Actinic reticuloid

L12_ACTINRETICU

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L57.1 Hospital discharge: ICD-9 — 6927G Cause of death: ICD-10 — L57.1 Cause of death: ICD-9 — 6927G 2 out of 7 registries used, show all original rules.	39
4. Check minimum number of events None	39
5. Include endpoints None	39
6. Filter based on genotype QC (FinnGen only)	39

Control definitions (FinnGen only)

Control exclude: L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L57
Name in latin: Reticuloides actinica

NAME	L12_ACTINRETICU
CONTROL_EXCLUDE	L12_RADIATIONRELATEDSKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L571
HD_ICD_9	6927G
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L571
COD_ICD_9	6927G
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Actinic reticuloid based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	245	99	144
Only index persons	204	85	119
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	71.82	76.74	68.40
Only index persons	70.93	74.72	68.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	39	14	25
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	68.59	69.66	67.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.41

2.75

1.2

1.8

—

(3002256) Pathology report gross observation

4.77

2.49

1.9

1.2

—

(40768804) Tissue Pathology biopsy report

2.77

2.36

4.5

1.8

—

(42870588) Differential panel, method unspecified - Blood

2.73

2.30

5.8

4.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

6.18

2.28

3.2

2.3

—

(3000494) Fungus identified in Specimen by Culture

3.46

2.25

2.3

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

5.55

2.14

3.2

3.0

—

(3026008) Bacteria identified in Urine by Culture

2.46

1.81

2.9

3.4

—

(3023368) Bacteria identified in Blood by Culture

2.16

1.42

3.4

4.3

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

207

2.25

1.42

6.0

7.5

73.3

73.5

u/l

0.01

198

(3018010) Neutrophils/100 leukocytes in Blood

127

1.97

1.19

6.4

4.9

62.0

57.7

0.75

116

(3009542) Hematocrit [Volume Fraction] of Blood

216

2.05

1.15

21.2

16.9

41.9

38.7

2.63

148

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

253

2.10

1.12

21.8

16.5

39.5

26.1

mg/l

0.72

211

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.10

1.03

3.5

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

1.94

1.00

2.9

2.3

—

(3019069) Monocytes/100 leukocytes in Blood

125

1.82

0.96

8.0

5.2

8.7

8.8

0.10

116

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

116

1.83

0.96

2.3

90.3

90.5

pmol/l

—

(3003338) MCHC [Mass/volume]

203

1.84

0.94

29.5

22.7

332.1

332.2

g/l

0.02

203

(3022096) Basophils/100 leukocytes in Blood

119

1.76

0.87

8.5

5.0

0.6

0.24

109

(3007853) Bacteria identified in Skin by Aerobe culture

2.03

0.86

1.8

1.5

—

(3006504) Eosinophils/100 leukocytes in Blood

122

1.70

0.78

8.6

5.1

3.5

2.9

0.33

111

(3012544) pH of Venous blood

1.83

0.66

2.2

4.6

—

(40758558) Short blood count panel - Blood

1.71

0.65

8.0

6.7

—

(3000850) Epithelial cells [#/volume] in Urine

1.62

0.59

3.2

2.7

1.4

4.1

e6/l

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

264

1.59

0.55

23.5

20.2

81.6

85.5

umol/l

0.36

264

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

230

1.57

0.55

21.9

15.6

75.0

74.0

ml/min/173m2

0.09

187

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.53

0.50

2.4

4.6

2.3

2.4

mmol/l

—

(40768797) Stomach Pathology biopsy report

1.64

0.44

1.4

1.3

—

(3026782) Osmolality of Urine

1.42

0.44

2.9

3.6

539.3

588.7

mosm/kgh2o

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

118

1.44

0.42

2.7

5.1

651.9

62.5

ng/l

—

(4010399)

0.00

0.41

0.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.46

0.40

4.2

3.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

178

1.39

0.38

6.6

4.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.50

0.38

2.5

2.1

—

(3018095) Leukocytes [#/volume] in Urine

1.40

0.33

5.8

4.7

11.3

36.8

e6/l

1.71

(40760892) CBC W Ordered Manual Differential panel - Blood

1.36

0.33

2.9

6.3

—

(3044889) 12 lead EKG panel

182

1.33

0.31

4.0

3.8

—

(3002582) Erythrocytes [#/volume] in Urine

1.39

0.30

4.7

3.6

47.0

771.3

e6/l

0.50

(1761868) Lipid panel - Serum or Plasma

0.63

0.29

5.4

3.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

115

1.34

0.29

4.6

4.0

—

(3015736) pH of Urine

1.31

0.22

3.8

4.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.22

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.22

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.22

0.0

1.2

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

0.00

0.21

0.0

1.7

—

149.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.9

—

24.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3013512) EKG study

1.29

0.20

3.4

4.3

—

(36304419) Bacteria [Presence] in Urine

1.22

0.18

5.1

3.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

104

0.83

0.15

3.0

4.2

—

(3009261) Glucose [Presence] in Urine by Test strip

132

0.87

0.08

4.0

4.3

—

0.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.86

0.08

3.0

3.5

—

(3009508) Creatinine [Moles/volume] in Urine

0.86

0.08

5.1

3.0

9.6

8.1

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

128

0.91

0.03

4.0

4.3

—

0.0

—

(40761511) CBC panel - Blood by Automated count

263

1.09

0.02

16.9

14.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

126

0.93

0.01

3.3

2.5

—

(3021589) Normoblasts [#/volume] in Blood

103

0.96

0.00

10.0

9.2

0.0

e9/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

125

0.94

0.00

6.4

6.1

—

0.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.8

—

(44790049)

0.00

0.0

1.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(44806118)

0.00

0.0

1.8

—

(44790047)

0.00

0.0

1.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

362.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.04

0.00

4.5

4.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.5

—

26.8

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

1.7

—

74.8

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

11.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

1.7

—

(44790048)

0.00

0.0

1.8

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.5

—

4.8

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.5

—

8.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.5

—

133.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.7

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.8

—

2.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.6

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.3

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

70.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.3

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.8

—

11.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3018418) pH of Serum or Plasma

0.93

0.00

6.9

4.7

—

7.4

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.4

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

2.6

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.2

—

6.8

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACTINRETICU and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
L12_ACTINRETICU	1.162 [0.82, 1.65]	0.403
Birth year	0.991 [0.98, 1.0]	0.056

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 111 males with L12_ACTINRETICU died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACTINRETICU.

N-year risk	Females	Males
1	No data	0.245%
5	No data	1.547%
10	No data	3.92%
15	No data	7.131%
20	No data	12.564%

Relationships between endpoints

↥

Index endpoint: L12_ACTINRETICU – Actinic reticuloid

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Actinic reticuloid

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints