This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

E4_CUSHING

Alcohol-induced pseudo-Cushing syndrome

Endpoint Browser

PSEUDOCUSHING

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E24.4 Cause of death: ICD-10 — E24.4 2 out of 7 registries used, show all original rules.	12
4. Check minimum number of events None	12
5. Include endpoints None	12
6. Filter based on genotype QC (FinnGen only)	12

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E24
Name in latin: Syndroma pseudo-Cushing alcoholicum

NAME	PSEUDOCUSHING
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E244
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E244
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Alcohol-induced pseudo-Cushing syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	58	44	13
Only index persons	53	40	13
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	39.17	36.68	47.92
Only index persons	39.21	36.38	47.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	12	10	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	38.42	36.32	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

13.43

3.52

2.5

1.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

5.56

2.07

1.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

4.92

1.87

1.3

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

3.80

1.39

1.4

2.0

—

(3026008) Bacteria identified in Urine by Culture

3.33

1.23

2.0

1.6

—

(3013512) EKG study

3.15

1.16

2.0

4.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.83

0.87

2.2

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.69

0.85

1.6

1.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

100

+∞

0.67

14.4

8.8

140.0

139.6

mmol/l

0.30

100

(40768797) Stomach Pathology biopsy report

0.00

0.67

0.0

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

101

+∞

0.67

5.5

3.8

1.5

1.6

mmol/l

0.46

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

0.00

0.67

0.0

1.2

—

4.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

+∞

0.67

5.1

3.4

1.3

1.1

mmol/l

0.47

(3015736) pH of Urine

1.80

0.47

1.8

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.48

0.47

3.7

3.5

—

(40761511) CBC panel - Blood by Automated count

103

+∞

0.44

15.6

9.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

103

+∞

0.44

6.4

3.9

2.7

2.8

mmol/l

0.17

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

102

+∞

0.43

5.7

3.6

4.8

mmol/l

0.09

(36660697) Celiac disease serology panel - Serum

0.00

0.22

0.0

1.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

109

+∞

0.22

16.5

9.6

65.8

70.6

umol/l

0.40

109

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.0

1.6

—

124.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

2.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3019225) pH of Specimen

0.00

0.0

7.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.00

0.0

1.9

—

109.6

—

(1002224) Polysomnography panel

0.00

0.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.2

—

(3000963) Hemoglobin [Mass/volume] in Blood

111

+∞

0.00

18.8

14.3

138.9

136.2

g/l

0.37

111

(3042936) Bacteria identified in Isolate by Culture

0.00

0.0

1.4

—

(3019060) Gas panel - Arterial blood

0.00

0.0

2.6

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

0.0

4.6

—

93.8

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.0

2.2

—

(3002256) Pathology report gross observation

0.00

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3000991) Gas panel - Venous blood

0.00

0.0

1.6

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.0

1.0

—

(3024731) MCV [Entitic volume]

111

+∞

0.00

18.4

14.2

90.8

90.5

0.05

111

(3035941) MCH [Entitic mass]

111

+∞

0.00

18.3

14.2

30.1

30.2

0.03

111

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

0.93

0.00

11.4

7.3

3.3

3.4

e9/l

—

Mortality – FinRegistry

↥

Association

Association between endpoint PSEUDOCUSHING and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have PSEUDOCUSHING.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: PSEUDOCUSHING – Alcohol-induced pseudo-Cushing syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Alcohol-induced pseudo-Cushing syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints