.03
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
1.50
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
0.84
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
75
0.93
-0.00
3.4
4.4
2.16
66.60
ug/l
—
7
60
0
5
0.00
-0.00
0.0
15.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
0.36
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.0
—
58.08
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_HIV_INFECT_PARASITES_WIDE – Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).