Intracranial laceration and haemorrhage due to birth injury

P16_INTRACR_LACERATION_HAEMORRHAGE_BIRTHINJY

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P10 Cause of death: ICD-10 — P10 2 out of 7 registries used, show all original rules.	18
4. Check minimum number of events None	18
5. Include endpoints None	18
6. Filter based on genotype QC (FinnGen only)	18

Control definitions (FinnGen only)

Control exclude: P16_BIRTH_TRAUMA

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P1[0-5]
Name in latin: Laceratio et haemorrhagia intracranialis ex laesione intranatali

NAME	P16_INTRACR_LACERATION_HAEMORRHAGE_BIRTHINJY
CONTROL_EXCLUDE	P16_BIRTH_TRAUMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Intracranial laceration and haemorrhage due to birth injury based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	340	139	200
Only index persons	205	88	117
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.01
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	4.00	9.07	0.12
Only index persons	10.38	23.85	0.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	18	12	6
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	21.28	30.39	3.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3005719) IgG [Mass/volume] in Serum or Plasma

3.65

1.46

1.4

4.8

11.20

9.67

g/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.08

1.38

1.3

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

151

+∞

1.09

14.1

11.2

11.50

21.15

mg/l

1.19

107

(3009542) Hematocrit [Volume Fraction] of Blood

152

+∞

1.09

10.3

12.2

40.95

39.24

0.62

130

(3026008) Bacteria identified in Urine by Culture

2.49

0.98

9.8

2.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.38

0.97

7.1

2.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.45

0.88

1.4

2.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

2.10

0.86

3.3

2.8

79.60

69.40

nmol/l

—

(3013512) EKG study

0.00

0.86

0.0

3.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.29

0.86

1.4

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

139

0.47

0.82

3.1

3.5

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

2.49

0.82

1.0

1.5

2.42

2.46

mmol/l

—

(42870588) Differential panel, method unspecified - Blood

1.94

0.70

1.9

5.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

2.12

0.67

2.4

3.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

158

+∞

0.64

16.0

9.7

61.61

66.63

umol/l

0.53

158

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

158

+∞

0.64

11.2

9.2

28.39

24.82

u/l

0.36

153

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

106

1.81

0.49

10.4

6.5

113.77

104.17

u/l

0.13

101

(3000850) Epithelial cells [#/volume] in Urine

1.77

0.47

4.2

1.8

2.10

5.07

e6/l

—

(3012516) Albumin [Mass/volume] in Urine

1.77

0.47

4.6

3.5

8701.44

130.57

mg/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.65

0.44

1.8

1.4

—

(3042936) Bacteria identified in Isolate by Culture

0.00

0.43

0.0

2.8

—

(40761511) CBC panel - Blood by Automated count

163

+∞

0.43

8.3

9.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.65

0.38

1.9

2.1

2.35

2.38

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.56

0.38

8.4

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.60

0.36

3.0

3.4

—

(1761868) Lipid panel - Serum or Plasma

1.39

0.25

1.6

1.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.22

0.0

1.2

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.00

0.22

0.0

5.0

—

233.91

—

(4035726)

0.00

0.22

0.0

1.5

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.22

0.0

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.22

0.0

1.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.22

0.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

115

0.71

0.22

16.2

7.2

100.21

93.85

ml/min/173m2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

117

1.40

0.21

5.3

3.2

1.17

1.29

mmol/l

0.28

111

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.1

—

(3044889) 12 lead EKG panel

1.31

0.20

4.8

2.4

—

(3003694) ABO and Rh group [Type] in Blood

1.26

0.11

2.0

1.5

—

(36304419) Bacteria [Presence] in Urine

1.19

0.11

5.8

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

1.19

0.11

2.4

2.5

—

(3030467) Casts [#/volume] in Urine by Automated count

1.12

0.11

5.8

2.6

0.37

0.26

e6/l

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

2.7

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

401.00

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

123

1.20

0.00

5.7

3.5

1.44

1.47

mmol/l

0.13

115

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

3.92

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

123

1.20

0.00

5.8

3.6

4.12

4.61

mmol/l

0.99

118

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.3

—

(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.43

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

2.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.7

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

3.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

0.22

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

47.50

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

175

+∞

0.00

19.1

15.7

140.22

135.06

g/l

0.67

175

(3006598) pH of Arterial cord blood

0.00

0.0

1.0

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.0

10.6

—

23.88

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.1

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

7.82

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.0

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

0.00

0.0

1.0

—

18.80

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

2.7

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.0

1.6

—

0.07

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

3.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

1.19

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.1

—

(3035941) MCH [Entitic mass]

174

+∞

0.00

18.9

15.5

30.18

29.69

0.46

174

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.6

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.1

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.1

—

(3004959) Base excess in Arterial cord blood by calculation

0.00

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.00

0.0

2.6

—

188.50

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3024731) MCV [Entitic volume]

174

+∞

0.00

19.0

15.5

89.28

88.69

0.18

174

(3015736) pH of Urine

1.06

0.00

11.8

2.9

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

121

0.98

0.00

7.6

4.6

42.59

38.97

mmol/mol

0.39

116

Mortality – FinRegistry

↥

Association

Association between endpoint P16_INTRACR_LACERATION_HAEMORRHAGE_BIRTHINJY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_INTRACR_LACERATION_HAEMORRHAGE_BIRTHINJY.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_INTRACR_LACERATION_HAEMORRHAGE_BIRTHINJY – Intracranial laceration and haemorrhage due to birth injury

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Intracranial laceration and haemorrhage due to birth injury

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints