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Human immunodeficiency virus [HIV] disease resulting in other specified diseases

AB1_OTHER_DISEASE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B22
  • Cause of death: ICD-10 B22

2 out of 7 registries used, show all original rules.

19

4. Check minimum number of events

None

19

5. Include endpoints

None

19

6. Filter based on genotype QC (FinnGen only)

19

Control definitions (FinnGen only)

Control exclude
AB1_HIV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 165 53 107
Only index persons 125 43 82
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 45.77 46.32 45.82
Only index persons 46.04 44.51 46.84

-FinnGen-

Key figures

All Female Male
Number of individuals 19 6 13
Unadjusted period prevalence (%) 0.00 0.00 0.01
Median age at first event (years) 49.76 47.20 50.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3017143) Hepatitis C virus Ab [Presence] in Serum
12
22
12.81
5.92
4.3
1.5
—
—
—
0
0
(3045462) Protein/Creatinine [Ratio] in Urine
5
0
+∞
5.44
4.8
0.0
g/mol
24.4
—
—
5
0
(3019832) Treponema pallidum Ab [Presence] in Serum
9
11
14.24
5.28
2.2
1.5
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
13
39
8.28
4.50
17.5
5.7
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
7
9
11.44
3.95
5.4
1.6
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
11
38
5.44
3.14
1.7
1.7
mmol/l
1.5
1.4
0.23
11
28
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
13
54
5.41
2.94
4.2
3.6
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
11
42
4.80
2.80
4.5
3.0
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
5
7
9.14
2.72
2.4
1.0
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
7
17
5.85
2.66
1.6
1.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
8
7.97
2.53
3.0
1.0
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
7
21
4.64
2.22
1.1
1.4
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
11
5.73
2.08
1.4
2.4
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
8
33
3.43
1.80
5.5
3.7
—
—
—
0
0
(3015736) pH of Urine
11
53
3.53
1.80
5.1
3.9
—
—
—
0
0
(40758558) Short blood count panel - Blood
9
40
3.35
1.71
21.3
8.0
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
11
57
3.19
1.71
3.6
8.4
mmol/l
1.2
1.2
0.03
11
49
(3021589) Normoblasts [#/volume] in Blood
12
66
3.20
1.64
24.8
11.4
e9/l
0.0
0.0
0.00
12
55
(3012544) pH of Venous blood
5
15
4.12
1.63
2.0
5.9
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
7
29
3.21
1.58
5.1
2.8
ng/l
11.3
184.5
—
7
21
(3042936) Bacteria identified in Isolate by Culture
6
24
3.17
1.43
1.5
1.7
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
11
61
2.89
1.40
18.1
9.2
inr
1.3
1.3
—
5
21
(3013650) Neutrophils [#/volume] in Blood by Automated count
13
84
2.72
1.27
24.1
14.9
e9/l
2.8
4.5
3.22
13
76
(3037467) Urinalysis macro (dipstick) panel - Urine
14
95
2.79
1.25
9.2
4.1
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
7
35
2.57
1.15
1.9
1.6
mg/l
2.5
1.0
—
7
30
(40768804) Tissue Pathology biopsy report
8
44
2.40
1.03
3.3
1.6
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
6
30
2.45
0.97
1.0
1.7
nmol/l
15.5
24.1
—
6
25
(3023368) Bacteria identified in Blood by Culture
7
42
2.05
0.79
4.3
5.7
—
—
—
0
0
(3018677) aPTT in Platelet poor plasma by Coagulation assay
5
25
2.34
0.79
1.6
2.0
s
30.2
29.0
—
5
25
(3009508) Creatinine [Moles/volume] in Urine
8
52
1.92
0.72
5.3
2.7
mmol/l
10.1
9.3
—
8
46
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
5
28
2.06
0.72
2.0
2.0
pmol/l
519.6
522.5
—
5
28
(3014576) Chloride [Moles/volume] in Serum or Plasma
0
20
0.00
0.64
0.0
4.2
—
104.6
—
0
20
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
0
20
0.00
0.64
0.0
4.2
—
26.9
—
0
9
(3013707) Erythrocyte sedimentation rate by Westergren method
14
117
1.74
0.48
6.4
3.6
mm/h
12.1
11.7
0.05
14
107
(3026008) Bacteria identified in Urine by Culture
5
35
1.58
0.43
2.6
2.6
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
17
0.00
0.43
0.0
1.4
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
18
0.00
0.42
0.0
2.1
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
7
54
1.47
0.36
4.3
1.9
u/l
97.4
129.2
—
7
48
(3044889) 12 lead EKG panel
14
118
1.70
0.34
3.7
3.5
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
5
36
1.52
0.27
2.2
3.9
ng/l
1696.2
2323.3
—
5
30
(3019225) pH of Specimen
0
11
0.00
0.22
0.0
10.1
—
—
—
0
0
(3020961) Endomysium IgA Ab [Titer] in Serum
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
0
11
0.00
0.22
0.0
4.1
—
4.8
—
0
11
(3022621) pH of Urine by Test strip
0
11
0.00
0.22
0.0
1.4
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
0
11
0.00
0.22
0.0
3.8
—
94.9
—
0
11
(4010399)
0
11
0.00
0.22
0.0
1.4
—
—
—
0
0
(3020891) Body temperature
0
11
0.00
0.22
0.0
4.0
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
0
10
0.00
0.22
0.0
3.6
—
0.7
—
0
10
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
0
10
0.00
0.22
0.0
3.6
—
1.4
—
0
10
(3039443) Prostate specific Ag panel - Serum or Plasma
0
12
0.00
0.22
0.0
1.7
—
—
—
0
0
(3022145) Colonoscopy Study observation
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
5
46
1.12
0.10
5.4
3.1
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
5
60
0.77
0.10
5.6
5.3
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
10
106
0.88
0.09
3.1
2.5
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3043409) Potassium [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
2.7
—
4.1
—
0
7
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
8
0.00
0.00
0.0
3.1
—
1.2
—
0
8
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
218.1
—
0
5
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
0
9
0.00
0.00
0.0
3.6
—
2.1
—
0
9
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
0
8
0.00
0.00
0.0
4.0
—
47.2
—
0
8
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
0
9
0.00
0.00
0.0
4.6
—
24.5
—
0
9
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(3005895) Myoglobin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.2
—
520.2
—
0
5
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
6
63
0.93
0.00
5.8
3.6
—
—
—
0
0
(3022313) Gas panel - Capillary blood
0
8
0.00
0.00
0.0
5.0
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_OTHER_DISEASE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_DISEASE.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_OTHER_DISEASE – Human immunodeficiency virus [HIV] disease resulting in other specified diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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