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Carcinoma in situ of skin of lower limb, including hip

CD2_INSITU_SKIN_LOWERLIMB

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D04.7&
  • Hospital discharge: ICD-9 2327
  • Cause of death: ICD-10 D04.7&
  • Cause of death: ICD-9 2327

2 out of 7 registries used, show all original rules.

630

4. Check minimum number of events

None

630

5. Include endpoints

None

630

6. Filter based on genotype QC (FinnGen only)

630

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D04
Name in latin
Carcinoma in situ cutis pelvis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 630 371 259
Unadjusted period prevalence (%) 0.12 0.13 0.11
Median age at first event (years) 74.73 73.77 76.10

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
553
Matched controls
5530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
+∞
323.0
552
*
L57.0
ICD-10 Finland
Actinic keratosis
22.7
218.7
383
499
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
21.3
199.2
339
382
TQW99
NOMESCO Finland
Other minor procedure on skin
28.0
177.2
255
164
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
27.7
129.2
182
96
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
40.5
103.9
131
42
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
9.7
94.6
220
352
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
91.1
89.7
98
13
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
21.5
88.0
133
80
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
67.5
87.6
100
18
R23.8
ICD-10 Finland
Other and unspecified skin changes
7.2
85.6
256
589
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
16.1
81.3
138
112
ZXC20
NOMESCO Finland
Use of chemical agents
23.8
79.7
116
61
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
9.2
76.1
177
269
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
9.8
73.7
163
226
ZXC50
NOMESCO Finland
Cryotherapy
14.3
73.1
130
116
D06BB10
ATC
imiquimod; topical
12.3
67.5
129
133
ZXC15
NOMESCO Finland
Use of photodynamic technique
22.4
65.7
97
52
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
108.7
62.4
67
7
ZQZ00
NOMESCO Finland
Treatment of several skin areas
62.4
61.5
71
13
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
13.1
60.9
112
105
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
8.3
60.9
148
233
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
12.8
57.6
107
102
C44.72
ICD-10 Finland
Spinocellular carcinoma of the skin of the lower extremity including the hip
88.8
57.3
63
8
S18
ICPC
Laceration/cut
4.3
55.3
378
1863
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
31.6
54.2
72
26
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
14.1
49.6
87
72
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
17.3
38.9
62
40
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
14.2
38.7
67
53
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
90.8
38.4
42
5
Z2221
NOMESCO Finland
Medical doctor
3.5
38.3
247
1041
L82
ICD-10 Finland
Seborrhoeic keratosis
3.5
31.0
174
638
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
13.5
30.2
53
43
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
5.0
30.0
105
248
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
28.6
29.7
40
15
127
Kela drug reimbursment
Transplant complication
18.7
29.3
45
26
Z94.0
ICD-10 Finland
Kidney transplant status
24.5
29.2
41
18
ZZR00
NOMESCO Finland
Flap of skin
8.8
29.1
64
81
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
67.8
28.2
32
5
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
37.2
27.8
35
10
ZZA00
NOMESCO Finland
Split skin graft
8.1
26.8
62
85
E0000UV
ATC
NA
2.6
24.5
272
1503
XQ848
NOMESCO Finland
Dermatological photography
8.0
23.8
55
75
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
20.7
23.8
35
18
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
5.7
23.6
71
140
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
9.9
22.8
46
50
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
26.3
22.0
30
12
L04AA01
ATC
[U] ciclosporin; systemic
13.1
21.2
37
30
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
25.4
21.1
29
12
ZXE00
NOMESCO Finland
One hour or less
2.4
21.0
271
1579
SPAT1153
SPAT
Removal of sutures
2.4
21.0
252
1417
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
23.5
20.6
29
13
S21
ICPC
Skin texture symptom/complaint
3.1
20.4
126
477
S29
ICPC
Skin symptom/complaint other
2.8
20.3
155
674
WX002
NOMESCO Finland
Sedation and analgesia
2.6
20.0
177
838
8070/3-C44.7
ICD-O-3
Squamous cell carcinoma, NOS, of skin of lower limb and hip
+∞
19.9
19
*
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
30.2
19.8
26
9
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
12.0
19.8
36
32
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
22.6
19.7
28
13
L04AD01
ATC
ciclosporin; systemic
11.6
19.5
36
33
A12BA01
ATC
potassium chloride; oral
4.1
19.1
78
211
DHB00
NOMESCO Finland
Excision of lesion of external nose
15.6
19.1
31
21
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
18.8
192
980
Z3231
NOMESCO Finland
Registered nurse
2.4
18.6
214
1156
205
Kela drug reimbursment
Chronic hypertension
2.3
18.3
258
1539
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
34.2
18.1
23
7
QDA50
NOMESCO Finland
Cryotherapy of skin of lower limb
98.3
17.7
19
*
S77
ICPC
Malignant neoplasm of skin
9.8
17.4
35
38
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
16.6
17.2
27
17
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
7.1
16.7
41
62
A12AA04
ATC
calcium carbonate; oral
10.0
16.6
33
35
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.8
16.6
42
66
R4110
NOMESCO Finland
Physiotherapy
2.3
16.4
196
1068
TQW80
NOMESCO Finland
Local dermatologic skincare
7.7
16.0
37
51
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
16.0
131
583
L04AA06
ATC
mycophenolic acid; systemic
10.9
15.9
30
29
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
8.6
15.7
34
42
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.4
15.7
164
832
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
9.4
15.6
32
36
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
4.7
15.3
53
122
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
15.3
252
1571
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
13.7
14.8
25
19
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.2
14.8
57
146
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
14.6
308
2112
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
14.5
260
1669
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
9.0
14.4
30
35
XQ845
NOMESCO Finland
Dermatoscopy
8.1
14.0
31
40
8090/3-C44.7
ICD-O-3
Basal cell carcinoma, NOS, of skin of lower limb and hip
20.7
13.9
20
10
7151
FHL
Kidney transplantation
143.4
13.5
14
*
A98
ICPC
Health maint/preventive medicine
3.3
13.3
520
4577
WX110
NOMESCO Finland
Local anesthesy
2.0
13.2
358
2659
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
13.2
259
1703
Z3226
NOMESCO Finland
Physiotherapist
2.3
12.9
139
707
D06BX02
ATC
ingenol mebutate; topical
6.6
12.6
32
51
KA1AE
NOMESCO Finland
Kidney ultrasound examination
6.1
12.6
34
59
D07AB08
ATC
desonide; topical
2.8
12.6
86
340
D07AC01
ATC
betamethasone; topical
2.0
12.5
211
1296
137
Kela drug reimbursment
Uraemia requiring dialysis
13.6
12.5
21
16
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.4
12.1
61
197
A11CC03
ATC
alfacalcidol; systemic
5.3
11.9
36
72
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
12.1
11.9
21
18
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
4.8
11.6
38
83
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.8
11.6
49
137
ZXA05
NOMESCO Finland
Left side
2.0
11.6
196
1200
L04AX01
ATC
azathioprine; systemic
4.6
11.5
40
93
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.8
11.5
32
58
C44.79
ICD-10 Finland
Malignant tumor of the skin of the lower extremity including hip or other unspecified histology
+∞
11.5
11
*
J01DB01
ATC
cefalexin; oral
2.1
11.4
447
3698
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
20.5
11.2
16
8
D02AE01
ATC
carbamide; topical
3.2
10.9
58
196
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
5.1
10.7
33
68
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.6
10.6
83
356
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
14.6
10.5
17
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
10.4
281
2005
L85.80
ICD-10 Finland
Hudhorn
16.4
10.4
16
10
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
23.9
10.3
14
6
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
6.4
10.3
26
42
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.4
9.9
21
26
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
4.5
9.9
34
79
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
20.5
9.8
14
7
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
9.8
9.8
19
20
S08
ICPC
Skin colour change
3.3
9.6
49
160
XF404
NOMESCO Finland
Ambulatory ECG
2.4
9.6
82
368
B07.9
ICD-10 Finland
Verruca simplex
4.7
9.6
32
72
C44.82
ICD-10 Finland
Overall spinocellular carcinoma of the skin
101.7
9.4
10
*
L04AA05
ATC
[U] tacrolimus; systemic
+∞
9.4
9
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.5
9.4
43
130
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
9.3
130
731
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.9
9.2
20
26
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
8.5
9.1
19
23
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
9.1
137
791
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
15.9
9.1
14
9
B03XA01
ATC
erythropoietin; parenteral
7.8
8.7
19
25
L17
ICPC
Foot/toe symptom/complaint
1.8
8.7
171
1083
40199
ICD-8 Finland
Essential benign hypertension
4.4
8.6
30
71
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.9
8.6
34
91
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
16.6
8.6
13
8
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
16.6
8.6
13
8
8070/3-C44.6
ICD-O-3
Squamous cell carcinoma, NOS, of skin of upper limb and shoulder
28.0
8.5
11
*
Z71.8
ICD-10 Finland
Other specified counselling
1.9
8.5
131
763
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
8.4
98
506
D03.5
ICD-10 Finland
Melanoma in situ of trunk
13.0
8.4
14
11
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
8.4
98
510
QCA30
NOMESCO Finland
Electrocoagulation of skin of upper limb
+∞
8.4
8
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
8.2
173
1115
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
8.2
121
690
C44.01
ICD-10 Finland
Basocellular carcinoma of the lip skin
33.9
8.1
10
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
8.1
58
237
RJ420
NOMESCO Finland
NA
22.4
8.0
11
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
7.9
110
612
DAB10
NOMESCO Finland
Partial excision of auricle
13.3
7.9
13
10
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
8.6
7.9
16
19
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.0
7.9
45
160
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.7
7.8
208
1442
DAB00
NOMESCO Finland
Excision of lesion of auricle
7.6
7.7
17
23
B01AB05
ATC
enoxaparin; parenteral
1.7
7.7
202
1393
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.6
236
1703
L01BB01
ATC
NA
25.4
7.6
10
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
25.4
7.6
10
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
7.6
188
1269
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
7.6
48
182
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.9
7.5
132
800
Z49.0
ICD-10 Finland
Preparatory care for dialysis
7.3
7.5
17
24
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.8
7.5
141
874
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
7.5
61
269
RJ120
NOMESCO Finland
NA
81.1
7.4
8
*
RJ512
NOMESCO Finland
NA
81.1
7.4
8
*
R4120
NOMESCO Finland
Occupational therapy
2.9
7.4
43
155
E000001
ATC
NA
1.9
7.3
119
701
6112
FHL
Installation of a peritoneal dialysis or lavage catheter in an operating room
+∞
7.3
7
*
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
6.4
7.3
18
29
E000007
ATC
NA
3.3
7.3
35
111
C44.60
ICD-10 Finland
Malignant tumor of the skin of the upper extremity including the shoulder without histology
16.0
7.3
11
7
M25.5
ICD-10 Finland
Pain in joint
1.8
7.2
144
908
WX320
NOMESCO Finland
Spinalanesthesy
1.8
7.2
150
961
N18.0
ICD-10 Finland
End-stage renal disease
6.2
7.1
18
30
S82
ICPC
Naevus/mole
2.1
7.1
79
402
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
7.1
7.0
16
23
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
7.0
57
247
C02CA01
ATC
prazosin; oral
4.7
7.0
22
48
H02AB04
ATC
methylprednisolone; systemic
2.0
6.9
97
539
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
6.9
155
1013
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.2
6.9
34
110
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
14.0
6.9
11
8
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
14.0
6.9
11
8
D02AX
ATC
Other emollients and protectives
4.0
6.9
26
68
D04
ICD-10 Finland
Carcinoma in situ of skin
16.9
6.8
10
6
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.5
6.7
22
50
C44.70
ICD-10 Finland
Malignant tumor of the skin of the lower extremity including the hip without histology
22.8
6.7
9
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
6.7
483
4330
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.0
6.7
36
125
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.0
6.6
35
120
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
6.6
182
1262
ZXA00
NOMESCO Finland
Right side
1.7
6.5
184
1280
L28
ICPC
Limited function/disability (L)
1.8
6.5
125
776
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
4.8
6.5
20
43
C44.69
ICD-10 Finland
Malignant tumor of the skin of the upper extremity including shoulder other or unspecified histology
70.6
6.4
7
*
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
14.5
6.4
10
7
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
14.5
6.4
10
7
C43.72
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip: 'superficial spreading' type
14.5
6.4
10
7
C03AA03
ATC
hydrochlorothiazide; oral
2.0
6.4
84
456
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.4
242
1817
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
6.4
95
543
D22
ICD-10 Finland
Melanocytic naevi
3.9
6.4
24
63
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
4.4
6.3
21
49
L12
ICPC
Hand/finger symptom/complaint
2.0
6.3
81
435
TQW40
NOMESCO Finland
Remowal of suture of skin
2.4
6.3
50
217
WXQ44
NOMESCO Finland
Photodynamic therapy of lower limb
+∞
6.3
6
*
8097/3-C44.9
ICD-O-3
Basal cell carcinoma, nodular of skin, NOS
7.2
6.3
14
20
M05BA04
ATC
alendronic acid; oral
2.0
6.1
80
432
M48.0
ICD-10 Finland
Spinal stenosis
1.9
6.1
98
573
L43.9
ICD-10 Finland
Lichen planus, unspecified
5.0
6.1
18
37
C08CA02
ATC
felodipine; oral
1.9
6.1
87
487
L03
ICPC
Low back symptom/complaint
1.7
6.1
136
882
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
5.3
6.1
17
33
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
6.1
6.0
15
25

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_SKIN_LOWERLIMB – Carcinoma in situ of skin of lower limb, including hip

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).