≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Myasthenia gravis

DOID EFO Endpoint Browser PheWeb

G6_MYASTHENIA

Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G70.0#
  • Hospital discharge: ICD-9 — 3580
  • Hospital discharge: ICD-8 — 7330
  • Cause of death: ICD-10 — G70.0#
  • Cause of death: ICD-9 — 3580
  • Cause of death: ICD-8 — 7330
  • KELA reimbursements: KELA codes — 108

3 out of 7 registries used, show all original rules.

584

4. Check minimum number of events

None

584

5. Include endpoints

None

584

6. Filter based on genotype QC (FinnGen only)

584

Control definitions (FinnGen only)

Control exclude
G6_MYONEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G70

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3518 1791 1681
Only index persons 2942 1550 1392
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.05
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 56.01 50.07 62.40
Only index persons 54.55 48.24 61.57

-FinnGen-

Key figures

All Female Male
Number of individuals 584 311 273
Unadjusted period prevalence (%) 0.11 0.11 0.12
Median age at first event (years) 54.73 47.39 63.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
525
Matched controls
5252
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
323.0
484
*
N07AA02
ATC
pyridostigmine; systemic
6685.3
323.0
420
*
108
Kela drug reimbursment
Myasthenia gravis
+∞
323.0
382
*
L04AX01
ATC
azathioprine; systemic
34.2
139.4
185
82
H53.2
ICD-10 Finland
Diplopia
30.3
97.9
133
58
GEC24
NOMESCO Finland
Thoracoscopic thymectomy
+∞
90.3
84
*
H02.4
ICD-10 Finland
Ptosis of eyelid
24.5
86.4
125
66
N07AA03
ATC
distigmine; systemic
309.1
79.9
79
*
G70.9
ICD-10 Finland
Myoneural disorder, unspecified
+∞
78.1
73
*
R03CA02
ATC
ephedrine; oral
300.7
54.2
54
*
3580A
ICD-9 Finland
Myoneural disorders, Myasthenia gravis
+∞
53.0
50
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
10.0
49.7
105
128
A12BA01
ATC
potassium chloride; oral
12.2
47.3
89
86
73300
ICD-8 Finland
Other diseases of muscle, tendon and fascia, Myasthenia gravis
+∞
42.3
40
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.1
39.1
116
232
H02AB06
ATC
prednisolone; systemic
3.3
36.3
335
1841
G70
ICD-10 Finland
Myasthenia gravis and other myoneural disorders
+∞
33.7
32
*
N99
ICPC
Neurological disease other
32.5
32.2
42
14
R13
ICD-10 Finland
Dysphagia
6.8
30.9
82
139
5872
FHL
Thymic exploration or thymectomy
+∞
30.5
29
*
GEC23
NOMESCO Finland
Transsternal thymectomy
308.1
29.1
29
*
GD1AD
NOMESCO Finland
Thorax CT examination
7.4
27.1
67
102
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
24.9
297
1736
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
23.1
22
*
2AB04
NOMESCO Finland
NA
109.2
19.7
21
*
H02AB07
ATC
prednisone; oral
3.0
18.8
121
472
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
18.7
125
497
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.1
18.3
75
204
G35
ICD-10 Finland
Multiple sclerosis
12.5
18.0
32
27
H50.2
ICD-10 Finland
Vertical strabismus
23.8
17.9
25
11
GEC26
NOMESCO Finland
Mediastinoscopic thymectomy
+∞
17.8
17
*
G70.28
ICD-10 Finland
Other congenital and developmental myasthenia
+∞
17.8
17
*
AA1AD
NOMESCO Finland
CT of head and brain
2.5
17.5
162
782
R4130
NOMESCO Finland
Speech therapy
9.7
16.9
34
37
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
16.9
202
1109
WW400
NOMESCO Finland
Plasmaferesis
65.5
16.8
19
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.9
16.2
69
194
ZXC96
NOMESCO Finland
Robot assisted procedure
7.7
16.0
37
51
R47.1
ICD-10 Finland
Dysarthria and anarthria
17.9
15.7
24
14
G70.8
ICD-10 Finland
Other specified myoneural disorders
+∞
15.7
15
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.4
15.1
56
139
G70.20
ICD-10 Finland
Congenital and developmental myasthenia
+∞
14.6
14
*
A02BC02
ATC
pantoprazole; systemic
2.0
13.3
359
2696
G70.1
ICD-10 Finland
Toxic myoneural disorders
+∞
12.5
12
*
N28
ICPC
Limited function/disability (N)
10.9
12.4
23
22
G70.21
ICD-10 Finland
Limb girdle myasthenia
+∞
11.5
11
*
R4110
NOMESCO Finland
Physiotherapy
2.0
10.9
159
920
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
16.4
10.4
16
10
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
17.9
9.4
14
8
73308
ICD-8 Finland
NA
+∞
9.4
9
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.5
9.1
76
338
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
15.9
9.1
14
9
XA100
NOMESCO Finland
Tensilon test
+∞
8.4
8
*
G73.1*C80.99
ICD-10 Finland
Eaton-Lambert syndrome
+∞
8.4
8
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.8
8.2
26
56
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
8.1
74
341
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
11.9
8.1
14
12
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
10.3
8.1
15
15
L28
ICPC
Limited function/disability (L)
2.2
8.0
89
451
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.3
7.8
38
121
N29
ICPC
Neurological sympt/complt other
6.1
7.8
20
34
ZX120
NOMESCO Finland
Intravenous
2.4
7.6
66
299
D38.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thymus
81.2
7.4
8
*
D15.0
ICD-10 Finland
Benign neoplasm: Thymus
81.2
7.4
8
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
7.4
95
513
R06.0
ICD-10 Finland
Dyspnoea
1.8
7.4
141
881
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
9.6
7.3
14
15
G72.8
ICD-10 Finland
Other specified myopathies
+∞
7.3
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
7.2
95
521
R1260
NOMESCO Finland
Evaluation of communicative skills
6.2
7.1
18
30
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
6.8
34
111
6BA02
NOMESCO Finland
NA
22.8
6.7
9
*
TAB00
NOMESCO Finland
Lumbar puncture
3.1
6.7
35
119
XKD03
NOMESCO Finland
Urethral pressure profilometry
4.2
6.6
23
56
XKC03
NOMESCO Finland
Water cystometry
3.9
6.5
25
67
CE2W4
NOMESCO Finland
Eye movement mapping
70.7
6.4
7
*
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
11.2
6.3
11
10
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.3
202
1460
8580/3-C37.9
ICD-O-3
Thymoma, NOS, of thymus
+∞
6.3
6
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
6.1
64
318
XCK00
NOMESCO Finland
Perimetry
2.6
6.0
43
177

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
223
34
105.49
307.65
1.3
1.1
11.6
0.1
nmol/l
—
149
5
325
1578
3.39
46.29
12.9
5.6
—
—
—
0
0
308
1466
3.33
45.00
2.9
2.0
153.7
152.0
u/l
0.03
300
1383
400
2382
3.16
37.01
13.9
5.6
0.0
0.0
e9/l
0.89
366
2070
399
2373
3.15
36.99
13.8
5.6
0.6
0.6
e9/l
0.19
365
2057
400
2426
3.06
34.95
14.0
5.6
1.6
2.0
e9/l
4.62
368
2150
403
2461
3.06
34.64
14.2
5.9
0.2
0.2
e9/l
2.47
370
2177
38
43
9.38
31.01
1.2
1.2
—
—
—
0
0
389
2424
2.81
30.46
8.1
7.0
1.2
1.2
mmol/l
0.47
342
2066
113
361
3.64
30.00
2.5
2.6
9.3
10.6
g/l
2.13
107
331
366
2223
2.73
29.95
7.3
6.0
1.2
1.2
mmol/l
0.30
352
2013
420
2789
2.80
27.86
16.4
9.1
4.3
4.1
e9/l
0.94
388
2451
177
787
2.79
26.46
3.2
3.4
0.8
0.8
mmol/l
0.29
172
741
34
46
7.79
23.99
3.3
1.8
1.1
1.1
e9/l
0.07
17
24
27
31
9.08
21.69
3.0
1.8
15.8
12.3
%
—
10
20
405
2849
2.38
20.41
7.0
4.8
6.6
6.7
mmol/l
0.94
393
2672
17
10
17.48
20.36
1.8
1.8
—
—
—
0
0
179
916
2.38
19.09
1.7
1.5
2.1
2.5
g/l
1.98
131
565
48
115
4.46
18.72
1.4
1.4
504.6
463.2
mg/l
0.39
48
106
27
40
7.03
17.55
3.3
1.9
799.4
831.2
e6/l
0.05
14
15
25
36
7.21
16.66
2.2
1.8
53.7
32.4
%
—
7
5
241
1468
2.09
16.21
4.1
4.1
7.4
7.4
ph
0.18
37
268
16
13
12.63
16.08
1.2
1.0
1830.8
1430.5
miu/ml
0.52
16
13
116
524
2.51
16.00
9.1
7.8
95.9
95.7
%
0.11
111
504
20
23
8.97
15.98
1.1
1.2
—
—
—
0
0
123
579
2.42
15.49
8.9
7.5
1.8
1.3
mmol/l
0.89
99
448
122
583
2.38
14.80
9.0
7.4
5.3
5.1
kpa
2.21
114
559
122
583
2.38
14.80
9.0
7.4
12.1
12.1
kpa
0.03
115
561
100
443
2.52
14.28
2.0
2.0
351.0
375.3
nmol/l
0.60
95
414
77
300
2.80
14.20
4.9
4.1
7.4
7.4
ph
—
8
38
199
1183
2.03
13.85
4.9
3.8
93.3
90.0
%
1.24
193
1154
39
102
4.03
13.55
1.5
1.3
2.8
11.8
e6/l
0.70
32
77
39
102
4.03
13.55
1.6
1.4
111.0
1228.7
e6/l
0.51
32
80
36
89
4.24
13.47
1.6
1.4
—
—
—
0
0
62
223
2.99
13.20
5.0
4.2
—
—
—
0
0
301
2087
1.91
13.16
4.6
4.9
34.7
35.5
g/l
1.53
285
1947
198
1196
1.99
13.03
11.0
7.0
—
—
—
0
0
25
48
5.40
12.59
1.6
1.5
—
—
—
0
0
290
2010
1.88
12.47
7.3
8.9
1.3
1.2
inr
0.19
58
581
454
3653
2.09
12.36
4.5
3.8
15.0
14.8
pmol/l
0.95
439
3282
89
402
2.43
12.11
9.5
8.4
—
—
—
0
0
93
429
2.39
12.08
8.8
6.8
1.3
1.3
mmol/l
0.05
88
408
116
603
2.15
11.29
1.4
1.3
433.5
479.1
titre
0.23
37
135
18
29
6.37
10.79
1.0
1.2
5.0
6.8
u/l
0.52
13
24
187
1179
1.86
10.42
2.9
2.3
—
—
—
0
0
75
335
2.42
10.41
6.5
4.9
—
—
—
0
0
294
2124
1.77
10.39
16.8
9.6
0.0
0.0
e9/l
0.05
241
1750
441
3597
1.92
10.37
4.9
4.1
11.9
12.4
mm/h
0.24
421
3301
41
134
3.22
10.26
3.7
3.3
—
—
—
0
0
510
4394
2.27
10.10
6.0
4.6
1.9
2.2
mu/l
0.53
493
3974
20
39
5.27
9.90
1.8
1.5
—
—
—
0
0
116
638
2.02
9.61
4.3
5.9
1.0
1.0
mmol/l
0.14
107
581
226
1547
1.75
9.37
3.4
2.3
—
—
—
0
0
61
260
2.50
9.35
10.7
9.5
25.3
24.7
mmol/l
1.04
56
244
61
262
2.48
9.20
11.0
9.9
—
—
—
0
0
73
341
2.30
9.14
1.6
2.6
—
—
—
0
0
276
2018
1.70
8.88
2.3
2.0
92.9
94.3
pmol/l
0.19
162
1040
42
152
2.90
8.84
2.0
1.4
0.2
0.2
g/l
1.57
42
145
44
165
2.80
8.69
1.7
2.4
21.9
21.5
s
0.14
39
151
27
76
3.68
8.50
1.1
1.1
—
—
—
0
0
66
305
2.31
8.47
1.2
1.3
—
—
—
0
0
91
482
2.05
8.30
4.3
4.2
—
—
—
0
0
196
1325
1.72
8.29
4.3
2.9
—
—
—
0
0
11
5
22.38
8.04
1.0
1.0
—
—
—
0
0
11
5
22.38
8.04
1.0
1.0
6.6
6.5
mg/g
—
11
5
240
1730
1.66
7.89
5.4
3.7
43.7
93.4
e6/l
1.15
185
1245
214
1498
1.68
7.87
4.5
3.1
44.6
99.4
e6/l
0.59
178
1166
444
3774
1.74
7.39
9.2
7.6
75.6
78.7
u/l
0.73
429
3529
390
3210
1.65
7.28
6.9
4.4
1713.9
1042.6
e6/l
—
8
56
402
3335
1.66
7.26
6.0
4.3
—
—
—
0
0
31
106
3.03
7.23
2.6
3.5
29.1
34.3
umol/l
0.92
26
88
118
714
1.82
7.20
1.4
1.8
—
—
—
0
0
207
1472
1.63
6.98
3.3
3.1
1409.6
1279.9
ng/l
0.19
176
1259
11
8
13.98
6.91
1.1
1.0
—
—
—
0
0
142
919
1.72
6.85
5.0
3.8
71.9
226.2
ng/l
1.97
115
722
255
1914
1.59
6.84
5.1
3.8
209.0
37.8
ng/l
0.46
197
1380
192
1346
1.64
6.83
4.7
4.1
—
—
—
0
0
158
1055
1.68
6.79
3.1
2.5
5.5
5.9
e6/l
0.13
143
929
159
1064
1.68
6.77
1.8
1.8
1.5
1.2
mg/l
0.59
126
815
148
979
1.69
6.56
3.2
2.8
556.9
561.4
mosm/kgh2o
0.10
131
833
14
29
4.92
6.48
1.4
1.2
2.2
1.8
mmol/l
0.34
14
29
22
65
3.48
6.48
1.2
1.2
—
75.1
—
0
5
99
591
1.81
6.27
1.3
1.6
—
—
—
0
0
225
1671
1.56
6.15
3.1
3.5
2.3
2.4
mmol/l
3.39
197
1461
176
1236
1.61
6.11
2.5
2.1
3.0
3.1
mg/l
0.20
155
1041
83
475
1.87
6.01
3.9
3.8
—
—
—
0
0
191
1377
1.58
5.90
4.5
3.0
0.5
0.5
e6/l
0.04
155
1038
540
4978
2.13
5.63
26.5
16.8
139.8
139.7
mmol/l
0.66
533
4844
541
4992
2.14
5.60
28.1
16.9
4.0
4.0
mmol/l
1.08
536
4850
17
48
3.62
5.36
1.5
1.2
—
—
—
0
0
18
53
3.47
5.34
2.4
2.8
3.4
6.8
nmol/l
0.53
18
53
523
4785
1.89
5.33
23.2
14.4
20.0
24.0
mg/l
2.82
454
3791
315
2572
1.49
5.25
6.5
6.3
11.8
11.3
umol/l
0.16
305
2434
10
19
5.34
5.05
2.4
3.0
600.3
831.3
u/ml
—
10
19
77
455
1.80
5.03
3.9
3.8
2.5
2.1
mmol/l
0.40
64
363
285
2295
1.47
5.01
5.5
4.0
—
—
—
0
0
293
2391
1.45
4.70
4.9
3.7
0.0
0.0
estimate
0.50
50
427
73
434
1.78
4.67
1.5
1.4
—
—
—
0
0
289
2358
1.45
4.61
6.5
5.0
0.0
0.0
estimate
0.50
54
443
11
25
4.47
4.58
1.1
1.3
121.2
138.0
nmol/l
0.78
11
25
26
106
2.52
4.44
6.2
2.8
—
—
—
0
0
194
1476
1.47
4.43
3.4
3.0
—
—
—
0
0
50
268
1.95
4.42
2.7
3.4
4.2
4.6
pmol/l
1.37
42
241
64
374
1.80
4.34
5.4
4.3
0.4
0.1
%
0.41
18
114
77
476
1.71
4.31
1.3
1.5
—
—
—
0
0
286
2350
1.43
4.28
4.8
3.7
0.0
0.0
estimate
0.00
52
444
114
785
1.56
4.15
4.4
2.8
5.7
1.8
e6/l
1.71
70
425
20
75
2.73
4.03
6.9
2.9
3.8
4.5
e9/l
0.71
20
75
130
932
1.51
3.93
1.8
1.7
1046.5
1205.2
nmol/l
1.30
104
702
255
2079
1.40
3.87
3.5
2.7
164.7
137.4
ug/l
0.55
247
1903
66
403
1.72
3.86
5.3
4.1
0.7
0.9
%
0.23
19
132
14
44
3.24
3.80
4.2
3.0
—
—
—
0
0
87
574
1.61
3.79
3.3
2.6
1.7
1.8
%
0.42
73
518
59
351
1.76
3.79
1.2
1.2
—
—
—
0
0
142
1044
1.48
3.78
10.1
4.8
—
—
—
0
0
20
78
2.62
3.75
7.3
3.4
60.5
57.3
%
0.57
20
78
148
1099
1.46
3.75
4.8
3.6
—
—
—
0
0
60
360
1.74
3.74
5.0
4.1
0.6
0.4
%
0.32
12
95
160
1213
1.44
3.62
1.8
1.5
19.6
21.1
nmol/l
0.78
143
1012
58
352
1.72
3.48
5.8
4.3
0.0
1.0
%
0.57
14
100
97
670
1.54
3.47
1.3
1.3
—
—
—
0
0
20
82
2.49
3.42
1.7
1.4
—
—
—
0
0
540
5102
1.78
3.38
19.1
10.6
27.1
25.7
u/l
0.84
532
4911
83
559
1.57
3.32
3.0
2.8
15.1
8.3
umol/l
0.75
73
491
54
326
1.72
3.31
3.5
2.4
4.0
4.2
e9/l
0.32
42
253
12
39
3.12
3.10
1.2
1.2
—
—
—
0
0
13
45
2.93
3.04
1.2
1.2
—
—
nmol/l
—
0
0
112
820
1.45
3.01
1.2
1.3
39.5
35.6
iu/ml
0.09
22
254
26
128
2.08
2.96
1.1
1.1
—
—
—
0
0
35
194
1.86
2.87
9.9
4.5
—
—
—
0
0
37
209
1.82
2.86
1.9
1.7
—
—
—
0
0
24
120
2.04
2.64
2.2
1.7
4.9
5.0
iu/l
—
7
40
14
55
2.58
2.63
1.1
1.2
—
—
—
0
0
17
74
2.34
2.60
1.1
1.1
—
—
—
0
0
50
317
1.63
2.59
1.2
1.2
184.0
156.0
iu/ml
0.12
15
127
11
38
2.93
2.59
1.3
1.2
—
—
—
0
0
131
1658
0.73
2.59
2.6
2.9
—
—
—
0
0
132
1023
1.38
2.56
1.3
1.2
0.7
1.4
u/ml
2.23
29
281
28
150
1.91
2.56
1.5
1.5
263.3
282.5
ug/g
0.21
18
89
21
101
2.12
2.56
3.2
2.4
17.3
16.1
%
0.71
13
52
122
934
1.39
2.55
2.3
3.1
2.4
2.5
mmol/l
1.15
103
827
105
785
1.41
2.52
2.4
2.5
12.5
13.1
umol/l
0.36
99
725
8
21
3.85
2.47
1.0
1.0
—
—
—
0
0
20
96
2.12
2.45
6.7
3.1
—
—
—
0
0
188
1548
1.32
2.43
2.9
2.5
58.8
56.6
u/l
0.45
176
1428
179
1464
1.32
2.43
4.4
4.0
—
—
—
0
0
42
260
1.66
2.40
1.4
1.3
—
—
—
0
0
16
71
2.29
2.36
1.0
1.0
—
—
—
0
0
160
1295
1.32
2.32
5.3
3.9
0.0
0.0
estimate
0.69
47
429
229
1947
1.29
2.31
2.3
2.1
—
—
—
0
0
8
23
3.51
2.27
1.0
1.1
—
—
—
0
0
80
581
1.44
2.25
2.2
1.7
—
—
—
0
0
91
677
1.41
2.25
2.5
2.5
22.8
22.7
%
0.02
79
585
13
54
2.44
2.21
1.2
1.1
—
—
—
0
0
18
87
2.10
2.19
6.9
1.8
69.9
62.6
%
0.79
18
87
82
602
1.42
2.18
1.5
1.4
—
—
—
0
0
19
94
2.06
2.18
3.2
2.6
—
—
—
0
0
53
360
1.52
2.09
1.4
1.4
—
—
—
0
0
56
386
1.50
2.06
3.5
3.1
146.2
187.6
ng/l
0.66
50
351
38
240
1.62
2.04
4.4
2.5
0.7
0.7
%
0.14
38
233
75
550
1.42
2.02
1.7
2.3
211.5
142.2
ug/g
0.44
59
436
19
98
1.97
1.97
10.7
3.5
2.4
2.6
mmol/l
0.12
14
64
21
113
1.89
1.94
1.1
1.2
—
—
—
0
0
22
121
1.85
1.91
1.1
1.2
—
55.7
—
0
7
521
4989
1.41
1.83
21.4
13.7
—
—
—
0
0
12
53
2.29
1.81
2.0
1.8
—
—
—
0
0
8
29
2.78
1.79
3.4
2.3
—
—
—
0
0
59
424
1.44
1.79
4.2
2.8
63.8
70.2
e9/l
0.65
43
332
175
1481
1.26
1.76
2.9
3.3
407.2
262.5
mg/l
0.16
116
951
7
24
2.94
1.72
1.0
1.5
—
—
—
0
0
18
96
1.90
1.72
1.2
1.3
—
—
—
0
0
11
48
2.32
1.71
1.3
1.4
—
—
—
0
0
10
42
2.41
1.68
1.0
1.0
—
—
—
0
0
8
31
2.60
1.66
3.3
3.8
—
—
—
0
0
129
1059
1.28
1.66
5.4
4.0
1.0
1.0
kg/l
0.04
19
149
181
1550
1.24
1.63
2.9
3.1
8.0
7.6
mmol/l
0.61
157
1282
12
56
2.17
1.62
1.3
1.6
27.4
64.0
%
—
7
42
8
32
2.52
1.60
4.8
3.1
—
—
—
0
0
5
15
3.35
1.52
1.4
1.2
—
—
—
0
0
5
15
3.35
1.52
1.6
1.1
1.2
2.3
mmol/l
—
5
15
44
312
1.44
1.46
4.5
3.3
129.2
127.3
g/l
0.24
44
306
12
59
2.06
1.44
2.0
1.1
—
—
—
0
0
13
66
1.99
1.44
1.2
1.2
—
—
—
0
0
6
23
2.62
1.37
6.3
3.2
—
—
—
0
0
179
1557
1.22
1.36
3.4
4.0
9.3
8.8
mg/mmol
0.03
112
977
15
258
0.57
1.35
1.3
1.4
—
—
—
0
0
13
68
1.93
1.34
1.9
3.0
—
—
—
0
0
9
42
2.16
1.34
1.7
1.4
—
—
—
0
0
58
440
1.35
1.33
1.4
1.4
—
—
—
0
0
67
520
1.33
1.32
1.5
1.7
—
—
—
0
0
421
3973
1.21
1.31
31.0
17.8
13.9
13.7
%
1.57
415
3900
150
1287
1.22
1.31
1.3
1.4
—
—
—
0
0
71
557
1.31
1.30
1.3
1.3
—
—
—
0
0
545
5304
1.41
1.28
37.9
21.3
256.8
246.3
e9/l
2.98
539
5165
148
1273
1.22
1.26
2.6
2.8
17346.8
7242.2
umol/l
0.80
133
1089
6
25
2.41
1.24
6.5
3.0
—
—
—
0
0
8
36
2.24
1.24
1.3
1.2
458.5
377.2
nmol/l
—
8
31
545
5308
1.40
1.23
37.9
21.3
4.5
4.5
e12/l
0.03
539
5151
12
63
1.92
1.23
3.8
3.4
—
—
—
0
0
545
5309
1.40
1.22
37.9
21.3
6.9
6.7
e9/l
0.95
538
5148
5
19
2.65
1.22
1.2
1.2
—
—
—
0
0
15
86
1.76
1.20
1.3
1.7
—
—
—
0
0
19
117
1.64
1.19
2.0
1.8
3004.0
5024.9
u/l
—
7
36
94
775
1.25
1.18
1.2
1.3
32.0
11.8
u/ml
0.68
24
288
44
328
1.37
1.14
3.0
2.9
—
—
—
0
0
40
296
1.38
1.09
1.2
1.2
—
—
—
0
0
19
122
1.58
1.03
1.6
1.7
5589.8
15870.1
e6/l
1.19
13
90
9
48
1.89
1.01
1.7
2.0
—
—
—
0
0
18
115
1.58
1.00
1.9
1.5
—
—
—
0
0
49
382
1.31
0.97
4.0
4.1
98.5
83.8
ng/l
0.34
44
341
0
30
0.00
0.97
0.0
1.1
—
—
—
0
0
7
36
1.96
0.97
5.0
1.7
13.1
11.2
%
—
7
36
76
632
1.23
0.91
25.9
22.8
1.4
1.2
inr
0.26
14
90
466
4492
1.19
0.90
6.1
6.0
40.2
40.1
mmol/mol
0.18
445
4147
88
745
1.21
0.89
2.2
2.0
—
—
—
0
0
54
433
1.27
0.89
3.5
2.5
3.9
6.3
ug/l
1.26
45
394
10
57
1.77
0.84
1.1
1.2
—
—
—
0
0
11
66
1.68
0.79
1.2
1.1
—
16.4
—
0
5
12
75
1.61
0.75
1.2
1.6
—
—
—
0
0
8
133
0.60
0.74
3.3
5.0
—
—
—
0
0
118
1048
1.16
0.71
1.8
1.7
400.4
429.6
pmol/l
0.55
106
864
28
213
1.33
0.70
1.6
1.7
—
—
—
0
0
19
135
1.42
0.70
1.2
1.3
—
—
—
0
0
16
110
1.47
0.69
3.1
4.2
44.8
27.9
mg/l
—
8
69
10
61
1.65
0.69
1.0
1.2
—
—
—
0
0
5
93
0.53
0.67
1.6
1.7
—
—
—
0
0
21
154
1.38
0.66
1.3
1.2
—
—
—
0
0
8
51
1.58
0.60
1.1
1.1
—
—
—
0
0
359
3441
1.11
0.60
4.1
3.9
—
—
—
0
0
8
53
1.52
0.58
2.1
1.3
—
—
—
0
0
6
35
1.72
0.58
1.5
1.2
—
—
—
0
0
6
35
1.72
0.58
4.5
1.5
—
—
—
0
0
8
54
1.49
0.57
2.3
2.6
—
—
—
0
0
24
185
1.31
0.57
2.5
3.4
0.1
0.2
g/l
1.63
13
75
69
601
1.17
0.55
1.3
1.3
—
—
—
0
0
8
122
0.65
0.55
1.0
1.1
—
—
—
0
0
9
61
1.48
0.54
5.9
2.1
33.7
33.0
pg
—
9
61
9
61
1.48
0.54
1.3
1.5
—
—
—
0
0
50
428
1.18
0.50
5.5
3.3
—
—
—
0
0
195
1828
1.10
0.49
4.5
5.1
3.0
2.6
ug/l
0.20
177
1620
47
403
1.18
0.47
5.3
3.7
—
—
—
0
0
27
219
1.24
0.46
5.4
5.4
1.5
1.5
%
0.07
22
207
12
87
1.39
0.42
2.5
1.7
—
—
—
0
0
8
57
1.41
0.42
1.0
1.5
—
—
—
0
0
8
57
1.41
0.42
1.0
1.5
—
—
—
0
0
8
57
1.41
0.42
1.0
1.5
—
—
—
0
0
8
57
1.41
0.42
1.0
1.5
—
—
—
0
0
8
58
1.38
0.41
1.9
1.4
—
—
—
0
0
15
114
1.32
0.41
1.2
1.3
215.4
243.4
miu/ml
—
5
49
0
17
0.00
0.40
0.0
2.4
—
—
—
0
0
480
4711
1.11
0.39
5.1
4.7
5.9
6.0
mmol/l
0.41
456
4278
8
61
1.32
0.39
1.3
1.1
—
—
—
0
0
8
61
1.32
0.39
1.4
1.3
5.6
6.3
mmol/l
—
8
56
31
366
0.84
0.39
1.4
1.4
—
—
—
0
0
12
89
1.36
0.38
1.7
1.7
—
—
—
0
0
12
89
1.36
0.38
1.3
1.5
—
—
—
0
0
14
107
1.32
0.37
2.3
2.0
—
—
—
0
0
39
338
1.16
0.36
1.3
1.6
—
—
—
0
0
26
218
1.20
0.35
2.5
2.7
—
—
—
0
0
26
218
1.20
0.35
5.5
5.4
1.0
0.9
%
1.51
21
204
17
136
1.26
0.34
1.4
1.4
248.7
266.9
mu/l
0.21
17
124
33
381
0.86
0.33
1.3
1.4
—
—
—
0
0
7
52
1.35
0.31
1.1
1.2
—
—
—
0
0
22
184
1.20
0.31
1.1
1.1
—
—
—
0
0
29
250
1.17
0.30
2.7
2.5
—
—
—
0
0
136
1286
1.08
0.29
4.6
3.4
—
—
—
0
0
8
64
1.25
0.27
2.1
1.7
—
—
—
0
0
9
120
0.75
0.27
1.6
1.3
—
—
—
0
0
15
122
1.24
0.27
3.8
4.2
—
—
—
0
0
25
215
1.17
0.27
1.0
1.2
—
—
—
0
0
11
86
1.28
0.26
2.5
2.9
—
—
—
0
0
5
71
0.70
0.26
2.4
2.9
—
—
—
0
0
5
74
0.67
0.26
2.4
2.8
4.0
4.1
mmol/l
—
5
74
5
74
0.67
0.26
2.4
2.8
106.4
105.3
mmol/l
—
5
74
9
74
1.22
0.25
1.6
1.4
32.4
32.7
g/l
—
9
63
137
1306
1.06
0.24
1.6
1.7
1.5
1.4
mmol/l
0.58
117
1086
0
11
0.00
0.21
0.0
5.0
—
8.0
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
7292.1
—
0
10
6
50
1.20
0.19
1.0
1.1
—
—
—
0
0
6
51
1.18
0.19
4.5
2.5
—
—
—
0
0
7
63
1.11
0.17
1.1
1.1
—
—
—
0
0
5
67
0.74
0.17
1.0
1.3
—
—
—
0
0
5
68
0.73
0.17
1.6
1.4
—
—
—
0
0
5
68
0.73
0.17
9.8
4.6
307.8
370.1
umol/l
—
5
61
5
68
0.73
0.17
1.6
1.4
—
—
—
0
0
5
70
0.71
0.16
1.6
1.5
—
—
—
0
0
12
101
1.19
0.16
1.3
1.4
—
—
—
0
0
22
244
0.90
0.15
3.0
3.7
—
—
—
0
0
469
4730
0.96
0.14
4.5
4.5
1.4
1.5
mmol/l
0.99
437
4320
51
538
0.94
0.12
3.5
4.1
26.0
34.6
ug/l
0.13
42
452
109
1060
1.03
0.10
2.7
3.1
0.6
0.7
ug/l
2.06
78
712
5
47
1.06
0.09
1.0
1.2
—
—
—
0
0
483
4858
0.97
0.09
5.0
5.1
2.7
2.7
mmol/l
0.21
445
4436
14
155
0.90
0.09
6.7
10.4
—
—
—
0
0
453
4560
0.97
0.09
4.1
4.1
1.4
1.3
mmol/l
1.61
423
4152
10
88
1.14
0.08
1.0
1.4
—
—
—
0
0
7
64
1.09
0.08
1.1
1.1
—
—
—
0
0
9
88
1.02
0.07
4.6
3.2
404.1
26.1
u/ml
—
9
88
474
4760
0.98
0.05
4.6
4.6
4.7
4.6
mmol/l
0.32
446
4382
12
130
0.92
0.04
1.3
1.4
—
—
—
0
0
12
130
0.92
0.04
1.3
1.4
—
—
—
0
0
12
129
0.93
0.03
1.3
1.4
—
—
—
0
0
12
128
0.94
0.02
1.3
1.4
—
—
—
0
0
431
4301
1.01
0.01
28.0
15.6
39.6
39.7
%
0.09
305
2998
12
126
0.95
0.00
1.6
1.6
33.4
41.4
nmol/l
1.12
12
118
16
166
0.96
0.00
1.1
1.1
—
—
—
0
0
17
166
1.02
0.00
1.8
1.6
—
—
—
0
0
12
122
0.98
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
0.00
2.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
0.00
1.4
2.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
—
—
0
0
6
69
0.87
0.00
1.5
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
41.6
—
0
8
5
52
0.96
0.00
1.2
2.4
54.6
4.7
umol/l
—
5
40
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_MYASTHENIA and mortality.

Females

Parameter HR [95% CI] p-value
G6_MYASTHENIA 1.455 [1.19, 1.78] < 0.001
Birth year 0.992 [0.98, 1.0] 0.096

During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 993 females with G6_MYASTHENIA died.

Males

Parameter HR [95% CI] p-value
G6_MYASTHENIA 1.196 [1.01, 1.42] 0.04
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 1043 males with G6_MYASTHENIA died.

Mortality risk

Mortality risk for people of age

years, who have G6_MYASTHENIA.

N-year risk Females Males
1 0.116% 0.157%
5 0.643% 1.359%
10 1.895% 3.372%
15 3.606% 6.583%
20 6.362% 11.147%

Relationships between endpoints

↥

Index endpoint: G6_MYASTHENIA – Myasthenia gravis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data