This is a non-core endpoint: only basic statistics are computed.

Myopathy due to other toxic agents

G6_MYOPTOX

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G72.2 Hospital discharge: ICD-9 — 3594A Cause of death: ICD-10 — G72.2 Cause of death: ICD-9 — 3594A 2 out of 7 registries used, show all original rules.	19
4. Check minimum number of events None	19
5. Include endpoints None	19
6. Filter based on genotype QC (FinnGen only)	19

Control definitions (FinnGen only)

Control exclude: G6_MYONEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G72
Name in latin: Myopathia toxica (non alcoholica)

NAME	G6_MYOPTOX
CONTROL_EXCLUDE	G6_MYONEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G722
HD_ICD_9	3594A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G722
COD_ICD_9	3594A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Myopathy due to other toxic agents based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	243	92	150
Only index persons	196	81	115
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	63.76	68.85	60.64
Only index persons	63.00	68.10	59.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	19	8	11
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	62.85	64.20	61.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018677) aPTT in Platelet poor plasma by Coagulation assay

6.45

3.10

2.4

2.8

30.7

29.8

—

(3023368) Bacteria identified in Blood by Culture

4.95

2.88

14.6

4.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

7.06

2.37

1.4

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

4.23

2.31

9.1

3.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.17

2.18

2.3

1.6

—

(3000850) Epithelial cells [#/volume] in Urine

4.00

2.10

5.9

3.4

13.5

5.2

e6/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.64

2.02

2.5

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.11

1.83

2.5

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.44

1.73

4.6

4.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.12

1.63

5.6

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

3.06

1.59

2.4

2.0

105.6

84.9

pmol/l

—

(42870588) Differential panel, method unspecified - Blood

3.18

1.54

4.5

5.0

—

(3015736) pH of Urine

2.71

1.39

8.2

4.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

3.02

1.37

3.3

1.7

16.7

21.5

—

(3026008) Bacteria identified in Urine by Culture

2.65

1.25

5.0

3.8

—

(3003396) Base excess in Arterial blood by calculation

3.01

1.23

12.4

6.3

3.9

0.8

mmol/l

—

(3026782) Osmolality of Urine

2.57

1.15

2.9

3.7

542.4

604.2

mosm/kgh2o

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.77

1.05

3.7

1.6

2.2

2.5

g/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

2.67

1.05

9.0

4.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.38

0.96

7.2

3.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

2.14

0.91

5.0

2.5

2.3

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.19

0.88

4.5

1.8

—

(40758558) Short blood count panel - Blood

2.18

0.83

5.9

6.4

—

(36304419) Bacteria [Presence] in Urine

2.05

0.79

7.3

2.9

—

(3042936) Bacteria identified in Isolate by Culture

2.24

0.77

4.2

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

2.08

0.76

7.5

3.5

23.1

16.1

e6/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

2.03

0.64

4.8

3.9

14.7

14.9

pmol/l

0.06

(3030467) Casts [#/volume] in Urine by Automated count

1.93

0.59

7.3

3.0

1.2

0.2

e6/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.82

0.57

9.1

5.2

—

(3018095) Leukocytes [#/volume] in Urine

1.83

0.54

8.4

4.6

72.0

84.4

e6/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.69

0.52

10.4

5.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.90

0.48

8.0

6.9

—

(40761511) CBC panel - Blood by Automated count

156

0.61

0.44

44.4

13.0

—

(3013512) EKG study

1.54

0.37

4.9

6.0

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.30

0.24

2.0

1.5

16.7

29.8

nmol/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.40

0.24

4.3

3.7

363.3

20723.4

umol/l

—

(3044640) Blood type and Crossmatch panel - Blood

1.29

0.22

6.5

1.8

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.22

0.0

1.0

—

(3009508) Creatinine [Moles/volume] in Urine

1.22

0.11

2.8

2.7

5.0

7.5

mmol/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

145

0.87

0.11

42.4

15.6

39.0

41.8

—

100

(40768804) Tissue Pathology biopsy report

1.16

0.10

3.7

2.1

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.74

0.10

6.6

4.2

1.3

1.9

ug/l

—

(3044889) 12 lead EKG panel

1.26

0.09

5.5

4.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.3

—

4.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.3

—

106.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.4

—

8.1

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.7

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.2

—

71.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.4

—

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

11.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.0

1.9

—

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.04

0.00

3.9

2.4

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.2

—

(3022621) pH of Urine by Test strip

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_MYOPTOX and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
G6_MYOPTOX	4.005 [1.69, 9.49]	0.002
Birth year	0.987 [0.98, 1.0]	0.006

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 129 males with G6_MYOPTOX died.

Mortality risk

Mortality risk for people of age

years, who have G6_MYOPTOX.

N-year risk	Females	Males
1	No data	0.809%
5	No data	4.477%
10	No data	11.36%
15	No data	21.072%
20	No data	33.822%

Relationships between endpoints

↥

Index endpoint: G6_MYOPTOX – Myopathy due to other toxic agents

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Myopathy due to other toxic agents

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints