Anetoderma (of Jadassohn-Pellizzari/Pasini and pierini)

L12_ANETODERMA

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L90.1, L90.2 Hospital discharge: ICD-9 — 7018E Cause of death: ICD-10 — L90.1, L90.2 Cause of death: ICD-9 — 7018E 2 out of 7 registries used, show all original rules.	25
4. Check minimum number of events None	25
5. Include endpoints None	25
6. Filter based on genotype QC (FinnGen only)	25

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	L12_ANETODERMA
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L90[1-2]
HD_ICD_9	7018E
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L90[1-2]
COD_ICD_9	7018E
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Anetoderma (of Jadassohn-Pellizzari/Pasini and pierini) based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	267	174	92
Only index persons	254	171	83
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	33.90	39.02	24.41
Only index persons	34.13	38.94	24.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	25	23	-
Unadjusted period prevalence (%)	0.01	0.01	-
Median age at first event (years)	41.55	40.06	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

205

+∞

1.72

13.4

12.3

14.5

20.8

mg/l

0.67

165

(3000494) Fungus identified in Specimen by Culture

4.18

1.70

3.0

1.3

—

(3013512) EKG study

2.85

1.63

3.5

3.4

—

(3019069) Monocytes/100 leukocytes in Blood

2.45

1.27

6.2

5.7

7.8

8.1

0.15

(3019309) Folate [Moles/volume] in Red Blood Cells

2.73

1.22

1.3

1.5

1120.4

1092.2

nmol/l

—

(3001604) Monocytes [#/volume] in Blood

2.37

1.19

5.2

6.4

0.5

e9/l

0.15

(3006315) Basophils [#/volume] in Blood

2.33

1.15

5.2

6.4

0.0

e9/l

0.60

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.19

1.10

2.2

3.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

154

2.49

1.08

5.8

6.6

65.5

70.3

u/l

0.51

145

(3002030) Lymphocytes/100 leukocytes in Blood

100

2.25

1.07

5.9

5.3

28.3

30.2

0.29

(3015736) pH of Urine

2.22

1.06

3.4

3.1

—

(3006504) Eosinophils/100 leukocytes in Blood

2.11

0.94

5.9

5.4

2.6

0.02

(3019198) Lymphocytes [#/volume] in Blood

104

2.11

0.92

5.3

6.1

1.9

e9/l

0.07

(40768804) Tissue Pathology biopsy report

0.44

0.90

1.8

2.2

—

(3013115) Eosinophils [#/volume] in Blood

105

2.07

0.89

5.7

6.0

0.2

e9/l

0.10

(42870588) Differential panel, method unspecified - Blood

2.02

0.80

7.4

4.9

—

(3023368) Bacteria identified in Blood by Culture

1.92

0.76

2.4

3.2

—

(36660697) Celiac disease serology panel - Serum

2.15

0.75

1.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.93

0.72

4.8

5.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.90

0.67

3.2

7.0

—

(4035726)

0.00

0.62

0.0

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

151

1.68

0.54

3.0

3.4

23.8

29.9

u/l

1.15

144

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

169

0.61

0.47

5.9

3.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.61

0.45

4.4

3.2

—

(3002256) Pathology report gross observation

1.59

0.43

1.2

1.1

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.42

0.0

1.4

—

21.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

1.48

0.38

1.7

1.3

30.8

25.6

nmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.63

0.31

3.2

3.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.66

0.31

8.2

2.8

—

(3026008) Bacteria identified in Urine by Culture

1.34

0.30

4.9

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

150

1.41

0.28

5.3

4.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.44

0.25

1.4

—

(3000991) Gas panel - Venous blood

0.00

0.22

0.0

9.5

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.22

0.0

1.9

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

2.2

—

24.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.22

0.0

1.7

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.22

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.22

0.0

1.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.22

0.0

1.5

—

(3019150) Specific gravity of Urine by Refractometry

1.26

0.22

1.8

3.9

—

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3010813) Leukocytes [#/volume] in Blood

237

+∞

0.21

20.8

17.3

6.3

6.4

e9/l

0.02

232

(3026361) Erythrocytes [#/volume] in Blood

237

+∞

0.21

20.7

17.3

4.6

4.4

e12/l

0.78

232

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.20

0.0

2.4

—

99.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.31

0.20

1.5

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.21

0.19

1.5

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

163

1.37

0.18

4.2

4.6

11.3

9.4

mm/h

0.22

151

(3021589) Normoblasts [#/volume] in Blood

1.26

0.13

12.0

6.0

0.0

e9/l

0.00

(3044889) 12 lead EKG panel

136

1.26

0.13

5.0

3.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

116

1.07

0.00

4.7

3.9

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

(1761868) Lipid panel - Serum or Plasma

0.89

0.00

4.4

2.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

7.0

—

160.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

47.0

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

8.7

—

24.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.2

—

(40758558) Short blood count panel - Blood

0.91

0.00

2.4

6.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.8

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.0

—

10.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.0

8.2

—

25.7

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

1.8

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

5.0

—

103.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3012501) Base excess in Blood by calculation

0.00

0.0

1.0

—

2.3

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.7

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.0

—

5.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

1.2

—

0.6

—

(4034850)

0.00

0.0

15.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

1.2

—

1.3

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.7

—

(3039000) Anion gap in Blood

0.00

0.0

5.0

—

9.8

—

(3003338) MCHC [Mass/volume]

191

0.98

0.00

13.2

14.9

334.9

332.4

g/l

0.68

191

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

5.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3010421) pH of Blood

0.00

0.0

1.2

—

7.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

5.8

—

105.5

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3026179) Normetanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.4

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.7

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.3

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

1.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3003694) ABO and Rh group [Type] in Blood

1.06

0.00

1.4

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

0.91

0.00

1.7

1.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ANETODERMA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ANETODERMA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: L12_ANETODERMA – Anetoderma (of Jadassohn-Pellizzari/Pasini and pierini)

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Anetoderma (of Jadassohn-Pellizzari/Pasini and pierini)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints