Medullary carcinoma of thyroid gland

C3_THYROID_MEDULLARY

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cause of death: ICD-10 — C73.94& Cause of death: ICD-9 — 193D Cancer registry: Topography ICD-O-3 — C73 Cancer registry: Morphology ICD-O-3 — 8510\|8513 Cancer registry: Behaviour codes — 3 2 out of 7 registries used, show all original rules.	31
4. Check minimum number of events None	31
5. Include endpoints None	31
6. Filter based on genotype QC (FinnGen only)	31

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF8

NAME	C3_THYROID_MEDULLARY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C7394
COD_ICD_9	193D
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C73
CANC_TOPO_EXCL
CANC_MORPH	8510\|8513
CANC_MORPH_EXCL
CANC_BEHAV	3

Similar endpoints

↥

List of similar endpoints to Medullary carcinoma of thyroid gland based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	24	7
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	40.06	42.84	30.52

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018840) Calcitonin [Moles/volume] in Serum or Plasma

+∞

30.21

9.1

0.0

227.8

—

pmol/l

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

42.66

10.90

4.5

1.0

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

+∞

8.72

3.3

0.0

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

114

5.86

4.59

9.0

5.2

1.2

mmol/l

0.50

103

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

8.94

3.21

2.2

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

0.00

2.37

0.0

1.3

—

14.8

—

(3000494) Fungus identified in Specimen by Culture

0.00

1.23

0.0

1.4

—

(40758558) Short blood count panel - Blood

2.11

1.03

2.3

10.5

—

(4035726)

2.23

0.93

1.3

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

188

0.53

0.86

2.9

4.0

—

(3026008) Bacteria identified in Urine by Culture

0.46

0.84

1.2

2.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.72

0.66

1.8

2.4

—

(3015736) pH of Urine

109

0.54

0.63

2.9

3.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.63

0.0

1.5

—

(3000492) Spirometry study

0.00

0.62

0.0

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

1.60

0.46

1.7

2.5

—

(3042936) Bacteria identified in Isolate by Culture

1.56

0.42

1.4

2.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.42

0.0

1.1

—

(36304419) Bacteria [Presence] in Urine

0.60

0.42

1.6

2.6

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.42

0.0

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.42

0.0

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

235

0.67

0.36

16.0

15.5

43.2

40.0

2.18

162

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

116

1.38

0.29

4.3

3.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.74

0.26

2.1

2.9

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.34

0.24

3.8

3.7

5.6

8.4

umol/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

269

0.79

0.23

13.6

14.6

26.4

25.0

mg/l

0.06

204

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.23

0.22

1.2

1.5

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

2.1

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.22

0.0

3.0

—

0.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.5

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.22

0.0

3.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.22

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.22

0.0

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.22

0.0

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.22

0.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.21

0.0

1.5

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.21

0.0

4.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.5

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.8

—

162.8

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

153.1

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.20

0.0

2.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.26

0.19

2.0

4.9

—

(3044889) 12 lead EKG panel

192

1.29

0.18

4.0

3.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.22

0.18

4.1

2.8

735.1

738.5

ng/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

106

0.79

0.16

2.7

3.7

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.08

0.10

1.8

2.0

1198.6

1457.6

nmol/l

—

(3023368) Bacteria identified in Blood by Culture

0.82

0.08

2.3

4.9

—

(3003694) ABO and Rh group [Type] in Blood

1.15

0.08

1.9

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.83

0.08

1.9

3.1

—

(40768804) Tissue Pathology biopsy report

114

1.09

0.01

2.4

2.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

145

0.94

0.00

2.9

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

153

0.96

0.00

8.4

7.1

9.7

9.9

umol/l

0.04

139

(1761868) Lipid panel - Serum or Plasma

1.01

0.00

2.8

3.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

171

0.99

0.00

2.9

3.1

82.3

61.2

u/l

0.18

156

(42870588) Differential panel, method unspecified - Blood

0.97

0.00

2.8

5.5

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.9

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.2

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.1

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.2

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.3

—

0.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.5

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.3

—

0.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.8

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.7

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

2.2

—

0.5

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.0

—

6.3

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

4.7

—

7.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

80.9

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.3

—

35.0

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.2

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

1.1

—

(1616796) Gas panel - Central venous blood

0.00

0.0

3.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3013512) EKG study

0.94

0.00

5.4

3.7

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.4

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.0

—

1.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.3

—

134.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

4.7

—

5.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.5

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(3036489) Thrombin time

0.00

0.0

1.3

—

19.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.2

—

(3039000) Anion gap in Blood

0.00

0.0

3.6

—

11.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.2

—

0.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.2

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

2.5

—

45.8

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

4.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.0

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.5

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

1.9

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

2.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.00

0.0

1.4

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.6

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

3.6

—

108.2

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.3

—

0.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(4094501)

0.00

0.0

1.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.2

—

91.8

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

3.2

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_THYROID_MEDULLARY – Medullary carcinoma of thyroid gland

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Medullary carcinoma of thyroid gland

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Case counts by code for Medullary carcinoma of thyroid gland (C3_THYROID_MEDULLARY)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints