This is a non-core endpoint: only basic statistics are computed.

Mixed disorder of acid-base balance

E4_MIXACIDBASE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E87.4 Hospital discharge: ICD-9 — 2764 Cause of death: ICD-10 — E87.4 Cause of death: ICD-9 — 2764 2 out of 7 registries used, show all original rules.	19
4. Check minimum number of events None	19
5. Include endpoints None	19
6. Filter based on genotype QC (FinnGen only)	19

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E87
Name in latin: Perturbationes aequilibrii acido-alkalici mixtae

NAME	E4_MIXACIDBASE
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E874
HD_ICD_9	2764
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E874
COD_ICD_9	2764
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Mixed disorder of acid-base balance based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	214	120	94
Only index persons	170	97	73
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	69.52	61.98
Only index persons	64.54	66.72	61.66

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	19	10	9
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	64.02	63.25	64.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40761535) Cells panel - Urine sediment

9.14

2.72

5.8

4.1

—

(3042936) Bacteria identified in Isolate by Culture

6.19

2.49

1.3

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.64

2.02

1.3

1.8

—

(42870588) Differential panel, method unspecified - Blood

3.84

2.02

4.1

6.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

3.55

1.93

9.6

3.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.57

1.77

7.9

2.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

4.12

1.63

10.8

9.3

—

(3023368) Bacteria identified in Blood by Culture

2.97

1.55

2.6

3.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.99

1.44

8.4

3.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.17

1.43

2.5

3.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

3.01

1.23

6.2

3.1

—

(3026008) Bacteria identified in Urine by Culture

2.76

1.21

8.4

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

2.57

1.15

2.3

3.4

—

(3013512) EKG study

2.47

1.05

3.6

3.5

—

(3015736) pH of Urine

2.40

1.03

11.4

3.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

2.30

1.02

12.1

4.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.85

0.0

2.7

—

0.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.98

0.69

11.8

6.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

1.84

0.64

5.1

3.4

21.8

12.7

mm/h

1.38

(3009508) Creatinine [Moles/volume] in Urine

1.69

0.45

5.8

2.8

4.4

9.6

mmol/l

—

(3012516) Albumin [Mass/volume] in Urine

1.69

0.45

5.8

3.3

256.0

8.7

mg/l

—

(36304419) Bacteria [Presence] in Urine

1.63

0.44

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.50

0.37

3.4

4.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.59

0.34

2.8

2.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

1.56

0.33

3.9

4.0

17.2

15.4

pmol/l

—

(3044889) 12 lead EKG panel

0.69

0.32

3.6

4.1

—

(3000492) Spirometry study

0.00

0.22

0.0

1.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.22

0.0

2.4

—

(4035726)

0.00

0.22

0.0

1.3

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

0.00

0.22

0.0

2.4

—

30.7

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

108

1.30

0.20

4.8

4.5

1.6

2.1

mu/l

—

(1761868) Lipid panel - Serum or Plasma

1.12

0.10

4.2

2.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

136

0.86

0.10

33.3

16.3

84.1

77.7

umol/l

0.41

136

(40761511) CBC panel - Blood by Automated count

131

1.26

0.10

31.4

13.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

109

1.27

0.09

20.6

12.3

40.1

38.6

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

11.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.0

7.7

—

23.4

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

17.6

—

(4010399)

0.00

0.0

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.3

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

30.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.0

—

(3022145) Colonoscopy Study observation

0.00

0.0

1.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_MIXACIDBASE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_MIXACIDBASE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_MIXACIDBASE – Mixed disorder of acid-base balance

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Mixed disorder of acid-base balance

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints