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Cushing syndrome

DOID EFO Endpoint Browser PheWeb

E4_CUSHING

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E24
  • Hospital discharge: ICD-9 — 2550|2593
  • Hospital discharge: ICD-8 — 2580
  • Cause of death: ICD-10 — E24
  • Cause of death: ICD-9 — 2550|2593
  • Cause of death: ICD-8 — 2580

2 out of 7 registries used, show all original rules.

428

4. Check minimum number of events

None

428

5. Include endpoints

None

428

6. Filter based on genotype QC (FinnGen only)

414

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
E20-E35
Name in latin
Syndroma Cushing

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2517 1702 780
Only index persons 1932 1354 578
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 52.43 51.81 53.66
Only index persons 48.38 47.55 50.32

-FinnGen-

Key figures

All Female Male
Number of individuals 414 292 122
Unadjusted period prevalence (%) 0.09 0.10 0.06
Median age at first event (years) 52.33 49.26 59.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
428
Matched controls
4280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
126.8
307.7
174
23
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
+∞
164.5
147
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
38.7
136.9
87
28
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
126.5
115
*
E24.8
ICD-10 Finland
Other Cushing syndrome
+∞
120.7
110
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
49.4
95.1
56
13
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
17.1
89.3
79
56
H02AA02
ATC
fludrocortisone; oral
51.3
85.7
50
11
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
297.2
75.0
74
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
105.3
58.7
63
7
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
214.1
55.4
56
*
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
163.9
55.3
57
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
51.1
48
*
C03DA01
ATC
spironolactone; oral
5.8
50.0
111
245
E24.2
ICD-10 Finland
Drug-induced Cushing syndrome
+∞
48.9
46
*
V04CD01
ATC
metyrapone; oral
+∞
44.6
42
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.4
40.0
74
136
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
+∞
35.9
34
*
E24.3
ICD-10 Finland
Ectopic ACTH syndrome
+∞
33.8
32
*
E87.6
ICD-10 Finland
Hypokalaemia
7.6
32.5
49
72
A10AE04
ATC
insulin glargine; parenteral
4.8
31.3
80
195
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
336.2
31.3
31
*
C03CA01
ATC
furosemide; systemic
3.3
29.5
162
669
25800
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Cushing's syndrome
+∞
29.5
28
*
103
Kela drug reimbursment
Diabetes, insulin-treated
3.2
27.6
157
658
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
27.6
106
348
A10AB05
ATC
insulin aspart; parenteral
5.0
27.5
65
148
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
27.4
26
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
25.3
198
983
BCA30
NOMESCO Finland
Unilateral adrenalectomy
+∞
24.2
23
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
22.7
100
355
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
22.4
235
1331
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.9
22.3
141
616
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
22.3
83
264
C08CA01
ATC
amlodipine; oral
2.7
22.2
195
1011
2550A
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SDR CUSHING E HYPERPLASIA GLANDULAE SUPRARENALI]
+∞
22.1
21
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
6.2
21.9
39
68
H03AA01
ATC
levothyroxine sodium; systemic
2.8
21.9
150
684
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.1
21.6
115
456
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
21.6
152
702
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
20.6
126
538
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.9
20.5
129
559
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
19.9
19
*
A10BA02
ATC
metformin; oral
2.7
19.9
149
705
205
Kela drug reimbursment
Chronic hypertension
2.8
19.5
131
586
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
18.9
70
221
2550X
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING NUD]
+∞
18.9
18
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
18.9
18
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
18.9
18
*
JN4BD
NOMESCO Finland
Extensive body CT
3.4
18.6
75
250
TPH07
NOMESCO Finland
Cathetrisation of artery
3.5
18.3
69
220
A10AC01
ATC
insulin (human); parenteral
3.8
18.0
59
171
BCA41
NOMESCO Finland
Endoscopic bilateral adrenalectomy
+∞
17.8
17
*
E23.03
ICD-10 Finland
Lack of ACTH
+∞
17.8
17
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
17.5
193
1085
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
17.2
194
1099
AA1AD
NOMESCO Finland
CT of head and brain
2.6
17.2
140
684
2550B
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERFUNCTIO GLAN SUPRARENALI]
+∞
16.8
16
*
C74.0
ICD-10 Finland
Malignant neoplasm: Cortex of adrenal gland
+∞
16.8
16
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.5
16.5
61
192
SPAT1262
SPAT
Handing over of treatment supplies
2.9
16.4
93
377
T90
ICPC
Diabetes non-insulin dependent
2.6
16.1
118
545
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.2
16.1
72
255
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
15.9
86
340
E24
ICD-10 Finland
Cushing syndrome
+∞
15.7
15
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.8
15.7
51
147
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.0
15.5
24
36
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
6.4
15.3
26
43
R53
ICD-10 Finland
Malaise and fatigue
2.4
15.3
134
672
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.5
15.2
39
94
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.4
15.1
40
99
JN3AD
NOMESCO Finland
Abdominal CT examination
3.2
14.9
67
238
L01XX23
ATC
mitotane; oral
+∞
14.7
14
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
14.7
14
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
14.7
14
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
14.7
14
*
BC1AD
NOMESCO Finland
CT of adrenal glands
13.2
14.6
25
20
R03BB04
ATC
tiotropium bromide; inhalant
3.3
14.5
59
197
C07AB07
ATC
bisoprolol; oral
2.2
14.5
225
1429
R60.0
ICD-10 Finland
Localized oedema
3.0
14.5
70
259
WX892
NOMESCO Finland
Monitored bed care
3.7
14.2
48
142
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
13.9
63
224
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.2
13.8
29
59
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
13.7
38
97
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
13.7
79
321
C08CA13
ATC
lercanidipine; oral
2.8
13.7
79
321
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
77.7
13.7
15
*
E26.0
ICD-10 Finland
Primary hyperaldosteronism
77.7
13.7
15
*
B01AB05
ATC
enoxaparin; parenteral
2.2
13.6
158
887
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
13.6
13
*
ZXC86
NOMESCO Finland
Use of endoscopic device
35.3
13.6
17
5
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
13.5
143
772
N02AA05
ATC
oxycodone; systemic
2.6
13.5
92
407
R4110
NOMESCO Finland
Physiotherapy
2.3
13.4
145
789
BC1CD
NOMESCO Finland
Very extensive CT of adrenal glands
41.5
13.2
16
*
J01MA12
ATC
levofloxacin; systemic
2.5
13.0
95
434
E66.01
ICD-10 Finland
Obesity due to excess calories
3.1
12.8
60
217
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
12.8
54
184
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
12.6
263
1834
E24.4
ICD-10 Finland
Alcohol-induced pseudo-Cushing syndrome
+∞
12.6
12
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
+∞
12.6
12
*
C02AC05
ATC
moxonidine; oral
4.8
12.1
28
62
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
11.9
121
638
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
4.0
11.7
34
90
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.0
11.6
55
200
N91.1
ICD-10 Finland
Secondary amenorrhoea
14.1
11.6
19
14
2533
FHL
Unilateral removal of additional egg
+∞
11.5
11
*
AA4WT
NOMESCO Finland
Selective blood sample from sinus petrosus inferior
+∞
11.5
11
*
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
17.6
11.3
17
10
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.9
11.3
59
227
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.0
11.1
32
84
L28
ICPC
Limited function/disability (L)
2.4
11.1
86
402
E66.8
ICD-10 Finland
Other obesity
3.5
11.1
39
118
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
11.0
77
343
N04BC06
ATC
cabergoline; oral
44.5
11.0
13
*
N03AX16
ATC
[U] pregabalin
2.2
10.9
120
651
JN4AD
NOMESCO Finland
Body CT examination
2.9
10.8
56
214
B01AB04
ATC
dalteparin; parenteral
3.9
10.8
32
86
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.6
10.7
37
111
Z3226
NOMESCO Finland
Physiotherapist
2.3
10.6
99
501
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.8
10.6
24
52
TKC20
NOMESCO Finland
Catheterisation of bladder
3.4
10.6
40
127
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
112.7
10.5
11
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
112.7
10.5
11
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
10.5
10
*
WX402
NOMESCO Finland
General anaesthesia
2.2
10.4
106
557
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
10.1
118
652
J01FF01
ATC
clindamycin; systemic
2.1
10.1
133
770
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
10.1
179
1151
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
10.0
110
595
N02AX02
ATC
tramadol; systemic, rectal
1.9
9.9
195
1294
UJF32
NOMESCO Finland
Coloscopy
2.1
9.9
120
672
A46
ICD-10 Finland
Erysipelas
2.5
9.8
66
288
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
9.8
67
295
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
4.1
9.7
27
69
A10BJ06
ATC
semaglutide; parenteral
3.8
9.7
30
83
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
56.3
9.7
11
*
R06.0
ICD-10 Finland
Dyspnoea
2.0
9.6
125
719
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
102.2
9.5
10
*
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
4.5
9.4
23
53
H01AC01
ATC
somatropin; parenteral
+∞
9.4
9
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
9.4
9
*
E23.05
ICD-10 Finland
Lack of TSH
+∞
9.4
9
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
9.4
9
*
A10AB04
ATC
insulin lispro; parenteral
4.0
9.4
27
71
A02BC02
ATC
pantoprazole; systemic
2.0
9.4
297
2291
A12BA01
ATC
potassium chloride; oral
4.1
9.3
26
67
ZXD05
NOMESCO Finland
Urgent procedure
2.0
9.2
147
905
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
9.2
25
63
J46
ICD-10 Finland
Status asthmaticus
4.9
9.2
20
42
A28
ICPC
Limited function/disability NOS
2.3
9.1
75
358
WZC30
NOMESCO Finland
Teaching
2.2
9.1
83
414
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
9.1
108
598
M05BX04
ATC
denosumab; parenteral
3.4
9.1
33
102
WX002
NOMESCO Finland
Sedation and analgesia
2.2
9.0
93
488
130
Kela drug reimbursment
Malignant tumour
2.9
9.0
45
169
B01AB10
ATC
tinzaparin; parenteral
2.6
9.0
57
242
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.8
8.7
27
75
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
8.7
31
95
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
8.6
64
292
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.7
8.5
27
76
OAB93, ,
SPAT
3.2
8.5
35
117
ZX120
NOMESCO Finland
Intravenous
2.6
8.5
51
210
WX110
NOMESCO Finland
Infiltration anesthesia
2.0
8.5
313
2493
ZXE00
NOMESCO Finland
One hour or less
1.8
8.5
179
1199
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
28.1
8.5
11
*
I15.2
ICD-10 Finland
Hypertension secondary to endocrine disorders
91.8
8.4
9
*
A10BH01
ATC
sitagliptin; oral
2.7
8.4
48
193
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
8.4
136
838
E66.00
ICD-10 Finland
Metabolic syndrome
3.2
8.4
34
113
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.2
8.4
34
113
E24.1
ICD-10 Finland
Nelson syndrome
+∞
8.4
8
*
301
Kela drug reimbursment
Growth hormone
+∞
8.4
8
*
C74.9
ICD-10 Finland
Malignant neoplasm: Adrenal gland, unspecified
+∞
8.4
8
*
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.2
8.3
75
372
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
8.3
80
408
H02AB07
ATC
prednisone; oral
2.3
8.2
70
339
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.5
8.2
28
83
A07AA02
ATC
nystatin; oral
3.1
8.1
34
115
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
8.0
70
342
A10BJ02
ATC
liraglutide; parenteral
4.4
8.0
20
47
C10AA01
ATC
simvastatin; oral
1.8
8.0
163
1077
E0000UV, ,
ATC
1.8
8.0
189
1306
M04AA01
ATC
allopurinol; systemic
2.5
8.0
54
236
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
8.0
56
249
R50.9
ICD-10 Finland
Fever, unspecified
2.2
7.9
72
358
C08CA02
ATC
felodipine; oral
2.7
7.9
43
169
G47.3
ICD-10 Finland
Sleep apnoea
2.0
7.9
106
612
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
7.8
38
140
Z3231
NOMESCO Finland
Registered nurse
1.9
7.8
128
789
R11
ICD-10 Finland
Nausea and vomiting
2.6
7.7
48
201
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.4
7.7
28
87
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
8.3
7.7
16
20
R03DA04
ATC
theophylline; systemic, rectal
3.4
7.7
27
82
JN4CD
NOMESCO Finland
Very extensive body CT
3.9
7.6
22
58
C03AA03
ATC
hydrochlorothiazide; oral
2.7
7.5
43
173
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
6.7
7.5
18
28
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
3.1
7.4
31
105
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
7.3
7
*
C25.4
ICD-10 Finland
Malignant neoplasm: Endocrine pancreas
+∞
7.3
7
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
7.3
101
588
R4190
NOMESCO Finland
Nutritional therapy
3.5
7.2
25
75
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
6.8
7.2
17
26
Z2221
NOMESCO Finland
Medical doctor
1.8
7.1
130
826
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.4
7.1
25
76
A10AE05
ATC
insulin detemir; parenteral
3.1
7.1
29
97
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
7.0
47
204
A02BA02
ATC
ranitidine; systemic
2.0
7.0
86
478
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.4
7.0
51
230
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
7.0
89
501
WX882
NOMESCO Finland
High dependency care
6.5
7.0
17
27
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.1
7.0
19
48
C09DA01
ATC
losartan and diuretics; oral
2.4
6.9
51
232
C09AA05
ATC
ramipril; oral
1.9
6.8
102
608
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
40.7
6.8
8
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
6.7
59
289
T82
ICPC
Obesity
3.3
6.7
25
79
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
3.7
6.7
21
59
S10
ICPC
Boil/carbuncle
2.8
6.7
33
123
P25
ICPC
Phase of life problem adult
3.5
6.6
23
69
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.7
6.6
36
141
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.4
6.6
47
210
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.5
6.6
44
191
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.2
6.6
26
85
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.8
6.6
34
130
A02BA04
ATC
nizatidine; systemic
2.7
6.6
35
136
E66.9
ICD-10 Finland
Obesity, unspecified
3.3
6.5
24
75
A01AB09
ATC
miconazole; local oral
2.4
6.5
44
192
A10BK01
ATC
dapagliflozin; oral
2.8
6.5
32
119
N05CF01
ATC
zopiclone; oral
1.7
6.5
142
947
B01AA03
ATC
warfarin; systemic
2.1
6.5
66
343
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
70.9
6.4
7
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.9
6.4
19
51
H02AB06
ATC
prednisolone; systemic
1.7
6.4
204
1505
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.6
6.4
38
156
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.6
6.4
36
144
A02BC03
ATC
lansoprazole; oral
1.8
6.4
128
833
N02BE01
ATC
paracetamol; systemic, rectal
2.2
6.4
383
3387
M05BA04
ATC
alendronic acid; oral
2.5
6.3
40
169
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
6.3
89
518
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.3
83
473
OAB50, ,
SPAT
3.0
6.3
27
93
318
Kela drug reimbursment
Teriparatide
+∞
6.3
6
*
8370/3-C74.0
ICD-O-3
Adrenal cortical carcinoma of cortex of adrenal gland
+∞
6.3
6
*
H05AA02
ATC
teriparatide; parenteral
+∞
6.3
6
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
6.3
6
*
E26.9
ICD-10 Finland
Hyperaldosteronism, unspecified
+∞
6.3
6
*
A08
ICPC
Swelling
2.9
6.3
30
110
L04AX01
ATC
azathioprine; systemic
3.4
6.2
22
67
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.5
6.2
21
62
Z2446
NOMESCO Finland
Social worker
2.6
6.2
36
146
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
5.9
6.2
16
28
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
6.1
47
217
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.2
6.1
16
39
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
6.1
31
117
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
6.1
48
224
A02BC01
ATC
omeprazole; systemic
1.8
6.1
117
749
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.7
6.1
19
53
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.6
6.1
20
58
ZX114
NOMESCO Finland
Intramuscular
6.2
6.0
15
25
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.0
6.0
66
352
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
6.0
47
219

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
172
28
102.03
307.65
4.8
1.4
—
—
—
0
0
133
11
174.97
270.02
3.1
1.2
752.56
54.00
nmol/24h
1.67
133
11
244
322
16.30
196.18
8.6
1.7
361.62
368.93
nmol/l
0.11
237
300
73
47
18.52
86.63
1.3
1.1
0.35
—
nmol/l
—
6
0
68
38
21.09
86.30
1.2
1.2
—
—
nmol/l
—
0
0
69
46
17.69
80.29
1.3
1.1
—
—
—
0
0
54
78
7.78
36.48
2.5
1.3
10.53
11.53
u/l
0.16
46
62
298
1619
3.77
36.31
10.2
5.8
1.22
1.21
mmol/l
0.26
245
1375
216
1001
3.34
33.20
5.2
3.3
7.40
7.40
ph
0.16
58
184
275
1484
3.39
32.49
8.9
5.0
1.21
1.21
mmol/l
0.24
267
1341
262
1393
3.27
31.36
7.2
4.3
34.01
35.92
g/l
5.66
251
1304
115
369
3.89
31.25
7.9
6.7
104.26
104.08
mmol/l
0.13
115
369
269
1458
3.27
31.04
3.6
2.1
76.44
76.97
nmol/l
0.11
257
1291
79
212
4.34
27.21
2.7
3.2
4.21
4.53
pmol/l
1.71
74
186
31
32
10.37
27.08
1.5
1.2
282.00
277.83
mosm/kgh2o
0.29
24
24
148
646
2.97
23.69
3.4
2.6
528.98
542.66
mosm/kgh2o
0.24
122
550
111
436
3.09
21.16
2.5
2.0
2.34
2.38
g/l
0.34
102
405
94
339
3.27
20.67
9.8
7.1
0.89
1.17
mmol/l
0.27
79
274
88
306
3.36
20.52
1.5
1.4
—
—
—
0
0
75
236
3.64
20.41
10.1
7.7
—
—
—
0
0
105
410
3.07
20.13
2.6
2.0
19.37
23.45
%
2.16
90
352
79
264
3.44
19.57
3.6
3.5
—
—
—
0
0
255
1575
2.53
19.31
8.1
5.7
0.59
0.70
%
2.34
242
1463
296
1964
2.64
19.19
8.4
4.2
7.00
6.58
mmol/l
2.38
283
1830
264
1664
2.53
19.03
8.4
6.0
—
—
—
0
0
274
1759
2.55
18.95
7.5
5.6
0.04
0.04
e9/l
0.17
248
1535
259
1626
2.50
18.71
8.1
5.6
2.13
2.79
%
6.90
246
1511
72
233
3.51
18.71
6.2
6.3
9.64
8.96
mmol/l
0.40
72
222
277
1800
2.53
18.46
7.7
5.6
1.88
1.95
e9/l
0.42
258
1613
76
257
3.38
18.42
3.9
3.5
2.28
1.93
mmol/l
0.30
60
205
272
1754
2.51
18.41
7.6
5.6
0.64
0.56
e9/l
5.17
246
1530
258
1636
2.45
17.94
8.3
5.9
8.34
8.53
%
0.44
245
1527
30
50
6.38
17.55
3.1
1.4
0.23
0.43
nmol/l
0.97
20
41
277
1826
2.47
17.48
8.0
5.9
0.16
0.18
e9/l
2.83
254
1616
112
486
2.77
17.47
2.5
2.0
11.18
13.91
umol/l
3.64
104
452
183
1005
2.43
17.46
3.5
3.0
6.74
7.46
mmol/l
1.35
156
844
66
211
3.52
17.43
3.4
2.9
92.85
66.31
ng/l
2.10
61
187
260
1680
2.40
16.96
8.4
5.7
23.99
28.30
%
8.64
247
1571
159
834
2.44
16.64
6.3
3.9
—
—
—
0
0
169
919
2.39
16.24
3.5
3.1
407.38
352.14
mg/l
0.05
123
566
176
976
2.36
16.15
4.2
3.7
13.91
7.83
mg/mmol
0.66
121
581
52
150
3.81
15.95
11.7
8.2
—
—
—
0
0
92
381
2.80
15.54
2.1
1.6
—
—
—
0
0
165
902
2.35
15.52
4.1
2.6
—
—
—
0
0
58
185
3.47
15.31
2.1
1.3
21.00
26.30
iu/l
0.58
49
155
253
1662
2.28
15.23
8.1
5.5
61.87
56.97
%
8.12
243
1555
165
917
2.30
14.80
3.3
3.0
1647.94
1013.94
ng/l
0.94
144
771
30
60
5.30
14.53
3.5
1.8
—
—
—
0
0
149
808
2.29
14.03
2.8
2.0
3.02
3.07
mg/l
0.11
135
690
233
1521
2.17
13.73
19.8
10.2
1.22
1.17
inr
0.43
85
469
162
919
2.23
13.60
4.1
2.7
0.30
0.49
e6/l
0.94
125
677
180
1076
2.16
13.15
3.4
2.4
54.04
61.02
u/l
0.75
165
983
262
1809
2.16
13.13
8.8
6.0
8.86
10.52
umol/l
4.51
253
1712
171
1004
2.17
13.06
4.4
2.8
53.49
126.80
e6/l
0.47
132
758
284
2044
2.16
12.50
11.8
9.1
5.04
3.98
e9/l
9.74
256
1801
233
1563
2.08
12.30
14.3
8.8
0.00
0.00
e9/l
0.00
201
1287
128
689
2.22
11.98
3.5
2.3
6.59
6.61
e6/l
0.00
110
618
96
465
2.37
11.48
2.6
1.8
—
—
—
0
0
65
263
2.73
11.30
3.3
4.2
0.00
0.24
%
1.03
24
71
24
50
5.03
11.09
3.0
1.9
—
—
—
0
0
139
795
2.11
11.02
2.2
1.7
0.81
1.11
mg/l
1.56
110
607
341
2701
2.29
10.92
12.0
7.2
84.33
76.44
u/l
1.58
331
2527
33
91
3.85
10.74
3.1
3.2
—
—
—
0
0
174
1089
2.01
10.72
3.2
2.2
—
—
—
0
0
187
1201
1.99
10.70
5.1
3.3
59.33
64.83
e6/l
0.09
143
824
200
1323
1.96
10.43
2.1
1.9
89.06
97.04
pmol/l
1.82
106
667
347
2791
2.29
10.34
7.0
3.9
15.09
14.63
pmol/l
2.53
331
2541
27
66
4.30
10.31
3.0
2.0
3.39
3.26
mmol/l
0.05
19
40
230
1600
1.95
10.29
3.6
2.6
125.53
98.26
ug/l
1.19
216
1468
180
1159
1.95
10.07
4.5
3.2
2.35
2.35
mmol/l
0.12
163
1016
112
610
2.13
9.96
5.2
2.8
2.47
2.45
mmol/l
1.47
102
538
37
118
3.34
9.71
2.5
2.2
20.16
21.29
s
0.87
31
106
63
271
2.55
9.66
3.2
3.9
0.96
0.65
%
0.42
25
85
164
1035
1.95
9.64
4.0
2.8
—
—
—
0
0
49
187
2.83
9.48
1.4
1.2
—
—
—
0
0
64
280
2.51
9.46
3.5
4.2
0.04
0.19
%
1.56
25
88
67
301
2.45
9.36
3.5
4.0
1.41
1.06
%
0.45
28
109
53
215
2.67
9.13
2.2
2.5
199.25
159.94
ng/l
0.39
48
194
72
339
2.35
9.06
3.4
2.7
1.89
1.77
%
0.46
67
307
328
2635
2.05
8.98
5.8
4.0
15.67
11.40
mm/h
4.10
309
2419
95
505
2.13
8.90
3.6
2.6
2.20
2.92
e6/l
0.53
53
261
48
188
2.75
8.84
3.7
3.6
7.42
7.42
ph
—
9
20
25
65
4.02
8.82
1.3
1.7
—
—
—
0
0
37
126
3.12
8.74
1.8
2.1
1.99
1.46
g/l
1.71
31
110
209
1484
1.80
8.09
2.4
2.0
—
—
—
0
0
51
216
2.55
8.05
2.3
2.3
—
—
—
0
0
104
593
2.00
8.00
4.3
3.4
467.55
192.31
ng/l
0.46
85
427
378
3263
2.36
7.75
8.9
5.3
42.83
39.19
mmol/mol
7.04
365
3042
23
62
3.86
7.73
2.3
3.1
4.24
4.91
e9/l
0.58
23
62
22
58
3.94
7.62
3.1
1.8
16.43
16.11
%
0.14
13
25
20
49
4.23
7.62
3.2
2.1
—
—
—
0
0
289
2282
1.82
7.61
6.6
4.2
951.83
483.95
e6/l
—
6
37
18
28
6.66
7.49
2.2
1.3
—
—
—
0
0
23
64
3.74
7.40
2.7
3.4
58.22
59.28
%
0.14
23
64
180
1248
1.76
7.37
4.2
3.5
24.60
35.39
ng/l
0.95
123
828
301
2418
1.83
7.35
6.1
4.1
—
—
—
0
0
29
95
3.20
7.31
1.6
1.3
220.18
305.57
ug/g
1.16
17
55
135
867
1.81
7.12
3.7
2.6
2467.96
7847.81
umol/l
1.24
123
748
124
777
1.84
7.08
1.8
1.5
19.70
20.76
nmol/l
0.34
114
651
301
2433
1.80
7.03
4.5
3.5
—
—
—
0
0
133
855
1.81
6.97
1.4
1.3
0.77
1.76
u/ml
1.05
36
229
21
58
3.76
6.83
2.4
1.8
128.88
130.24
g/l
0.08
16
41
219
1638
1.69
6.59
3.7
2.4
—
—
—
0
0
18
35
5.32
6.39
4.7
1.6
50.28
17.40
ug/l
1.06
18
35
13
16
8.34
6.37
1.1
1.1
209.15
159.29
mmol/24h
0.61
13
16
166
1161
1.70
6.37
3.6
3.1
35.55
30.05
u/l
0.54
152
1103
6
0
+∞
6.26
1.5
0.0
0.90
—
nmol/l
—
6
0
87
505
1.91
6.24
1.5
1.3
675.79
514.67
titre
0.23
19
120
379
3345
2.16
6.20
7.6
4.7
1.67
1.86
mu/l
2.04
355
3060
84
489
1.89
5.95
1.4
1.2
—
—
—
0
0
50
245
2.18
5.68
2.1
2.9
73.78
71.08
e9/l
0.19
37
192
114
740
1.74
5.62
1.5
1.5
2.15
2.38
g/l
0.75
73
448
108
692
1.75
5.57
1.8
1.7
413.21
12696095.04
pmol/l
0.50
90
575
24
84
2.97
5.44
1.2
1.3
2.05
12.19
e6/l
0.72
19
68
59
314
2.02
5.41
3.0
2.3
30.96
34.03
u/l
0.30
51
271
55
292
2.01
5.07
4.0
3.6
—
—
—
0
0
71
412
1.87
5.05
1.5
1.3
—
—
—
0
0
67
383
1.89
4.99
4.1
3.0
6.22
7.14
umol/l
0.19
57
334
41
196
2.21
4.96
6.6
4.3
—
—
—
0
0
75
450
1.81
4.79
2.5
2.1
243.24
115.65
ug/g
0.96
65
351
71
419
1.83
4.79
1.2
1.5
—
—
—
0
0
134
943
1.61
4.76
4.4
3.1
—
—
—
0
0
25
97
2.68
4.73
1.2
1.3
429.12
471.69
mg/l
0.34
25
89
32
141
2.37
4.67
3.7
3.8
—
—
—
0
0
16
50
3.29
4.38
1.4
1.2
40.20
5.10
u/ml
—
5
21
12
24
5.11
4.35
1.0
1.2
—
—
—
0
0
45
237
2.00
4.25
2.2
2.5
5.29
7.19
e9/l
0.50
37
192
125
886
1.58
4.24
9.2
6.9
—
—
—
0
0
389
3565
2.00
4.23
26.6
12.5
21.98
22.02
mg/l
0.01
341
2755
217
1736
1.51
4.21
4.7
3.5
0.00
0.01
estimate
0.50
54
324
23
91
2.61
4.20
1.8
1.8
3.25
5.82
iu/l
—
8
31
17
57
3.06
4.17
1.2
1.2
—
—
—
0
0
214
1711
1.50
4.14
4.6
3.4
0.00
0.00
estimate
0.50
62
353
214
1715
1.50
4.07
6.4
4.7
0.00
0.00
estimate
0.50
55
335
9
16
5.72
3.67
1.6
3.3
2374.67
620.75
u/ml
—
9
16
15
51
3.01
3.61
1.2
1.8
—
—
—
0
0
9
17
5.38
3.52
1.4
4.1
22.68
13.72
mu/l
—
9
17
19
76
2.57
3.42
1.2
1.3
—
—
—
0
0
86
585
1.59
3.42
2.0
1.6
1033.87
1178.69
nmol/l
0.85
70
425
57
350
1.73
3.36
2.0
4.1
11.97
19.95
ug/l
0.25
44
291
12
33
3.71
3.31
1.4
1.3
—
—
—
0
0
173
1371
1.44
3.28
4.1
3.3
6.12
5.79
ph
0.90
13
118
16
60
2.73
3.26
4.5
2.5
—
—
—
0
0
27
130
2.15
3.26
2.3
1.8
3.74
4.33
ug/l
0.07
27
118
130
981
1.47
3.18
4.1
3.6
—
—
—
0
0
346
3131
1.55
3.16
31.3
14.9
14.59
14.72
%
0.27
341
3091
278
2413
1.43
3.12
4.6
3.0
96.53
44.88
u/l
2.29
265
2252
67
440
1.62
3.07
1.4
1.2
—
—
—
0
0
12
36
3.40
3.04
4.8
4.0
—
—
—
0
0
29
149
2.02
2.97
4.0
3.5
—
—
—
0
0
12
37
3.31
2.95
1.2
1.3
—
—
—
0
0
13
46
2.88
2.94
1.6
2.7
—
—
—
0
0
18
76
2.43
2.93
2.9
2.4
139.20
119.76
ug/min
—
10
43
22
102
2.22
2.92
1.2
1.4
—
—
—
0
0
14
52
2.75
2.91
4.1
3.5
0.36
1.34
%
1.95
14
47
16
64
2.56
2.90
1.3
5.0
—
—
—
0
0
26
132
2.03
2.76
2.1
1.9
4472.70
3111.76
u/l
—
9
44
31
168
1.91
2.75
2.1
2.5
—
—
—
0
0
13
48
2.76
2.74
5.0
1.9
57.38
60.19
%
0.16
13
48
10
29
3.51
2.70
3.5
3.3
—
—
—
0
0
46
284
1.69
2.68
1.3
1.2
159.98
146.25
iu/ml
0.07
18
123
125
964
1.42
2.66
2.0
1.6
1.62
1.36
mmol/l
1.84
106
815
9
25
3.65
2.59
1.3
1.3
1.81
1.93
mmol/l
—
9
25
122
947
1.40
2.49
4.8
3.7
0.00
0.00
estimate
0.50
56
331
62
421
1.55
2.48
1.9
1.3
—
—
—
0
0
7
16
4.43
2.48
1.1
1.6
—
—
—
0
0
13
51
2.60
2.46
1.7
1.5
—
—
—
0
0
47
299
1.64
2.46
1.1
1.2
—
—
—
0
0
25
132
1.95
2.41
2.7
3.3
23.85
1236.56
u/ml
0.61
20
113
76
544
1.48
2.39
1.3
1.5
—
—
—
0
0
5
8
6.31
2.38
1.2
1.9
—
—
—
0
0
88
658
1.42
2.20
1.6
1.8
—
—
—
0
0
90
677
1.42
2.18
1.3
1.3
29.52
33.32
iu/ml
0.10
21
219
57
393
1.52
2.14
1.6
1.7
—
—
—
0
0
11
43
2.60
2.09
1.5
1.4
—
—
—
0
0
7
20
3.54
2.06
1.1
1.2
—
—
—
0
0
36
226
1.65
2.01
3.8
2.6
—
—
—
0
0
16
80
2.04
1.82
1.2
1.2
—
—
—
0
0
8
29
2.79
1.80
1.0
1.2
—
—
—
0
0
21
118
1.82
1.73
3.9
3.1
0.21
0.19
g/l
0.12
13
40
23
378
0.59
1.73
1.3
1.4
—
—
—
0
0
366
3457
1.41
1.70
6.3
4.3
6.27
5.86
mmol/l
3.74
351
3175
10
40
2.54
1.67
1.1
1.4
—
—
—
0
0
17
90
1.93
1.67
1.2
1.2
—
—
—
0
0
16
83
1.96
1.66
2.4
2.5
—
—
—
0
0
21
120
1.79
1.65
3.5
4.6
—
—
—
0
0
84
657
1.35
1.61
1.3
1.3
1.22
10.54
u/ml
4.18
29
253
6
20
3.03
1.58
1.2
1.3
—
—
—
0
0
8
33
2.45
1.54
1.3
1.2
—
—
—
0
0
24
146
1.68
1.54
1.6
1.7
—
—
—
0
0
5
15
3.36
1.52
1.4
1.3
—
—
—
0
0
5
125
0.39
1.52
12.6
8.2
—
—
—
0
0
7
27
2.62
1.52
1.1
1.2
—
—
—
0
0
46
328
1.45
1.51
1.5
1.4
—
—
—
0
0
390
3744
1.47
1.47
24.4
11.7
—
—
—
0
0
7
28
2.52
1.45
1.1
1.7
—
—
—
0
0
13
66
2.00
1.45
1.2
1.5
—
—
—
0
0
12
59
2.06
1.45
1.3
1.4
275.71
250.14
u/ml
—
7
34
5
16
3.15
1.44
3.2
2.8
10.20
8.56
mmol/l
—
5
16
27
173
1.60
1.44
4.3
2.5
0.19
0.17
e6/l
0.05
27
168
5
17
2.96
1.36
1.0
2.2
1.89
1.02
nmol/l
—
5
12
13
68
1.94
1.34
3.0
3.1
1.68
1.37
mmol/l
0.58
13
68
6
24
2.52
1.31
1.7
1.4
—
—
—
0
0
8
34
2.38
1.30
1.3
1.9
—
—
—
0
0
8
35
2.31
1.27
1.3
1.9
33.13
32.63
pg
—
8
35
35
250
1.44
1.17
1.4
1.3
32.76
44.98
au/ml
—
5
17
24
159
1.54
1.14
1.1
1.0
—
—
—
0
0
20
127
1.60
1.13
1.9
1.6
—
—
—
0
0
7
30
2.35
1.13
1.0
1.2
—
—
—
0
0
7
31
2.28
1.11
1.4
1.5
—
—
—
0
0
376
3621
1.32
1.07
6.1
4.7
2.69
2.83
mmol/l
2.05
351
3339
11
60
1.86
1.03
1.1
1.5
—
—
—
0
0
7
34
2.08
1.03
1.4
1.0
—
—
—
0
0
36
266
1.39
1.02
1.2
1.4
—
—
—
0
0
25
174
1.46
0.97
1.0
1.1
—
—
—
0
0
9
50
1.82
0.97
1.6
1.2
—
—
—
0
0
40
305
1.34
0.95
5.9
3.8
—
—
—
0
0
6
28
2.16
0.92
1.0
1.2
—
—
—
0
0
92
795
1.20
0.80
4.1
3.4
—
—
—
0
0
353
3402
1.21
0.80
5.0
3.8
1.58
1.25
mmol/l
6.56
331
3124
6
33
1.83
0.79
3.2
2.7
—
—
—
0
0
0
27
0.00
0.77
0.0
1.1
—
—
—
0
0
16
107
1.51
0.77
1.3
1.2
—
—
—
0
0
365
3537
1.22
0.72
5.6
4.2
1.41
1.52
mmol/l
4.77
344
3263
34
266
1.30
0.71
4.7
3.2
—
—
—
0
0
12
77
1.57
0.69
4.9
4.6
—
—
—
0
0
7
44
1.60
0.65
1.9
2.6
—
—
—
0
0
11
72
1.54
0.59
7.5
4.1
20.00
30.35
mg/l
—
6
48
6
35
1.72
0.58
1.2
1.1
—
—
—
0
0
365
3556
1.18
0.56
5.6
4.2
4.61
4.76
mmol/l
2.00
344
3298
6
37
1.63
0.55
1.7
2.2
—
—
—
0
0
19
143
1.34
0.53
1.5
1.2
—
—
—
0
0
9
64
1.41
0.51
3.8
3.2
10.08
7.54
mmol/l
—
9
64
17
224
0.75
0.51
1.6
1.7
—
—
—
0
0
7
45
1.56
0.49
3.1
3.0
0.69
0.79
nmol/l
—
7
36
33
272
1.23
0.49
1.3
1.4
—
—
—
0
0
7
49
1.44
0.46
1.3
1.1
—
—
—
0
0
7
49
1.44
0.46
1.0
1.1
—
—
—
0
0
5
84
0.59
0.46
1.0
1.1
—
—
—
0
0
108
992
1.12
0.43
1.5
1.4
—
—
—
0
0
5
31
1.62
0.43
1.2
1.2
0.02
0.42
u/ml
—
5
13
8
58
1.39
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1388.33
—
0
15
29
346
0.83
0.41
1.4
1.6
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
388
3819
1.17
0.39
17.1
9.8
27.83
25.46
u/l
1.59
383
3687
6
46
1.31
0.33
1.2
1.0
—
—
—
0
0
11
142
0.77
0.31
1.9
1.4
—
—
—
0
0
11
142
0.77
0.31
1.9
1.4
—
—
—
0
0
43
382
1.14
0.31
1.5
1.4
—
—
—
0
0
11
141
0.77
0.30
1.9
1.4
—
—
—
0
0
8
110
0.72
0.29
1.3
1.2
—
—
—
0
0
14
112
1.26
0.28
3.6
2.8
—
—
—
0
0
5
71
0.70
0.26
1.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
6.80
—
0
8
6
49
1.23
0.20
1.0
1.2
—
—
—
0
0
72
761
0.94
0.18
5.9
5.0
2.42
2.57
ug/l
0.09
67
672
12
142
0.84
0.17
1.9
1.4
—
—
—
0
0
129
1329
0.96
0.13
4.1
2.7
—
—
—
0
0
402
3997
1.09
0.13
38.5
18.5
271.62
255.15
e9/l
4.65
397
3905
402
3998
1.09
0.12
39.5
18.5
39.80
40.25
%
0.77
383
3775
402
4001
1.08
0.10
38.6
18.5
7.73
6.60
e9/l
17.98
395
3897
402
4001
1.08
0.10
38.5
18.5
4.44
4.48
e12/l
0.91
395
3902
10
87
1.15
0.09
2.2
1.9
—
—
—
0
0
12
133
0.90
0.07
1.8
1.4
—
—
—
0
0
74
762
0.97
0.07
5.8
3.6
1.02
1.02
kg/l
0.36
13
91
22
232
0.95
0.05
1.6
1.5
—
—
—
0
0
25
238
1.05
0.05
1.2
1.3
—
—
—
0
0
44
447
0.98
0.01
3.5
3.0
0.84
0.72
ug/l
0.33
30
293
11
113
0.97
0.00
1.9
1.5
—
—
—
0
0
17
167
1.02
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
44.20
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
79
1.01
-0.00
1.1
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
79
0.88
-0.00
1.6
3.1
17.00
27.34
u/ml
—
7
79
0
8
0.00
-0.00
0.0
3.3
—
6.20
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
60
1.00
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_CUSHING and mortality.

Females

Parameter HR [95% CI] p-value
E4_CUSHING 3.602 [2.92, 4.44] < 0.001
Birth year 0.996 [0.99, 1.0] 0.334

During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 978 females with E4_CUSHING died.

Males

Parameter HR [95% CI] p-value
E4_CUSHING 3.754 [2.69, 5.23] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 409 males with E4_CUSHING died.

Mortality risk

Mortality risk for people of age

years, who have E4_CUSHING.

N-year risk Females Males
1 0.26% 0.602%
5 2.009% 4.136%
10 5.011% 10.054%
15 9.495% 19.573%
20 16.424% 30.551%

Relationships between endpoints

↥

Index endpoint: E4_CUSHING – Cushing syndrome

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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