This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Toxic myoneural disorders

G6_TOXMYONEU

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G70.1 Hospital discharge: ICD-9 — 3582 Cause of death: ICD-10 — G70.1 Cause of death: ICD-9 — 3582 2 out of 7 registries used, show all original rules.	18
4. Check minimum number of events None	18
5. Include endpoints None	18
6. Filter based on genotype QC (FinnGen only)	18

Control definitions (FinnGen only)

Control exclude: G6_MYONEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G70
Name in latin: Morbositates myoneurales toxicae

NAME	G6_TOXMYONEU
CONTROL_EXCLUDE	G6_MYONEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G701
HD_ICD_9	3582
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G701
COD_ICD_9	3582
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Toxic myoneural disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	149	85	63
Only index persons	128	73	55
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	58.80	58.36	59.58
Only index persons	57.32	58.36	55.94

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	18	13	5
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	54.43	53.85	55.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

10.87

2.94

1.0

—

(42870588) Differential panel, method unspecified - Blood

4.67

2.38

10.8

6.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.69

2.38

2.8

2.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.88

1.85

2.4

1.8

—

(40758558) Short blood count panel - Blood

3.71

1.80

11.1

8.3

—

(3026782) Osmolality of Urine

2.97

1.42

9.3

2.7

508.4

504.3

mosm/kgh2o

—

(40768797) Stomach Pathology biopsy report

2.74

1.11

1.0

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

2.49

1.07

8.1

4.8

0.0

estimate

—

(3026008) Bacteria identified in Urine by Culture

2.45

0.98

7.9

3.9

—

(3009261) Glucose [Presence] in Urine by Test strip

2.38

0.87

8.6

4.8

0.0

estimate

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.86

0.0

5.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

2.32

0.85

3.6

2.4

—

(36304419) Bacteria [Presence] in Urine

2.02

0.75

6.8

2.8

—

(3015736) pH of Urine

1.99

0.71

3.6

4.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.99

0.71

10.0

2.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

2.00

0.67

11.5

7.4

0.0

estimate

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.86

0.62

1.0

1.2

—

46.0

—

(3030467) Casts [#/volume] in Urine by Automated count

1.86

0.55

8.5

3.0

0.1

0.7

e6/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.70

0.54

2.7

4.3

1940.7

939.2

ng/l

—

(3002582) Erythrocytes [#/volume] in Urine

1.81

0.54

12.8

3.1

9.9

62.3

e6/l

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.00

0.43

0.0

2.9

—

5.6

—

(3023368) Bacteria identified in Blood by Culture

1.54

0.39

4.5

4.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.61

0.35

2.8

4.0

—

(3033658) Prothrombin time (PT) actual/Normal

1.48

0.26

6.6

3.1

96.8

94.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.30

0.24

5.2

3.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.37

0.24

9.7

4.6

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

4.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

2.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.22

0.0

3.0

—

130.9

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.00

0.22

0.0

2.7

—

4.4

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(4010399)

0.00

0.21

0.0

1.2

—

(3012544) pH of Venous blood

0.00

0.21

0.0

2.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.21

0.0

2.5

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.21

0.0

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

1.19

0.11

2.8

2.5

—

(1761868) Lipid panel - Serum or Plasma

0.77

0.10

4.4

3.0

—

(3044889) 12 lead EKG panel

102

1.20

0.09

5.4

3.8

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

1.19

0.09

7.8

3.9

6.2

6.7

mmol/l

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

3.2

—

26.3

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

1.1

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

12.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.2

—

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.2

—

5.6

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

2.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

7.8

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

2.9

—

0.7

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

3.3

—

41.8

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

2.9

—

0.8

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

3.2

—

25.2

—

(40768804) Tissue Pathology biopsy report

0.90

0.00

1.8

1.5

—

(3013512) EKG study

1.09

0.00

5.2

4.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.91

0.00

9.8

4.8

—

(3002385) Erythrocyte distribution width [Ratio]

128

1.06

0.00

32.5

17.2

13.8

13.9

0.02

121

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_TOXMYONEU and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_TOXMYONEU.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: G6_TOXMYONEU – Toxic myoneural disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Toxic myoneural disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints