Myasthenia gravis, drug-induced

G6_MYASTHENIA_ADVERSE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — G70.0# 1 out of 7 registries used, show all original rules.	56
4. Check minimum number of events None	56
5. Include endpoints None	56
6. Filter based on genotype QC (FinnGen only)	56

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5
Parent code in ICD-10: G70

NAME	G6_MYASTHENIA_ADVERSE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	G700
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Myasthenia gravis, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	56	41	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	42.83	38.91	53.53

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
52: Matched controls
520

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G70.0

ICD-10 Finland

Myasthenia gravis

+∞

72.7

108

Kela drug reimbursment

Myasthenia gravis

+∞

69.3

N07AA02

ATC

pyridostigmine; systemic

+∞

67.1

N07AA03

ATC

distigmine; systemic

+∞

32.8

3580A

ICD-9 Finland

Myoneural disorders, Myasthenia gravis

+∞

23.8

R03CA02

ATC

ephedrine; oral

+∞

20.1

G70.9

ICD-10 Finland

Myoneural disorder, unspecified

+∞

20.1

A12BA01

ATC

potassium chloride; oral

38.5

19.8

5872

FHL

Thymic exploration or thymectomy

+∞

16.5

L04AX01

ATC

azathioprine; systemic

26.0

15.1

73300

ICD-8 Finland

Other diseases of muscle, tendon and fascia, Myasthenia gravis

+∞

14.2

G70

ICD-10 Finland

Myasthenia gravis and other myoneural disorders

+∞

8.6

GEC23

NOMESCO Finland

Transsternal thymectomy

+∞

8.6

H53.2

ICD-10 Finland

Diplopia

21.3

6.5

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019060) Gas panel - Arterial blood

5.38

5.33

4.3

4.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.46

3.70

2.1

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.74

3.54

6.6

8.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

209

2.80

3.38

9.3

6.3

1.2

mmol/l

0.47

176

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

153

2.66

3.17

7.0

2.8

—

(3000991) Gas panel - Venous blood

3.71

2.93

6.8

5.8

—

(42870588) Differential panel, method unspecified - Blood

147

2.43

2.64

11.0

4.8

—

(3002385) Erythrocyte distribution width [Ratio]

371

3.05

2.62

30.9

17.0

14.0

13.9

0.29

364

(3012544) pH of Venous blood

3.07

2.24

3.8

2.7

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

2.21

0.0

4.8

—

30.8

—

(3023368) Bacteria identified in Blood by Culture

109

2.30

2.13

4.0

3.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

5.36

2.11

3.4

3.6

2.2

4.3

g/l

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.65

2.04

4.1

3.4

115.3

128.7

g/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.87

1.98

1.8

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.61

1.97

1.6

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.60

1.80

1.3

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.68

1.79

1.6

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.39

1.76

6.6

2.3

1.4

2.4

e6/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.41

1.71

13.7

10.7

93.8

95.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.81

1.65

1.4

3.0

101.0

99.0

—

(3002032) Base excess in Venous blood by calculation

2.66

1.61

3.9

2.7

4.1

3.4

mmol/l

—

(3019150) Specific gravity of Urine by Refractometry

2.08

1.57

6.6

3.8

—

1.0

—

(3029937) Albumin [Presence] in Urine by Test strip

130

1.98

1.56

7.3

4.0

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

229

1.93

1.56

6.5

3.6

0.0

estimate

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.93

1.48

1.7

1.3

—

(3020891) Body temperature

3.32

1.47

11.6

4.4

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.29

1.44

4.9

5.1

0.9

1.0

mmol/l

0.28

(3035350) Ketones [Presence] in Urine by Test strip

224

1.86

1.43

6.5

3.7

0.0

estimate

—

(40758558) Short blood count panel - Blood

117

1.94

1.42

13.3

7.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.79

1.41

9.2

6.3

23.2

24.7

mmol/l

—

(36304419) Bacteria [Presence] in Urine

126

1.91

1.40

4.8

2.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.37

0.0

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.57

1.36

1.5

1.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

227

1.82

1.34

8.3

4.9

0.0

estimate

—

(3022096) Basophils/100 leukocytes in Blood

200

1.80

1.31

13.1

5.6

0.6

0.7

0.25

190

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

364

1.97

1.24

9.3

8.3

80.2

79.2

u/l

0.03

333

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.21

0.0

1.6

—

(3000492) Spirometry study

2.52

1.17

2.1

1.5

—

(3006504) Eosinophils/100 leukocytes in Blood

205

1.73

1.17

13.4

5.6

2.5

0.01

196

(3044640) Blood type and Crossmatch panel - Blood

124

1.81

1.17

2.3

2.2

—

(3044889) 12 lead EKG panel

335

1.84

1.16

3.9

3.8

—

(3019069) Monocytes/100 leukocytes in Blood

206

1.72

1.14

13.6

5.9

9.1

8.6

0.55

197

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.11

1.14

1.6

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

100

1.84

1.12

6.2

3.6

—

(3015736) pH of Urine

179

1.72

1.12

5.4

3.4

—

(3018010) Neutrophils/100 leukocytes in Blood

208

1.69

1.09

13.1

5.7

59.0

57.5

0.35

200

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

128

1.73

1.04

3.6

2.4

61.8

53.7

u/l

0.68

118

(3002030) Lymphocytes/100 leukocytes in Blood

212

1.64

0.99

13.5

5.7

25.8

27.2

0.35

202

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.95

0.90

3.0

1.5

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.90

0.89

4.8

3.0

1.6

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

116

1.67

0.88

9.1

5.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.81

0.73

3.3

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

186

1.51

0.72

6.8

3.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.64

0.71

1.5

1.2

0.6

1.6

u/ml

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.75

0.70

2.6

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

179

1.48

0.66

1.8

1.9

96.0

99.7

pmol/l

—

(3026008) Bacteria identified in Urine by Culture

134

1.51

0.64

6.2

2.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

309

1.46

0.61

6.7

4.2

—

(3009508) Creatinine [Moles/volume] in Urine

126

1.50

0.61

4.2

2.9

6.2

7.6

mmol/l

0.94

102

(4010399)

1.85

0.61

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

1.61

0.59

4.7

2.1

0.4

0.8

e6/l

—

(40761535) Cells panel - Urine sediment

1.69

0.57

7.8

2.8

—

(3025159) Blasts/100 leukocytes in Blood

1.60

0.55

3.5

3.8

—

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.53

0.50

1.5

1.4

—

(40761511) CBC panel - Blood by Automated count

476

1.80

0.50

23.8

12.8

—

(3032080) INR in Blood by Coagulation assay

160

1.39

0.48

8.1

10.0

1.4

1.3

inr

—

(40761536) Microorganisms panel - Urine sediment

1.46

0.47

4.9

3.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

459

1.54

0.44

24.9

13.7

16.4

22.3

mg/l

1.23

338

(3013512) EKG study

133

0.70

0.39

7.5

3.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

414

0.74

0.39

30.5

14.1

37.7

39.7

0.64

308

(3020564) Creatinine [Moles/volume] in Serum or Plasma

473

1.53

0.36

29.3

16.3

77.1

75.5

umol/l

0.08

473

(3022145) Colonoscopy Study observation

1.37

0.35

1.0

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

421

0.76

0.34

6.3

5.4

39.8

39.5

mmol/mol

0.06

393

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

179

1.28

0.31

4.7

4.0

31.3

23.3

ng/l

0.26

118

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

272

1.22

0.25

3.2

2.8

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.35

0.24

2.8

3.7

—

0.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

194

1.22

0.23

5.0

3.9

—

(3022313) Gas panel - Capillary blood

0.00

0.21

0.0

3.5

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

269.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.4

—

92.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.2

—

2296.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.28

0.21

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.21

0.0

3.0

—

2.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.21

0.0

3.1

—

24.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

430

1.24

0.18

5.4

4.7

1.8

1.9

mu/l

0.38

381

(3001122) Ferritin [Mass/volume] in Serum or Plasma

198

1.18

0.18

3.0

2.6

175.2

92.6

ug/l

0.48

180

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.17

0.17

1.6

2.2

2.7

2.5

g/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.83

0.15

1.8

1.4

—

(1761868) Lipid panel - Serum or Plasma

168

0.85

0.14

3.2

2.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

135

1.15

0.11

5.9

3.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.12

0.10

4.8

3.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.80

0.09

13.0

8.7

—

(3000963) Hemoglobin [Mass/volume] in Blood

499

1.25

0.09

38.8

20.5

130.7

133.5

g/l

0.64

488

(3035941) MCH [Entitic mass]

498

1.27

0.09

38.1

20.4

30.7

30.4

0.41

488

(3024731) MCV [Entitic volume]

497

1.29

0.08

38.1

20.5

92.0

91.6

0.21

487

(3042936) Bacteria identified in Isolate by Culture

1.13

0.08

1.6

2.1

—

(3026493) Urate [Moles/volume] in Serum or Plasma

112

0.87

0.08

2.6

2.8

298.9

8106.1

umol/l

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.09

0.08

1.8

2.2

13.2

16.3

umol/l

—

(3003694) ABO and Rh group [Type] in Blood

109

0.90

0.04

1.1

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.09

0.02

2.2

2.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

429

1.01

0.00

23.0

13.2

83.8

80.0

ml/min/173m2

0.55

347

(40768804) Tissue Pathology biopsy report

205

0.96

0.00

2.2

1.9

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.4

—

159.2

—

(4268621)

0.00

0.0

1.6

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.4

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.95

0.00

2.3

1.9

396.8

542.4

pmol/l

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

1.8

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.7

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.4

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.88

0.00

29.2

23.1

—

1.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

1.4

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.7

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.6

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.5

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40768797) Stomach Pathology biopsy report

0.94

0.00

1.4

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.6

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: G6_MYASTHENIA_ADVERSE – Myasthenia gravis, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Myasthenia gravis, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Myasthenia gravis, drug-induced (G6_MYASTHENIA_ADVERSE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints