info icon

This is a non-core endpoint: only basic statistics are computed.

Myxoedema coma

E4_MYXOCO

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E03.5
  • Cause of death: ICD-10 E03.5

2 out of 7 registries used, show all original rules.

22

4. Check minimum number of events

None

22

5. Include endpoints

None

22

6. Filter based on genotype QC (FinnGen only)

22

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Coma myxoedematicum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 177 127 50
Only index persons 167 120 47
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population - 60.66 61.80
Only index persons 60.31 59.61 62.10

-FinnGen-

Key figures

All Female Male
Number of individuals 22 15 7
Unadjusted period prevalence (%) 0.00 0.01 0.00
Median age at first event (years) 49.71 46.33 56.97

-FinRegistry-

Age distribution of first events

02030405060708005101520253035AgeIndividuals

-FinnGen-

Age distribution of first events

010204060900123456789AgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220510152025303540455055YearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200520230246810121416YearIndividuals

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
127
+∞
4.85
10.2
2.7
15.95
14.35
pmol/l
1.69
22
108
22
168
+∞
2.26
11.0
3.3
2.71
1.79
mu/l
0.56
22
146
6
16
4.73
2.10
2.0
1.3
—
—
—
0
0
7
22
4.16
2.09
3.9
1.6
—
—
—
0
0
12
58
3.35
1.95
3.5
2.8
—
—
—
0
0
10
43
3.43
1.94
4.9
3.9
9.30
4.74
mg/mmol
—
5
26
6
22
3.35
1.56
1.3
1.8
31.08
29.11
s
—
6
22
6
23
3.19
1.48
1.8
1.9
—
—
—
0
0
10
50
2.83
1.44
4.1
4.8
—
—
—
0
0
14
85
2.77
1.41
3.7
5.8
0.61
0.54
e9/l
0.39
14
76
14
86
2.72
1.41
3.7
5.8
0.05
0.04
e9/l
0.66
14
76
12
67
2.74
1.40
2.0
1.7
113.37
95.49
pmol/l
—
7
32
14
87
2.66
1.40
3.7
5.8
1.73
1.77
e9/l
0.08
14
78
11
59
2.73
1.38
14.0
3.3
—
—
—
0
0
14
90
2.52
1.35
3.9
5.6
0.25
0.16
e9/l
0.82
14
83
9
47
2.54
1.23
3.0
4.1
—
—
—
0
0
9
51
2.29
1.13
3.1
1.8
—
—
—
0
0
5
22
2.63
1.09
2.0
1.7
9.84
21.32
umol/l
—
5
17
5
22
2.63
1.09
2.6
1.6
2.11
2.45
g/l
—
5
17
22
190
+∞
1.07
25.1
15.1
93.36
74.29
umol/l
0.70
22
190
22
192
+∞
1.06
27.2
11.9
—
—
—
0
0
11
67
2.28
0.99
3.2
2.5
—
—
—
0
0
8
45
2.21
0.98
1.3
2.2
346.25
19099.51
umol/l
—
8
39
16
125
2.02
0.75
3.9
4.3
—
—
—
0
0
13
160
0.54
0.67
26.5
16.5
328.99
332.02
g/l
1.01
13
160
6
36
1.91
0.63
2.0
1.7
—
—
—
0
0
13
101
1.70
0.57
3.6
11.2
4.07
3.96
e9/l
0.08
13
92
8
57
1.63
0.50
3.8
2.7
—
—
—
0
0
5
34
1.61
0.44
1.8
1.7
—
—
—
0
0
0
16
0.00
0.43
0.0
1.3
—
—
—
0
0
22
204
+∞
0.43
33.4
18.9
4.30
4.48
e12/l
0.56
22
199
22
204
+∞
0.43
33.5
18.8
6.92
6.52
e9/l
0.45
22
199
7
53
1.47
0.36
3.6
6.8
—
—
—
0
0
14
122
1.40
0.30
4.1
3.7
—
—
—
0
0
16
173
0.73
0.23
23.6
12.1
39.79
39.98
%
—
9
126
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.21
0.11
6.2
5.5
—
—
—
0
0
7
63
1.16
0.09
3.7
1.9
132.33
16.00
e6/l
—
7
44
8
74
1.13
0.09
2.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.96
0.00
1.5
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
113.14
—
0
7
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
4.74
—
0
5
0
5
0.00
0.00
0.0
1.8
—
0.21
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
10.16
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
1.56
—
0
5
0
5
0.00
0.00
0.0
1.6
—
92.42
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
2.67
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
776.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.6
—
777.50
—
0
8
0
6
0.00
-0.00
0.0
4.2
—
1.41
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
1.15
—
0
6

Mortality – FinRegistry

Association

Association between endpoint E4_MYXOCO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_MYXOCO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_MYXOCO – Myxoedema coma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
9
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
7
-
-
0 (0.00)
-
-
12
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
7 (0.01)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
2
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
35
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
3
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
3
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
11 (0.01)
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
7 (0.02)
-
-
-
-
-
8 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
5
-
-
0 (0.00)
-
-
2
-
-
0 (0.00)
-
-
1
-
-
-
-
-
12
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
8 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
2
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
6
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
8
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
13 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
14
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
6
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
14 (0.01)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
5
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
1
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
-
-
-
-
-
-
0 (0.00)
-
-
-
-
-
0 (0.00)
-
-
-
-
-
16 (0.01)
-
-
-
-
-
11 (0.00)
-
-
-
-
-
-
-
-
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-
11 (0.00)
-
-
-
75
-
17 (0.01)
-
-
-
2
-
10 (0.00)
0 (0.00)
-
-
28
-
17 (0.01)
-
-
-
5
-
16 (0.01)
-
-
-
6
-
22 (0.01)
-
-
-
8
-
23 (0.01)
-
-
-
64
-
12 (0.00)
-
-
-
11
-
10 (0.00)
-
-
-
9
-
25 (0.01)
-
-
-
65
-
14 (0.00)
-
-
-
35
-
26 (0.01)
-
-
-
104
-
19 (0.01)
5 (0.01)
-
-
20
-
7 (0.00)
-
-
-
141
-
14 (0.00)
5 (0.01)
-
-
44
-
5 (0.00)
-
-
-
2
-
14 (0.00)
-
-
-
15
-
12 (0.00)
-
-
-
68
-
13 (0.00)
-
-
-
4
-
14 (0.00)
0 (0.00)
-
-
40
-
14 (0.00)
5 (0.01)
-
-
45
-
19 (0.01)
-
-
-
14
-
23 (0.01)
-
-
-
11
-
23 (0.01)
-
-
-
1
-
23 (0.01)
-
-
-
33
-
8 (0.00)
-
-
-
25
-
15 (0.00)
-
-
-
47
-
26 (0.01)
5 (0.01)
-
-
12
-
21 (0.01)
-
-
-
13
-
18 (0.01)
-
-
-
2
-
33 (0.01)
5 (0.01)
-
-
6
-
25 (0.01)
-
-
-
52
-
7 (0.00)
-
-
-
37
-
12 (0.00)
-
-
-
12
-
20 (0.01)
-
-
-
212
-
16 (0.00)
5 (0.01)
-
-
33
-
19 (0.00)
-
-
-
-
-
18 (0.00)
-
-
-
125
-
23 (0.01)
-
-
-
44
-
23 (0.01)
-
-
-
-
-
20 (0.00)
-
-
-
6
-
118 (0.03)
-
-
-
235
-
10 (0.00)
-
-
-
120
-
24 (0.01)
-
-
-
40
-
31 (0.01)
-
-
-
114
-
24 (0.01)
-
-
-
102
-
27 (0.01)
-
-
-
12
-
24 (0.01)
-
-
-
10
-
31 (0.01)
-
-
-
111
-
42 (0.01)
-
-
-
1
-
15 (0.00)
-
-
-
-
-
32 (0.01)
8 (0.01)
-
-
26
-
23 (0.00)
-
-
-
81
-
43 (0.01)
-
-
-
250
-
30 (0.01)
7 (0.01)
-
-
1
-
41 (0.01)
-
-
-
15
-
40 (0.01)
-
-
-
10
-
26 (0.01)
-
-
-
41
-
34 (0.01)
-
-
-
5
-
40 (0.01)
7 (0.01)
-
-
40
-
29 (0.01)
6 (0.01)
-
-
-
-
50 (0.01)
8 (0.01)
-
-
2
-
38 (0.01)
7 (0.01)
-
-
28
-
44 (0.01)
6 (0.01)
-
-
4
-
26 (0.00)
11 (0.02)
-
-
81
-
177 (0.03)
22 (0.03)
-
-
172
-
24 (0.00)
-
-
-
-
-
14 (0.00)
-
-
-
23
-
42 (0.01)
7 (0.01)
-
-
38
-
65 (0.01)
10 (0.01)
-
-
54
-
48 (0.01)
8 (0.01)
-
-
160
-
36 (0.01)
5 (0.01)
-
-
72
-
37 (0.01)
-
-
-
17
-
31 (0.00)
6 (0.01)
-
-
115
-
43 (0.01)
-
-
-
147
-
36 (0.01)
-
-
-
33
-
38 (0.01)
6 (0.01)
-
-
4
-
37 (0.01)
6 (0.01)
-
-
3
-
51 (0.01)
8 (0.01)
-
-
53
-
33 (0.00)
-
-
-
105
-
46 (0.01)
-
-
-
104
-
49 (0.01)
8 (0.01)
-
-
58
-
36 (0.00)
6 (0.01)
-
-
106
-
59 (0.01)
12 (0.01)
-
-
39
-
59 (0.01)
6 (0.01)
-
-
10
-
55 (0.01)
9 (0.01)
-
-
107
-
30 (0.00)
-
-
-
-
-
50 (0.01)
-
-
-
37
-
55 (0.01)
5 (0.00)
-
-
16
-
51 (0.01)
7 (0.01)
-
-
29
-
51 (0.01)
6 (0.01)
-
-
8
-
56 (0.01)
7 (0.00)
-
-
108
-
136 (0.01)
17 (0.01)
-
-
207
-
55 (0.01)
6 (0.01)
-
-
7
-
55 (0.01)
5 (0.01)
-
-
131
-
50 (0.00)
5 (0.01)
-
-
78
-
71 (0.01)
10 (0.01)
-
-
67
-
38 (0.00)
7 (0.01)
-
-
5
-
52 (0.00)
9 (0.01)
-
-
27
-
36 (0.00)
7 (0.01)
-
-
3
-
46 (0.00)
5 (0.00)
-
-
6
-
81 (0.01)
14 (0.01)
-
-
327
-
59 (0.00)
8 (0.01)
-
-
62
-
44 (0.00)
7 (0.01)
-
-
67
-
36 (0.00)
8 (0.01)
-
-
8
-
68 (0.01)
10 (0.01)
-
-
52
-
76 (0.01)
13 (0.01)
-
-
300
-
85 (0.01)
14 (0.01)
-
-
392
-
72 (0.01)
11 (0.01)
-
-
16
-
84 (0.01)
10 (0.01)
-
-
64
-
85 (0.00)
12 (0.01)
-
-
45
-
78 (0.00)
11 (0.01)
-
-
13
-
123 (0.00)
17 (0.01)
-
-
101
-
147 (0.00)
22 (0.00)
-
-
33
-