This is a non-core endpoint: only basic statistics are computed.

Malnutrition in pregnancy

O15_PREG_MALNUT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O25 Cause of death: ICD-10 — O25 2 out of 7 registries used, show all original rules.	14
4. Check minimum number of events None	14
5. Include endpoints None	14
6. Filter based on genotype QC (FinnGen only)	14

Control definitions (FinnGen only)

Control exclude: O15_PREG_OTHER_MAT_DISORD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF3
Parent code in ICD-10: O20-O29
Name in latin: Malnutritio in graviditate

NAME	O15_PREG_MALNUT
CONTROL_EXCLUDE	O15_PREG_OTHER_MAT_DISORD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O25
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O25
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Malnutrition in pregnancy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	102	102	-
Only index persons	102	102	-
Unadjusted period prevalence (%)
Whole population	0.00	0.00	-
Only index persons	0.00	0.00	-
Median age at first event (years)
Whole population	-	34.30	-
Only index persons	-	34.30	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	14	14	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	32.49	32.49	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3033658) Prothrombin time (PT) actual/Normal

4.44

1.82

2.7

86.8

103.6

—

(3003694) ABO and Rh group [Type] in Blood

3.19

1.18

1.8

1.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.62

0.99

1.3

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.51

0.95

1.3

1.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

2.51

0.95

3.5

2.6

24.3

27.1

u/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.39

0.83

3.4

3.7

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.31

0.77

1.4

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.42

0.71

2.8

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.11

0.71

2.6

2.7

—

(42870588) Differential panel, method unspecified - Blood

2.32

0.71

10.5

4.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.10

0.63

1.6

1.9

—

(3022096) Basophils/100 leukocytes in Blood

1.88

0.56

9.1

3.3

0.6

—

(3015736) pH of Urine

1.87

0.45

4.7

3.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.66

0.45

1.4

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.55

0.44

4.0

3.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.69

0.43

4.8

2.4

—

(3019069) Monocytes/100 leukocytes in Blood

1.77

0.40

9.5

3.4

7.0

8.1

—

(3006504) Eosinophils/100 leukocytes in Blood

1.77

0.40

9.5

3.2

2.1

2.6

—

(3002030) Lymphocytes/100 leukocytes in Blood

1.67

0.39

9.4

3.3

22.0

30.9

—

(3018010) Neutrophils/100 leukocytes in Blood

1.67

0.39

9.6

3.2

65.2

56.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

1.69

0.39

6.9

5.7

79.3

73.1

u/l

—

(3044889) 12 lead EKG panel

1.69

0.39

4.1

2.8

—

(3026008) Bacteria identified in Urine by Culture

1.49

0.27

2.6

2.1

—

(3001604) Monocytes [#/volume] in Blood

1.45

0.24

9.1

3.4

0.5

e9/l

—

(3006315) Basophils [#/volume] in Blood

1.41

0.23

9.0

3.3

0.0

e9/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.22

0.0

1.5

—

(3002256) Pathology report gross observation

0.00

0.22

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.22

0.0

2.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.22

0.0

1.1

—

(40768804) Tissue Pathology biopsy report

1.21

0.11

1.2

1.8

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

1.23

0.11

4.0

4.7

7.3

9.4

umol/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

0.75

0.11

5.7

4.2

—

(3013115) Eosinophils [#/volume] in Blood

1.37

0.11

9.1

3.5

0.1

0.2

e9/l

—

(3019198) Lymphocytes [#/volume] in Blood

1.33

0.11

9.1

3.3

1.6

1.9

e9/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.19

0.10

9.5

8.3

5.8

4.0

e9/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

0.97

0.00

5.3

4.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.8

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.3

—

(40761535) Cells panel - Urine sediment

0.00

0.0

2.8

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.8

—

(3000492) Spirometry study

0.00

0.0

1.4

—

(4035726)

0.00

0.0

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.7

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

1.2

—

35.6

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(4094501)

0.00

0.0

1.0

—

(3020891) Body temperature

0.00

0.0

6.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

1.03

0.00

5.8

3.4

13.0

7.8

mm/h

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

42.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

1.7

—

24.8

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_PREG_MALNUT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREG_MALNUT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_PREG_MALNUT – Malnutrition in pregnancy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Malnutrition in pregnancy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints