info icon

This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_THYROID_MEDULLARY_EXALLC for full statistics.

Medullary carcinoma of thyroid gland

C3_THYROID_MEDULLARY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C73.94&
  • Cause of death: ICD-9 193D
  • Cancer registry: Topography ICD-O-3 C73
  • Cancer registry: Morphology ICD-O-3 8510|8513
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

31

4. Check minimum number of events

None

31

5. Include endpoints

None

31

6. Filter based on genotype QC (FinnGen only)

31

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Similar endpoints

List of similar endpoints to Medullary carcinoma of thyroid gland based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 31 24 7
Unadjusted period prevalence (%) 0.01 0.01 0.00
Median age at first event (years) 40.06 42.84 30.52

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3018840) Calcitonin [Moles/volume] in Serum or Plasma
24
0
+∞
30.21
9.1
0.0
pmol/l
227.8
—
—
13
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
13
5
42.66
10.90
4.5
1.0
—
—
—
0
0
(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma
8
0
+∞
8.72
3.3
0.0
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
24
114
5.86
4.59
9.0
5.2
mmol/l
1.2
1.2
0.50
24
103
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
6
8
8.94
3.21
2.2
1.3
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
0
57
0.00
2.37
0.0
1.3
—
14.8
—
0
23
(3000494) Fungus identified in Specimen by Culture
0
36
0.00
1.23
0.0
1.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
11
64
2.11
1.03
2.3
10.5
—
—
—
0
0
(4035726)
6
30
2.23
0.93
1.3
1.2
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
14
188
0.53
0.86
2.9
4.0
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
5
92
0.46
0.84
1.2
2.5
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
8
52
1.72
0.66
1.8
2.4
—
—
—
0
0
(3015736) pH of Urine
7
109
0.54
0.63
2.9
3.1
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
20
0.00
0.63
0.0
1.5
—
—
—
0
0
(3000492) Spirometry study
0
22
0.00
0.62
0.0
1.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
10
71
1.60
0.46
1.7
2.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
5
34
1.56
0.42
1.4
2.4
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
5
75
0.60
0.42
1.6
2.6
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
0
17
0.00
0.42
0.0
1.4
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
0
17
0.00
0.42
0.0
1.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
21
235
0.67
0.36
16.0
15.5
%
43.2
40.0
2.18
16
162
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
14
116
1.38
0.29
4.3
3.4
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
8
99
0.74
0.26
2.1
2.9
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
5
39
1.34
0.24
3.8
3.7
umol/l
5.6
8.4
—
5
33
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
26
269
0.79
0.23
13.6
14.6
mg/l
26.4
25.0
0.06
19
204
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
5
42
1.23
0.22
1.2
1.5
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
0
11
0.00
0.22
0.0
2.1
—
—
—
0
0
(3007930) Methemoglobin/Hemoglobin.total in Blood
0
10
0.00
0.22
0.0
3.0
—
0.8
—
0
10
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
0
10
0.00
0.22
0.0
1.5
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
0
10
0.00
0.22
0.0
3.3
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.22
0.0
1.7
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
10
0.00
0.22
0.0
1.2
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
0
13
0.00
0.21
0.0
4.0
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.8
—
162.8
—
0
6
(42529406) Shigella sp [Presence] in Stool by Culture
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(3005322) IgE [Units/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
1.4
—
153.1
—
0
13
(3000330) Specific gravity of Urine by Test strip
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
8
67
1.26
0.19
2.0
4.9
—
—
—
0
0
(3044889) 12 lead EKG panel
21
192
1.29
0.18
4.0
3.8
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
9
78
1.22
0.18
4.1
2.8
ng/l
735.1
738.5
—
9
67
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
9
106
0.79
0.16
2.7
3.7
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
5
47
1.08
0.10
1.8
2.0
nmol/l
1198.6
1457.6
—
5
31
(3023368) Bacteria identified in Blood by Culture
6
70
0.82
0.08
2.3
4.9
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
8
72
1.15
0.08
1.9
1.3
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
7
81
0.83
0.08
1.9
3.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
12
114
1.09
0.01
2.4
2.2
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
14
145
0.94
0.00
2.9
2.9
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
15
153
0.96
0.00
8.4
7.1
umol/l
9.7
9.9
0.04
15
139
(1761868) Lipid panel - Serum or Plasma
10
99
1.01
0.00
2.8
3.2
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
17
171
0.99
0.00
2.9
3.1
u/l
82.3
61.2
0.18
17
156
(42870588) Differential panel, method unspecified - Blood
8
82
0.97
0.00
2.8
5.5
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
7
0.00
0.00
0.0
4.9
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
0.2
—
0
7
(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
0.0
—
0
8
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
0.0
—
0
8
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024980) IgG subclass 4 [Mass/volume] in Serum
0
5
0.00
0.00
0.0
2.2
—
0.5
—
0
5
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
3.0
—
6.3
—
0
5
(3027315) Oxygen [Partial pressure] in Blood
0
7
0.00
0.00
0.0
4.7
—
7.5
—
0
7
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.3
—
80.9
—
0
9
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
35.0
—
0
8
(3027008) Opiates [Presence] in Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038026) Centromere Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
0
7
0.00
0.00
0.0
1.0
—
1.1
—
0
7
(1616796) Gas panel - Central venous blood
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3013512) EKG study
8
84
0.94
0.00
5.4
3.7
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
3.0
—
1.3
—
0
5
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.3
—
134.0
—
0
6
(3013290) Carbon dioxide [Partial pressure] in Blood
0
7
0.00
0.00
0.0
4.7
—
5.2
—
0
7
(3014051) Protein [Presence] in Urine by Test strip
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
1.4
—
0
7
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3036489) Thrombin time
0
6
0.00
0.00
0.0
1.3
—
19.2
—
0
6
(3050129) First trimester maternal screen panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3039000) Anion gap in Blood
0
5
0.00
0.00
0.0
3.6
—
11.6
—
0
5
(40768795) Lymph node Pathology biopsy report
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis
0
9
0.00
0.00
0.0
1.2
—
0.0
—
0
9
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
6
0.00
0.00
0.0
2.5
—
45.8
—
0
6
(3004616) Nuclear Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
8
0.00
0.00
0.0
4.1
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3018572) Chloride [Moles/volume] in Blood
0
5
0.00
0.00
0.0
3.6
—
108.2
—
0
5
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
0.0
—
0
8
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(4094501)
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
0
5
0.00
0.00
0.0
1.2
—
91.8
—
0
5
(3023419) Bacteria identified in Sputum by Culture
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_THYROID_MEDULLARY – Medullary carcinoma of thyroid gland

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).