Myasthenia gravis: Myasthenia gravis (MG) is a rare, clinically heterogeneous, autoimmune disorder of the neuromuscular junction characterized by fatigable weakness of voluntary muscles.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
619 |
4. Check minimum number of eventsNone |
619 |
5. Include endpointsNone |
619 |
6. Filter based on genotype QC (FinnGen only) |
594 |
Control definitions (FinnGen only)
- Control exclude
- G6_MYONEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G70
Similar endpoints
↥List of similar endpoints to
Myasthenia gravis
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3518 | 1791 | 1681 |
| Only index persons | 2942 | 1550 | 1392 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 56.01 | 50.07 | 62.40 |
| Only index persons | 54.55 | 48.24 | 61.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 594 | 314 | 280 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.13 |
| Median age at first event (years) | 55.60 | 48.17 | 63.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 619
- Matched controls
- 6190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AX01
ATC
azathioprine; systemic
34.2
317.3
221
99
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
307.7
571
*
N07AA02
ATC
pyridostigmine; systemic
9046.1
307.7
508
*
108
Kela drug reimbursment
Myasthenia gravis
+∞
307.7
454
*
H53.2
ICD-10 Finland
Diplopia
22.7
199.8
158
92
H02.4
ICD-10 Finland
Ptosis of eyelid
24.2
199.6
153
83
GEC24
NOMESCO Finland
Thoracoscopic thymectomy
1188.2
105.5
100
*
N07AA03
ATC
distigmine; systemic
207.4
87.8
89
5
G70.9
ICD-10 Finland
Myoneural disorder, unspecified
+∞
84.3
79
*
A12BA01
ATC
potassium chloride; oral
10.4
83.2
100
113
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.1
66.4
134
269
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.0
66.0
112
189
N99
ICPC
Neurological disease other
24.1
64.8
47
21
R03CA02
ATC
ephedrine; oral
225.1
60.2
61
*
3580A
ICD-9 Finland
Myoneural disorders, Myasthenia gravis
+∞
58.3
55
*
GD1AD
NOMESCO Finland
Thorax CT examination
6.3
55.4
104
193
H02AB06
ATC
prednisolone; systemic
3.6
50.4
411
2197
73300
ICD-8 Finland
Other diseases of muscle, tendon and fascia, Myasthenia gravis
+∞
49.7
47
*
G70
ICD-10 Finland
Myasthenia gravis and other myoneural disorders
+∞
46.4
44
*
R13
ICD-10 Finland
Dysphagia
4.7
39.4
101
245
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
37.9
176
648
GEC23
NOMESCO Finland
Transsternal thymectomy
+∞
34.7
33
*
R4130
NOMESCO Finland
Speech therapy
8.3
34.5
47
61
G35
ICD-10 Finland
Multiple sclerosis
12.9
33.5
33
27
5872
FHL
Thymic exploration or thymectomy
+∞
31.5
30
*
H02AB07
ATC
prednisone; oral
3.3
30.6
138
493
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
29.2
365
2207
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
28.3
27
*
R47.1
ICD-10 Finland
Dysarthria and anarthria
10.8
26.4
29
28
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
24.5
87
265
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.5
24.0
94
305
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.1
23.3
69
185
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
23.0
263
1480
ZXC96
NOMESCO Finland
Robot assisted procedure
5.5
22.5
45
87
N28
ICPC
Limited function/disability (N)
9.1
21.7
27
31
L04AA06
ATC
mycophenolic acid; systemic
7.6
20.9
30
41
G70.28
ICD-10 Finland
Other congenital and developmental myasthenia
+∞
19.9
19
*
2AB04, ,
NOMESCO Finland
108.5
19.7
21
*
WW400
NOMESCO Finland
Plasmaferesis
206.3
19.7
20
*
G70.8
ICD-10 Finland
Other specified myoneural disorders
+∞
18.8
18
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
18.2
208
1149
GEC26
NOMESCO Finland
Mediastinoscopic thymectomy
+∞
17.8
17
*
G70.20
ICD-10 Finland
Congenital and developmental myasthenia
+∞
17.8
17
*
H50.2
ICD-10 Finland
Vertical strabismus
16.5
17.2
27
17
N29
ICPC
Neurological sympt/complt other
6.7
16.3
26
40
R06.0
ICD-10 Finland
Dyspnoea
2.0
13.8
197
1162
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
13.8
89
378
A02BC02
ATC
pantoprazole; systemic
2.0
13.6
445
3459
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
23.1
13.0
18
8
R4110
NOMESCO Finland
Physiotherapy
2.0
12.7
193
1160
G70.1
ICD-10 Finland
Toxic myoneural disorders
+∞
12.5
12
*
XKD03
NOMESCO Finland
Urethral pressure profilometry
5.2
12.5
26
52
L28
ICPC
Limited function/disability (L)
2.1
11.8
125
657
G70.21
ICD-10 Finland
Limb girdle myasthenia
+∞
11.5
11
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.3
11.2
29
70
ZX120
NOMESCO Finland
Intravenous
2.5
11.1
76
331
D38.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thymus
44.1
11.0
13
*
D15.0
ICD-10 Finland
Benign neoplasm: Thymus
+∞
10.4
10
*
TAB00
NOMESCO Finland
Lumbar puncture
3.2
10.4
41
133
CBJ30
NOMESCO Finland
Plastic repair of levator aponeurosis of eyelid
19.2
10.3
15
8
WX725
NOMESCO Finland
Noninvasive ventilation
2.9
10.2
48
173
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
14.9
10.0
16
11
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
9.8
82
390
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
9.7
124
694
XCK00
NOMESCO Finland
Perimetry
2.8
9.5
50
191
73308, ,
ICD-8 Finland
+∞
9.4
9
*
XA100
NOMESCO Finland
Tensilon test
+∞
9.4
9
*
G73.1*C80.99
ICD-10 Finland
Eaton-Lambert syndrome
+∞
9.4
9
*
XKC03
NOMESCO Finland
Water cystometry
3.8
9.1
28
77
R03DA04
ATC
theophylline; systemic, rectal
2.9
9.1
44
161
N03AX16
ATC
[U] pregabalin
1.8
9.0
153
938
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
37.3
9.0
11
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
8.9
265
1908
WX882
NOMESCO Finland
High dependency care
4.0
8.8
25
65
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
8.7
91
473
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
8.7
38
131
G72.8
ICD-10 Finland
Other specified myopathies
50.7
8.7
10
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
8.7
242
1709
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
8.5
108
602
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
8.4
43
162
CBJ40
NOMESCO Finland
Resection of levator muscle of eyelid
9.6
8.3
16
17
Z3226
NOMESCO Finland
Physiotherapist
1.9
8.1
122
719
6BA02, ,
NOMESCO Finland
33.8
8.1
10
*
NXL00
NOMESCO Finland
Biopsy of muscle
33.8
8.1
10
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
9.1
8.1
16
18
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.2
8.1
31
99
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
7.8
63
296
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
7.7
116
684
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
8.2
7.6
16
20
H03AA01
ATC
levothyroxine sodium; systemic
1.8
7.6
144
910
M05BA04
ATC
alendronic acid; oral
2.3
7.5
57
260
B03BA03
ATC
hydroxocobalamin; parenteral
2.6
7.4
43
173
G51.0
ICD-10 Finland
Bell palsy
3.8
7.4
22
59
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.5
7.3
48
205
G71.9
ICD-10 Finland
Primary disorder of muscle, unspecified
+∞
7.3
7
*
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
7.2
49
213
CE2W4
NOMESCO Finland
Eye movement mapping
30.4
7.2
9
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
6.7
7.2
17
26
R32
ICD-10 Finland
Unspecified urinary incontinence
3.7
7.1
22
61
G47.3
ICD-10 Finland
Sleep apnoea
1.7
7.0
147
953
J96.1
ICD-10 Finland
Chronic respiratory failure
3.8
7.0
21
57
R5140
NOMESCO Finland
Monitoring the use of the aid
2.0
6.9
80
431
XG466
NOMESCO Finland
Sleep oxymetry
3.1
6.9
28
93
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
6.8
118
724
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
6.6
69
358
PA7BD
NOMESCO Finland
CT angiography of neck and brain
4.2
6.6
17
41
B81
ICPC
Anaemia vit B12/folate deficiency
3.0
6.6
29
101
WX892
NOMESCO Finland
Monitored bed care
2.3
6.5
51
236
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
70.6
6.4
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
6.4
222
1625
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.8
6.3
30
109
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.9
6.3
18
47
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
3.9
6.3
18
47
8580/3-C37.9
ICD-O-3
Thymoma, NOS, of thymus
+∞
6.3
6
*
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
6.3
6
*
R02
ICPC
Shortness of breath/dyspnoea
1.9
6.2
82
461
104
Kela drug reimbursment
Thyroid insufficiency
2.3
6.2
47
214
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
6.2
72
388
XA402
NOMESCO Finland
ENMG
3.5
6.2
21
62
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.2
6.1
24
78
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
6.0
51
244
N03AE01
ATC
clonazepam; systemic
2.5
6.0
38
160
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
246
36
112.74
307.65
1.3
1.1
11.98
0.10
nmol/l
—
160
5
101
9
133.77
96.25
1.1
1.0
—
—
—
0
0
330
1551
3.42
49.76
2.9
2.0
152.41
166.49
u/l
0.25
321
1463
389
2351
2.76
32.37
7.1
6.1
1.21
1.21
mmol/l
0.19
372
2143
412
2574
2.80
31.91
7.9
7.0
1.21
1.21
mmol/l
0.38
363
2209
120
384
3.64
31.74
2.4
2.5
9.31
10.63
g/l
2.40
114
351
40
49
8.66
30.68
1.2
1.1
—
—
—
0
0
184
845
2.68
25.47
3.1
3.4
0.81
0.82
mmol/l
0.44
177
797
436
2977
2.57
25.33
16.0
9.1
4.27
4.11
e9/l
0.91
400
2616
32
44
7.61
22.24
1.2
1.1
—
—
—
0
0
432
3029
2.41
22.18
6.7
4.8
6.51
6.72
mmol/l
1.62
419
2843
34
52
6.86
21.50
1.2
1.1
—
—
—
0
0
194
982
2.42
21.34
1.7
1.5
2.13
2.46
g/l
1.73
142
608
32
49
6.83
20.20
1.2
1.1
—
—
—
0
0
130
614
2.41
16.20
8.5
7.6
1.78
1.31
mmol/l
0.84
106
482
128
618
2.35
15.10
8.6
7.5
5.34
5.11
kpa
1.99
120
594
128
618
2.35
15.10
8.6
7.5
12.06
12.14
kpa
0.06
121
596
42
107
4.14
15.10
1.6
1.4
119.24
1157.68
e6/l
0.50
34
85
42
107
4.14
15.10
1.4
1.3
2.68
11.07
e6/l
0.70
34
82
213
1275
2.02
14.48
4.7
3.9
94.03
89.77
%
1.92
206
1244
486
3890
2.16
13.91
4.6
3.8
14.99
14.80
pmol/l
0.88
466
3500
78
309
2.74
13.88
4.7
4.1
1.53
1.73
mmol/l
0.18
72
229
318
2220
1.89
13.41
4.5
4.9
34.74
35.45
g/l
1.46
301
2077
80
331
2.63
13.06
4.8
4.0
5.23
5.12
kpa
0.60
80
318
24
23
10.81
12.84
1.1
1.0
—
—
—
0
0
341
2467
1.85
12.54
12.7
14.0
1.33
1.26
inr
0.49
78
714
101
476
2.34
12.45
2.0
2.0
351.02
376.54
nmol/l
0.65
95
442
82
353
2.52
12.32
1.6
1.6
—
—
—
0
0
18
10
18.49
12.11
1.2
1.0
—
—
—
0
0
472
3812
2.00
12.09
4.9
4.2
11.76
12.27
mm/h
0.33
450
3507
98
462
2.33
12.06
8.6
7.0
1.30
1.35
mmol/l
0.14
93
449
23
26
9.14
11.34
1.1
1.0
0.95
1.13
u/l
—
10
16
544
4693
2.31
10.81
6.0
4.6
1.91
2.17
mu/l
0.49
523
4250
145
853
1.91
9.83
2.0
1.8
—
—
—
0
0
195
1260
1.80
9.81
2.9
2.3
—
—
—
0
0
46
170
2.84
9.31
1.9
1.4
0.21
0.23
g/l
1.27
46
161
46
171
2.83
9.21
2.2
1.8
—
—
—
0
0
120
676
1.96
9.20
4.2
6.0
1.03
1.02
mmol/l
0.11
111
619
291
2147
1.67
8.85
2.2
2.0
92.14
94.70
pmol/l
0.39
169
1108
16
15
10.91
8.83
1.2
1.0
1830.75
1567.00
miu/ml
0.32
16
15
48
188
2.68
8.71
1.8
1.7
—
—
—
0
0
43
159
2.83
8.70
1.6
1.5
0.96
0.04
iu/ml
—
7
33
264
1912
1.66
8.54
4.7
3.1
—
—
—
0
0
19
28
6.96
8.12
1.0
1.3
5.33
6.88
u/l
0.39
14
23
36
126
2.97
8.04
1.1
1.2
—
—
—
0
0
222
1558
1.66
7.99
3.2
3.1
1356.15
1292.58
ng/l
0.09
188
1335
32
105
3.16
7.97
1.4
1.2
73.88
34.27
u/ml
—
6
9
472
4007
1.75
7.96
9.0
7.7
75.86
78.75
u/l
0.70
455
3751
415
3410
1.66
7.85
6.8
4.4
1371.80
2257.93
e6/l
—
10
59
38
139
2.85
7.85
1.2
1.3
—
—
—
0
0
15
16
9.58
7.81
3.2
1.9
—
—
—
0
0
19
30
6.50
7.76
3.4
1.9
—
—
—
0
0
225
1602
1.64
7.56
4.5
3.1
43.29
98.55
e6/l
0.65
185
1244
275
2058
1.61
7.53
2.4
2.3
74.60
76.67
nmol/l
0.62
253
1815
271
2022
1.61
7.51
5.0
3.7
198.13
38.79
ng/l
0.45
210
1464
230
1652
1.62
7.43
3.2
3.3
31.62
30.74
u/l
0.16
222
1575
169
1124
1.69
7.36
1.8
1.8
1.44
1.15
mg/l
0.62
131
865
34
122
2.89
7.28
1.1
1.2
—
8.47
—
0
11
151
979
1.72
7.21
4.9
3.8
69.37
235.97
ng/l
2.27
122
766
62
305
2.15
6.82
1.9
1.6
—
—
—
0
0
47
208
2.36
6.65
1.9
1.8
—
—
—
0
0
239
1771
1.57
6.59
3.0
3.6
2.32
2.35
mmol/l
2.70
210
1560
46
204
2.36
6.48
1.3
2.3
—
—
—
0
0
164
1120
1.63
6.33
3.1
2.5
5.28
5.81
e6/l
0.16
151
1010
574
5286
2.18
6.16
26.0
16.8
139.80
139.66
mmol/l
0.78
565
5146
575
5300
2.19
6.13
27.4
16.9
3.96
3.98
mmol/l
1.18
568
5152
338
2742
1.51
5.95
6.3
6.3
11.86
11.35
umol/l
0.20
328
2597
184
1311
1.57
5.90
2.5
2.1
3.02
3.07
mg/l
0.11
161
1104
556
5089
1.91
5.67
22.6
14.5
19.72
24.32
mg/l
3.79
482
4033
199
1470
1.52
5.34
4.5
3.0
0.50
0.47
e6/l
0.07
159
1111
312
2529
1.47
5.27
4.8
3.7
0.00
0.01
estimate
0.50
51
452
533
4841
1.73
5.26
19.8
13.3
81.15
79.91
ml/min/173m2
0.71
475
3997
308
2496
1.47
5.18
6.4
5.0
0.00
0.00
estimate
0.50
55
469
80
475
1.79
5.12
2.3
2.3
47.11
31.74
u/l
0.93
71
402
81
483
1.78
5.11
3.9
3.8
2.35
2.09
mmol/l
0.25
70
397
13
24
5.51
4.93
1.1
1.1
—
—
—
0
0
306
2496
1.45
4.86
4.7
3.7
0.00
0.00
estimate
0.50
58
507
9
10
9.11
4.79
1.4
1.8
—
—
—
0
0
25
97
2.64
4.69
1.6
1.4
—
—
—
0
0
25
97
2.64
4.69
1.6
1.4
—
—
—
0
0
18
58
3.17
4.67
2.4
2.7
3.45
6.43
nmol/l
0.52
18
58
10
14
7.24
4.66
1.1
1.2
—
—
—
0
0
10
14
7.24
4.66
1.1
1.1
—
—
—
0
0
10
14
7.24
4.66
1.1
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
26
5.08
4.65
1.1
1.2
—
—
—
0
0
12
22
5.54
4.62
1.3
1.3
—
—
—
0
0
299
2455
1.42
4.45
3.5
2.5
—
—
—
0
0
385
3308
1.43
4.43
3.9
3.2
49.74
50.75
u/l
0.08
363
3086
29
127
2.35
4.26
1.2
1.3
—
—
—
0
0
9
13
7.01
4.17
1.0
1.2
—
—
—
0
0
9
13
7.01
4.17
1.0
1.2
—
—
—
0
0
137
981
1.51
4.14
1.8
1.7
1023.53
1200.23
nmol/l
1.59
108
740
125
879
1.53
4.11
1.3
1.3
36.99
34.22
iu/ml
0.07
24
285
272
2221
1.40
4.06
3.4
2.7
165.43
136.66
ug/l
0.62
259
2036
170
1278
1.46
4.02
1.8
1.5
19.38
21.10
nmol/l
0.94
152
1067
7
7
10.10
4.02
1.4
1.1
—
—
—
0
0
91
599
1.61
3.98
2.9
2.8
14.62
8.51
umol/l
0.70
77
522
91
601
1.60
3.93
2.2
1.8
—
—
—
0
0
575
5419
1.86
3.92
18.6
10.6
27.15
25.73
u/l
0.98
564
5218
11
23
4.85
3.88
1.2
1.3
—
—
—
0
0
119
839
1.52
3.85
4.4
2.8
5.70
1.91
e6/l
1.69
71
457
51
291
1.82
3.75
2.6
3.5
4.23
4.63
pmol/l
1.63
43
262
125
898
1.49
3.69
4.1
2.6
1.08
1.08
e6/l
0.00
77
513
8
12
6.74
3.68
1.1
1.3
—
—
—
0
0
89
596
1.58
3.62
2.2
1.8
—
—
—
0
0
16
57
2.85
3.54
1.2
1.9
—
—
—
0
0
17
63
2.75
3.51
1.2
1.8
—
—
—
0
0
10
22
4.60
3.44
2.4
2.7
600.30
964.50
u/ml
—
10
22
20
82
2.49
3.41
6.8
2.9
3.78
4.47
e9/l
0.73
20
82
7
10
7.06
3.37
1.1
1.3
—
—
—
0
0
205
1643
1.37
3.27
2.9
2.4
58.59
108.40
u/l
0.51
193
1519
6
7
8.64
3.27
1.2
1.6
—
—
—
0
0
20
85
2.40
3.18
7.2
3.3
60.55
57.48
%
0.53
20
85
31
159
2.00
3.15
1.5
1.5
256.90
286.46
ug/g
0.39
20
96
18
74
2.48
3.07
1.1
1.1
1.40
1.65
u/ml
—
5
20
6
8
7.56
3.06
1.2
1.4
—
—
—
0
0
29
150
1.98
2.89
1.3
1.2
—
—
—
0
0
143
1100
1.39
2.89
1.3
1.2
0.66
1.73
u/ml
1.77
30
304
13
47
2.80
2.83
1.3
1.1
—
—
—
0
0
13
47
2.80
2.83
1.3
1.1
—
—
—
0
0
5
6
8.39
2.75
1.0
1.2
—
—
—
0
0
41
242
1.74
2.74
1.7
2.0
1.53
1.52
g/l
0.01
36
212
13
48
2.74
2.73
1.3
1.1
—
—
—
0
0
13
48
2.74
2.73
1.3
1.1
—
—
—
0
0
13
48
2.74
2.73
1.3
1.1
—
—
—
0
0
22
105
2.14
2.72
3.1
2.4
17.56
16.14
%
0.95
14
53
6
10
6.05
2.70
1.0
1.1
—
—
—
0
0
12
43
2.83
2.66
1.1
1.3
—
—
—
0
0
24
120
2.04
2.64
1.2
1.1
—
—
—
0
0
26
134
1.98
2.64
2.1
1.8
4.87
4.73
iu/l
—
7
44
170
1363
1.34
2.63
5.3
3.9
0.00
0.01
estimate
0.69
48
455
53
340
1.61
2.61
1.2
1.2
172.83
150.32
iu/ml
0.10
16
135
21
101
2.12
2.55
1.7
1.7
—
—
—
0
0
111
836
1.40
2.53
2.3
2.4
12.57
13.11
umol/l
0.30
106
778
17
76
2.27
2.46
1.2
1.4
—
—
—
0
0
97
719
1.41
2.42
2.4
2.5
22.75
22.58
%
0.03
85
620
46
291
1.63
2.41
1.5
1.4
—
—
—
0
0
17
77
2.24
2.39
1.2
1.4
—
—
—
0
0
17
77
2.24
2.39
1.2
1.4
—
—
—
0
0
17
78
2.21
2.33
1.2
1.4
—
—
—
0
0
17
78
2.21
2.33
1.2
1.4
—
—
—
0
0
17
78
2.21
2.33
1.2
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
171
1.79
2.29
2.2
3.1
0.33
0.38
u/ml
0.42
15
96
127
1000
1.34
2.19
2.3
3.1
2.44
2.45
mmol/l
0.80
108
888
8
25
3.23
2.10
1.0
1.0
—
—
—
0
0
8
25
3.23
2.10
1.1
1.2
—
—
—
0
0
10
37
2.73
2.07
1.1
1.3
—
—
—
0
0
7
20
3.53
2.06
1.0
1.1
—
—
—
0
0
139
1121
1.31
2.03
5.4
4.0
1.02
1.02
kg/l
0.03
19
153
10
38
2.66
2.01
1.1
1.3
—
—
—
0
0
5
11
4.57
1.94
1.0
1.3
—
—
—
0
0
16
78
2.08
1.92
1.1
1.1
1.60
6.48
u/ml
—
5
33
13
58
2.27
1.92
1.5
1.3
—
—
—
0
0
5
12
4.19
1.82
1.2
1.2
—
—
—
0
0
60
431
1.43
1.81
1.9
2.6
80.78
65.43
ml/min/173m2
2.06
23
171
58
414
1.44
1.81
3.4
3.1
141.56
196.94
ng/l
1.03
52
377
469
4400
1.27
1.80
29.0
17.3
15.44
15.07
%
0.60
463
4336
21
116
1.84
1.80
1.5
1.3
—
—
—
0
0
8
30
2.69
1.73
1.1
1.9
—
—
—
0
0
8
30
2.69
1.73
1.1
1.9
—
—
—
0
0
22
126
1.77
1.70
2.0
1.9
3003.99
4662.44
u/l
—
7
39
12
55
2.21
1.68
4.0
3.1
67.00
51.92
%
1.66
12
50
6
19
3.18
1.66
1.7
1.7
44.12
67.75
ug/l
—
6
19
22
127
1.76
1.66
1.3
1.6
—
—
—
0
0
104
829
1.31
1.66
1.2
1.3
30.80
12.08
u/ml
0.65
25
307
14
69
2.05
1.65
1.0
1.1
—
—
—
0
0
581
5637
1.50
1.65
37.4
21.4
40.43
40.10
%
0.66
552
5258
29
182
1.62
1.63
2.0
2.9
—
—
—
0
0
24
144
1.69
1.60
1.4
1.4
—
—
—
0
0
327
2973
1.21
1.60
3.2
2.9
—
—
—
0
0
580
5634
1.47
1.53
36.9
21.3
256.47
246.40
e9/l
2.92
571
5485
5
15
3.35
1.52
1.6
1.1
1.16
2.29
mmol/l
—
5
15
46
326
1.44
1.52
4.5
3.3
129.48
127.19
g/l
0.31
46
320
16
86
1.88
1.51
1.1
1.1
—
—
—
0
0
580
5638
1.46
1.48
36.9
21.3
4.49
4.47
e12/l
0.24
571
5471
182
1575
1.22
1.44
2.9
3.3
392.62
246.51
mg/l
0.17
122
1018
580
5641
1.45
1.44
37.1
21.4
134.71
135.12
g/l
0.26
575
5549
12
59
2.05
1.44
1.3
1.6
27.43
62.00
%
—
7
44
190
1652
1.22
1.44
2.8
3.1
7.89
7.56
mmol/l
0.49
166
1374
25
158
1.61
1.39
2.3
1.6
—
—
—
0
0
6
23
2.62
1.37
1.0
1.0
—
—
—
0
0
16
90
1.80
1.34
1.1
1.6
—
—
—
0
0
16
90
1.80
1.34
1.1
1.6
—
—
—
0
0
22
137
1.63
1.31
1.3
1.7
—
—
—
0
0
6
24
2.51
1.30
1.2
2.1
—
—
—
0
0
6
24
2.51
1.30
1.2
2.1
—
—
—
0
0
16
91
1.78
1.30
1.4
1.7
—
—
—
0
0
218
1942
1.19
1.26
5.3
3.9
—
—
—
0
0
6
25
2.41
1.24
1.3
2.0
—
—
—
0
0
6
25
2.41
1.24
1.5
1.7
—
—
—
0
0
497
4760
1.22
1.21
6.0
6.0
40.00
40.03
mmol/mol
0.02
472
4400
6
26
2.32
1.19
1.5
1.7
—
—
—
0
0
187
1651
1.19
1.18
3.2
3.8
9.66
8.54
mg/mmol
0.09
118
1033
84
686
1.26
1.14
4.0
4.6
30.12
31.73
%
0.87
65
455
157
1370
1.20
1.13
2.5
2.7
16270.13
7117.51
umol/l
0.76
142
1190
7
30
2.35
1.12
1.0
1.3
—
—
—
0
0
53
408
1.33
1.12
3.9
4.1
98.04
85.78
ng/l
0.30
48
365
129
1107
1.21
1.11
1.8
1.7
405.28
429.34
pmol/l
0.39
115
910
7
31
2.27
1.10
1.4
1.8
—
—
—
0
0
7
32
2.20
1.08
1.4
1.6
—
—
—
0
0
7
32
2.20
1.08
1.4
1.3
—
—
—
0
0
7
32
2.20
1.08
1.3
1.2
—
—
—
0
0
16
97
1.67
1.07
1.3
1.5
—
—
—
0
0
10
52
1.94
1.06
1.7
2.0
—
—
—
0
0
20
130
1.56
1.04
1.6
1.7
5639.79
16338.42
e6/l
1.39
14
98
5
22
2.28
1.03
1.6
1.2
5.16
6.87
mmol/l
—
5
22
10
53
1.90
1.01
1.1
1.8
—
—
—
0
0
10
53
1.90
1.01
1.1
1.8
—
—
—
0
0
10
53
1.90
1.01
1.1
1.8
—
—
—
0
0
9
48
1.89
1.00
1.1
1.4
—
—
—
0
0
18
115
1.58
1.00
3.1
4.2
39.90
27.14
mg/l
—
9
72
14
84
1.68
0.98
1.3
1.3
—
—
—
0
0
0
29
0.00
0.98
0.0
2.2
—
49.66
—
0
22
9
50
1.81
0.97
1.1
1.1
—
79.00
—
0
6
58
465
1.27
0.94
3.4
2.5
3.91
6.45
ug/l
1.49
48
419
6
27
2.23
0.93
1.0
1.4
—
—
—
0
0
12
70
1.73
0.93
1.4
1.6
—
—
—
0
0
10
55
1.83
0.92
1.5
1.6
—
—
—
0
0
12
71
1.70
0.89
1.2
1.0
1.42
1.76
u/ml
—
5
28
8
42
1.92
0.89
1.0
1.3
—
—
—
0
0
8
42
1.92
0.89
1.0
1.2
—
—
—
0
0
21
144
1.47
0.88
2.0
1.5
—
—
—
0
0
19
128
1.50
0.87
1.3
1.6
—
—
—
0
0
6
31
1.94
0.84
1.8
1.6
—
—
—
0
0
6
31
1.94
0.84
1.8
1.6
—
—
—
0
0
17
113
1.52
0.83
1.5
1.6
—
—
—
0
0
6
32
1.88
0.82
1.0
1.3
—
—
—
0
0
6
32
1.88
0.82
1.0
1.3
—
—
—
0
0
32
243
1.33
0.79
1.1
1.0
—
—
—
0
0
212
1950
1.13
0.76
4.5
5.1
2.96
2.62
ug/l
0.18
191
1733
5
25
2.01
0.73
1.4
1.3
—
—
—
0
0
12
76
1.59
0.72
1.3
1.6
—
—
—
0
0
22
160
1.39
0.71
1.3
1.1
—
—
—
0
0
513
4994
1.16
0.69
5.1
4.7
5.93
5.99
mmol/l
0.58
486
4544
22
161
1.38
0.69
1.3
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
2.1
87.60
103.93
%
—
5
27
15
102
1.48
0.68
1.5
1.8
4.08
4.85
mmol/24h
0.29
15
88
7
44
1.60
0.65
1.0
1.0
—
—
—
0
0
91
799
1.16
0.64
1.5
1.4
—
—
—
0
0
5
29
1.73
0.64
1.0
1.2
—
—
—
0
0
5
29
1.73
0.64
1.0
1.2
—
—
—
0
0
11
71
1.56
0.62
1.4
1.6
—
—
—
0
0
5
30
1.67
0.61
2.0
1.2
69.40
80.27
umol/l
—
5
30
8
54
1.49
0.57
3.0
3.9
—
—
—
0
0
6
36
1.67
0.57
1.0
1.0
319.50
292.26
mg/l
—
6
31
23
177
1.31
0.55
1.1
1.6
—
—
—
0
0
12
82
1.47
0.54
4.8
3.4
0.42
1.28
%
0.87
12
76
6
38
1.58
0.54
1.8
1.6
—
—
—
0
0
150
1379
1.12
0.54
1.6
1.7
1.45
1.38
mmol/l
0.50
128
1147
14
193
0.72
0.54
1.4
1.8
2.75
2.99
mg/l
—
9
146
11
74
1.50
0.53
1.2
1.1
—
16.44
—
0
5
15
108
1.40
0.53
1.1
1.2
—
—
—
0
0
6
39
1.54
0.53
1.0
1.6
—
—
—
0
0
9
135
0.66
0.52
1.3
1.4
—
—
—
0
0
10
67
1.50
0.50
1.3
1.3
6.96
7.41
mmol/l
—
10
55
7
45
1.56
0.49
1.0
1.1
—
—
—
0
0
33
395
0.83
0.46
1.5
1.8
—
—
—
0
0
5
84
0.59
0.45
1.6
1.5
—
—
—
0
0
5
84
0.59
0.45
1.6
1.5
—
—
—
0
0
5
84
0.59
0.45
1.6
1.5
—
—
—
0
0
28
229
1.23
0.44
1.3
1.6
—
—
—
0
0
19
148
1.29
0.44
1.3
1.3
—
—
—
0
0
28
230
1.23
0.43
5.2
5.3
1.52
1.54
%
0.07
23
218
6
91
0.66
0.42
1.7
1.5
—
—
—
0
0
17
131
1.31
0.42
1.5
1.4
—
—
—
0
0
11
150
0.73
0.42
1.5
1.6
—
—
—
0
0
64
717
0.88
0.41
1.6
1.4
—
—
—
0
0
8
60
1.34
0.40
1.0
1.5
—
—
—
0
0
8
60
1.34
0.40
1.0
1.5
—
—
—
0
0
9
70
1.29
0.36
1.0
1.1
—
—
—
0
0
5
76
0.66
0.36
2.4
2.8
106.40
105.28
mmol/l
—
5
76
5
78
0.64
0.36
1.8
1.7
—
—
—
0
0
166
1567
1.08
0.36
3.9
4.4
22.25
21.03
%
0.46
80
779
62
557
1.13
0.35
4.3
3.2
—
—
—
0
0
6
43
1.40
0.35
1.3
1.2
9.33
11.47
u/l
—
6
38
11
83
1.33
0.32
1.5
1.6
—
—
—
0
0
12
153
0.78
0.31
1.5
1.5
—
—
—
0
0
15
122
1.24
0.27
1.2
1.3
215.40
261.81
miu/ml
—
5
53
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
6
49
1.23
0.20
1.0
1.5
—
—
—
0
0
17
146
1.17
0.19
1.4
1.5
248.71
271.19
mu/l
0.27
17
133
118
1132
1.05
0.17
2.7
3.1
0.61
0.75
ug/l
2.08
84
771
70
661
1.07
0.17
12.5
7.6
—
—
—
0
0
8
72
1.11
0.16
1.1
1.5
—
—
—
0
0
53
563
0.94
0.15
3.5
4.2
26.03
33.56
ug/l
0.12
42
476
43
402
1.07
0.14
1.7
1.8
—
—
—
0
0
6
57
1.05
0.08
2.2
1.4
—
—
—
0
0
5
61
0.82
0.08
1.6
1.5
—
—
—
0
0
506
5049
1.01
0.02
4.6
4.6
4.66
4.62
mmol/l
0.42
476
4656
13
137
0.95
0.01
1.7
1.7
32.38
41.61
nmol/l
1.48
13
128
501
5018
0.99
0.01
4.6
4.5
1.43
1.46
mmol/l
1.16
467
4590
55
557
0.99
0.01
1.7
1.8
1.47
1.49
%
0.05
48
478
45
445
1.01
0.00
1.8
1.9
—
—
—
0
0
15
148
1.01
0.00
1.1
1.3
—
—
—
0
0
26
262
0.99
0.00
1.3
1.3
—
—
—
0
0
515
5153
1.00
0.00
5.1
5.1
2.75
2.72
mmol/l
0.37
475
4710
484
4839
1.00
0.00
4.1
4.1
1.36
1.28
mmol/l
1.82
451
4410
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
64
0.94
-0.00
1.7
1.4
19.32
27.38
u/l
—
6
53
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
77
0.91
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
71.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
-0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
-0.00
8.5
4.8
283.33
368.44
umol/l
—
6
62
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
2.2
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
-0.00
1.2
2.5
54.58
4.70
umol/l
—
5
42
Mortality – FinRegistry
↥Association
Association between endpoint G6_MYASTHENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYASTHENIA | 1.455 [1.19, 1.78] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.096 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 993 females with G6_MYASTHENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYASTHENIA | 1.196 [1.01, 1.42] | 0.04 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 1043 males with G6_MYASTHENIA died.
Mortality risk
Mortality risk for people of age
years, who have G6_MYASTHENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.157% |
| 5 | 0.643% | 1.359% |
| 10 | 1.895% | 3.372% |
| 15 | 3.606% | 6.583% |
| 20 | 6.362% | 11.147% |
Relationships between endpoints
↥Index endpoint: G6_MYASTHENIA – Myasthenia gravis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data