Histoplasmosis

AB1_HISTOPLASMOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B39 Hospital discharge: ICD-9 — 115 Hospital discharge: ICD-8 — 115 Cause of death: ICD-10 — B39 Cause of death: ICD-9 — 115 Cause of death: ICD-8 — 115 2 out of 7 registries used, show all original rules.	20
4. Check minimum number of events None	20
5. Include endpoints None	20
6. Filter based on genotype QC (FinnGen only)	20

Control definitions (FinnGen only)

Control exclude: AB1_MYCOSES

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_HISTOPLASMOSIS
CONTROL_EXCLUDE	AB1_MYCOSES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B39
HD_ICD_9	115
HD_ICD_8	115
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B39
COD_ICD_9	115
COD_ICD_8	115
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Histoplasmosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	274	155	119
Only index persons	225	128	97
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	29.96	14.87
Only index persons	19.98	26.48	11.40

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	20	14	6
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	39.44	30.91	59.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013512) EKG study

3.55

1.91

3.7

3.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

3.55

1.91

7.8

2.0

2.9

2.5

mg/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

3.48

1.80

3.7

4.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

4.38

1.73

2.8

4.1

—

(3000494) Fungus identified in Specimen by Culture

4.07

1.63

1.2

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.88

1.53

2.6

2.7

—

(3002256) Pathology report gross observation

3.34

1.37

1.8

1.2

—

(3026008) Bacteria identified in Urine by Culture

2.74

1.35

2.6

2.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

171

+∞

1.08

18.4

13.7

72.3

71.1

umol/l

0.10

171

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.15

0.91

3.2

3.3

—

(3044640) Blood type and Crossmatch panel - Blood

2.23

0.85

2.4

2.7

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

2.55

0.83

2.2

5.4

38.0

31.4

—

(3003694) ABO and Rh group [Type] in Blood

1.89

0.71

1.4

1.8

—

(42870588) Differential panel, method unspecified - Blood

1.86

0.68

12.6

6.8

—

(36660697) Celiac disease serology panel - Serum

0.00

0.64

0.0

1.2

—

(40761511) CBC panel - Blood by Automated count

181

+∞

0.64

12.6

10.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.88

0.62

1.0

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.82

0.61

2.5

3.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.75

0.56

4.4

3.9

35.0

28.2

u/l

—

(3023368) Bacteria identified in Blood by Culture

1.68

0.45

9.4

4.9

—

(40768804) Tissue Pathology biopsy report

1.41

0.33

5.0

2.2

—

(3044889) 12 lead EKG panel

1.56

0.32

2.9

3.1

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.37

0.25

2.6

1.4

17.9

23.4

nmol/l

—

(1761868) Lipid panel - Serum or Plasma

1.28

0.22

2.2

2.9

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.22

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.22

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.22

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.22

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.22

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.22

0.0

1.5

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.22

0.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.7

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

0.22

0.0

3.6

—

1.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

11.0

—

104.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.35

0.21

4.1

2.6

99.9

76.7

nmol/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

14.9

—

25.4

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.21

0.0

1.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

1.35

0.17

12.5

8.0

10.1

9.7

umol/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

154

0.90

0.10

2.5

4.1

1.2

1.5

mmol/l

4.13

146

(3002385) Erythrocyte distribution width [Ratio]

147

0.84

0.10

18.3

16.1

13.9

13.3

0.88

142

(3018095) Leukocytes [#/volume] in Urine

0.76

0.10

2.8

4.0

18.9

37.0

e6/l

—

(3006315) Basophils [#/volume] in Blood

1.13

0.09

17.7

6.6

0.0

e9/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

113

1.15

0.09

5.2

4.6

—

(3001604) Monocytes [#/volume] in Blood

1.11

0.09

17.8

6.6

0.6

0.5

e9/l

—

(3021589) Normoblasts [#/volume] in Blood

0.88

0.00

26.6

8.2

0.0

e9/l

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.6

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3007461) Platelets [#/volume] in Blood

191

+∞

0.00

26.4

18.6

248.6

250.4

e9/l

0.03

185

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.6

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.00

0.00

2.8

3.4

—

(3016502) Oxygen saturation in Arterial blood

0.00

0.0

19.3

—

96.7

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3010813) Leukocytes [#/volume] in Blood

192

+∞

0.00

26.5

18.5

6.7

6.5

e9/l

0.18

187

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

33.5

—

(3026361) Erythrocytes [#/volume] in Blood

192

+∞

0.00

26.4

18.5

4.4

4.5

e12/l

0.09

187

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

6.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

22.8

—

0.8

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

4.1

—

24.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

22.8

—

0.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

0.00

0.0

19.5

—

12.1

—

(40758558) Short blood count panel - Blood

0.97

0.00

22.6

6.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

0.96

0.00

6.4

2.9

39.0

71.6

ug/l

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

14.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(36304419) Bacteria [Presence] in Urine

0.97

0.00

2.4

2.8

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

6.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

139

1.02

0.00

3.7

—

(3030467) Casts [#/volume] in Urine by Automated count

1.08

0.00

2.6

3.2

0.2

0.0

e6/l

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3019198) Lymphocytes [#/volume] in Blood

1.06

0.00

22.9

6.6

1.9

1.8

e9/l

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.5

—

(3015736) pH of Urine

0.91

0.00

2.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.4

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.7

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

0.00

0.0

19.7

—

5.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.7

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.8

—

239.2

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

383.3

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

1.4

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.7

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.03

0.00

1.2

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HISTOPLASMOSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_HISTOPLASMOSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_HISTOPLASMOSIS – Histoplasmosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Histoplasmosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints