Acné excoriée

L12_ACNE_EXCOR

acne: An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L70.5 Cause of death: ICD-10 — L70.5 2 out of 7 registries used, show all original rules.	44
4. Check minimum number of events None	44
5. Include endpoints None	44
6. Filter based on genotype QC (FinnGen only)	44

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L70
Name in latin: Acne excoriata

NAME	L12_ACNE_EXCOR
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L705
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L705
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acné excoriée based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	281	225	55
Only index persons	276	223	53
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	33.60	33.87	32.62
Only index persons	33.63	33.87	32.62

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	44	37	7
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	34.27	34.13	35.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

3.44

3.90

8.3

5.1

—

(3023368) Bacteria identified in Blood by Culture

3.14

2.79

5.0

3.0

—

(3026008) Bacteria identified in Urine by Culture

101

2.80

2.72

2.3

2.4

—

(3052851) Hemolysis interference index of Serum or Plasma

7.86

2.61

2.0

1.9

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

4.98

2.59

1.4

2.1

0.3

0.2

g/l

—

(3000330) Specific gravity of Urine by Test strip

6.10

2.27

7.6

4.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.96

2.15

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.52

2.13

1.5

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.52

2.13

1.5

1.2

—

(3028300) Cannabinoids [Presence] in Urine

3.58

1.97

1.9

1.7

—

(3016879) Cocaine [Presence] in Urine

3.58

1.97

1.9

1.7

—

(3027944) Amphetamines [Presence] in Urine

3.58

1.97

2.0

1.7

—

(3027008) Opiates [Presence] in Urine

3.58

1.97

1.9

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

132

2.33

1.96

7.4

6.9

1.2

mmol/l

0.15

109

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.91

1.91

1.0

2.0

—

(3028707) Methadone [Presence] in Urine by Screen method

4.55

1.87

2.2

1.7

—

(3000494) Fungus identified in Specimen by Culture

2.71

1.57

1.6

1.5

—

(3011288) Drugs identified in Urine by Screen method

3.62

1.57

2.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

3.14

1.56

2.3

1.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

2.19

1.56

1.3

0.7

3.1

u/ml

—

(3022145) Colonoscopy Study observation

2.78

1.52

1.4

1.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.56

1.51

1.6

1.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

3.38

1.48

4.8

11.3

9.0

8.9

mmol/l

—

(3000764) Benzodiazepines [Presence] in Urine

2.85

1.42

2.0

1.7

—

(3042936) Bacteria identified in Isolate by Culture

2.56

1.35

6.6

1.3

—

(4035726)

2.73

1.35

1.5

1.2

—

(3015736) pH of Urine

140

1.96

1.31

4.0

3.2

—

(3032080) INR in Blood by Coagulation assay

106

1.98

1.27

6.6

4.3

1.0

inr

—

(3020682) Albumin/Creatinine [Ratio] in Urine

2.07

1.23

5.2

3.9

11.0

10.1

mg/mmol

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.01

1.19

1.5

1.3

2.1

g/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.19

1.17

1.4

1.9

—

(3037522) Nuclear Ab [Titer] in Serum

2.19

1.17

1.2

1.4

—

240.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.98

1.15

1.4

1.5

0.6

0.7

mg/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.05

0.94

1.5

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

255

1.73

0.83

6.3

3.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

105

1.65

0.72

4.3

3.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.79

0.72

1.4

1.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.88

0.68

3.6

2.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.88

0.68

1.0

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.69

0.65

2.0

1.8

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.62

0.0

1.5

—

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.65

0.60

1.5

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

327

0.67

0.52

3.9

3.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.63

0.44

4.0

2.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.48

0.42

1.7

1.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.42

0.0

1.6

—

(40761536) Microorganisms panel - Urine sediment

1.53

0.42

2.8

3.0

—

(3012516) Albumin [Mass/volume] in Urine

1.50

0.41

4.5

3.4

48.8

48.6

mg/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

363

1.65

0.40

20.6

10.0

19.2

16.2

mg/l

0.21

263

(40768797) Stomach Pathology biopsy report

1.54

0.38

1.5

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

178

1.34

0.36

4.6

3.3

0.0

estimate

—

(3044889) 12 lead EKG panel

208

1.34

0.35

2.8

3.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

102

1.39

0.35

4.2

3.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

179

1.33

0.34

7.9

4.9

0.0

estimate

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

114

0.74

0.32

1.3

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

180

1.32

0.32

4.6

3.4

0.0

estimate

—

(3013512) EKG study

1.39

0.32

4.9

3.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.35

0.27

4.0

6.0

—

(3019150) Specific gravity of Urine by Refractometry

0.68

0.27

2.5

3.2

—

1.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

112

0.75

0.23

1.6

1.8

—

(36660697) Celiac disease serology panel - Serum

1.28

0.23

1.0

1.1

—

(3022313) Gas panel - Capillary blood

0.00

0.21

0.0

5.5

—

(40768804) Tissue Pathology biopsy report

148

1.24

0.21

1.9

1.7

—

(40758558) Short blood count panel - Blood

1.30

0.21

16.9

8.1

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.20

0.0

1.6

—

4.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

139

1.24

0.20

4.2

3.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

280

1.22

0.18

4.5

2.4

35.9

34.3

u/l

0.11

265

(3018095) Leukocytes [#/volume] in Urine

112

1.23

0.17

6.2

3.7

10.1

72.1

e6/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.17

0.17

3.6

3.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.14

0.16

1.6

2.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.78

0.16

1.9

1.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

344

1.26

0.15

3.5

5.6

mmol/l

0.07

317

(3044640) Blood type and Crossmatch panel - Blood

106

1.18

0.11

2.3

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

107

1.17

0.10

1.8

1.7

—

(21494755) Public health laboratory ask at order entry panel

0.81

0.09

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

128

1.14

0.08

2.1

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.07

2.0

2.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

331

1.12

0.04

16.2

9.1

90.1

90.9

ml/min/173m2

0.08

270

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

102

1.10

0.03

4.2

3.0

14.6

26.5

ng/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.08

0.01

2.8

1.7

2.1

1.2

mmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

171

0.99

0.00

3.9

3.7

—

(3003694) ABO and Rh group [Type] in Blood

114

0.95

0.00

1.6

1.7

—

(1761868) Lipid panel - Serum or Plasma

146

1.04

0.00

5.3

2.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

5.9

—

1.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(36304419) Bacteria [Presence] in Urine

0.91

0.00

5.0

3.0

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3020891) Body temperature

0.00

0.0

7.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

358

1.03

0.00

24.8

10.8

39.7

40.5

0.61

288

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.1

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.3

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.1

—

2.8

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

172.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.1

—

0.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

1.6

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.1

—

1.1

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.1

—

0.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.1

—

0.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

-0.00

0.0

1.1

—

40.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACNE_EXCOR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE_EXCOR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_ACNE_EXCOR – Acné excoriée

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acné excoriée

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints