Risteys · C3_PIRIFORMSINUS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Cause of death: ICD-10 — C12& Cause of death: ICD-9 — 1481A Cause of death: ICD-8 — 1481 Cancer registry: Topography ICD-O-3 — C12 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 3 2 out of 7 registries used, show all original rules.	21
4. Check minimum number of events None	21
5. Include endpoints None	21
6. Filter based on genotype QC (FinnGen only)	21

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	21	-	19
Unadjusted period prevalence (%)	0.01	-	0.01
Median age at first event (years)	69.51	-	69.86

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3012095) Magnesium [Moles/volume] in Serum or Plasma

8.91

5.13

8.2

3.2

mmol/l

0.7

0.8

1.10

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

10.90

4.32

1.6

1.1

—

(4035726)

7.43

3.76

1.6

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

8.88

3.51

1.6

2.3

—

(3022313) Gas panel - Capillary blood

8.77

3.09

2.0

4.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

5.03

2.82

2.2

2.4

—

(1761868) Lipid panel - Serum or Plasma

0.00

2.57

0.0

3.4

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

4.23

2.52

4.4

2.4

u/l

51.4

62.9

0.66

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

7.75

2.51

2.2

5.8

mmol/l

26.0

25.0

—

(40758558) Short blood count panel - Blood

3.64

2.05

13.9

8.0

—

(3023368) Bacteria identified in Blood by Culture

3.56

1.99

4.3

4.8

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

3.30

1.75

5.9

5.8

mmol/l

1.2

0.07

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

2.99

1.67

8.6

mmol/l

1.2

0.29

(3033658) Prothrombin time (PT) actual/Normal

3.07

1.64

6.4

3.3

76.9

85.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.39

1.56

1.8

4.7

mmol/l

103.7

103.2

—

(40768804) Tissue Pathology biopsy report

2.83

1.54

4.1

2.3

—

(3032080) INR in Blood by Coagulation assay

2.79

1.48

7.2

10.1

—

1.3

—

(3003694) ABO and Rh group [Type] in Blood

2.60

1.30

1.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.81

1.29

1.3

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.95

1.22

2.4

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.95

1.22

2.2

2.3

—

(3026008) Bacteria identified in Urine by Culture

2.45

1.05

3.0

2.7

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

2.30

0.93

1.5

1.8

28.2

29.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.18

0.83

1.7

1.6

nmol/l

523.3

1142.6

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

2.53

0.83

2.2

4.0

29.8

30.8

—

(3013512) EKG study

1.91

0.72

6.4

4.1

—

(3018418) pH of Serum or Plasma

1.91

0.72

3.6

5.6

—

7.4

—

(42870588) Differential panel, method unspecified - Blood

1.87

0.68

9.8

5.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.63

0.0

3.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.82

0.55

2.7

3.6

—

(36304419) Bacteria [Presence] in Urine

1.73

0.52

3.1

2.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

1.69

0.51

3.1

3.5

umol/l

316.9

386.0

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

105

1.62

0.44

3.8

2.7

u/l

72.6

51.6

0.29

(40761536) Microorganisms panel - Urine sediment

0.00

0.43

0.0

3.7

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.43

0.0

1.7

—

(4010399)

0.00

0.42

0.0

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.70

0.41

1.7

3.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

132

0.65

0.32

4.0

4.5

ug/l

1.2

1.9

1.51

113

(3044889) 12 lead EKG panel

129

0.69

0.25

4.5

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.22

0.0

1.9

—

263.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

3.6

—

0.2

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.22

0.0

1.3

—

(3015736) pH of Urine

1.25

0.21

1.6

3.6

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

41.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.34

0.16

2.6

3.0

—

(3000850) Epithelial cells [#/volume] in Urine

1.18

0.11

1.6

2.7

e6/l

2.2

3.5

—

(3009508) Creatinine [Moles/volume] in Urine

1.10

0.10

2.0

3.3

mmol/l

6.6

8.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.80

0.10

1.6

3.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

1.22

0.09

2.4

4.6

—

0.0

—

(3035350) Ketones [Presence] in Urine by Test strip

1.17

0.09

1.7

3.5

—

0.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

103

1.14

0.02

3.5

4.4

29.6

20.1

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.4

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

3.8

—

4.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3009261) Glucose [Presence] in Urine by Test strip

0.96

0.00

1.6

3.5

—

0.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

12.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(1002224) Polysomnography panel

0.00

0.0

1.2

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.0

1.9

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.0

1.6

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

3.5

—

1.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(4094501)

0.00

0.0

1.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

4.2

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.5

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.0

1.5

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

4.9

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.3

—

30.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.0

1.6

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_PIRIFORMSINUS – Malignant neoplasm of pyriform sinus

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

NAME	C3_PIRIFORMSINUS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C12
COD_ICD_9	1481A
COD_ICD_8	1481
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C12
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	3

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Malignant neoplasm of pyriform sinus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Case counts by code for Malignant neoplasm of pyriform sinus (C3_PIRIFORMSINUS)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints