No definition available.
Pituitary-dependent Cushing's disease
E4_PITUITARY_DEPENDENT_CUSHINGS_DISEASE
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
116 |
4. Check minimum number of eventsNone |
116 |
5. Include endpointsNone |
116 |
6. Filter based on genotype QC (FinnGen only) |
112 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Pituitary-dependent Cushing's disease
based on the number of shared cases.
Similar with more cases:
- Cushing syndrome
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 112 | 88 | 24 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | 46.27 | 44.68 | 52.09 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 116
- Matched controls
- 1160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
164.3
115
*
H02AB09
ATC
hydrocortisone; systemic
223.0
156.8
79
11
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
315.5
65.6
61
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
480.1
57.8
53
*
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
+∞
52.1
46
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
242.1
46.7
45
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
41.0
29.9
37
13
H02AA02
ATC
fludrocortisone; oral
+∞
26.0
24
*
V04CD01
ATC
metyrapone; oral
+∞
26.0
24
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
24.9
23
*
E24.8
ICD-10 Finland
Other Cushing syndrome
+∞
22.6
21
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
126.9
20.3
21
*
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
+∞
19.3
18
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.7
19.2
28
41
C03DA01
ATC
spironolactone; oral
6.6
16.1
31
61
H03AA01
ATC
levothyroxine sodium; systemic
4.5
14.3
56
200
ZXC86
NOMESCO Finland
Use of endoscopic device
157.7
13.8
14
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.8
12.9
37
103
BCA41
NOMESCO Finland
Endoscopic bilateral adrenalectomy
+∞
12.7
12
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
12.7
12
*
E23.00
ICD-10 Finland
Panhypopituitarism
145.0
12.7
13
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
24.6
12.4
17
8
AA4WT
NOMESCO Finland
Selective blood sample from sinus petrosus inferior
+∞
11.6
11
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.1
10.9
39
127
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
10.6
50
197
E24
ICD-10 Finland
Cushing syndrome
+∞
10.6
10
*
A10BA02
ATC
metformin; oral
3.6
10.0
46
177
N04BC06
ATC
cabergoline; oral
60.2
9.8
11
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
60.2
9.8
11
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.3
9.0
20
44
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
96.8
8.5
9
*
E23.03
ICD-10 Finland
Lack of ACTH
96.8
8.5
9
*
2550C
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING E HYPERSECRETIO HYPOFYSEOS]
+∞
8.4
8
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
8.4
8
*
ZXC95
NOMESCO Finland
Use of surgical navigator
36.1
8.2
10
*
C03CA01
ATC
furosemide; systemic
3.3
7.9
39
154
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
4.1
7.6
24
70
C08CA01
ATC
amlodipine; oral
3.0
7.6
51
241
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
85.3
7.5
8
*
L28
ICPC
Limited function/disability (L)
3.7
7.4
27
87
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.1
7.3
39
161
WX882
NOMESCO Finland
High dependency care
21.7
7.3
10
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.1
7.0
36
145
103
Kela drug reimbursment
Diabetes, insulin-treated
3.1
6.9
39
165
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.7
6.9
17
29
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
6.9
37
152
H01AC01
ATC
somatropin; parenteral
73.7
6.5
7
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
73.7
6.5
7
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
73.7
6.5
7
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
6.5
54
281
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
6.4
61
339
A02BC02
ATC
pantoprazole; systemic
3.1
6.3
91
622
E24.3
ICD-10 Finland
Ectopic ACTH syndrome
+∞
6.3
6
*
2550X
ICD-9 Finland
Disorders of adrenal glands, Cushing's syndrome[SYNDROMA CUSHING NUD]
+∞
6.3
6
*
E24.1
ICD-10 Finland
Nelson syndrome
+∞
6.3
6
*
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
6.3
6
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
6.3
22
69
C08CA13
ATC
lercanidipine; oral
3.4
6.2
25
86
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
6.2
56
302
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
6.0
20
60
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
15
44.96
67.11
2.5
1.3
—
—
—
0
0
53
6
159.77
53.38
4.5
1.0
212.66
46.50
nmol/24h
—
53
6
96
439
7.88
19.64
9.9
7.0
1.22
1.22
mmol/l
0.01
78
383
30
49
7.91
18.72
8.9
3.8
24.20
24.80
mmol/l
0.35
30
49
36
92
5.22
13.99
10.6
6.2
0.44
1.82
mmol/l
1.90
27
73
17
6
32.78
13.39
1.2
2.2
—
—
—
0
0
33
107
3.91
9.14
11.3
5.9
105.82
104.27
mmol/l
1.17
33
107
38
136
3.67
9.12
2.6
3.3
0.78
0.81
mmol/l
0.98
38
131
12
5
26.49
9.11
2.5
2.0
73.93
84.60
ug/l
—
12
5
33
111
3.76
8.63
3.2
7.0
0.91
1.04
mmol/l
1.43
33
102
116
999
+∞
7.01
30.7
12.9
139.68
139.84
mmol/l
0.29
116
971
116
1004
+∞
6.56
30.6
13.1
3.90
3.94
mmol/l
1.04
116
976
11
11
10.90
6.18
1.2
1.2
—
—
—
0
0
16
43
4.16
5.59
18.5
7.0
95.61
95.14
%
0.34
16
43
22
75
3.39
5.50
3.8
3.6
—
—
—
0
0
8
5
17.02
5.49
1.0
5.6
56.38
158.20
nmol/l
—
8
5
85
585
2.70
5.37
6.9
10.0
4.96
3.97
e9/l
2.66
77
517
21
72
3.34
5.19
1.8
3.9
2.40
1.73
mmol/l
0.40
15
52
16
48
3.71
4.81
18.5
6.4
1.09
1.29
%
0.40
16
48
16
48
3.71
4.81
18.5
6.4
0.50
0.65
%
1.05
16
48
42
219
2.44
4.75
3.0
2.0
—
—
—
0
0
12
23
5.69
4.60
2.0
2.9
185.53
185.26
%
0.00
12
23
52
309
2.24
4.27
3.4
3.1
—
—
—
0
0
39
213
2.25
3.86
1.5
1.8
0.78
0.79
mg/l
0.02
28
170
67
453
2.13
3.86
3.5
2.4
—
—
—
0
0
11
24
4.95
3.85
2.1
1.5
29.82
37.88
nmol/l
0.54
11
24
44
253
2.19
3.84
3.0
2.8
0.23
0.22
e6/l
0.02
33
189
10
22
4.87
3.52
1.2
1.2
—
—
—
0
0
7
10
7.36
3.41
1.0
1.0
—
—
—
0
0
44
265
2.06
3.34
3.8
3.9
1.94
11.84
mg/mmol
2.43
33
154
58
395
1.94
3.05
18.7
9.5
1.25
1.20
inr
0.16
22
117
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
6
8.63
2.77
1.8
1.0
179.90
131.67
%
—
5
6
29
161
2.07
2.67
2.6
3.2
40.71
33.52
ng/l
0.13
24
110
8
20
4.21
2.62
3.4
4.2
62.38
59.80
%
—
8
20
31
179
2.00
2.56
1.9
1.7
467.08
481.29
pmol/l
0.09
25
151
25
137
2.05
2.37
2.3
2.5
11.52
14.35
umol/l
1.13
25
125
23
123
2.09
2.32
2.1
2.6
2.48
2.48
g/l
0.00
23
110
13
54
2.59
2.29
1.7
1.6
—
—
—
0
0
38
249
1.78
2.11
1.4
1.3
1.11
1.04
u/ml
—
10
77
13
58
2.40
1.99
2.1
2.1
5.30
5.16
ug/l
0.02
13
50
47
334
1.68
1.94
3.6
3.3
17.76
19.98
ng/l
0.32
35
204
6
17
3.66
1.86
1.2
1.1
—
—
—
0
0
23
134
1.89
1.83
1.3
1.6
—
—
—
0
0
61
470
1.63
1.80
3.5
2.8
127.43
78.26
ug/l
0.68
61
441
6
18
3.46
1.77
1.2
1.4
—
—
—
0
0
105
944
2.18
1.70
23.1
11.0
84.83
85.43
ml/min/173m2
0.10
97
754
8
31
2.69
1.69
1.3
1.2
89.75
208.21
e6/l
—
8
24
8
31
2.69
1.69
1.1
1.1
2.25
2.91
e6/l
—
8
22
23
138
1.83
1.68
2.3
2.7
2.47
3.53
e6/l
0.27
13
70
116
1115
+∞
1.53
32.3
18.4
134.79
134.65
g/l
0.04
116
1103
23
147
1.70
1.36
2.3
2.6
0.44
1.03
e6/l
1.28
13
79
28
192
1.60
1.27
1.2
1.3
44.57
26.89
iu/ml
—
8
71
13
71
1.94
1.25
1.5
1.6
—
—
—
0
0
35
257
1.52
1.19
3.7
3.7
0.00
0.00
estimate
-0.00
19
92
7
33
2.19
1.07
1.1
1.8
—
—
—
0
0
7
34
2.13
1.05
1.1
1.9
—
—
—
0
0
57
473
1.40
1.00
6.5
4.9
0.00
0.00
estimate
-0.00
20
92
15
93
1.70
0.99
1.5
1.7
—
—
—
0
0
0
31
0.00
0.98
0.0
1.6
—
—
—
0
0
15
94
1.68
0.96
1.4
1.5
—
—
—
0
0
12
71
1.77
0.93
1.4
3.3
62.05
66.54
g/l
1.09
12
65
47
386
1.37
0.85
1.9
1.9
96.07
101.31
pmol/l
0.32
25
190
8
46
1.79
0.84
1.1
1.6
—
—
—
0
0
57
484
1.35
0.83
4.4
3.5
0.00
0.00
estimate
-0.00
21
97
6
33
1.86
0.80
1.7
1.3
—
—
—
0
0
0
26
0.00
0.79
0.0
1.9
—
—
—
0
0
6
34
1.81
0.77
1.2
1.1
—
—
—
0
0
56
481
1.32
0.73
4.5
3.5
0.00
0.00
estimate
-0.00
17
86
5
28
1.82
0.67
1.2
1.0
—
0.78
—
0
5
45
380
1.30
0.65
4.8
3.5
—
—
—
0
0
11
72
1.58
0.61
1.4
1.3
48.19
142.24
u/ml
2.35
11
67
24
188
1.35
0.57
1.2
1.3
1.21
6.80
u/ml
—
8
78
13
94
1.43
0.48
1.5
1.4
—
—
—
0
0
27
223
1.27
0.45
1.5
1.5
20.36
23.03
nmol/l
0.45
27
190
5
34
1.49
0.41
1.6
1.3
—
—
—
0
0
5
34
1.49
0.41
2.0
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
12
89
1.39
0.39
1.5
1.2
350.10
123.70
iu/ml
—
6
36
6
42
1.45
0.36
1.5
1.4
—
—
—
0
0
6
45
1.35
0.34
1.5
1.3
—
—
—
0
0
27
235
1.19
0.29
1.4
1.4
—
—
—
0
0
13
160
0.79
0.28
1.8
2.1
—
—
—
0
0
5
37
1.37
0.24
1.2
2.9
—
—
—
0
0
11
89
1.26
0.21
2.0
2.6
29.09
29.12
u/l
0.00
11
76
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
74
713
1.10
0.16
3.4
3.4
—
—
—
0
0
10
113
0.87
0.09
1.9
1.7
—
—
—
0
0
5
61
0.81
0.08
1.0
1.0
—
—
—
0
0
5
64
0.77
0.08
1.2
1.3
—
—
—
0
0
14
129
1.10
0.06
4.9
4.4
22.10
23.79
%
—
6
60
11
103
1.08
0.02
9.5
6.6
—
—
—
0
0
24
247
0.96
0.01
1.8
1.6
—
—
—
0
0
14
143
0.98
0.00
1.7
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
706.78
—
0
9
0
8
0.00
-0.00
0.0
1.5
—
6.96
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
15.45
—
0
6
0
5
0.00
-0.00
0.0
4.0
—
15.54
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: E4_PITUITARY_DEPENDENT_CUSHINGS_DISEASE – Pituitary-dependent Cushing's disease
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).